Lack of Decorin Expression by Human Bladder Cancer Cells Offers New Tools in the Therapy of Urothelial Malignancies

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Sainio, Annele ^a   Nyman, Marie ^a   Lund, Riikka ^a   Vuorikoski, Sanna ^a   Boström, Pia ^a   Laato, Matti ^b   Boström, Peter J ^b   Järveläinen, Hannu ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; DECORIN;

ADULT; AGED; ARTICLE; BLADDER CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER GRADING; CELL PROLIFERATION; CONTROLLED STUDY; CYSTECTOMY; DNA METHYLATION; EXTRACELLULAR MATRIX; FEMALE; GENE TARGETING; GENETIC TRANSDUCTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SMOKING; TRANSITIONAL CELL CARCINOMA; TUMOR INVASION;

ADENOVIRIDAE; ADULT; AGED; AGED, 80 AND OVER; CELL LINE, TUMOR; CELL PROLIFERATION; DECORIN; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; TRANSDUCTION, GENETIC; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 84885409173     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076190     Document Type: Article

References (38)

1. Hynes RO, (2009) The extracellular matrix: not just pretty fibrils. Science 326: 1216-1219.
2. Krusius T, Ruoslahti E, (1986) Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA. Proc Natl Acad Sci USA 83: 7683-7687.
3. Iozzo RV, (1999) The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins. J Biol Chem 274: 18843-18846.
4. Daley WP, Peters SB, Larsen M, (2008) Extracellular matrix dynamics in development and regenerative medicine. J Cell Sci 121: 255-264.
5. Iozzo RV, Murdoch AD, (1996) Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function. FASEB J 10: 598-614.
6. Schaefer L, Iozzo RV, (2008) Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction. J Biol Chem 283: 21305-21309.
7. Danielson KG, Fazzio A, Cohen I, Cannizzaro LA, Eichstetter I, et al. (1993) The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5′ untranslated region, and mapping of the gene to chromosome 12q23. Genomics 15: 146-60.
8. Kobe B, Deisenhofer J, (1993) Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature 366: 751-756.
9. Neill T, Schaefer L, Iozzo RV, (2012) Decorin. A Guardian from the Matrix. Am J Pathol 181: 380-387.
10. Iozzo RV, Chakrani F, Perrotti D, McQuillan DJ, Skorski T, et al. (1999) Cooperative action of germ-line mutations in decorin and P53 accelerates lymphoma tumorigenesis. Proc Natl Acad Sci USA 96: 3092-3097.
11. Theocharis AD, Skandalis SS, Tzanakakis GN, Karamanos NK, (2010) Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting. The FEBS J 277: 3904-3923.
12. Augoff K, Rabczynski J, Tabola R, Czapla L, Ratajczak K, et al. (2008) Immunohistochemical study of decorin expression in polyps and carcinomas of the colon. Med Sci Monit 14: 530-535.
13. Banerjee AG, Liu J, Yuan Y, Gopalakrishnan VK, Johansson SL, et al. (2003) Expression of biomarkers modulating prostate cancer angiogenesis: differential expression of annexin II in prostate carcinomas from India and USA. Mol Cancer 2: 34.
14. Shridhar V, Lee J, Pandita A, Iturria S, Avula R, et al. (2001) Genetic analysis of early-versus late-stage ovarian tumors. Cancer Res 61: 5895-5904.
15. Troup S, Njue C, Kliewer EV, Parisien M, Roskelley C, et al. (2003) Reduced expression of the small leucine-rich proteoglycans, lumican and decorin is associated with poor outcome in node-negative breast cancer. Clin Cancer Res 9: 207-217.
16. Reed CC, Gauldie J, Iozzo RV, (2002) Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin. Oncogene 21: 3688-3695.
17. Reed CC, Waterhouse A, Kirby S, Kay P, Owens RT, et al. (2005) Decorin prevents metastatic spreading of breast cancer. Oncogene 24: 1104-1110.
18. Goldoni S, Iozzo RV, (2008) Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs. Int J Cancer 123: 2473-2479.
19. Boström P, Sainio A, Kakko T, Savontaus M, Söderström M, et al. (2013) Localization of decorin gene expression in normal human breast tissue and in benign and malignant tumors of the human breast. Histochem Cell Biol 139: 161-171.
20. Lu J, Xu Z, Jiang F, Wang Y, Hou Y, et al. (2012) Primary clear cell adenocarcinoma of the bladder with recurrence: a case report and literature review. World J Surg Oncol 10: 33.
21. Dyrskjøt L, Kruhøffer M, Thykjaer T, Marcussen N, Jensen JL, et al. (2004) Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res 64: 4040-4048.
22. Sánchez-Carbayo M, Socci ND, Lozano J, Saint F, Cordon-Cardo C, (2006) Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. J Clin Oncol 24: 778-789.
23. Iozzo RV, Buraschi S, Genua M, Xu SQ, Solomides CC, et al. (2011) Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling. J Biol Chem 286: 34712-34721.
24. Morrione A, Neill T, Iozzo RV (2013) Dichotomy of decorin activity on the insulin-like growth factor-I system. FEBS J doi:10.1111/febs.12149.
25. Vecchione A, Fassan M, Anesti V, Morrione A, Goldoni S, et al. (2009) MITOSTATIN, a putative suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer. Oncogene 28: 257-269.
26. Kilpinen S, Autio R, Ojala K, Iljin K, Bucher E, et al. (2008) Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues. Genome Biol 9: R139.
27. Salomäki HH, Sainio AO, Söderström M, Pakkanen S, Laine J, et al. (2008) Differential expression of decorin by human malignant and benign vascular tumors. J Histochem Cytochem 56: 639-646.
28. Fisher LW, Termine JD, Young MF, (1989) Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. J Biol Chem 264: 4571-4576.
29. Adany R, Heimer R, Caterson B, Sorrell JM, Iozzo RV, (1990) Altered expression of chondroitin sulfate proteoglycan in the stroma of human colon carcinoma. Hypomethylation of PG-40 gene correlates with increased PG-40 content and mRNA levels. J Biol Chem 265: 11389-11396.
30. Scholzen T, Solursh M, Suzuku S, Reiter R, Morgan JL, et al. (1994) The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation. J Biol Chem 269: 28270-28281.
31. Pucci-Minafra I, Cancemi P, Di Cara G, Minafra L, Feo S, et al. (2008) Decorin transfection induces proteomic and phenotypic modulation in breast cancer cells 8701-BC. Connect Tissue Res 49: 30-41.
32. Buraschi S, Neill T, Owens RT, Iniguez LA, Purkins G, et al. (2012) Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model. PLoS One 7: e45559.
33. Shen Z, Shen T, Wientjes MG, O'Donnell MA, Au JL, (2008) Intravesical treatments of bladder cancer: review. Pharm Res 25: 1500-1510.
34. Prasad SM, Decastro GJ, Steinberg GD, (2011) Medscape (2011) Urothelial carcinoma of the bladder: definition, treatment and future efforts. Nat Rev Urol 8: 631-642.
35. Hildebrand A, Romarís M, Rasmussen LM, Heinegård D, Twardzik DR, et al. (1994) Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J 302: 527-534.
36. Bianco P, Fisher LW, Young MF, Termine JD, Robey PG, (1990) Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J Histochem Cytochem 38: 1549-1563.
37. Zhang G, Chen S, Goldoni S, Calder BW, Simpson HC, et al. (2009) Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan. J Biol Chem 284: 8888-8897.
38. Maciejewski CC, Honardoust D, Tredget EE, Metcalfe PD, (2012) Differential expression of class I small leucine-rich proteoglycans in an animal model of partial bladder outlet obstruction. J Urol 188: 1543-1548.