Interleukin-1β orchestrates underlying inflammatory responses in microglia via Krüppel-like factor 4

Journal of Neurochemistry

Volumn 127, Issue 2, 2013, Pages 233-244

  Kaushik, Deepak K ^a   Thounaojam, Menaka C ^a   Kumawat, Kanhaiya L ^a   Gupta, Malvika ^a   Basu, Anirban ^a  

^a NATIONAL BRAIN RESEARCH CENTRE   (India)

Author keywords

brain; cytokines; iNOS; Kr ppel like factor 4; neuroinflammation

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; INTERLEUKIN 6; KRUPPEL LIKE FACTOR 4; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL STIMULATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION; IN VITRO STUDY; MALE; MICROGLIA; MOLECULAR DYNAMICS; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION;

BRAIN; CYTOKINES; INOS; KRÜPPEL-LIKE FACTOR 4; NEUROINFLAMMATION;

ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CYCLOOXYGENASE 2; CYTOKINES; FEMALE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERLEUKIN-1BETA; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICROGLIA; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; NITRIC OXIDE SYNTHASE TYPE II; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; REAL-TIME POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 84885402134     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12382     Document Type: Article

References (37)

1. Basu A., Krady J. K., Enterline J. R., and, Levison S. W., (2002) Transforming growth factor beta1 prevents IL-1beta-induced microglial activation, whereas TNFalpha- and IL-6-stimulated activation are not antagonized. Glia 40, 109-120.
2. Basu A., Krady J. K., and, Levison S. W., (2004) Interleukin-1: a master regulator of neuroinflammation. J. Neurosci. Res. 78, 151-156.
3. Brondello J. M., Pouyssegur J., and, McKenzie F. R,. (1999) Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science 286, 2514-2517.
4. Caretti G., Salsi V., Vecchi C., Imbriano C., and, Mantovani R., (2003) Dynamic recruitment of NF-Y and histone acetyltransferases on cell-cycle promoters. J. Biol. Chem. 278, 30435-30440.
5. Chen B., Tardell C., Higgins B., Packman K., Boylan J. F., and, Niu H., (2012) BRAFV600E negatively regulates the AKT pathway in melanoma cell lines. PLoS ONE 7, e42598.
6. Cullingford T. E., Butler M. J., Marshall A. K., el Tham L., Sugden P. H., and, Clerk A., (2008) Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Biochim. Biophys. Acta 1783, 1229-1236.
7. Davies C. A., Loddick S. A., Toulmond S., Stroemer R. P., Hunt J., and, Rothwell N. J., (1999) The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 19, 87-98.
8. Feinberg M. W., Cao Z., Wara A. K., Lebedeva M. A., Senbanerjee S., and, Jain M. K., (2005) Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages. J. Biol. Chem. 280, 38247-38258.
9. Ghoshal A., Das S., Ghosh S., Mishra M. K., Sharma V., Koli P., Sen E., and, Basu A., (2007) Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis. Glia 55, 483-496.
10. Halle A., Hornung V., Petzold G. C., Stewart C. R., Monks B. G., Reinheckel T., Fitzgerald K. A., Latz E., Moore K. J., and, Golenbock D. T., (2008) The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat. Immunol. 9, 857-865.
11. Katz J. P., Perreault N., Goldstein B. G., Lee C. S., Labosky P. A., Yang V. W., and, Kaestner K. H,. (2002) The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development 129, 2619-2628.
12. Kaushik D. K., Gupta M., Das S., and, Basu A., (2010) Kruppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation. J. Neuroinflammation 7, 68.
13. Kaushik D. K., Mukhopadhyay R., Kumawat K. L., Gupta M., and, Basu A., (2012) Therapeutic targeting of Kruppel-like factor 4 abrogates microglial activation. J. Neuroinflammation 9, 57.
14. Kim Y. J., Hwang S. Y., Oh E. S., Oh S., and, Han I. O., (2006) IL-1beta, an immediate early protein secreted by activated microglia, induces iNOS/NO in C6 astrocytoma cells through p38 MAPK and NF-kappaB pathways. J. Neurosci. Res. 84, 1037-1046.
15. Liao X., Sharma N., Kapadia F., et al,. (2011) Kruppel-like factor 4 regulates macrophage polarization. J. Clin. Investig. 121, 2736-2749.
16. Liu J., Yang T., Liu Y., Zhang H., Wang K., Liu M., Chen G., and, Xiao X., (2012) Kruppel-like factor 4 inhibits the expression of interleukin-1 beta in lipopolysaccharide-induced RAW264.7 macrophages. FEBS Lett. 586, 834-840.
17. Luyendyk J. P., Schabbauer G. A., Tencati M., Holscher T., Pawlinski R., and, Mackman N., (2008) Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages. J. Immunol. 180, 4218-4226.
18. Mariathasan S., and, Monack D. M., (2007) Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat. Rev. 7, 31-40.
19. McMahan C. J., Slack J. L., Mosley B., et al,. (1991) A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J. 10, 2821-2832.
20. McNamee E. N., Ryan K. M., Kilroy D., and, Connor T. J., (2010) Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity. Eur. J. Pharmacol. 626, 219-228.
21. Meda L., Baron P., Prat E., Scarpini E., Scarlato G., Cassatella M. A., and, Rossi F., (1999) Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35]. J. Neuroimmunol. 93, 45-52.
22. Obermeier F., Gross V., Scholmerich J., and, Falk W., (1999) Interleukin-1 production by mouse macrophages is regulated in a feedback fashion by nitric oxide. J. Leukoc. Biol. 66, 829-836.
23. Ogimoto K., Harris M. K., Jr, and, Wisse B. E., (2006) MyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 beta. Endocrinology 147, 4445-4453.
24. Pathak S. K., Bhattacharyya A., Pathak S., Basak C., Mandal D., Kundu M., and, Basu J., (2004) Toll-like receptor 2 and mitogen- and stress-activated kinase 1 are effectors of Mycobacterium avium-induced cyclooxygenase-2 expression in macrophages. J. Biol. Chem. 279, 55127-55136.
25. Peng D. J., Zhou J. Y., and, Wu G. S., (2010) Post-translational regulation of mitogen-activated protein kinase phosphatase-2 (MKP-2) by ERK. Cell cycle 9, 4650-4655.
26. Perrella M. A., Patterson C., Tan L., Yet S. F., Hsieh C. M., Yoshizumi M., and, Lee M. E., (1996) Suppression of interleukin-1beta-induced nitric-oxide synthase promoter/enhancer activity by transforming growth factor-beta1 in vascular smooth muscle cells. Evidence for mechanisms other than NF-kappaB. J. Biol. Chem. 271, 13776-13780.
27. Pinteaux E., Parker L. C., Rothwell N. J., and, Luheshi G. N., (2002) Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells. J. Neurochem. 83, 754-763.
28. Ravichandran K., Tyagi A., Deep G., Agarwal C., and, Agarwal R., (2011) Interleukin-1beta-induced iNOS expression in human lung carcinoma A549 cells: involvement of STAT and MAPK pathways. Indian J. Exp. Biol. 49, 840-847.
29. Rothwell N. J., and, Luheshi G. N., (2000) Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci. 23, 618-625.
30. Ryu S. Y., Jeong K. S., Kang B. N., Park S. J., Yoon W. K., Kim S. H., and, Kim T. H., (2000) Modulation of transferrin synthesis, transferrin receptor expression, iNOS expression and NO production in mouse macrophages by cytokines, either alone or in combination. Anticancer Res. 20, 3331-3338.
31. Saper C. B., and, Breder C. D,. (1992) Endogenous pyrogens in the CNS: role in the febrile response. Prog. Brain Res. 93, 419-428. discussion 428-419.
32. Segre J. A., Bauer C., and, Fuchs E., (1999) Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat. Genet. 22, 356-360.
33. Sheng W., Zong Y., Mohammad A., et al,. (2011) Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA(2)-IIA expression in astrocytes and microglia. J. Neuroinflammation 8, 121.
34. Toda Y., Tsukada J., Misago M., Kominato Y., Auron P. E., and, Tanaka Y., (2002) Autocrine induction of the human pro-IL-1beta gene promoter by IL-1beta in monocytes. J. Immunol. 168, 1984-1991.
35. Tsujino M., Hirata Y., Imai T., Kanno K., Eguchi S., Ito H., and, Marumo F., (1994) Induction of nitric oxide synthase gene by interleukin-1 beta in cultured rat cardiocytes. Circulation 90, 375-383.
36. Turke A. B., Song Y., Costa C., Cook R., Arteaga C. L., Asara J. M., and, Engelman J. A., (2012) MEK inhibition leads to PI3K/AKT activation by relieving a negative feedback on ERBB receptors. Cancer Res. 72, 3228-3237.
37. Wong H. R., Finder J. D., Wasserloos K., Lowenstein C. J., Geller D. A., Billiar T. R., Pitt B. R., and, Davies P., (1996) Transcriptional regulation of iNOS by IL-1 beta in cultured rat pulmonary artery smooth muscle cells. Am. J. Physiol. 271, L166-L171.