Association of Multiple Sclerosis Susceptibility Variants and Early Attack Location in the CNS

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Mowry, Ellen M ^a   Carey, Robert F ^b   Blasco, Maria R ^c   Pelletier, Jean ^d   Duquette, Pierre ^e   Villoslada, Pablo ^f   Malikova, Irina ^d   Roger, Elaine ^e   Kinkel, R Phillip ^g   McDonald, Jamie ^b   Bacchetti, Peter ^h   Waubant, Emmanuelle ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^d TIMONE HOSPITAL   (France)

^e CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^f BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^g HARVARD MEDICAL SCHOOL   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CD6 ANTIGEN; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERLEUKIN 12P35; INTERLEUKIN 17 RECEPTOR; PLACEBO;

ADULT; ANALYTICAL ERROR; ARTICLE; BRAIN STEM; CAUCASIAN; CD6 GENE; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; IL12A GENE; IL7R GENE; IRF8 GENE; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL PARAMETERS; MULTIPLE SCLEROSIS; OPTIC NEURITIS; RETROSPECTIVE STUDY; SPINAL CORD; TNFRSF1A GENE;

ADULT; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CEREBELLUM; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MULTIPLE SCLEROSIS; OPTIC NEURITIS; POLYMORPHISM, GENETIC; SPINAL CORD;

EID: 84885399550     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075565     Document Type: Article

References (27)

1. Mowry EM, Deen S, Malikova I, Pelletier J, Bacchetti P, et al. (2009) The onset location of multiple sclerosis predicts the location of subsequent relapses. J? Neurol Neurosurg Psychiatry 80: 400-403.
2. Kinkel RP, Kollman C, O'Connor P, Murray TJ, Simon J, et al. (2006) IM interferon beta-1a delays definite multiple sclerosis 5 years after a first demyelinating event. Neurology 66: 678-684.
3. Beck RW, Clearly PA, Anderson MM, Keltner JL, Shults WT, et al. (1992) A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. N? Engl? J? Med 326: 581-588.
4. Waubant E, Pelletier D, Mass M, Cohen JA, Kita M, et al. (2012) Randomized controlled trial of atorvastatin in CIS: the STAyCIS study. Neurology 78: 1171-1178.
5. Marcus JF, Spain RI, McDonald J, Julian LJ, Okuda DT, et al. (2010) Baseline data and rationale for study of riluzole for neuroprotection in early relapsing remitting multiple sclerosis. Mult Scler 16: 1004.
6. Confavreux C, (1994) Establishment and use of multiple sclerosis registers-EDMUS. Ann Neurol 36: S136-139.
7. Toledo J, Sepulcre J, Salinas-Alaman A, Garcia-Layana A, Murie-Fernandez M, et al. (2008) Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis. Mult Scler 14: 906-912.
8. Optic Neuritis Study Group (1991) The clinical profile of optic neuritis: experience of the optic neuritis treatment trial. Arch Ophthalmol 109;1673-1678.
9. Jacobs LD, Beck RW, Simon JH, Kinkel RP, Brownscheidle CM, et al. (2000) Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS study group. N? Engl? J? Med 343: 898-904.
10. International Multiple Sclerosis Genetics Consortium (2007) Risk alleles for multiple sclerosis identified by a genomewide study. N? Engl? J? Med 357: 851-862.
11. International Multiple Sclerosis Genetics Consortium (2010) Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci. Hum Mol Gen 19: 953-962.
12. DeJager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, et al. (2009) The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci? U? S? A 106: 5264-5269.
13. Ban M, Goris A, Lorentzen AR, Baker A, Mihalova T, et al. (2009) Replication analysis identifies TYK2 as a multiple sclerosis susceptibility gene. Eur? J? Hum Genet 17: 1309-1013.
14. DeJager PL, Jia X, Wang J, deBakker PI, Ottoboni L, et al. (2009) Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 41: 776-782.
15. Australia and New Zealand Multiple Sclerosis Genetics Consortium (2009) Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat Genet 41: 824-828.
16. Baranzini SE, Wang J, Gibson RA, Galwey N, Naegelin Y, et al. (2009) Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet 18: 767-778.
17. Johnson BA, Wang J, Taylor EM, Caillier SJ, Herbert J, et al. (2010) Multiple sclerosis susceptibility alleles in African Americans. Genes Immun 11: 343-350.
18. Hoppenbrouwers IA, Aulchenko YS, Janssens AC, Ramagopalan SV, Broer L, et al. (2009) Replication of CD58 and CLEC16 as genome-wide significant risk genes for multiple sclerosis. J? Hum Genet 54: 676-680.
19. International Multiple Sclerosis Genetics Consortium (2009) The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes Immun 10: 11-14.
20. International Multiple Sclerosis Genetics Consortium (2010) IL12A, PHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes Immun 11: 397-405.
21. Kress-Bennett JM, Ehrlich GD, Bruno A, Post JC, Hu FZ, et al. (2011) Preliminary study: treatment with intramuscular interferon beta-1a results in increased levels of IL12Rβ2+ and decreased levels of IL23R+ CD4+ T-lymphocytes in multiple sclerosis. BMC Neurol 11: 155.
22. Deen S, Bacchetti P, High A, Bostrom A, Waubant E, (2008) Predictors of the location of multiple sclerosis relapse. J? Neurol Neurosurg Psychiatry 79: 1190-1193.
23. Beck RW, Chandler DL, Cole SR, Simon JH, Jacobs LD, et al. (2002) Interferon beta-1a for early multiple sclerosis: CHAMPS trial subgroup analysis. Ann Neurol 51: 481-490.
24. Miyagawa F, Zhang H, Terunuma A, Ozato K, Tagaya Y, et al. (2012) Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8+ T cells. Proc Natl Acad Sci? U? S? A 109: 12123-12128.
25. Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, et al. (2007) Interleukin 7 receptor α chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet 39: 1083-1091.
26. Kofler DM, Severson CA, Mousissian N, DeJager PL, Hafler DA, (2011) The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation. J? Immunol 187: 3286-2391.
27. Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, et al. (2011) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476: 214-219.