Hypofractionated whole breast irradiation for patients with large breasts: A randomized trial comparing prone and supine positions

Radiotherapy and Oncology

Volumn 108, Issue 2, 2013, Pages 203-208

  Mulliez, Thomas ^a   Veldeman, Liv ^a   Van Greveling, Annick ^a   Speleers, Bruno ^a   Sadeghi, Simin ^a   Berwouts, Dieter ^a   Decoster, Frederik ^a   Vercauteren, Tom ^a   De Gersem, Werner ^a   Van Den Broecke, Rudy ^a   De Neve, Wilfried ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Acute toxicity; Breast cancer; Hypofractionation; Prone; Radiotherapy

Indexed keywords

ADULT; ARTICLE; BODY POSTURE; BREAST CANCER; COMPARATIVE STUDY; CONTROLLED STUDY; DERMATITIS; EDEMA; FEMALE; HUMAN; INTENSITY MODULATED RADIATION THERAPY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MAJOR CLINICAL STUDY; MASTALGIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; PRURITUS; RADIATION DOSE FRACTIONATION; RANDOMIZED CONTROLLED TRIAL; SKIN EXFOLIATION; SUPINE POSITION;

ACUTE TOXICITY; BREAST CANCER; HYPOFRACTIONATION; PRONE; RADIOTHERAPY;

ADULT; AGED; AGED, 80 AND OVER; BELGIUM; BREAST; BREAST NEOPLASMS; DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; HOSPITALS, UNIVERSITY; HUMANS; HYPERTROPHY; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PATIENT POSITIONING; PROGNOSIS; PRONE POSITION; PROSPECTIVE STUDIES; RADIATION INJURIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY, INTENSITY-MODULATED; RISK ASSESSMENT; SUPINE POSITION; TREATMENT OUTCOME;

EID: 84885390959     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2013.08.040     Document Type: Article

References (33)

1. S. Darby, P. McGale, and C. Correa Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials Lancet 378 2011 1707 1716
2. V. Vinh-Hung, and C. Verschraegen Breast-conserving surgery with or without radiotherapy: pooled-analysis for risks of ipsilateral breast tumor recurrence and mortality J Natl Cancer Inst 96 2004 115 121
3. K.E. Henson, P. McGale, C. Taylor, and S.C. Darby Radiation-related mortality from heart disease and lung cancer more than 20 years after radiotherapy for breast cancer Br J Cancer 108 2013 179 182
4. S.C. Darby, P. McGale, C.W. Taylor, and R. Peto Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registries Lancet Oncol 6 2005 557 565
5. J. Cuzick, H. Stewart, and L. Rutqvist Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy J Clin Oncol 12 1994 447 453
6. S.C. Darby, M. Ewertz, and P. McGale Risk of ischemic heart disease in women after radiotherapy for breast cancer N Engl J Med 368 2013 987 998
7. J. Cuzick, H. Stewart, and R. Peto Overview of randomized trials of postoperative adjuvant radiotherapy in breast cancer Cancer Treat Rep 71 1987 15 29
8. J.P. Pignol, I. Olivotto, and E. Rakovitch A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis J Clin Oncol 26 2008 2085 2092
9. E. Donovan, N. Bleakley, and E. Denholm Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy Radiother Oncol 82 2007 254 264
10. S.C. Formenti, D. Gidea-Addeo, and J.D. Goldberg Phase I-II trial of prone accelerated intensity modulated radiation therapy to the breast to optimally spare normal tissue J Clin Oncol 25 2007 2236 2242
11. S.C. Formenti, J.K. DeWyngaert, G. Jozsef, and J.D. Goldberg Prone vs. supine positioning for breast cancer radiotherapy JAMA 308 2012 861 863
12. A.M. Kirby, P.M. Evans, E.M. Donovan, H.M. Convery, J.S. Haviland, and J.R. Yarnold Prone versus supine positioning for whole and partial-breast radiotherapy: a comparison of non-target tissue dosimetry Radiother Oncol 96 2010 178 184
13. S.C. Lymberis, J.K. Dewyngaert, and P. Parhar Prospective assessment of optimal individual position (prone versus supine) for breast radiotherapy: volumetric and dosimetric correlations in 100 patients Int J Radiat Oncol Biol Phys 84 2012 902 909
14. L. Veldeman, B. Speleers, and M. Bakker Preliminary results on setup precision of prone-lateral patient positioning for whole breast irradiation Int J Radiat Oncol Biol Phys 78 2010 111 118
15. L. Veldeman, W. De Gersem, and B. Speleers Alternated prone and supine whole-breast irradiation using IMRT: setup precision, respiratory movement and treatment time Int J Radiat Oncol Biol Phys 82 2012 2055 2064
16. J. Buijsen, J.J. Jager, and J. Bovendeerd Prone breast irradiation for pendulous breasts Radiother Oncol 82 2007 337 340
17. K.L. Griem, P. Fetherston, M. Kuznetsova, G.S. Foster, S. Shott, and J. Chu Three-dimensional photon dosimetry: a comparison of treatment of the intact breast in the supine and prone position Int J Radiat Oncol Biol Phys 57 2003 891 899
18. T. Mulliez, B. Speleers, I. Madani, W. De Gersem, L. Veldeman, and W. De Neve Whole breast radiotherapy in prone and supine position: is there a place for multi-beam IMRT? Radiat Oncol 8 2013 151
19. S.T. Group, S.M. Bentzen, and R.K. Agrawal The UK standardisation of breast radiotherapy (START) trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial Lancet 371 2008 1098 1107
20. A. Trotti, A.D. Colevas, and A. Setser CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment Semin Radiat Oncol 13 2003 176 181
21. A. Harsolia, L. Kestin, and I. Grills Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy Int J Radiat Oncol Biol Phys 68 2007 1375 1380
22. C. Bergom, T. Kelly, and N. Morrow Prone whole-breast irradiation using three-dimensional conformal radiotherapy in women undergoing breast conservation for early disease yields high rates of excellent to good cosmetic outcomes in patients with large and/or pendulous breasts Int J Radiat Oncol Biol Phys 83 2012 821 828
23. T.E. Merchant, and B. McCormick Prone position breast irradiation Int J Radiat Oncol Biol Phys 30 1994 197 203
24. R. Hannan, R.F. Thompson, and Y. Chen Hypofractionated whole-breast radiation therapy: does breast size matter? Int J Radiat Oncol Biol Phys 84 2012 894 901
25. M.E. Hardee, S. Raza, and S.J. Becker Prone hypofractionated whole-breast radiotherapy without a boost to the tumor bed: comparable toxicity of IMRT versus a 3D conformal technique Int J Radiat Oncol Biol Phys 82 2012 e415 e423
26. L.D. Stegman, K.P. Beal, M.A. Hunt, M.N. Fornier, and B. McCormick Long-term clinical outcomes of whole-breast irradiation delivered in the prone position Int J Radiat Oncol Biol Phys 68 2007 73 81
27. P.A. Lind, R. Pagnanelli, and L.B. Marks Myocardial perfusion changes in patients irradiated for left-sided breast cancer and correlation with coronary artery distribution Int J Radiat Oncol Biol Phys 55 2003 914 920
28. R.G. Prosnitz, J.L. Hubbs, and E.S. Evans Prospective assessment of radiotherapy-associated cardiac toxicity in breast cancer patients: analysis of data 3-6 years after treatment Cancer 110 2007 1840 1850
29. L.B. Marks, X. Yu, and R.G. Prosnitz The incidence and functional consequences of RT-associated cardiac perfusion defects Int J Radiat Oncol Biol Phys 63 2005 214 223
30. C.W. Taylor, D. Bronnum, and S.C. Darby Cardiac dose estimates from Danish and Swedish breast cancer radiotherapy during 1977-2001 Radiother Oncol 100 2011 176 183
31. Z. Varga, K. Hideghety, T. Mezo, A. Nikolenyi, L. Thurzo, and Z. Kahan Individual positioning: a comparative study of adjuvant breast radiotherapy in the prone versus supine position Int J Radiat Oncol Biol Phys 75 2009 94 100
32. V.M. Remouchamps, F.A. Vicini, M.B. Sharpe, L.L. Kestin, A.A. Martinez, and J.W. Wong Significant reductions in heart and lung doses using deep inspiration breath hold with active breathing control and intensity-modulated radiation therapy for patients treated with locoregional breast irradiation Int J Radiat Oncol Biol Phys 55 2003 392 406
33. K.E. Sixel, M.C. Aznar, and Y.C. Ung Deep inspiration breath hold to reduce irradiated heart volume in breast cancer patients Int J Radiat Oncol Biol Phys 49 2001 199 204