A class II phosphoinositide 3-kinase plays an indispensable role in hepatitis C virus replication

Biochemical and Biophysical Research Communications

Volumn 440, Issue 1, 2013, Pages 150-156

  Maehama, Tomohiko ^a   Fukasawa, Masayoshi ^a   Date, Tomoko ^a   Wakita, Takaji ^a   Hanada, Kentaro ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Hepatitis C virus (HCV); Phosphoinositide; Phosphoinositide 3 kinase (PI3K)

Indexed keywords

CORE PROTEIN; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3,4 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE 3 KINASE; RNA ISOFORM;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENE LOCATION; GENE SILENCING; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; REPLICON; VIRUS INHIBITION; VIRUS REPLICATION;

HEPATITIS C VIRUS (HCV); PHOSPHOINOSITIDE; PHOSPHOINOSITIDE 3-KINASE (PI3K);

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; GENE KNOCKDOWN TECHNIQUES; HEPACIVIRUS; HEPATITIS C; HOST-PATHOGEN INTERACTIONS; HUMANS; LIVER; LIVER NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; VIRAL CORE PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 84885385773     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.09.048     Document Type: Article

References (26)

1. Di Paolo G., De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature 2006, 443:651-657.
2. Kutateladze T.G. Translation of the phosphoinositide code by PI effectors. Nat. Chem. Biol. 2010, 6:507-513.
3. Levrero M. Viral hepatitis and liver cancer: the case of hepatitis C. Oncogene 2006, 25:3834-3847.
4. Dubuisson J. Hepatitis C virus proteins. World J. Gastroenterol. 2007, 13:2406-2415.
5. Jones D.M., McLauchlan J. Hepatitis C virus: assembly and release of virus particles. J. Biol. Chem. 2010, 285:22733-22739.
6. Joyce M.A., Tyrrell D.L. The cell biology of hepatitis C virus. Microbes Infect. 2010, 12:263-271.
7. Ogawa K., Hishiki T., Shimizu Y., Funami K., Sugiyama K., Miyanari Y., Shimotohno K. Hepatitis C virus utilizes lipid droplet for production of infectious virus. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 2009, 85:217-228.
8. Berger K.L., Cooper J.D., Heaton N.S., Yoon R., Oakland T.E., Jordan T.X., Mateu G., Grakoui A., Randall G. Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. Proc. Natl. Acad. Sci. USA 2009, 106:7577-7582.
9. Borawski J., Troke P., Puyang X., Gibaja V., Zhao S., Mickanin C., Leighton-Davies J., Wilson C.J., Myer V., Cornellataracido I., Baryza J., Tallarico J., Joberty G., Bantscheff M., Schirle M., Bouwmeester T., Mathy J.E., Lin K., Compton T., Labow M., Wiedmann B., Gaither L.A. Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication. J. Virol. 2009, 83:10058-10074.
10. Tai A.W., Benita Y., Peng L.F., Kim S.S., Sakamoto N., Xavier R.J., Chung R.T. A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe 2009, 5:298-307.
11. Trotard M., Lepere-Douard C., Regeard M., Piquet-Pellorce C., Lavillette D., Cosset F.L., Gripon P., Le Seyec J. Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening. FASEB J. 2009, 23:3780-3789.
12. Vaillancourt F.H., Pilote L., Cartier M., Lippens J., Liuzzi M., Bethell R.C., Cordingley M.G., Kukolj G. Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication. Virology 2009, 387:5-10.
13. Reiss S., Rebhan I., Backes P., Romero-Brey I., Erfle H., Matula P., Kaderali L., Poenisch M., Blankenburg H., Hiet M.S., Longerich T., Diehl S., Ramirez F., Balla T., Rohr K., Kaul A., Buhler S., Pepperkok R., Lengauer T., Albrecht M., Eils R., Schirmacher P., Lohmann V., Bartenschlager R. Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe 2011, 9:32-45.
14. Lim Y.S., Hwang S.B. Hepatitis C virus NS5A protein interacts with phosphatidylinositol 4-kinase type III alpha and regulates viral propagation. J. Biol. Chem. 2011, 286:11290-11298.
15. Reiss S., Harak C., Romero-Brey I., Radujkovic D., Klein R., Ruggieri A., Rebhan I., Bartenschlager R., Lohmann V. The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A. PLoS Pathog. 2013, 9:e1003359.
16. Street A., Macdonald A., Crowder K., Harris M. The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade. J. Biol. Chem. 2004, 279:12232-12241.
17. Street A., Macdonald A., McCormick C., Harris M. Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription. J. Virol. 2005, 79:5006-5016.
18. Miyamoto M., Kato T., Date T., Mizokami M., Wakita T. Comparison between subgenomic replicons of hepatitis C virus genotypes 2a (JFH-1) and 1b (Con1 NK5.1). Intervirology 2006, 49:37-43.
19. Date T., Miyamoto M., Kato T., Morikawa K., Murayama A., Akazawa D., Tanabe J., Sone S., Mizokami M., Wakita T. An infectious and selectable full-length replicon system with hepatitis C virus JFH-1 strain. Hepatol. Res. 2007, 37:433-443.
20. Zhang Y.Y., Zhang B.H., Ishii K., Liang T.J. Novel function of CD81 in controlling hepatitis C virus replication. J. Virol. 2010, 84:3396-3407.
21. Posor Y., Eichhorn-Gruenig M., Puchkov D., Schoneberg J., Ullrich A., Lampe A., Muller R., Zarbakhsh S., Gulluni F., Hirsch E., Krauss M., Schultz C., Schmoranzer J., Noe F., Haucke V. Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate. Nature 2013, 499:233-237.
22. 2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. Biochem. J. 2002, 361:525-536.
23. Furutani M., Tsujita K., Itoh T., Ijuin T., Takenawa T. Application of phosphoinositide-binding domains for the detection and quantification of specific phosphoinositides. Anal. Biochem. 2006, 355:8-18.
24. Yokogawa T., Nagata S., Nishio Y., Tsutsumi T., Ihara S., Shirai R., Morita K., Umeda M., Shirai Y., Saitoh N., Fukui Y. Evidence that 3'-phosphorylated polyphosphoinositides are generated at the nuclear surface: use of immunostaining technique with monoclonal antibodies specific for PI 3,4-P(2). FEBS Lett. 2000, 473:222-226.
25. Bishe B., Syed G.H., Field S.J., Siddiqui A. Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion. J. Biol. Chem. 2012, 287:27637-27647.
26. Miyanari Y., Atsuzawa K., Usuda N., Watashi K., Hishiki T., Zayas M., Bartenschlager R., Wakita T., Hijikata M., Shimotohno K. The lipid droplet is an important organelle for hepatitis C virus production. Nat. Cell Biol. 2007, 9:1089-1097.