Amorphous dispersion formulation development: Phase-appropriate integrated approaches to optimizing performance, manufacturability, stability & dosage form

Drug Development and Delivery

Volumn 13, Issue 6, 2013, Pages 30-37

  Baumann, John ^a   Dobry, Dan ^a   Ray, Rod ^b  

^a OREGON STATE UNIVERSITY   (United States)

^b Bend Research Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMORPHOUS DISPERSION FORMULATION; ARTICLE; CRYSTALLIZATION; DISPERSION; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG MANUFACTURE; DRUG STABILITY; IN VITRO STUDY; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; SPRAY DRYING; TABLET COMPRESSION; TABLET FORMULATION; TABLET HARDNESS;

EID: 84885366608     PISSN: 15372898     EISSN: 1944818X     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (5)

1. Bloom CJ, Lyon DK. Formulation selection: amorphous dispersions & other tools for drug discovery formulation support. Drug Dev Delivery. 2013;13(3):32-37.
2. Butler J, Dressman J. The developability classification system: application of biopharmaceutics concepts to formulation development. J Pharm Sci. 2010;99:4940-4954.
3. Friesen DT, Shanker RM, Crew MD, Smithey DT, Curatolo WJ, Nightingale JAS. Hydroxypropyl methylcellulose acetate succinate-based spray-dried dispersions: an overview. Mol Pharm. 2008;5(6):1003-1019.
4. Dobry D, Settell DM, Baumann JM, Ray RJ, Graham LJ, Beyerinck RA. A modelbased methodology for spray-drying process development. J Pharm Innovat. 2009;4(3):133-142.
5. Bloom CJ, Marsac P, Jordan FD, Sather CA, Vodak DT, Lowinger M, Liu HXi, Lupton L. Prediction of crystallization kinetics for a spray-dried dispersion using isothermal calorimetry. Poster 3293 presented at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, Chicago, Illinois, October 14-18, 2012.