Establishment of MLL/AF4 transgenic mice with the phenotype of lymphoblastic leukemia or lymphoma

Journal of Nippon Medical School

Volumn 80, Issue 5, 2013, Pages 326-327

  Tamai, Hayato ^a   Inokuchi, Koiti ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCYCLIN; MIXED LINEAGE LEUKEMIA PROTEIN; TRANSCRIPTION FACTOR HOXA9;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANEMIA; ANIMAL MODEL; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HEPATOSPLENOMEGALY; HUMAN; HUMAN CELL; KARYOTYPING; LEUKEMOGENESIS; MOUSE; NONHUMAN; NOTE; PHENOTYPE; WESTERN BLOTTING;

ANIMALS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, LEUKEMIC; GENOTYPE; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; PHENOTYPE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TIME FACTORS; UP-REGULATION;

EID: 84885351693     PISSN: 13454676     EISSN: 13473409     Source Type: Journal    
DOI: 10.1272/jnms.80.326     Document Type: Note

References (3)

1. Pui CH, Gaynon PS, Boyett JM, et al.: Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region. Lancet 2002; 359: 1909-1915.
2. Tamai H, Miyake K, Takatori M, et al.: Activated K-Ras protein accelerates human MLL/AF4-induced leukemolymphomogenicity in a transgenic mouse model. Leukemia 2011; 25: 888-891.
3. Tamai H, Miyake K, Yamaguchi H, et al.: AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4-positive ALL model mice. Blood 2012; 119: 64-71.