Pax7 is critical for the normal function of satellite cells in adult skeletal muscle

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 41, 2013, Pages 16474-16479

  Von Maltzahn, Julia ^a,b   Jones, Andrew E ^a,b   Parks, Robin J ^a   Rudnicki, Michael A ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

CreERT2; Stem cell

Indexed keywords

MYOGENIC FACTOR; TAMOXIFEN; TRANSCRIPTION FACTOR PAX7;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL EXPANSION; CELL FUNCTION; CELL GROWTH; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; MOUSE; MUSCLE DEVELOPMENT; MUSCLE REGENERATION; MYOBLAST; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SKELETAL MUSCLE; SKELETAL MUSCLE SATELLITE CELL;

CREERT2; STEM CELL;

ANIMALS; BLOTTING, WESTERN; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; MICE; MUSCLE DEVELOPMENT; MUSCLE, SKELETAL; PAX7 TRANSCRIPTION FACTOR; REGENERATION; SATELLITE CELLS, SKELETAL MUSCLE; TAMOXIFEN;

EID: 84885340880     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1307680110     Document Type: Article

References (24)

1. Relaix F, et al. (2006) Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells. J Cell Biol 172(1):91-102.
2. Lepper C, Partridge TA, Fan CM (2011) An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration. Development 138(17):3639-3646.
3. Sambasivan R, et al. (2011) Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration. Development 138(17):3647-3656.
4. Seale P, Ishibashi J, Scimè A, Rudnicki MA (2004) Pax7 is necessary and sufficient for the myogenic specification of CD45+:Sca1+ stem cells from injured muscle. PLoS Biol 2(5):E130.
5. Oustanina S, Hause G, Braun T (2004) Pax7 directs postnatal renewal and propagation of myogenic satellite cells but not their specification. EMBO J 23(16):3430-3439.
6. Yin H, Price F, Rudnicki MA (2013) Satellite cells and the muscle stem cell niche. Physiol Rev 93(1):23-67.
7. von Maltzahn J, Chang NC, Bentzinger CF, Rudnicki MA (2012) Wnt signaling in myogenesis. Trends Cell Biol 22(11):602-609.
8. Bentzinger CF, et al. (2013) Fibronectin regulates Wnt7a signaling and satellite cell expansion. Cell Stem Cell 12(1):75-87.
9. Bentzinger CF, Wang YX, Rudnicki MA (2012) Building muscle: Molecular regulation of myogenesis. Cold Spring Harb Perspect Biol 4(2):a008342.
10. Bentzinger CF, Wang YX, von Maltzahn J, Rudnicki MA (2012) The emerging biology of muscle stem cells: Implications for cell-based therapies. BioEssays 35(3):231-241.
11. Seale P, et al. (2000) Pax7 is required for the specification of myogenic satellite cells. Cell 102(6):777-786.
12. Kuang S, Chargé SB, Seale P, Huh M, Rudnicki MA (2006) Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis. J Cell Biol 172(1):103-113.
13. McKinnell IW, et al. (2008) Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex. Nat Cell Biol 10(1):77-84.
14. Kawabe Y, Wang YX, McKinnell IW, Bedford MT, Rudnicki MA (2012) Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Cell Stem Cell 11(3):333-345.
15. Olguin HC, Olwin BB (2004) Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: A potential mechanism for self-renewal. Dev Biol 275(2): 375-388.
16. Olguin HC, Yang Z, Tapscott SJ, Olwin BB (2007) Reciprocal inhibition between Pax7 and muscle regulatory factors modulates myogenic cell fate determination. J Cell Biol 177(5):769-779.
17. Soleimani VD, et al. (2012) Transcriptional dominance of Pax7 in adult myogenesis is due to high-affinity recognition of homeodomain motifs. Dev Cell 22(6):1208-1220.
18. Lepper C, Conway SJ, Fan CM (2009) Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements. Nature 460(7255):627-631.
19. Chargé SB, Rudnicki MA (2004) Cellular and molecular regulation of muscle regeneration. Physiol Rev 84(1):209-238.
20. Kuang S, Kuroda K, Le Grand F, Rudnicki MA (2007) Asymmetric self-renewal and commitment of satellite stem cells in muscle. Cell 129(5):999-1010.
21. Yin H, et al. (2013) MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metab 17(2):210-224.
22. Seale P, Ishibashi J, Holterman C, Rudnicki MA (2004) Muscle satellite cell-specific genes identified by genetic profiling of MyoD-deficient myogenic cell. Dev Biol 275(2):287-300.
23. Huh MS, Parker MH, Scimè A, Parks R, Rudnicki MA (2004) Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation. J Cell Biol 166(6):865-876.
24. von Maltzahn J, Bentzinger CF, Rudnicki MA (2012) Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle. Nat Cell Biol 14(2):186-191.