Direct, quantitative, and noninvasive imaging of the transport of active agents through intact brain with positron emission tomography

Molecular Imaging and Biology

Volumn 15, Issue 5, 2013, Pages 596-605

  Sirianni, Rachael W ^a,c   Zheng, Ming Qiang ^a   Saltzman, W Mark ^b   Huang, Yiyun ^a   Carson, Richard E ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Yale University   (United States)

^c BARROW NEUROLOGICAL INSTITUTE   (United States)

Author keywords

Diffusion; Drug delivery to the brain; Mathematical modeling; PET; Polymer; Radiolabeling

Indexed keywords

1 [4 (2 METHOXYISOPROPYL) PHENYL] 3 [2 (4 METHYL PIPERAZIN 1 YL)BENZYL] PYRROLIDIN 2 1 C 11; 2 [2 (DIMETHYLAMINOMETHYL)PHENYLTHIO] 5 FLUOROMETHYLPHENYLAMIN C 11; 2 [6 CHLORO 2 (4 (3 FLUOROPROPOXY)PHENYL)IMIDAZO(1,2 A)PYRIDIN 3 YL] N,N DIETHYLACETAMIDE F 18; 3 AMINO 4 [2 [(DI(METHYL)AMINO)METHYL]PHENYL]SULFANYLBENZONITRILE C 11; 3 FLUORO 5 (2 PYRIDINYLETHYNYL)BENZONITRILE F 18; FLUORINE 18; FLUOROBENZYLAMINE POLY(ETHYLENE GLYCOL)4 BIOTIN F 18; FLUORODEOXYGLUCOSE F 18; PROPYLHEXAHYDRONAPTHOOXAZIN C 11; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTOMATED SYRINGE PUMP; BRAIN FUNCTION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DIFFUSION; DRUG HALF LIFE; DRUG TRANSPORT; EXTRACELLULAR SPACE; ISOTOPE LABELING; MALE; MEDICAL DEVICE; MOLECULAR WEIGHT; NEUROIMAGING; NON INVASIVE PROCEDURE; NONHUMAN; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIOISOTOPE DISTRIBUTION; RADIOLOGY PHANTOM; RAT;

RATTUS;

ANIMALS; BIOLOGICAL TRANSPORT; BRAIN; DIFFUSION; MALE; MOLECULAR WEIGHT; NEOSTRIATUM; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; SEPHAROSE; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 84885327852     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-013-0636-9     Document Type: Article

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