-
1
-
-
58249100113
-
Transcription inactivation through local refolding of the RNA polymerase structure
-
18946472 10.1038/nature07510 1:CAS:528:DC%2BD1MXlvFWmsw%3D%3D
-
Belogurov GA, Vassylyeva MN, Sevostyanova A, Appleman JR, Xiang AX, Lira R, Webber SE, Klyuyev S, Nudler E, Artsimovitch I, Vassylyev DG (2009) Transcription inactivation through local refolding of the RNA polymerase structure. Nature 457:332-335
-
(2009)
Nature
, vol.457
, pp. 332-335
-
-
Belogurov, G.A.1
Vassylyeva, M.N.2
Sevostyanova, A.3
Appleman, J.R.4
Xiang, A.X.5
Lira, R.6
Webber, S.E.7
Klyuyev, S.8
Nudler, E.9
Artsimovitch, I.10
Vassylyev, D.G.11
-
2
-
-
33745018355
-
Analysis of myxobacterial secondary metabolism goes molecular
-
16491362 10.1007/s10295-006-0082-7 1:CAS:528:DC%2BD28XlsVCju70%3D
-
Bode HB, Müller R (2006) Analysis of myxobacterial secondary metabolism goes molecular. J Ind Microbiol Biotechnol 33:577-588
-
(2006)
J Ind Microbiol Biotechnol
, vol.33
, pp. 577-588
-
-
Bode, H.B.1
Müller, R.2
-
3
-
-
84871258933
-
Antibiotics in the clinical pipeline in 2011
-
Butler MS, Cooper MA. (2011) Antibiotics in the clinical pipeline in 2011. J Antibiot (Tokyo) 64413-64425
-
(2011)
J Antibiot (Tokyo)
, pp. 64413-64425
-
-
Butler, M.S.1
Cooper, M.A.2
-
4
-
-
33845708150
-
New antibiotics from bacterial natural products
-
17160060 10.1038/nbt1266 1:CAS:528:DC%2BD28Xht12gtbrF
-
Clardy J, Fischbach MA, Walsh CT (2006) New antibiotics from bacterial natural products. Nat Biotechnol 24:1541-1550
-
(2006)
Nat Biotechnol
, vol.24
, pp. 1541-1550
-
-
Clardy, J.1
Fischbach, M.A.2
Walsh, C.T.3
-
5
-
-
0036834373
-
The future challenges facing the development of new antimicrobial drugs
-
12415249 10.1038/nrd940 1:CAS:528:DC%2BD38XotleqtLk%3D
-
Coates A, Hu Y, Bax R, Page C (2002) The future challenges facing the development of new antimicrobial drugs. Nat Rev Drug Discov. 1:895-910
-
(2002)
Nat Rev Drug Discov.
, vol.1
, pp. 895-910
-
-
Coates, A.1
Hu, Y.2
Bax, R.3
Page, C.4
-
6
-
-
79851514236
-
How to discover new antibiotics: Harvesting the parvome
-
21111668 10.1016/j.cbpa.2010.11.001 1:CAS:528:DC%2BC3MXhvFKitb0%3D
-
Davies J (2011) How to discover new antibiotics: harvesting the parvome. Curr Opin Chem Biol 15:5-10
-
(2011)
Curr Opin Chem Biol
, vol.15
, pp. 5-10
-
-
Davies, J.1
-
7
-
-
78649327971
-
Sources of novel antibiotics
-
20865256 10.1007/s00253-010-2877-8 1:CAS:528:DC%2BC3cXhsVWqt77P
-
Donadio S, Maffioli S, Monciardini P, Sosio M, Jabes D (2010) Sources of novel antibiotics. Appl Microbiol Biotechnol 88:1261-1267
-
(2010)
Appl Microbiol Biotechnol
, vol.88
, pp. 1261-1267
-
-
Donadio, S.1
Maffioli, S.2
Monciardini, P.3
Sosio, M.4
Jabes, D.5
-
8
-
-
77953455694
-
Biosynthesis of the myxobacterial antibiotic corallopyronin A
-
20503218 10.1002/cbic.201000085 1:CAS:528:DC%2BC3cXnsVWnsbg%3D
-
Erol Ö, Schäberle TF, Schmitz A, Kehraus S, Piel J, Gurgui C, Rachid S, Müller R, König GM (2010) Biosynthesis of the myxobacterial antibiotic corallopyronin A. ChemBioChem 11:1253-1265
-
(2010)
ChemBioChem
, vol.11
, pp. 1253-1265
-
-
Erol, Ö.1
Schäberle, T.F.2
Schmitz, A.3
Kehraus, S.4
Piel, J.5
Gurgui, C.6
Rachid, S.7
Müller, R.8
König, G.M.9
-
9
-
-
79957560165
-
How to cope with the quest for new antibiotics
-
21513713 10.1016/j.febslet.2011.04.029 1:CAS:528:DC%2BC3MXmvFaitrc%3D
-
Fabbretti A, Gualerzi CO, Brandi L (2011) How to cope with the quest for new antibiotics. FEBS Lett 585:1673-1681
-
(2011)
FEBS Lett
, vol.585
, pp. 1673-1681
-
-
Fabbretti, A.1
Gualerzi, C.O.2
Brandi, L.3
-
10
-
-
70349748499
-
Antibiotics from microbes: Converging to kill
-
19695947 10.1016/j.mib.2009.07.002 1:CAS:528:DC%2BD1MXht1CmtLfI
-
Fischbach MA (2009) Antibiotics from microbes: converging to kill. Curr Opin Microbiol 12:520-527
-
(2009)
Curr Opin Microbiol
, vol.12
, pp. 520-527
-
-
Fischbach, M.A.1
-
12
-
-
0035079997
-
Haliangicin, a novel antifungal metabolite produced by a marine myxobacterium. 2
-
10.7164/antibiotics.54.153 1:CAS:528:DC%2BD3MXhsFyntrs%3D
-
Fudou R, Iizuka T, Sato S, Ando T, Shimba N, Yamanaka S (2001b) Haliangicin, a novel antifungal metabolite produced by a marine myxobacterium. 2. Isolation and structural elucidation. J Antibiot (Tokyo) 54:153-156
-
(2001)
Isolation and Structural Elucidation. J Antibiot (Tokyo)
, vol.54
, pp. 153-156
-
-
Fudou, R.1
Iizuka, T.2
Sato, S.3
Ando, T.4
Shimba, N.5
Yamanaka, S.6
-
13
-
-
0036328445
-
Haliangium ochraceum gen. Nov., Sp. Nov. and Haliangium tepidum sp. Nov.: Novel moderately halophilic myxobacteria isolated from coastal saline environments
-
12469307 10.2323/jgam.48.109 1:CAS:528:DC%2BD38Xlt1Kksb0%3D
-
Fudou R, Jojima Y, Iizuka T, Yamanaka S (2002) Haliangium ochraceum gen. nov., sp.nov. and Haliangium tepidum sp. nov.: Novel moderately halophilic myxobacteria isolated from coastal saline environments. J Gen Appl Microbiol 48:109-115
-
(2002)
J Gen Appl Microbiol
, vol.48
, pp. 109-115
-
-
Fudou, R.1
Jojima, Y.2
Iizuka, T.3
Yamanaka, S.4
-
14
-
-
62149089979
-
Genomic mining - A concept for the discovery of new bioactive natural products
-
19333866 1:CAS:528:DC%2BD1MXnt12lurg%3D
-
Gross H (2009) Genomic mining - a concept for the discovery of new bioactive natural products. Curr Opin Drug Discov Devel 12:207-219
-
(2009)
Curr Opin Drug Discov Devel
, vol.12
, pp. 207-219
-
-
Gross, H.1
-
15
-
-
77956307436
-
The antibiotics market
-
20811374 10.1038/nrd3267 1:CAS:528:DC%2BC3cXhtFSisLjP
-
Hamad B (2010) The antibiotics market. Nat Rev Drug Discov. 9:675-676
-
(2010)
Nat Rev Drug Discov.
, vol.9
, pp. 675-676
-
-
Hamad, B.1
-
16
-
-
78249286198
-
Antibacterials from the sea
-
20845412 10.1002/chem.201001279 1:CAS:528:DC%2BC3cXhtlCksrbK
-
Hughes CC, Fenical W (2010) Antibacterials from the sea. Chem Eur J 16:12512-12525
-
(2010)
Chem Eur J
, vol.16
, pp. 12512-12525
-
-
Hughes, C.C.1
Fenical, W.2
-
17
-
-
0037216056
-
Plesiocystis pacifica gen. Nov., Sp. Nov., a marine myxobacterium that contains dihydrogenated menaquinone, isolated from the Pacific coasts of Japan
-
12656172 10.1099/ijs.0.02418-0 1:CAS:528:DC%2BD3sXitVSntLk%3D
-
Iizuka T, Jojima Y, Fudou R, Hiraishi A, Ahn JW, Yamanaka S (2003a) Plesiocystis pacifica gen. nov., sp. nov., a marine myxobacterium that contains dihydrogenated menaquinone, isolated from the Pacific coasts of Japan. Int J Syst Evol Microbiol 53:189-195
-
(2003)
Int J Syst Evol Microbiol
, vol.53
, pp. 189-195
-
-
Iizuka, T.1
Jojima, Y.2
Fudou, R.3
Hiraishi, A.4
Ahn, J.W.5
Yamanaka, S.6
-
18
-
-
0038005026
-
Enhygromyxa salina gen. Nov., Sp. Nov., a slightly halophilic myxobacterium isolated from the coastal areas of Japan
-
12866845 10.1078/072320203322346038
-
Iizuka T, Jojima Y, Fudou R, Tokura M, Hiraishi A, Yamanaka S (2003b) Enhygromyxa salina gen. nov., sp. nov., a slightly halophilic myxobacterium isolated from the coastal areas of Japan. Syst Appl Microbiol 26:189-196
-
(2003)
Syst Appl Microbiol
, vol.26
, pp. 189-196
-
-
Iizuka, T.1
Jojima, Y.2
Fudou, R.3
Tokura, M.4
Hiraishi, A.5
Yamanaka, S.6
-
19
-
-
0021958873
-
On antibiotics from gliding bacteria. The corallopyronins, new inhibitors of bacterial RNA-synthesis from myxobacteria
-
10.7164/antibiotics.38.145 1:CAS:528:DyaL2MXhs1ensbo%3D
-
Irschik H, Jansen R, Höfle G, Gerth K, Reichenbach H (1985) On antibiotics from gliding bacteria. The corallopyronins, new inhibitors of bacterial RNA-synthesis from myxobacteria. J Antibiot (Tokyo) 38:145-152
-
(1985)
J Antibiot (Tokyo)
, vol.38
, pp. 145-152
-
-
Irschik, H.1
Jansen, R.2
Höfle, G.3
Gerth, K.4
Reichenbach, H.5
-
20
-
-
34447344496
-
Etnangien, a macrolide-polyene antibiotic from Sorangium cellulosum that inhibits nucleic acid polymerase
-
17547459 10.1021/np070115h 1:CAS:528:DC%2BD2sXmtVKksb0%3D
-
Irschik H, Schummer D, Höfle G, Reichenbach H, Steinmetz H, Jansen R (2007) Etnangien, a macrolide-polyene antibiotic from Sorangium cellulosum that inhibits nucleic acid polymerase. J Nat Prod 70:1060-1063
-
(2007)
J Nat Prod
, vol.70
, pp. 1060-1063
-
-
Irschik, H.1
Schummer, D.2
Höfle, G.3
Reichenbach, H.4
Steinmetz, H.5
Jansen, R.6
-
21
-
-
0021989355
-
Corallopyronin A, corallopyronin B, and corallopyronin C - 3 novel antibiotics from Corallococcus coralloides
-
10.1002/jlac.198519850418
-
Jansen R, Irschnik H, Reichenbach H, Höfle G (1985) Corallopyronin A, corallopyronin B, and corallopyronin C - 3 novel antibiotics from Corallococcus coralloides. Liebigs Ann Chem 4:822-826
-
(1985)
Liebigs Ann Chem
, vol.4
, pp. 822-826
-
-
Jansen, R.1
Irschnik, H.2
Reichenbach, H.3
Höfle, G.4
-
22
-
-
76649111057
-
Functionally distinct modules operate two consecutive α, β→β, γ double-bond shifts in the rhizoxin polyketide assembly line
-
20033973 10.1002/anie.200905467 1:CAS:528:DC%2BC3cXitVWjsbk%3D
-
Kusebauch B, Busch B, Scherlach K, Roth M, Hertweck C (2010) Functionally distinct modules operate two consecutive α, β→β, γ double-bond shifts in the rhizoxin polyketide assembly line. Angew Chem Int Ed Engl 49:1460-1464
-
(2010)
Angew Chem Int Ed Engl
, vol.49
, pp. 1460-1464
-
-
Kusebauch, B.1
Busch, B.2
Scherlach, K.3
Roth, M.4
Hertweck, C.5
-
23
-
-
0036242962
-
A simple method to isolate salt-tolerant myxobacteria from marine samples
-
11997170 10.1016/S0167-7012(02)00029-5 1:CAS:528:DC%2BD38Xjtl2is7c%3D
-
Li YZ, Hu W, Zhang YQ, Qiu ZJ, Zhang Y, Wu BH (2002) A simple method to isolate salt-tolerant myxobacteria from marine samples. J Microbiol Methods 50:205-209
-
(2002)
J Microbiol Methods
, vol.50
, pp. 205-209
-
-
Li, Y.Z.1
Hu, W.2
Zhang, Y.Q.3
Qiu, Z.J.4
Zhang, Y.5
Wu, B.H.6
-
24
-
-
77956254492
-
Bioprospecting microbial natural product libraries from the marine environment for drug discovery
-
10.1038/ja.2010.56 1:CAS:528:DC%2BC3cXhtVOnsb%2FI
-
Liu X, Ashforth E, Ren B, Song F, Dai H, Liu M, Wang J, Xie Q, Zhang L (2010) Bioprospecting microbial natural product libraries from the marine environment for drug discovery. J Antibiot (Tokyo) 63:415-422
-
(2010)
J Antibiot (Tokyo)
, vol.63
, pp. 415-422
-
-
Liu, X.1
Ashforth, E.2
Ren, B.3
Song, F.4
Dai, H.5
Liu, M.6
Wang, J.7
Xie, Q.8
Zhang, L.9
-
25
-
-
54849419509
-
Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA polymerase inhibitor from the myxobacterium Sorangium cellulosum
-
18826315 10.1021/ja804194c 1:CAS:528:DC%2BD1cXht1SjtrnJ
-
Menche D, Arikan F, Perlova O, Horstmann N, Ahlbrecht W, Wenzel SC, Jansen R, Irschik H, Müller R (2008) Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA polymerase inhibitor from the myxobacterium Sorangium cellulosum. J Am Chem Soc 130:14234-14243
-
(2008)
J Am Chem Soc
, vol.130
, pp. 14234-14243
-
-
Menche, D.1
Arikan, F.2
Perlova, O.3
Horstmann, N.4
Ahlbrecht, W.5
Wenzel, S.C.6
Jansen, R.7
Irschik, H.8
Müller, R.9
-
26
-
-
76649090949
-
The final steps of bacillaene biosynthesis in Bacillus amyloliquefaciens FZB42: Direct evidence for beta, gamma dehydration by a trans-acyltransferase polyketide synthase
-
20087918 10.1002/anie.200905468 1:CAS:528:DC%2BC3cXitVWjtLo%3D
-
Moldenhauer J, Götz DC, Albert CR, Bischof SK, Schneider K, Süssmuth RD, Engeser M, Gross H, Bringmann G, Piel J (2010) The final steps of bacillaene biosynthesis in Bacillus amyloliquefaciens FZB42: direct evidence for beta, gamma dehydration by a trans-acyltransferase polyketide synthase. Angew Chem Int Ed Engl 49:1465-1467
-
(2010)
Angew Chem Int Ed Engl
, vol.49
, pp. 1465-1467
-
-
Moldenhauer, J.1
Götz, D.C.2
Albert, C.R.3
Bischof, S.K.4
Schneider, K.5
Süssmuth, R.D.6
Engeser, M.7
Gross, H.8
Bringmann, G.9
Piel, J.10
-
27
-
-
53549085430
-
The RNA polymerase "switch region" is target for inhibitors
-
18957204 10.1016/j.cell.2008.09.033 1:CAS:528:DC%2BD1cXhtlWhsrzP
-
Mukhopadhyay J, Das K, Ismail S, Koppstein D, Jang M, Hudson B, Sarafianos S, Tuske S, Patel J, Jansen R, Irschik H, Arnold E, Ebright RH (2008) The RNA polymerase "switch region" is target for inhibitors. Cell 135:295-307
-
(2008)
Cell
, vol.135
, pp. 295-307
-
-
Mukhopadhyay, J.1
Das, K.2
Ismail, S.3
Koppstein, D.4
Jang, M.5
Hudson, B.6
Sarafianos, S.7
Tuske, S.8
Patel, J.9
Jansen, R.10
Irschik, H.11
Arnold, E.12
Ebright, R.H.13
-
28
-
-
79961203458
-
Fidaxomicin: First-in-class macrocyclic antibiotic
-
21810048 10.1586/eri.11.53 1:CAS:528:DC%2BC3MXps1yju74%3D
-
Mullane KM, Gorbach S (2011) Fidaxomicin: first-in-class macrocyclic antibiotic. Expert Rev Anti Infect Ther 9:767-777
-
(2011)
Expert Rev Anti Infect Ther
, vol.9
, pp. 767-777
-
-
Mullane, K.M.1
Gorbach, S.2
-
29
-
-
36348933875
-
The chemistry of gliding bacteria
-
18033578 10.1039/b612668p 1:CAS:528:DC%2BD2sXhtlemsbjJ
-
Nett M, König GM (2007) The chemistry of gliding bacteria. Nat Prod Rep 24:1245-1261
-
(2007)
Nat Prod Rep
, vol.24
, pp. 1245-1261
-
-
Nett, M.1
König, G.M.2
-
30
-
-
0033750982
-
RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus
-
11036042 10.1128/AAC.44.11.3163-3166.2000
-
O'Neill A, Oliva B, Storey C, Hoyle A, Fishwick C, Chopra I (2000) RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus. Antimicrob Agents Chemother 44:3163-3166
-
(2000)
Antimicrob Agents Chemother
, vol.44
, pp. 3163-3166
-
-
O'Neill, A.1
Oliva, B.2
Storey, C.3
Hoyle, A.4
Fishwick, C.5
Chopra, I.6
-
31
-
-
33845903833
-
Drugs for bad bugs: Confronting the challenges of antibacterial discovery
-
17159923 10.1038/nrd2201 1:CAS:528:DC%2BD28XhtlGktbfM
-
Payne DJ, Gwynn MN, Holmes DJ, Pompliano DL (2007) Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 6:29-40
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 29-40
-
-
Payne, D.J.1
Gwynn, M.N.2
Holmes, D.J.3
Pompliano, D.L.4
-
32
-
-
77954675603
-
Biosynthesis of polyketides by trans-AT polyketide synthases
-
20464003 10.1039/b816430b 1:CAS:528:DC%2BC3cXnvFKqurw%3D
-
Piel J (2010) Biosynthesis of polyketides by trans-AT polyketide synthases. Nat Prod Rep 27:996-1047
-
(2010)
Nat Prod Rep
, vol.27
, pp. 996-1047
-
-
Piel, J.1
-
33
-
-
0242291985
-
Why is big pharma getting out of antibacterial drug discovery?
-
14572532 10.1016/j.mib.2003.08.003
-
Projan SJ (2003) Why is big pharma getting out of antibacterial drug discovery? Curr Opin Microbiol 6:427-430
-
(2003)
Curr Opin Microbiol
, vol.6
, pp. 427-430
-
-
Projan, S.J.1
-
34
-
-
0002822082
-
Biology of myxobacteria: Ecology and taxonomy
-
M. Dworkin D. Kaiser (eds) American Society for Microbiology Washington, DC
-
Reichenbach H (1993) Biology of myxobacteria: ecology and taxonomy. In: Dworkin M, Kaiser D (eds) Myxobacteria II. American Society for Microbiology, Washington, DC, pp 13-62
-
(1993)
Myxobacteria II
, pp. 13-62
-
-
Reichenbach, H.1
-
35
-
-
0035735010
-
Myxobacteria, producers of novel bioactive substances
-
11780785 10.1038/sj.jim.7000025 1:CAS:528:DC%2BD3MXns1WksLc%3D
-
Reichenbach H (2001) Myxobacteria, producers of novel bioactive substances. J Ind Microbiol Biotechnol 27:149-156
-
(2001)
J Ind Microbiol Biotechnol
, vol.27
, pp. 149-156
-
-
Reichenbach, H.1
-
36
-
-
77958050621
-
Marine myxobacteria as a source of antibiotics - Comparison of the physiology, polyketide-type genes and antibiotic production of three new isolates of Enhygromyxa salina
-
20948900 10.3390/md8092466
-
Schäberle TF, Goralski E, Neu E, Erol Ö, Hölzl G, Dörmann P, Bierbaum G, König GM (2010) Marine myxobacteria as a source of antibiotics - Comparison of the physiology, polyketide-type genes and antibiotic production of three new isolates of Enhygromyxa salina. Marine Drugs 8:2466-2479
-
(2010)
Marine Drugs
, vol.8
, pp. 2466-2479
-
-
Schäberle, T.F.1
Goralski, E.2
Neu, E.3
Erol, Ö.4
Hölzl, G.5
Dörmann, P.6
Bierbaum, G.7
König, G.M.8
-
37
-
-
84862855021
-
Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo
-
(in press)
-
Schiefer A, Schmitz A, Schäberle TF, Specht S, Lämmer C, Johnston KL, Vassylyev DG, König GM, Hoerauf A, Pfarr K (2012) Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo. J Infect Dis (in press)
-
(2012)
J Infect Dis
-
-
Schiefer, A.S.1
-
38
-
-
35948983363
-
Complete genome sequence of the myxobacterium Sorangium cellulosum
-
17965706 10.1038/nbt1354 1:CAS:528:DC%2BD2sXht1Oru7%2FF
-
Schneiker S, Perlova O, Kaiser O, Gerth K, Alici A, Altmeyer MO, Bartels D, Bekel T, Beyer S, Bode E et al (2007) Complete genome sequence of the myxobacterium Sorangium cellulosum. Nat Biotechnol 25:1281-1289
-
(2007)
Nat Biotechnol
, vol.25
, pp. 1281-1289
-
-
Schneiker, S.1
Perlova, O.2
Kaiser, O.3
Gerth, K.4
Alici, A.5
Altmeyer, M.O.6
Bartels, D.7
Bekel, T.8
Beyer, S.9
Bode, E.10
-
39
-
-
77956688537
-
New antibiotic structures from fermentations
-
20653459 10.1517/13543776.2010.509347 1:CAS:528:DC%2BC3cXhtFGgs7rI
-
Singh SB, Young K (2010) New antibiotic structures from fermentations. Expert Opin Ther Pat 20:1359-1371
-
(2010)
Expert Opin Ther Pat
, vol.20
, pp. 1359-1371
-
-
Singh, S.B.1
Young, K.2
-
40
-
-
62149106396
-
The biosynthetic potential of myxobacteria and their impact in drug discovery
-
1:CAS:528:DC%2BD1MXnt12lurk%3D
-
Wenzel SC, Müller R (2009) The biosynthetic potential of myxobacteria and their impact in drug discovery. Curr Opin Drug Discov Dev 12:220-230
-
(2009)
Curr Opin Drug Discov Dev
, vol.12
, pp. 220-230
-
-
Wenzel, S.C.1
Müller, R.2
|