Serum concentrations of tamoxifen and its metabolites increase with age during steady-state treatment

Breast Cancer Research and Treatment

Volumn 141, Issue 2, 2013, Pages 243-248

  Lien, Ernst A ^a,b   Søiland, Håvard ^b,c   Lundgren, Steinar ^d,e   Aas, Turid ^a   Steen, Vidar M ^a,b   Mellgren, Gunnar ^a,b   Gjerde, Jennifer ^a,b  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

^c STAVANGER UNIVERSITY HOSPITAL   (Norway)

^d TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^e NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Age; CYP2D6; Endoxifen; Metabolites; Tamoxifen

Indexed keywords

AFIMOXIFENE; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; CYTOCHROME P450 2D6; ENDOXIFEN; N DESDIMETHYLTAMOXIFEN; NORTAMOXIFEN; TAMOXIFEN; TAMOXIFEN N OXIDE; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ALLELE; ARTICLE; BREAST CANCER; CLIMACTERIUM; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; FEMALE; GENETIC POLYMORPHISM; HOMOZYGOSITY; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; PROGESTERONE RECEPTOR POSITIVE BREAST CANCER; STEADY STATE; TANDEM MASS SPECTROMETRY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CYTOCHROME P-450 CYP2D6; FEMALE; HUMANS; MIDDLE AGED; TAMOXIFEN;

EID: 84885324195     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-013-2677-9     Document Type: Article

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