Stem cell transplantation in systemic sclerosis

Current Opinion in Rheumatology

Volumn 25, Issue 6, 2013, Pages 719-725

  Van Laar, Jacob M ^a   Sullivan, Keith ^b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Immunoablation; Poor prognosis; Stem cell transplantation; Systemic sclerosis

Indexed keywords

CYCLOPHOSPHAMIDE; THYMOCYTE ANTIBODY;

AUTOLOGOUS STEM CELL TRANSPLANTATION; B LYMPHOCYTE; CLINICAL TRIAL; HEART CATHETERIZATION; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; LUNG FUNCTION; MORTALITY; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; QUALITY OF LIFE; RETROSPECTIVE STUDY; REVIEW; SKINFOLD; SYSTEMIC SCLEROSIS; T LYMPHOCYTE;

HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; PATIENT SELECTION; PROGNOSIS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SCLERODERMA, SYSTEMIC; TREATMENT OUTCOME;

EID: 84885311188     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/01.bor.0000434669.32150.ac     Document Type: Review

References (31)

1. Hügle T, van Laar JM. Stem cell transplantation for rheumatic autoimmune diseases. Arthritis Res Ther 2008; 10:217
2. van Bekkum DW. Stem cell transplantation for autoimmune disorders. Preclinical experiments. Best Pract Res Clin Hematol 2004; 17:201-222
3. van Bekkum DW. Experimental basis for the treatment of autoimmune diseases with autologous hematopoietic stem cell transplantation. Bone Marrow Transpl 2003; 32 (Suppl 1):S37-S39
4. Snowden JA, Kearney P, Kearney A, et al. Long-Term outcome of autoimmune disease following allogeneic bone marrow transplantation. Arthritis Rheum 1998; 41:453-459
5. Tyndall A, Black C, Finke J, et al. Treatment of systemic sclerosis with autologous haemopoietic stem cell transplantation. Lancet 1997; 349: 254
6. Gabrielli A, Avvedimento EV, Krieg T. Scleroderma. N Engl J Med 2009; 360:1989-2003
7. Binks M, Passweg JR, Furst D, et al. Phase I/II trial of autologous stem cell transplantation in systemic sclerosis: Procedure related mortality and impact on skin disease. Ann Rheum Dis 2001; 60:577-584
8. McSweeney PA, Nash RA, Sullivan KM, et al. High-dose immunosuppressive therapy for severe systemic sclerosis: Initial outcomes. Blood 2002; 100: 1602-1610
9. Farge D, Marolleau JP, Zohar S, et al. Autologous bone marrow transplantation in the treatment of refractory systemic sclerosis: Early results from a French multicentre phase I-II study. Br J Haematol 2002; 119:726-739
10. Farge D, Passweg J, van Laar JM, et al. Autologous stem cell transplantation in the treatment of systemic sclerosis: Report from the EBMT/EULAR Registry. Ann Rheum Dis 2004; 63:974-981
11. Vonk MC, Marjanovic Z, van den Hoogen FH, et al. Long-Term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis. Ann Rheum Dis 2008; 67:98-104
12. .Burt RK, Oliveira MC, Shah SJ, et al. Cardiac involvement and treatmentrelated mortality after nonmyeloablative haemopoietic stem-cell transplantation with unselected autologous peripheral blood for patients with systemic sclerosis: A retrospective analysis. Lancet 2013; 381:1116-1124
13. .Henes JC, Schmalzing M, Vogel W, et al. Optimization of autologous stem cell transplantation for systemic sclerosis: A single-center long-Term experience in 26 patients with severe organ manifestations. J Rheumatol 2012; 39:269-275
14. Naraghi KN, van Laar JM. Update on stem cell transplantation for systemic sclerosis: Recent trial results. Curr Rheumatol Rep 2013; 15:326
15. Burt RK, Shah SJ, Dill K, et al. Autologous nonmyeloablative haemopoietic stem-cell transplantation compared with pulse cyclophosphamide once per month for systemic sclerosis (ASSIST): An open-label, randomised phase 2 trial. Lancet 2011; 378:498-506
16. Sullivan KM, Wigley FM, Denton CP, et al. Haemopoietic stem-cell transplantation for systemic sclerosis (letter). Lancet 2012; 379:219
17. .van Laar JM, Farge D, Sont JK, et al. The ASTIS trial: Autologous stem cell transplantation versus IV pulse cyclophosphamide in poor prognosis systemic sclerosis, first results. EULAR, Annual Congress of the European League Against Rheumatism. Ann Rheum Dis 2012; 71 (Suppl 3):151
18. Farge D, van Laar JM, Sont JK, et al. Autologous hematopoietic stem cell transplantation versus intravenous pulse therapy cyclophosphamide for severe or rapidly progressive systemic sclerosis: The ASTIS Trial. Blood (ASH Annual Meeting Abstracts) 2012; 120:964
19. ClinicalTrials.gov: Scleroderma: Cyclophosphamide or transplantation (SCOT). http://www.clinicaltrials.gov/ct2/show/NCT00114530?term= SCOTtrial&rank=6. [Accessed May 2013]
20. Craciunescu OI, Steffey BA, Kelsey CR, et al. Renal shielding and dosimetry for patients with severe systemic sclerosis receiving immunoablation with total body irradiation in the scleroderma: Cyclophosphamide or transplantation trial. Int J Radiat Oncol Biol Phys 2011; 79:1248-1255
21. Hosing C, Nash R, McSweeney P, et al. Acute kidney injury in patients with systemic sclerosis participating in hematopoietic cell transplantation trials in the United States. Biol Blood Marrow Transplant 2011; 17:674-681
22. Tsukamoto H, Nagafuji K, Horiuchi T, et al. Analysis of immune reconstitution after autologous CD34 stem/progenitor cell transplantation for systemic sclerosis: Predominant reconstitution of Th1 CD4 T cells. Rheumatology 2011; 50:944-952
23. Szodoray P, Varoczy L, Papp G, et al. Immunological reconstitution after autologous stem cell transplantation in patients with refractory systemic autoimmune diseases. Scand J Rheumatol 2012; 41:110-115
24. Fleming JN, Nash RA, McLeod DO, et al Capillary regeneration in scleroderma: Stem cell therapy reverses phenotype? PLoS One 2008; 3:e1452
25. Miniati I, Guiducci S, Conforti ML, et al. Autologous stem cell transplantation improves microcirculation in systemic sclerosis. Ann Rheum Dis 2009; 68: 94-98
26. Chizzolini C, Vukicevic M, Rochat T, et al. Acute natural killer cell pneumonia in a patient transplanted with autologous haematopoietic stem cells for systemic sclerosis. Rheumatology 2013; 52:954-956
27. Daikeler T, Labopin M, Di Gioia M, et al. Secondary autoimmune diseases occurring after HSCT for an autoimmune disease: A retrospective study of the EBMT Autoimmune Disease Working Party. Blood 2011; 118:1693-1698
28. Yabuuchi H, Matsuo Y, Tsukamoto H, et al. Correlation between pretreatment or follow-up CT findings and therapeutic effect of autologous peripheral blood stem cell transplantation for interstitial pneumonia associated with systemic sclerosis. Eur J Radiol 2011; 79:e74-e79
29. Pasquini MC, Voltarelli J, Atkins HL, et al. Transplantation for autoimmune diseases in North and South America: A report of the Center for International Blood and Marrow Transplant Research. Biol Blood Marrow Transplant 2012; 18:1471-1478
30. Tyndall A. Stem cells: HSCT for systemic sclerosis: Swallows and summers. Nat Rev Rheumatol 2011; 7:624-626
31. Nihtyanova SI, Tang SI, Coghlan JG, et al. Improved survival in systemic sclerosis is associated with better ascertainment of internal organ disease: A retrospective cohort study. QJM 2010; 103:109-115