Lower plasma testosterone or dihydrotestosterone, but not estradiol, is associated with symptoms of intermittent claudication in older men

Clinical Endocrinology

Volumn 79, Issue 5, 2013, Pages 725-732

  Yeap, Bu B ^a,b   Alfonso, Helman ^c   Chubb, S A Paul ^a,d   Handelsman, David J ^e   Hankey, Graeme J ^a   Golledge, Jonathan ^f   Flicker, Leon ^a,c   Norman, Paul E ^g  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b FREMANTLE HOSPITAL   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d ROYAL PERTH HOSPITAL   (Australia)

^e UNIVERSITY OF SYDNEY   (Australia)

^f JAMES COOK UNIVERSITY   (Australia)

^g UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; CREATININE; ESTRADIOL; TESTOSTERONE;

AGED; ARTICLE; AUSTRALIA; BODY MASS; CARDIOVASCULAR DISEASE; CIRCADIAN RHYTHM; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DYSLIPIDEMIA; GERIATRIC PATIENT; GROUPS BY AGE; HUMAN; HYPERTENSION; INTERMITTENT CLAUDICATION; LEG PAIN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; SMOKING; TANDEM MASS SPECTROMETRY; TESTOSTERONE BLOOD LEVEL; WAIST HIP RATIO;

AGED; AGED, 80 AND OVER; DIHYDROTESTOSTERONE; ESTRADIOL; HUMANS; INTERMITTENT CLAUDICATION; MALE; QUESTIONNAIRES; TESTOSTERONE;

EID: 84885235043     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12208     Document Type: Article

References (33)

1. Bhasin, S., (2008) Testicular disorders. In:, H.M. Kronenberg, S. Melmed, K.S. Polonsky, P.R. Larsen, eds. Williams Textbook of Endocrinology, 11th edn. Saunders Elsevier, Philadelphia, 645-699.
2. Kaufman, J.M., &, Vermeulen, A., (2005) The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocrine Reviews, 26, 833-876.
3. Isidori, A.M., Giannetta, E., Greco, E.A., et al,. (2005) Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clinical Endocrinology, 63, 280-293.
4. Yeap, B.B., (2010) Androgens and cardiovascular disease. Current Opinion in Endocrinology, Diabetes & Obesity, 17, 269-276.
5. Araujo, A.B., Dixon, J.M., Suarez, E.A., et al,. (2011) Endogenous testosterone and mortality in men: a systematic review and meta-analysis. Journal of Clinical Endocrinology & Metabolism, 96, 3007-3019.
6. Cunningham, G.R., &, Toma, S.M., (2011) Why is androgen replacement in males controversial? Journal of Clinical Endocrinology & Metabolism, 96, 38-52.
7. Yeap, B.B., Hyde, Z., Almeida, O.P., et al,. (2009) Lower testosterone levels predict incident stroke and transient ischemic attack in older men. Journal of Clinical Endocrinology & Metabolism, 94, 2353-2359.
8. Arnlov, J., Pencina, M.J., Amin, S., et al,. (2006) Endogenous sex hormones and cardiovascular disease incidence in men. Annals of Internal Medicine, 145, 176-184.
9. Vikan, T., Schirmer, H., Njolstad, I., et al,. (2009) Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: the Tromso study. European Journal of Endocrinology, 161, 435-442.
10. Ohlsson, C., Barrett-Connor, E., Bhasin, S., et al,. (2011) High serum testosterone is associated with reduced risk of cardiovascular events in elderly men. Journal of the American College of Cardiology, 58, 1674-1681.
11. Araujo, A.B., Kupelian, V., Page, S.T., et al,. (2007) Sex steroids and all-cause and cause-specific mortality in men. Archives of Internal Medicine, 167, 1252-1260.
12. Tivesten, A., Hulthe, J., Wallenfeldt, K., et al,. (2006) Circulating estradiol is an independent predictor of progression of carotid artery intima-media thickness in middle-aged men. Journal of Clinical Endocrinology & Metabolism, 91, 4433-4437.
13. Abbott, R.D., Launer, L.J., Rodriguez, B.L., et al,. (2007) Serum estradiol and risk of stroke in elderly men. Neurology, 68, 563-568.
14. Tivesten, A., Vandenput, L., Labrie, F., et al,. (2009) Low serum testosterone and estradiol predict mortality in elderly men. Journal of Clinical Endocrinology & Metabolism, 94, 2482-2488.
15. Tivesten, A., Mellstrom, D., Jutberger, H., et al,. (2007) Low serum testosterone and high serum estradiol associate with lower extremity peripheral arterial disease in elderly men. The MrOS Study in Sweden. Journal of the American College of Cardiology, 50, 1070-1076.
16. Haring, R., Travison, T.G., Bhasin, S., et al,. (2011) Relation between sex hormone concentrations, peripheral arterial disease, and change in ankle-brachial index: findings from the Framingham Heart Study. Journal of Clinical Endocrinology & Metabolism, 96, 3724-3732.
17. Price, J.F., Lee, A.J., &, Fowkes, F.G.R., (1997) Steroid sex hormones and peripheral arterial disease in the Edinburgh Artery Study. Steroids, 62, 789-794.
18. Maggio, M., Cattabiani, C., Lauretani, F., et al,. (2012) The relationship between sex hormones, sex hormone binding globulin and peripheral artery disease in older persons. Atherosclerosis, 225, 469-474.
19. Norman, P.E., Flicker, L., Almeida, O.P., et al,. (2009) Cohort profile: the Health In Men Study (HIMS). International Journal of Epidemiology, 38, 48-52.
20. The Australian Diabetes, Obesity and Lifestyle Study. (2000) Diabesity and Associated Disorders in Australia 2000. International Diabetes Institute, Melbourne, 7-12.
21. Leng, G.C., &, Fowkes, F.G., (1992) The Edinburgh Claudication Questionnaire: an improved version of the WHO/Rose Questionnaire for use in epidemiological surveys. Journal of Clinical Epidemiology, 45, 1101-1109.
22. Harwood, D.T., &, Handelsman, D.J., (2009) Development and validation of a sensitive liquid chromatography-tandem mass spectrometry assay to simultaneously measure androgens and estrogens in serum without derivatization. Clinica Chimica Acta, 409, 78-84.
23. Yeap, B.B., Alfonso, H., Chubb, S.A.P., et al,. (2012) Reference ranges and determinants of testosterone, dihydrotestosterone and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men. Journal of Clinical Endocrinology & Metabolism, 97, 4030-4039.
24. Yeap, B.B., Almeida, O.P., Hyde, Z., et al,. (2007) In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health In Men Study. European Journal of Endocrinology, 156, 585-594.
25. Ly, L.P., Sartorius, G., Hull, L., et al,. (2010) Accuracy of calculated free testosterone formulae in men. Clinical Endocrinology, 73, 382-388.
26. Armitage, P., Berry, G., &, Matthews, J.N.S., (2002) Statistical Methods in Medical Research, 4th edn. Blackwell Science, Oxford, 83-146.
27. Ly, L.P., &, Handelsman, D.J., (2005) Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassays. European Journal of Endocrinology, 152, 471-478.
28. Nofer, J.-R., (2012) Estrogens and atherosclerosis: insights from animal models and cell systems. Journal of Molecular Endocrinology, 48, R13-R29.
29. Sieveking, D.P., Lim, P., Chow, R.W.Y., et al,. (2010) A sex-specific role for androgens in angiogenesis. Journal of Experimental Medicine, 207, 345-352.
30. Price, J., &, Leng, G.C., (2001) Steroid sex hormones for lower limb atherosclerosis. Cochrane Database of Systematic Reviews, 3, CD000188.
31. Shores, M.M., Smith, N.L., Forsberg, C.W., et al,. (2012) Testosterone treatment and mortality in men with low testosterone levels. Journal of Clinical Endocrinology & Metabolism, 97, 2050-2058.
32. Wu, F.C.W., (2012) Caveat emptor: does testosterone treatment reduce mortality in men? Journal of Clinical Endocrinology & Metabolism, 97, 1884-1886.
33. Basaria, S., Coviello, A.D., Travison, T.G., et al,. (2010) Adverse events associated with testosterone administration. New England Journal of Medicine, 363, 109-122.