Clinical effects of subgingivally delivered spirulina gel in chronic periodontitis cases: A placebo controlled clinical trial

Journal of Clinical and Diagnostic Research

Volumn 7, Issue 10, 2013, Pages 2330-2333

  Mahendra, Jaideep ^a   Mahendra, Little ^b   Muthu, Jananni ^a   John, Libby ^a   Romanos, Georgios E ^c  

^a MEENAKSHI AMMAL DENTAL COLLEGE AND HOSPITAL   (India)

^b ANNAMALAI UNIVERSITY   (India)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Green algae; Local drug delivery; Periodontitis; Spirulina

Indexed keywords

SPIRULINA EXTRACT;

ADJUVANT THERAPY; ADULT; ANALYTICAL PARAMETERS; ARTICLE; CHRONIC PERIODONTITIS; CLINICAL ARTICLE; CLINICAL ATTACHMENT LEVEL; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG FORMULATION; FEMALE; GEL; HUMAN; INTERMETHOD COMPARISON; MALE; PERIODONTAL DRUG ADMINISTRATION; PERIODONTAL EXAMINATION; PREVENTIVE DENTISTRY; PROBING POCKET DEPTH; RANDOMIZED CONTROLLED TRIAL; UNSPECIFIED SIDE EFFECT;

EID: 84885209033     PISSN: 2249782X     EISSN: 0973709X     Source Type: Journal    
DOI: 10.7860/JCDR/2013/5793.3517     Document Type: Article

References (20)

1. Nadkarni KM, Nadkarni AK. Indian Materia Medica - with Ayurvedic, Unani-Tibbi, Siddha, Allopathic, Homeopathic, Naturopathic and Home remedies. Popular Prakashan Private Ltd., Bombay, India. 1999; (1):142-49.
2. Williamson EM. ed Major Herbs of Ayurveda; United Kingdom Churchill- Livingstone. 2002.
3. Bhat VB, Madyastha KM. C-phycocyanin: a potent peroxyl radical scavenger in vivo and in vitro. Biochem Biophys Res Commun. 2000; 275: 20-25.
4. Kay RA. Microalgae as food and nutrition. Crit. Rev. Food Sci. Nutr, 1991; 30: 555-73.
5. González De Rivera C, Miranda-Zamora R, Díaz-Zagoya JC, Juarez-Oropeza MA. Preventive effect of Spirulina maxima on the fatty liver induced by a fructose-rich diet in the rat, a preliminary report. Life Sci. 1993; 53:57-61.
6. Berns DS.The aggregation properties of C-phycocyanin. Biochem. Biophys. Res. Commun., 1970; 38: 65-73.
7. Feng Z, Weinberg A. Role of bacteria in health and disease of periodontal tissues. Periodontol. 2000. 2006; 40: 50-76.
8. World Medical Association Declaration of Helsinky: Ethical principles for medical research involving human subjects. 18th WMA General Assembly. Helsinky, 1964.
9. Greenstein G. Non-surgical periodontal therapy in 2000: A literature review. J Am Dent Assoc. 2000; 131: 1580-92.
10. Francetti L, Tombelli L, Lambordo G. Evaluation of efficacy of enamel matrix derivative in treatment of infrabony defects. Int J Perio Rest Dent. 2005; 25: 461-73.
11. Robert Henrikson. Spirulina: Health Discoveries from the Source of Life. Positive Health Online. 1998 (32).
12. Ishikawa S, Pierre B. Non surgical periodontal therapy - Where do we stand? Periodontology 2000. 2006; 36: 6-13.
13. Romay C, Armesto J, Remirez D, González R, Ledon N, Garcia I. Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae. Inflammation Research. 1998; 47 (1): 36-41.
14. Madhava Reddy C, Bhat VB, Kiranmai G, Narsa Reddy M, Reddanna P, Madyastha KM. Selective Inhibition of Cyclooxygenase-2 by C-Phycocyanin, a Biliprotein from Spirulina platensis. Biochemical and Biophysical Research Communications. 2000; 277(3):599-603.
15. Bhat G, Kudva P, Dodwad V. Aloe Vera: Nature's soothing healer to periodontal disease. J Indian Soc Periodontal. 2011;15:205-09.
16. Yvonne MW, Jansenn Heininger, Poynter ME, Patrick A, Baeuerle. Recent advances towards understanding redox mechanisms in the activation of nuclear factor κb. Free Radical Biology and Medicine. 2000; 28(9): 1317-27.
17. Van Dijk APN, Keuskamp ZJ, Wilson JHP, and Zijlstra FJ. Sequential release of cytokines, lipid mediators and nitric oxide in experimental colitis. Mediators Inflamm. 1995;4(3): 186-90.
18. Romay C, Gonzalez R, Ledon N, Remirez D, Rimbau V. C-Phycocyanin: A Biliprotein with Antioxidant, Anti-Inflammatory and Neuroprotective Effects. Current Protein and Peptide Science. 2003; 4(3): 207-16.
19. Panigrahi BB, Panda PK, Patro VJ. Wound healing activity of spirulina extracts. International Journal of Pharmaceutical Sciences Review and Research. 2011; 6 (2).
20. Romay C, Ledón N, González R. Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation. Inflammation Research. 1998; 47(8): 334-38.