Higher expression of latency-associated peptide on the surface of peripheral blood monocytes in patients with rheumatoid arthritis may be protective against articular erosions

Inflammation

Volumn 36, Issue 5, 2013, Pages 1075-1078

  Slobodin, Gleb ^a,b   Kaly, Lisa ^a   Peri, Regina ^a   Kessel, Aharon ^a,b   Rosner, Itzhak ^a,b   Toubi, Elias ^a,b   Rimar, Doron ^a,b   Boulman, Nina ^a,b   Rozenbaum, Michael ^a,b   Odeh, Majed ^a,b  

^a BNAI ZION MEDICAL CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

articular erosion; latency associated peptide; rheumatoid arthritis; transforming growth factor beta

Indexed keywords

CD14 ANTIGEN; LATENCY ASSOCIATED PEPTIDE;

ADULT; AGED; ARTICLE; BONE EROSION; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; ISRAEL; MALE; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PILOT STUDY; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS;

ANTIGENS, CD14; ARTHRITIS, RHEUMATOID; CROSS-SECTIONAL STUDIES; HUMANS; LEUKOCYTES, MONONUCLEAR; PEPTIDES; PILOT PROJECTS; PROTEIN PRECURSORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84885185175     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-013-9639-6     Document Type: Article

References (12)

1. Janssens, K., P. ten Dijke, S. Janssens, and W. van Hul. 2005. Transforming growth factor-β1 to the bone. Endocrine Reviews 26: 743-774.
2. Ghandi, R., D.E. Anderson, and H.L. Weiner. 2007. Cutting edge: immature human dendritic cells express latency-associated peptide and inhibit T cell activation in a TGF-beta-dependent manner. Journal of Immunology 178: 4017-4021.
3. + T cells: a novel regulatory T cell subset. Journal of Immunology 184: 4620-4624.
4. + mononuclear cells in peripheral blood positively correlate with BASRI scores in patients with ankylosing spondylitis: a pilot study. Joint, Bone, Spine 79: 633-634.
5. Chu, C.Q., M. Field, S. Allard, E. Abney, M. Feldmann, and R.N. Maini. 1992. Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repair. British Journal of Rheumatology 31: 653-661.
6. Mattey, D.L., N. Nixon, P.T. Dawes, and J. Kerr. 2005. Association of polymorphism in the transforming growth factor β1 gene with disease outcome and mortality in rheumatoid arthritis. Annals of the Rheumatic Diseases 64: 1190-1194.
7. Ceccarelli, F., C. Perricone, M. Fabris, C. Alessandri, A. Iagnocco, C. Fabro, et al. 2011. Transforming growth factor β 869C/T and interleukin 6-174G/C polymorphisms relate to the severity and progression of bone-erosive damage detected by ultrasound in rheumatoid arthritis. Arthritis Research & Therapy 13: R111.
8. Drynda, S., C. Kuhne, and J. Kekow. 2002. Soluble tumor necrosis factor necrosis treatment does not affect raised transforming growth factor beta levels in rheumatoid arthritis. Annals of the Rheumatic Diseases 61: 254-256.
9. Pohlers, D., A. Beyer, D. Koczan, T. Wilhelm, H.-J. Thiesen, and R.W. Kinne. 2007. Constitutive upregulation of the transforming growth factor β pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Research & Therapy 9: R59.
10. Ehrenstein, M.R., J.G. Evans, A. Singh, S. Moore, G. Warnes, D. Isenberg, and C. Mauri. 2004. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF-α therapy. The Journal of Experimental Medicine 200: 277-285.
11. Zamvil, Scott. 2012. Regulatory monocytes in CNS autoimmune disease. http://www.labome.org/grant/r01/ns/regulatory/monocytes/regulatory-monocytes-in- cns-autoimmune-disease-7876658.html
12. + T cells. Blood 116: 210-217.