Influence of clinically significant portal hypertension on survival after hepatic resection for hepatocellular carcinoma in cirrhotic patients

Liver International

Volumn 33, Issue 10, 2013, Pages 1594-1600

  Giannini, Edoardo G ^a   Savarino, Vincenzo ^a   Farinati, Fabio ^b   Ciccarese, Francesca ^c   Rapaccini, Gianludovico ^d   Marco, Mariella Di ^e   Benvegnù, Luisa ^b   Zoli, Marco ^f   Borzio, Franco ^g   Caturelli, Eugenio ^h   Chiaramonte, Maria ⁱ   Trevisani, Franco ^f  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c Divisione di Chirurgia   (Italy)

^d CATHOLIC UNIVERSITY   (Italy)

^e BOLOGNINI HOSPITAL   (Italy)

^f UNIVERSITY OF BOLOGNA   (Italy)

^g FATEBENEFRATELLI HOSPITAL   (Italy)

^h BELCOLLE HOSPITAL   (Italy)

ⁱ SACRO CUORE DON CALABRIA HOSPITAL   (Italy)

Author keywords

Hepatic venous pressure gradient; Hepatocellular carcinoma; Oesophageal varices; Portal hypertension; Surgery; Survival; Thrombocytopaenia

Indexed keywords

BILIRUBIN;

AGED; ARTICLE; CANCER PROGNOSIS; CANCER SURGERY; CANCER SURVIVAL; ESOPHAGUS VARICES; FEMALE; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; PORTAL HYPERTENSION; SPLENOMEGALY; STOMACH DISEASE; STOMACH VARICES; THROMBOCYTE COUNT;

HEPATIC VENOUS PRESSURE GRADIENT; HEPATOCELLULAR CARCINOMA; OESOPHAGEAL VARICES; PORTAL HYPERTENSION; SURGERY; SURVIVAL; THROMBOCYTOPAENIA;

AGED; CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATECTOMY; HUMANS; HYPERTENSION, PORTAL; ITALY; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PLATELET COUNT; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 84885181242     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12199     Document Type: Article

References (35)

1. Nordenstedt H, White DL, El-Serag HB. The changing pattern of epidemiology in hepatocellular carcinoma. Dig Liver Dis 2010; 42(Suppl 3): S206-14.
2. Mirici-Cappa F, Gramenzi A, Santi V, et al. Treatments for hepatocellular carcinoma in elderly patients are as effective as in younger patients: a 20-year multicentre experience. Gut 2010; 59: 387-96.
3. Clavien PA, Lesurtel M, Bossuyt PM, et al. Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report. Lancet Oncol 2012; 13: e11-22.
4. Vitale A, Morales RR, Zanus G, et al. Barcelona Clinic Liver Cancer staging and transplant survival benefit for patients with hepatocellular carcinoma: a multicentre, cohort study. Lancet Oncol 2011; 12: 654-62.
5. Farinati F, Giacomin A, Vanin V, et al. Liver transplantation for hepatocellular carcinoma in clinical practice: the lesson from a 20-year multicentre experience in Italy. Eur J Gastroenterol Hepatol 2012; 24: 195-202.
6. Cucchetti A, Cescon M, Trevisani F, et al. Current concepts in hepatic resection for hepatocellular carcinoma in cirrhotic patients. World J Gastroenterol 2012; 18: 6398-08.
7. Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet 2012; 379: 1245-55.
8. Bruix J, Castells A, Bosch J, et al. Surgical resection of hepatocellular carcinoma in cirrhotic patients: prognostic value of preoperative portal pressure. Gastroenterology 1996; 111: 1018-22.
9. Llovet JM, Fuster J, Bruix J. Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation. Hepatology 1999; 30: 1434-40.
10. Boleslawski E, Petrovai G, Truant S, et al. Hepatic venous pressure gradient in the assessment of portal hypertension before liver resection in patients with cirrhosis. Br J Surg 2012; 99: 855-63.
11. Capussotti L, Ferrero A, Viganò L, et al. Portal hypertension: contraindication to liver surgery? World J Surg 2006; 30: 992-9.
12. Kawano Y, Sasaki A, Kai S, et al. Short- and long-term outcomes after hepatic resection for hepatocellular carcinoma with concomitant esophageal varices in patients with cirrhosis. Ann Surg Oncol 2008; 15: 1670-6.
13. Ishizawa T, Hasegawa K, Aoki T, et al. Neither multiple tumors nor portal hypertension are surgical contraindications for hepatocellular carcinoma. Gastroenterology 2008; 134: 908-16.
14. Cucchetti A, Ercolani G, Vivarelli M, et al. Is portal hypertension a contraindication to hepatic resection? Ann Surg 2009; 250: 922-8.
15. Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology 2011; 53: 1020-2.
16. European Association For The Study Of The Liver; European Organisation For Research And Treatment Of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 2012; 56: 908-43.
17. Santi V, Buccione D, Di Micoli A, et al. The changing scenario of hepatocellular carcinoma over the last two decades in Italy. J Hepatol 2012; 56: 397-405.
18. de Franchis R. Evolving consensus in portal hypertension. Report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol 2005; 43: 167-76.
19. Berry K, Ioannou GN. Are patients with Child's A cirrhosis and hepatocellular carcinoma appropriate candidates for liver transplantation? Am J Transplant 2012; 12: 706-17.
20. Levi DM, Nishida S. Liver transplantation for hepatocellular carcinoma: lessons learned and future directions. Clin Liver Dis 2011; 15: 717-25.
21. Santambrogio R, Kluger MD, Costa M, et al. Hepatic resection for hepatocellular carcinoma in patients with Child-Pugh's A cirrhosis: is clinical evidence of portal hypertension a contraindication? HPB 2013; 15: 78-84.
22. D'Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol 2006; 44: 217-31.
23. Lau H, Man K, Fan ST, et al. Evaluation of preoperative hepatic function in patients with hepatocellular carcinoma undergoing hepatectomy. Br J Surg 1997; 84: 1255-9.
24. Groszmann RJ, Wongcharatrawee S. The hepatic venous pressure gradient: anything worth doing should be done right. Hepatology 2004; 39: 280-2.
25. Qamar AA, Grace ND, Groszmann RJ, et al. Platelet count is not a predictor of the presence or development of gastroesophageal varices in cirrhosis. Hepatology 2008; 47: 153-9.
26. Groszmann RJ, Garcia-Tsao G, Bosch J, et al. Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med 2005; 353: 2254-61.
27. Giannini EG, Savarino V. Thrombocytopenia in liver disease. Curr Opin Hematol 2008; 15: 473-80.
28. Giannini EG. Thrombocytopenia in patients with chronic liver disease: what's in a name? Dig Dis Sci 2013; 58: 299-301.
29. Sugimachi K, Ikeda Y, Tomikawa M, et al. Appraisal of hepatic resection in the treatment of hepatocellular carcinoma with severe thrombocytopenia. World J Surg 2008; 32: 1077-81.
30. Kim SU, Ahn SH, Park JY, et al. Prediction of postoperative hepatic insufficiency by liver stiffness measurement (FibroScan((R))) before curative resection of hepatocellular carcinoma: a pilot study. Hepatol Int 2008; 2: 471-7.
31. Llop E, Berzigotti A, Reig M, et al. Assessment of portal hypertension by transient elastography in patients with compensated cirrhosis and potentially resectable liver tumors. J Hepatol 2012; 56: 103-8.
32. Cescon M, Colecchia A, Cucchetti A, et al. Value of transient elastography measured with FibroScan in predicting the outcome of hepatic resection for hepatocellular carcinoma. Ann Surg 2012; 256: 706-12.
33. Fuks D, Dokmak S, Paradis V, et al. Benefit of initial resection of hepatocellular carcinoma followed by transplantation in case of recurrence: an intention-to-treat analysis. Hepatology 2012; 55: 132-40.
34. Sapisochin G, Castells L, Dopazo C, et al. Single HCC in cirrhotic patients: liver resection or liver transplantation? Long-term outcome according to an intention-to-treat basis. Ann Surg Oncol 2013; 20: 1194-202.
35. Cucchetti A, Cescon M, Trevisani F, et al. What is the probability of being too old for salvage transplantation after hepatocellular carcinoma resection? Dig Liver Dis 2012; 44: 523-9.