A link between the intrarenal renin angiotensin system and hypertension in autosomal dominant polycystic kidney disease

American Journal of Nephrology

Volumn 38, Issue 3, 2013, Pages 218-225

  Kocyigit, Ismail ^a   Yilmaz, Mahmut Ilker ^b   Unal, Aydin ^a   Ozturk, Fahir ^a   Eroglu, Eray ^a   Yazici, Cevat ^a   Orscelik, Ozcan ^a   Sipahioglu, Murat Hayri ^a   Tokgoz, Bulent ^a   Oymak, Oktay ^a  

^a ERCIYES UNIVERSITY MEDICAL FACULTY   (Turkey)

^b GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

Hypertension; Polycystic kidney disease; Urinary angiotensinogen

Indexed keywords

ANGIOTENSINOGEN; CALCIUM; CREATININE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHORUS; URIC ACID;

ADULT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE MONITORING; CALCIUM BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; HYPERTENSION; KIDNEY POLYCYSTIC DISEASE; MAJOR CLINICAL STUDY; MALE; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEINURIA; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SYSTOLIC BLOOD PRESSURE; URIC ACID BLOOD LEVEL; URINE LEVEL;

ADULT; ANGIOTENSINOGEN; BLOOD PRESSURE; BLOOD PRESSURE MONITORING, AMBULATORY; CASE-CONTROL STUDIES; COHORT STUDIES; CREATININE; CROSS-SECTIONAL STUDIES; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; PROTEINURIA; REGRESSION ANALYSIS; RENIN-ANGIOTENSIN SYSTEM;

EID: 84885081017     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000354317     Document Type: Article

References (40)

1. Gabow PA: Autosomal dominant polycystic kidney disease. N Engl J Med 1993; 329: 332-342.
2. Chapman AB, Schrier RW: Pathogenesis of hypertension in autosomal dominant polycystic kidney disease. Semin Nephrol 1991; 11: 653-660.
3. Ecder T, Schrier RW: Hypertension in autosomal-dominant polycystic kidney disease: early occurrence and unique aspects. J Am Soc Nephrol 2001; 12: 194-200.
4. Kelleher CL, McFann KK, Johnson AM, Schrier RW: Characteristics of hypertension in young adults with autosomal dominant polycystic kidney disease compared with the general U.S. population. Am J Hypertens 2004; 17: 1029-1034.
5. Fick-Brosnahan GM, Tran ZV, Johnson AM, Strain JD, Gabow PA: Progression of autosomal-dominant polycystic kidney disease in children. Kidney Int 2001; 59: 1654-1662.
6. Helal I, Reed B, Mettler P, Mc Fann K, Tkachenko O, Yan XD, Schrier RW: Prevalence of cardiovascular events in patients with autosomal dominant polycystic kidney disease. Am J Nephrol 2012; 36: 362-370.
7. Fick GM, Johnson AM, Hammond WS, Gabow PA: Causes of death in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 1995; 5: 2048-2056.
8. Chapman AB, Johnson A, Gabow PA, Schrier RW: The renin-Angiotensin-Aldosterone system and autosomal dominant polycystic kidney disease. N Engl J Med 1990; 323: 1091-1096.
9. Nash DA Jr.: Hypertension in polycystic kidney disease without renal failure. Arch Intern Med 1977; 137: 1571-1575.
10. Valvo E, Gammaro L, Tessitore N, Panzetta G, Lupo A, Loschiavo C, Oldrizzi L, Fabris A, Rugiu C, Ortalda V, et al: Hypertension of polycystic kidney disease: mechanisms and hemodynamic alterations. Am J Nephrol 1985; 5: 176-181.
11. Doulton TW, Saggar-Malik AK, He FJ, Carney C, Markandu ND, Sagnella GA, Mac-Gregor GA: The effect of sodium and angiotensin-converting enzyme inhibition on the classic circulating renin-Angiotensin system in autosomal-dominant polycystic kidney disease patients. J Hypertens 2006; 24: 939-945.
12. Gabow PA, Chapman AB, Johnson AM, Tangel DJ, Duley IT, Kaehny WD, Manco-Johnson M, Schrier RW: Renal structure and hypertension in autosomal dominant polycystic kidney disease. Kidney Int 1990; 38: 1177-1180.
13. Bell PE, Hossack KF, Gabow PA, Durr JA, Johnson AM, Schrier RW: Hypertension in autosomal dominant polycystic kidney disease. Kidney Int 1988; 34: 683-690.
14. Seeman T, Sikut M, Konrad M, Vondrichová H, Janda J, Schärer K: Blood pressure and renal function in autosomal dominant polycystic kidney disease. Pediatr Nephrol 1997; 11: 592-596.
15. Navar LG, Harrison-Bernard LM, Nishiyama A, Kobori H: Regulation of intrarenal angiotensin II in hypertension. Hypertension 2002; 39: 316-322.
16. Kobori H, Nangaku M, Navar LG, Nishiyama A: The intrarenal renin-Angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 2007; 59: 251-287.
17. Torres VE, Donovan KA, Scicli G, Holley KE, Thibodeau SN, Carretero OA, Inagami T, McAteer JA, Johnson CM: Synthesis of renin by tubulocystic epithelium in autosomaldominant polycystic kidney disease. Kidney Int 1992; 42: 364-373.
18. Loghman-Adham M, Soto CE, Inagami T, Cassis L: The intrarenal renin-Angiotensin system in autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol 2004; 287:F775-F788.
19. Rohrwasser A, Morgan T, Dillon HF, Zhao L, Callaway CW, Hillas E, Zhang S, Cheng T, Inagami T, Ward K, Terreros DA, Lalouel JM: Elements of a paracrine tubular renin-Angiotensin system along the entire nephron. Hypertension 1999; 34: 1265-1274.
20. Kobori H, Harrison-Bernard LM, Navar LG: Expression of angiotensinogen mRNA and protein in angiotensin II-dependent hypertension. J Am Soc Nephrol 2001; 12: 431-439.
21. Kobori H, Harrison-Bernard LM, Navar LG: Enhancement of angiotensinogen expression in angiotensin II-dependent hypertension. Hypertension 2001; 37: 1329-1335.
22. Kobori H, Harrison-Bernard LM, Navar LG: Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production. Kidney Int 2002; 61: 579-585.
23. Katsurada A, Hagiwara Y, Miyashita K, Satou R, Miyata K, Ohashi N, Navar LG, Kobori H: Novel sandwich ELISA for human angiotensinogen. Am J Physiol Renal Physiol 2007; 293:F956-F960.
24. Kobori H, Alper AB Jr., Shenava R, Katsurada A, Saito T, Ohashi N, Urushihara M, Miyata K, Satou R, Hamm LL, Navar LG: Urinary angiotensinogen as a novel biomarker of the intrarenal renin-Angiotensin system status in hypertensive patients. Hypertension 2009; 53: 344-350.
25. Yamamoto T, Nakagawa T, Suzuki H, Ohashi N, Fukasawa H, Fujigaki Y, Kato A, Nakamura Y, Suzuki F, Hishida A: Urinary angiotensinogen as a marker of intrarenal angiotensin II activity associated with deterioration of renal function in patients with chronic kidney disease. J Am Soc Nephrol 2007; 18: 1558-1565.
26. Sawaguchi M, Araki SI, Kobori H, Urushihara M, Haneda M, Koya D, Kashiwagi A, Uzu T, Maegawa H: Association between urinary angiotensinogen levels and renal and cardiovascular prognoses in patients with type 2 diabetes mellitus. J Diabetes Investig 2012; 3: 318-324.
27. Myers GL, Miller WG, Coresh J, et al: National Kidney Disease Education Program Laboratory Working Group. Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem 2006; 52: 5-18.
28. Chapman AB, Stepniakowski K, Rahbari-Oskoui F: Hypertension in autosomal dominant polycystic kidney disease. Adv Chronic Kidney Dis 2010; 17: 153-163.
29. Kocyigit I, Kaya MG, Orscelik O, Kaya C, Akpek M, Zengin H, Sipahioglu MH, Unal A, Yilmaz MI, Tokgoz B, Oymak O, Axelsson J: Early arterial stiffness and inflammatory biomarkers in normotensive polycystic kidney disease patients. Am J Nephrol 2012; 36: 11-18.
30. Chapman AB, Bost JE, Torres VE, Guay-Woodford L, Bae KT, Landsittel D, Li J, King BF, Martin D, Wetzel LH, Lockhart ME, Harris PC, Moxey-Mims M, Flessner M, Bennett WM, Grantham JJ: Kidney volume and functional outcomes in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 2012; 7: 479-486.
31. Harrap SB, Davies DL, Macnicol AM, Dominiczak AF, Fraser R, Wright AF, Watson ML, Briggs JD: Renal, cardiovascular and hormonal characteristics of young adults with autosomal dominant polycystic kidney disease. Kidney Int 1991; 40: 501-508.
32. Watson ML, Macnicol AM, Allan PL, Wright AF: Effects of angiotensin converting enzyme inhibition in adult polycystic kidney disease. Kidney Int 1992; 41: 206-210.
33. Aybal Kutlugun A, Altun B, Buyukasik Y, Aki T, Turkmen E, Altindal M, Yildirim T, Yilmaz R, Turgan C: Elevated urinary angiotensinogen a marker of intrarenal renin angiotensin system in hypertensive renal transplant recipients: does it play a role in development of proteinuria in hypertensive renal transplant patients? Transpl Int 2012; 25: 13-18.
34. Navar LG, Kobori H, Prieto MC, Gonzalez-Villalobos RA: Intratubular renin-Angiotensin system in hypertension. Hypertension 2011; 57: 355-362.
35. Kobori H, Navar LG: Urinary angiotensinogen as a novel biomarker of intrarenal reninangiotensin system in chronic kidney disease. Int Rev Thromb 2011; 6: 108-116.
36. Nishiyama A, Konishi Y, Ohashi N, Morikawa T, Urushihara M, Maeda I, Hamada M, Kishida M, Hitomi H, Shirahashi N, Kobori H, Imanishi M: Urinary angiotensinogen reflects the activity of intrarenal renin-Angiotensin system in patients with IgA nephropathy. Nephrol Dial Transplant 2011; 26: 170-177.
37. Kutlugün AA, Altun B, Aktan U, Turkmen E, Altindal M, Yildirim T, Yilmaz R, Arici M, Erdem Y, Turgan C: The relation between urinary angiotensinogen and proteinuria in renal AA amyloidosis patients. Amyloid 2012; 19: 28-32.
38. Urushihara M, Kondo S, Kagami S, Kobori H: Urinary angiotensinogen accurately reflects intrarenal renin-Angiotensin system activity. Am J Nephrol 2010; 31: 318-325.
39. Kobori H, Ohashi N, Katsurada A, Miyata K, Satou R, Saito T, Yamamoto T: Urinary angiotensinogen as a potential biomarker of severity of chronic kidney diseases. J Am Soc Hypertens 2008; 2: 349-354.
40. Saito T, Urushihara M, Kotani Y, Kagami S, Kobori H: Increased urinary angiotensinogen is precedent to increased urinary albumin in patients with type 1 diabetes. Am J Med Sci 2009; 338: 478-480.