Simultaneous determination of blonanserin and its four metabolites in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 939, Issue , 2013, Pages 59-66

  Zhou, Ying ^a   Liu, Ming ^a   Jiang, Ji ^a   Wang, Hongyun ^a   Hu, Pei ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

Blonanserin; Determination; Human plasma; Metabolite; UPLC MS MS

Indexed keywords

BLONANSERIN; DETERMINATION; HUMAN PLASMAS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MULTIPLE-REACTION MONITORING MODES; POSITIVE ELECTROSPRAY IONIZATION; ULTRAPERFORMANCE LIQUID CHROMATOGRAPHY; UPLC-MS/MS;

BIOMOLECULES; CARBOXYLATION; ELECTROSPRAY IONIZATION; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA (HUMAN);

METABOLITES;

ACETONITRILE; AMMONIUM FORMATE; BLONANSERIN; CARBOXYLIC ACID; DRUG METABOLITE; ETHYLENEDIAMINE; FORMIC ACID; WATER;

ACCURACY; ARTICLE; CHINESE; CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); DRUG BLOOD LEVEL; ELECTROSPRAY; FLOW RATE; HUMAN; HUMAN TISSUE; LIMIT OF QUANTITATION; NORMAL HUMAN; PKA; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION STUDY;

BLONANSERIN; DETERMINATION; HUMAN PLASMA; METABOLITE; UPLC-MS/MS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HUMANS; LEAST-SQUARES ANALYSIS; PIPERAZINES; PIPERIDINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

EID: 84885062195     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.09.007     Document Type: Article

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