Prediction of outcome in patients with low-grade squamous intraepithelial lesions by fluorescence in situ hybridization analysis of human papillomavirus, terc, and myc

Cancer Cytopathology

Volumn 121, Issue 8, 2013, Pages 423-431

  Obermann, Ellen C ^a   Prince, Spasenija Savic ^a   Barascud, Audrey ^a   Grilli, Bruno ^a   Herzog, Michelle ^a   Kaup, Daniela ^b   Cathomas, Gieri ^b   Tirri, Brigitte Frey ^c   Zlobec, Inti ^d   Wight, Edward ^e   Bubendorf, Lukas ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b Cantonal Institute of Pathology Liestal   (Switzerland)

^c Womens' Hospital   (Switzerland)

^d UNIVERSITY OF BERN   (Switzerland)

^e UNIVERSITY WOMEN S HOSPITAL   (Switzerland)

Author keywords

Cervical cytology; Fluorescence in situ hybridization; Human papillomavirus; Myc; Squamous intraepithelial lesion; Telomerase rna component (terc)

Indexed keywords

ARTICLE; ATYPICAL SQUAMOUS CELLS OF UNDETERMINED SIGNIFICANCE; CANCER GROWTH; CONTROLLED STUDY; CYTODIAGNOSIS; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE DOSAGE; HIGH GRADE SQUAMOUS INTRAEPITHELIAL LESION; HUMAN; HUMAN TISSUE; LOW GRADE SQUAMOUS INTRAEPITHELIAL LESION; MAJOR CLINICAL STUDY; ONCOGENE MYC; PAPANICOLAOU TEST; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; TERC GENE; UTERINE CERVIX CARCINOMA IN SITU; VIRUS DETECTION; VIRUS TYPING; WART VIRUS;

CERVICAL CYTOLOGY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN PAPILLOMAVIRUS; MYC; SQUAMOUS INTRAEPITHELIAL LESION; TELOMERASE RNA COMPONENT (TERC);

AREA UNDER CURVE; CARCINOMA, SQUAMOUS CELL; CERVICAL INTRAEPITHELIAL NEOPLASIA; FEMALE; GENE DOSAGE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-MYC; RNA; ROC CURVE; TELOMERASE; UTERINE CERVICAL NEOPLASMS;

EID: 84885057242     PISSN: None     EISSN: 19346638     Source Type: Journal    
DOI: 10.1002/cncy.21280     Document Type: Article

References (38)

1. Koss LG. The Papanicolaou test for cervical cancer detection. A triumph and a tragedy. JAMA. 1989;261:737-743. (Pubitemid 19047323)
2. The Atypical Squamous Cells of Undetermined Significance/Low- Grade Squamous Intraepithelial Lesions Triage Study (ALTS) Group. Human papillomavirus testing for triage of women with cytologic evidence of low-grade squamous intraepithelial lesions: baseline data from a randomized trial. J Natl Cancer Inst. 2000;92:397-402.
3. Castle PE, Schiffman M, Wheeler CM, Solomon D. Evidence for frequent regression of cervical intraepithelial neoplasia-grade 2. Obstet Gynecol. 2009;113:18-25.
4. Gravitt PE, Coutlee F, Iftner T, Sellors JW, Quint WG, Wheeler CM. New technologies in cervical cancer screening. Vaccine. 2008;26(suppl 10):K42-K52.
5. Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer. 2002;2:342-350. (Pubitemid 37328947)
6. Solomon D, Schiffman M, Tarone R, ALTS Study Group. Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial. J Natl Cancer Inst. 2001;93:293-299. (Pubitemid 32219816)
7. Sherman ME, Schiffman M, Cox JT; Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study Group. Effects of age and human papilloma viral load on colposcopy triage: data from the randomized Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study (ALTS). J Natl Cancer Inst. 2002;94:102-107. (Pubitemid 34121289)
8. Gupta N, Srinivasan R, Rajwanshi A. Functional biomarkers in cervical precancer: An overview. Diagn Cytopathol. 2010;38:618- 623.
9. Schmidt D, Bergeron C, Denton KJ, Ridder R; European CINtec Cytology Study Group. p16/ki-67 dual-stain cytology in the triage of ASCUS and LSIL Papanicolaou cytology: results from the European equivocal or mildly abnormal Papanicolaou cytology study. Cancer (Cancer Cytopathol). 2011;119:158-166.
10. Rao PH, Arias-Pulido H, Lu XY, et al. Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinoma. BMC Cancer. 2004;4:5.
11. Meyerson M. Role of telomerase in normal and cancer cells. J Clin Oncol. 2000;18:2626-2634. (Pubitemid 30432531)
12. Hopman AH, Theelen W, Hommelberg PP, et al. Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer. J Pathol. 2006;210:412-419. (Pubitemid 44830601)
13. Heselmeyer-Haddad K, Sommerfeld K, White NM, et al. Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer. Am J Pathol. 2005;166:1229-1238. (Pubitemid 40524445)
14. Grandori C, Cowley SM, James LP, Eisenman RN. The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu Rev Cell Dev Biol. 2000;16:653-699. (Pubitemid 32037520)
15. Peter M, Rosty C, Couturier J, Radvanyi F, Teshima H, Sastre- Garau X. MYC activation associated with the integration of HPV DNA at the MYC locus in genital tumors. Oncogene. 2006;25:5985-5993. (Pubitemid 44477292)
16. Yu T, Ferber MJ, Cheung TH, Chung TK, Wong YF, Smith DI. The role of viral integration in the development of cervical cancer. Cancer Genet Cytogenet. 2005;158:27-34. (Pubitemid 40354321)
17. Sokolova I, Algeciras-Schimnich A, Song M, et al. Chromosomal biomarkers for detection of human papillomavirus associated genomic instability in epithelial cells of cervical cytology specimens. J Mol Diagn. 2007;9:604-611. (Pubitemid 350158419)
18. Algeciras-Schimnich A, Policht F, Sitailo S, Song M, Morrison L, Sokolova I. Evaluation of quantity and staining pattern of human papillomavirus (HPV)-infected epithelial cells in thin-layer cervical specimens using optimized HPV-CARD assay. Cancer. 2007;111:330-338.
19. Alameda F, Espinet B, Corzo C, et al. 3q26 (hTERC) gain studied by fluorescence in situ hybridization as a persistence-progression indicator in low-grade squamous intraepithelial lesion cases. Hum Pathol. 2009;40:1474-1478.
20. Pett M, Coleman N. Integration of high-risk human papillomavirus: A key event in cervical carcinogenesis? J Pathol. 2007;212:356- 367. (Pubitemid 47099012)
21. Evans MF, Cooper K. Human papillomavirus integration: detection by in situ hybridization and potential clinical application. J Pathol. 2004;202:1-4. (Pubitemid 38072839)
22. Woodman CB, Collins SI, Young LS. The natural history of cervical HPV infection: unresolved issues. Nat Rev Cancer. 2007;7:11- 22. (Pubitemid 46020844)
23. Sano T, Hikino T, Niwa Y, et al. In situ hybridization with biotinylated tyramide amplification: detection of human papillomavirus DNA in cervical neoplastic lesions. Mod Pathol. 1998;11:19-23. (Pubitemid 28177359)
24. Evans MF, Mount SL, Beatty BG, Cooper K. Biotinyl-tyramidebased in situ hybridization signal patterns distinguish human papillomavirus type and grade of cervical intraepithelial neoplasia. Mod Pathol. 2002;15:1339-1347. (Pubitemid 35463003)
25. Hopman AH, Kamps MA, Smedts F, Speel EJ, Herrington CS, Ramaekers FC. HPV in situ hybridization: impact of different protocols on the detection of integrated HPV. Int J Cancer. 2005;115:419-428. (Pubitemid 40663746)
26. Swindle CS, Zou N, Van Tine BA, Shaw GM, Engler JA, Chow LT. Human papillomavirus DNA replication compartments in a transient DNA replication system. J Virol. 1999;73:1001-1009. (Pubitemid 29036751)
27. Andersson S, Sowjanya P, Wangsa D, et al. Detection of genomic amplification of the human telomerase gene TERC, a potential marker for triage of women with HPV-positive, abnormal Pap smears. Am J Pathol. 2009;175:1831-1847.
28. Jiang J, Wei LH, Li YL, et al. Detection of TERC amplification in cervical epithelial cells for the diagnosis of high-grade cervical lesions and invasive cancer: A multicenter study in China. J Mol Diagn. 2010;12:808-817.
29. Heitmann ER, Lankachandra KM, Wall J, et al. 3q26 amplification is an effective negative triage test for LSIL: A historical prospective study. PLoS One. 2012;7:e39101.
30. Chen S, Yang Z, Zhang Y, et al. Genomic amplification patterns of human telomerase RNA gene and C-MYC in liquid-based cytological specimens used for the detection of high-grade cervical intraepithelial neoplasia. Diagn Pathol. 2012;7:40.
31. Heselmeyer-Haddad K, Janz V, Castle PE, et al. Detection of genomic amplification of the human telomerase gene (TERC) in cytologic specimens as a genetic test for the diagnosis of cervical dysplasia. Am J Pathol. 2003;163:1405-1416. (Pubitemid 37175088)
32. Caraway NP, Khanna A, Dawlett M, et al. Gain of the 3q26 region in cervicovaginal liquid-based pap preparations is associated with squamous intraepithelial lesions and squamous cell carcinoma. Gynecol Oncol. 2008;110:37-42.
33. Tu Z, Zhang A, Wu R, et al. Genomic amplification of the human telomerase RNA gene for differential diagnosis of cervical disorders. Cancer Genet Cytogenet. 2009;191:10-16.
34. Richardson H, Kelsall G, Tellier P, et al. The natural history of type-specific human papillomavirus infections in female university students. Cancer Epidemiol Biomarkers Prev. 2003;12:485-490. (Pubitemid 36713640)
35. Insinga RP, Dasbach EJ, Elbasha EH. Epidemiologic natural history and clinical management of Human Papillomavirus (HPV) Disease: A critical and systematic review of the literature in the development of an HPV dynamic transmission model. BMC Infect Dis. 2009;9:119.
36. Schiffman M, Wentzensen N, Wacholder S, Kinney W, Gage JC, Castle PE. Human papillomavirus testing in the prevention of cervical cancer. J Natl Cancer Inst. 2011;103:368-383.
37. Koskimaa HM, Kurvinen K, Costa S, Syrjanen K, Syrjanen S. Molecular markers implicating early malignant events in cervical carcinogenesis. Cancer Epidemiol Biomarkers Prev. 2010;19:2003-2012.
38. Lehoux M, D'Abramo CM, Archambault J. Molecular mechanisms of human papillomavirus-induced carcinogenesis. Public Health Genomics. 2009;12:268-280.