A prospective study evaluating the role of donor-specific anti-endothelial crossmatch (XM-ONE assay) in predicting living donor kidney transplant outcome

Human Immunology

Volumn 74, Issue 11, 2013, Pages 1431-1436

  Zitzner, Jennifer R ^a   Shah, Shivani ^a   Jie, Chunfa ^a   Wegner, Wendy ^a   Tambur, Anat R ^a   Friedewald, John J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

AECAs; EPCs; ESRD; FSGS; HLA; MICA MICB; SAB; SOC; UA

Indexed keywords

CREATININE; ENDOTHELIAL CELL ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADULT; ARTICLE; ASSAY; BLOOD SAMPLING; CREATININE BLOOD LEVEL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY GRAFT; KIDNEY GRAFT REJECTION; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEINURIA; XM ONE ASSAY;

AECAS; ANTI-ENDOTHELIAL CELL ANTIBODIES; END STAGE RENAL DISEASE; ENDOTHELIAL PRECURSOR CELLS; EPCS; ESRD; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; FSGS; HLA; HUMAN LEUKOCYTE ANTIGEN; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I CHAIN RELATED ANTIGEN A AND B; MICA/MICB; SAB; SINGLE ANTIGEN BEAD; SOC; STANDARD OF CARE; UA; URINALYSIS;

ADULT; ENDOTHELIAL CELLS; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HISTOCOMPATIBILITY TESTING; HUMANS; ISOANTIBODIES; KIDNEY; KIDNEY TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84885056241     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2013.06.007     Document Type: Article

References (20)

1. Nankivell B.J., Alexander S.I. Rejection of the kidney allograft. N Engl J Med 2010, 363(15):1451-1462.
2. Terasaki P.I. Humoral theory of transplantation. Am J Transplant 2003, 3(6):665-673.
3. Zhang X., Reed E.F. Effect of antibodies on endothelium. Am J Transplant 2009, 9(11):2459-2465.
4. Glotz D., et al. Endothelial cells as targets of allograft rejection. Transplantation 2006, 82(1 Suppl):S19-S21.
5. Zhang Q., Reed E.F. Non-MHC antigenic targets of the humoral immune response in transplantation. Curr Opin Immunol 2010, 22(5):682-688.
6. Zou Y., et al. Antibodies against MICA antigens and kidney-transplant rejection. N Engl J Med 2007, 357(13):1293-1300.
7. Solgi G., et al. Clinical relevance of pre and post-transplant immune markers in kidney allograft recipients: anti-HLA and MICA antibodies and serum levels of sCD30 and sMICA. Transpl Immunol 2012, 26(2-3):81-87.
8. Cox S.T., et al. Major histocompatibility complex class I-related chain A allele mismatching, antibodies, and rejection in renal transplantation. Hum Immunol 2011, 72(10):827-834.
9. Nath D.S., et al. Characterization of immune responses to cardiac self-antigens myosin and vimentin in human cardiac allograft recipients with antibody-mediated rejection and cardiac allograft vasculopathy. J Heart Lung Transplant 2010, 29(11):1277-1285.
10. Dragun D., et al. Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection. N Engl J Med 2005, 352(6):558-569.
11. Reinsmoen N.L., et al. Anti-angiotensin type 1 receptor antibodies associated with antibody mediated rejection in donor HLA antibody negative patients. Transplantation 2010, 90(12):1473-1477.
12. Wehner J., et al. Antibody and complement in transplant vasculopathy. Circ Res 2007, 100(2):191-203.
13. Vermehren D., Sumitran-Holgersson S. Isolation of precursor endothelial cells from peripheral blood for donor-specific crossmatching before organ transplantation. Transplantation 2002, 74(11):1479-1486.
14. Asahara T., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997, 275(5302):964-967.
15. Alheim M., et al. A flow cytometric crossmatch test for simultaneous detection of antibodies against donor lymphocytes and endothelial precursor cells. Tissue Antigens 2010, 75(3):269-277.
16. Nowak G., et al. Expression of vascular endothelial growth factor receptor-2 or Tie-2 on peripheral blood cells defines functionally competent cell populations capable of reendothelialization. Circulation 2004, 110(24):3699-3707.
17. Breimer M.E., et al. Multicenter evaluation of a novel endothelial cell crossmatch test in kidney transplantation. Transplantation 2009, 87(4):549-556.
18. Jackson A.M., et al. Clinical relevance and IgG subclass determination of non-HLA antibodies identified using endothelial cell precursors isolated from donor blood. Transplantation 2011, 92(1):54-60.
19. Xavier P., et al. XM-ONE detection of endothelium cell antibodies identifies a subgroup of HLA-antibody negative patients undergoing acute rejection. Transplant Proc 2011, 43(1):91-94.
20. Hanaway M.J., et al. Alemtuzumab induction in renal transplantation. N Engl J Med 2011, 364(20):1909-1919.