Molecular background of urate transporter genes in patients with exercise-induced acute kidney injury

American Journal of Nephrology

Volumn 38, Issue 4, 2013, Pages 316-320

  Kaito, Hiroshi ^a   Ishimori, Shingo ^a   Nozu, Kandai ^a   Shima, Yuko ^b   Nakanishi, Koichi ^b   Yoshikawa, Norishige ^b   Iijima, Kazumoto ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Exercise induced acute kidney injury; Renal hypouricemia; Urate transporter

Indexed keywords

GENOMIC DNA; RNA; URATE; URATE TRANSPORTER; URIC ACID;

ACUTE KIDNEY FAILURE; ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; EXERCISE; EXERCISE INDUCED ACUTE KIDNEY INJURY; FEMALE; HUMAN; HYPOURICEMIA; LEUKOCYTE; LOSS OF FUNCTION MUTATION; MALE; PRIORITY JOURNAL; RNA ISOLATION; ANAEROBIC EXERCISE; CHILD; EXERCISE INDUCED ACUTE KIDNEY FAILURE; EXON; GENE; GENE SEQUENCE; GENETIC ANALYSIS; GENOTYPE; HETEROZYGOTE; HUMAN CELL; INTRON; MUTATIONAL ANALYSIS; SCHOOL CHILD; URATE TRANSPORTER GENE; URIC ACID BLOOD LEVEL;

ACUTE KIDNEY INJURY; ADOLESCENT; ADULT; CHILD; EXERCISE; FEMALE; GENOME; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; LEUKOCYTES; MALE; MUTATION; ORGANIC ANION TRANSPORTERS; ORGANIC CATION TRANSPORT PROTEINS; POLYMERASE CHAIN REACTION; RENAL TUBULAR TRANSPORT, INBORN ERRORS; SEQUENCE ANALYSIS, DNA; URIC ACID; URINARY CALCULI; YOUNG ADULT;

EID: 84885038015     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000355430     Document Type: Article

References (21)

1. Ishikawa I: Acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise in patients with or without renal hypouricemia. Nephron 2002; 91: 559-570.
2. Erley CM, Hirschberg RR, Hoefer W, Shaefer K: Acute renal failure due to uric acid nephropathy in a patient with renal hypouricemia. Klin Wochenschr 1989; 67: 308-312.
3. Komoda F, Sekine T, Inatomi J, Enomoto A, Endou H, Ota T, Matsuyama T, Ogata T, Ikeda M, Awazu M, Muroya K, Kamimaki I, Igarashi T: The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia. Pediatr Nephrol 2004; 19: 728-733.
4. Anzai N, Kanai Y, Endou H: New insights into renal transport of urate. Curr Opin Rheumatol 2007; 19: 151-157.
5. Takahashi T, Tsuchida S, Oyamada T, Ohno T, Miyashita M, Saito S, Komatsu K, Takashina K, Takada G: Recurrent URAT1 gene mutations and prevalence of renal hypouricemia in Japanese. Pediatr Nephrol 2005; 20: 576-578.
6. Vitart V, Rudan I, Hayward C, Gray NK, Floyd J, Palmer CN, Knott SA, Kolcic I, Polasek O, Graessler J, Wilson JF, Marinaki A, Riches PL, Shu X, Janicijevic B, Smolej-Narancic N, Gorgoni B, Morgan J, Campbell S, Biloglav Z, Barac-Lauc L, Pericic M, Klaric IM, Zgaga L, Skaric-Juric T, Wild SH, Richardson WA, Hohenstein P, Kimber CH, Tenesa A, Donnelly LA, Fairbanks LD, Aringer M, McKeigue PM, Ralston SH, Morris AD, Rudan P, Hastie ND, Campbell H, Wright AF: SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet 2008; 40: 437-442.
7. Anzai N, Ichida K, Jutabha P, Kimura T, Babu E, Jin CJ, Srivastava S, Kitamura K, Hisatome I, Endou H, Sakurai H: Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. J Biol Chem 2008; 283: 26834-26838.
8. Matsuo H, Chiba T, Nagamori S, Nakayama A, Domoto H, Phetdee K, Wiriyasermkul P, Kikuchi Y, Oda T, Nishiyama J, Nakamura T, Morimoto Y, Kamakura K, Sakurai Y, Nonoyama S, Kanai Y, Shinomiya N: Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia. Am J Hum Genet 2008; 83: 744-751.
9. Dinour D, Gray NK, Campbell S, Shu X, Sawyer L, Richardson W, Rechavi G, Amariglio N, Ganon L, Sela BA, Bahat H, Goldman M, Weissgarten J, Millar MR, Wright AF, Holtzman EJ: Homozygous SLC2A9 mutations cause severe renal hypouricemia. J Am Soc Nephrol 2010; 21: 64-72.
10. Kikuchi Y, Koga H, Yasutomo Y, Kawabata Y, Shimizu E, Naruse M, Kiyama S, Nonoguchi H, Tomita K, Sasatomi Y, Takebayashi S: Patients with renal hypouricemia with exerciseinduced acute renal failure and chronic renal dysfunction. Clin Nephrol 2000; 53: 467-472.
11. Tanaka M, Itoh K, Matsushita K, Matsushita K, Wakita N, Adachi M, Nonoguchi H, Kitamura K, Hosoyamada M, Endou H, Tomita K: Two male siblings with hereditary renal hypouricemia and exercise-induced ARF. Am J Kidney Dis 2003; 42: 1287-1292.
12. Ohta T, Sakano T, Ogawa T, Kato J, Awaya Y, Kihara H, Kinoshita Y: Exercise induced acute renal failure with renal hypouricemia: a case report and a review of the literature. Clin Nephrol 2002; 58: 313-316.
13. Fujinaga S, Ito A, Nakagawa M, Watanabe T, Ohtomo Y, Shimizu T: Posterior reversible encephalopathy syndrome with exercise-induced acute kidney injury in renal hypouricemia type 1. Eur J Pediatr DOI: 10.1007/ s00431-013-1986-7.
14. Shima Y, Nozu K, Nozu Y, Togawa H, Kaito H, Matsuo M, Iijima K, Nakanishi K, Yoshikawa N: Recurrent EIARF and PRES with severe renal hypouricemia by compound heterozygous SLC2A9 mutation. Pediatrics 2011; 127:e1621-e1625.
15. Iwai N, Mino Y, Hosoyamada M, Tago N, Kokubo Y, Endou H: A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese. Kidney Int 2004; 66: 935-944.
16. Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H: Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 2002; 417: 447-452.
17. Ichida K, Hosoyamada M, Hisatome I, Enomoto A, Hikita M, Endou H, Hosoya T: Clinical and molecular analysis of patients with renal hypouricemia in Japan: influence of URAT1 gene on urinary urate excretion. J Am Soc Nephrol 2004; 15: 164-173.
18. Ames BN, Cathcart R, Schwiers E, Hochstein P: Uric acid provides an antioxidant defense in humans against oxidant- and radicalcaused aging and cancer: a hypothesis. Proc Natl Acad Sci USA 1981; 78: 6858-6862.
19. Kaneko K, Taniguchi N, Tanabe Y, Nakano T, Hasui M, Nozu K: Oxidative imbalance in idiopathic renal hypouricemia. Pediatr Nephrol 2009; 24: 869-871.
20. Price KL, Sautin YY, Long DA, Zhang L, Miyazaki H, Mu W, Endou H, Johnson RJ: Human vascular smooth muscle cells express a urate transporter. J Am Soc Nephrol 2006; 17: 1791-1795.
21. Anzai N, Endou H: Urate transporters: an evolving field. Semin Nephrol 2011; 31: 400-409.