Prophylactic antibiotics in open fractures: A pilot randomized clinical safety study

Journal of Orthopaedic Trauma

Volumn 27, Issue 10, 2013, Pages 552-557

  Saveli, Carla C ^a   Morgan, Steven J ^b   Belknap, Robert W ^c   Ross, Erin ^a   Stahel, Philip F ^a   Chaus, George W ^a   Hak, David J ^a   Biffl, Walter L ^a   Knepper, Bryan ^d   Price, Connie S ^c  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b SWEDISH MEDICAL CENTER   (United States)

^c Infectious Diseases   (United States)

^d DENVER HEALTH MEDICAL CENTER   (United States)

Author keywords

MRSA; open fracture; prophylactic antibiotic; randomized trial; Staphylococcus aureus

Indexed keywords

CEFAZOLIN; VANCOMYCIN;

ABSENCE OF SIDE EFFECTS; ADULT; ANTIBIOTIC PROPHYLAXIS; BACTERIAL COLONIZATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG SAFETY; EMERGENCY WARD; FEMALE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MONOTHERAPY; OPEN FRACTURE; PATIENT ASSESSMENT; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STAPHYLOCOCCUS AUREUS; SURGICAL INFECTION;

ADULT; ANTI-BACTERIAL AGENTS; COLORADO; COMORBIDITY; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; FEMALE; FRACTURE FIXATION, INTERNAL; FRACTURES, OPEN; HUMANS; INCIDENCE; MALE; PILOT PROJECTS; PREMEDICATION; PROSTHESIS-RELATED INFECTIONS; RISK FACTORS; STAPHYLOCOCCAL INFECTIONS; TREATMENT OUTCOME; VANCOMYCIN;

EID: 84885023645     PISSN: 08905339     EISSN: 15312291     Source Type: Journal    
DOI: 10.1097/BOT.0b013e31828d92ee     Document Type: Conference Paper

References (28)

1. Mangram AJ, Horan TC, Pearson ML, et al. Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol. 1999;20:250-278; quiz 279-280
2. Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg Am. 1976;58:453-458
3. Gustilo RB, Mendoza RM, Williams DN. Problems in the management of type III (severe) open fractures: a new classification of type III open fractures. J Trauma. 1984;24:742-746
4. Braun R, Enzler MA, Rittmann WW. A double-blind clinical trial of prophylactic cloxacillin in open fractures. J Orthop Trauma. 1987;1:12-17
5. Bergman BR. Antibiotic prophylaxis in open and closed fractures: a controlled clinical trial. Acta Orthop. 1982;53:57-62
6. Patzakis MJ, Harvey JP Jr, Ivler D. The role of antibiotics in the management of open fractures. J Bone Joint Surg Am. 1974;56:532-541
7. Johnson KD, Johnston DW. Orthopedic experience with methicillinresistant Staphylococcus aureus during a hospital epidemic. Clin Orthop Relat Res. 1986;212:281-288
8. Ellis MW, Hospenthal DR, Dooley DP, et al. Natural history of community- acquired methicillin-resistant Staphylococcus aureus colonization and infection in soldiers. Clin Infect Dis. 2004;39:971-979
9. Hauser CJ, Adams CA Jr, Eachempati SR. Council of the Surgical Infection Society. Surgical Infection Society guideline: prophylactic antibiotic use in open fractures: an evidence-based guideline. Surg Infect (Larchmt). 2006;7:379-405
10. Dellinger EP, Gross PA, Barrett TL, et al. Quality standard for antimicrobial prophylaxis in surgical procedures. Infectious Diseases Society of America. Clin Infect Dis. 1994;18:422-427
11. Kalmeijer MD, van Nieuwland-Bollen E, Bogaers-Hofman D, et al. Nasal carriage of Staphylococcus aureus is a major risk factor for surgical- site infections in orthopedic surgery. Infect Control Hosp Epidemiol. 2000;21:319-323
12. Shukla S, Nixon M, Acharya M, et al. Incidence of MRSA surgical-site infection in MRSA carriers in an orthopaedic trauma unit. J Bone Joint Surg Br. 2009;91:225-228
13. Engemann JJ, Carmeli Y, Cosgrove SE, et al. Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection. Clin Infect Dis. 2003;36: 592-598
14. Anderson DJ, Kaye KS, Chen LF, et al. Clinical and financial outcomes due to methicillin resistant Staphylococcus aureus surgical site infection: a multi-center matched outcomes study. PLoS One. 2009;4:e8305.
15. Kim DH, Spencer M, Davidson SM, et al. Institutional prescreening for detection and eradication of methicillin-resistant Staphylococcus aureus in patients undergoing elective orthopaedic surgery. J Bone Joint Surg Am. 2010;92:1820-1826
16. Brown DF, Edwards DI, Hawkey PM, et al. Guidelines for the laboratory diagnosis and susceptibility testing of methicillin-resistant Staphylococcus aureus (MRSA). J Antimicrob Chemother. 2005;56:1000-1018
17. Horan TC, Gaynes RP, Martone WJ, et al. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol. 1992;13: 606-608
18. Yiannakopoulou EC. Methodological issues regarding safety evaluation in randomized controlled trials of the effectiveness of antibiotic prophylaxis for the prevention of post-operative wound infection: systematic review. J Antimicrob Chemother. 2009;63:843-845
19. Blakesley RE, Mazumdar S, Dew MA, et al. Comparisons of methods for multiple hypothesis testing in neuropsychological research. Neuropsychology. 2009;23:255-264
20. Kenner J, OConnor T, Piantanida N, et al. Rates of carriage of methicillinresistant and methicillin-susceptible Staphylococcus aureus in an outpatient population. Infect Control Hosp Epidemiol. 2003;24:439-444
21. Whitehouse JD, Friedman ND, Kirkland KB, et al. The impact of surgical- site infections following orthopedic surgery at a community hospital and a university hospital: adverse quality of life, excess length of stay, and extra cost. Infect Control Hosp Epidemiol. 2002;23:183-189
22. Lee J. Efficacy of cultures in the management of open fractures. Clin Orthop Relat Res. 1997;339:71-75
23. Dellinger EP, Caplan ES, Weaver LD, et al. Duration of preventive antibiotic administration for open extremity fractures. Arch Surg. 1988; 123:333-339
24. Patzakis MJ, Wilkins J. Factors influencing infection rate in open fracture wounds. Clin Orthop Relat Res. 1989;243:36-40
25. Donlan RM. Biofilms: microbial life on surfaces. Emerg Infect Dis. 2002; 8:881-890
26. Carsenti-Etesse H, Doyon F, Desplaces N, et al. Epidemiology of bacterial infection during management of open leg fractures. Eur J Clin Microbiol Infect Dis. 1999;18:315-323
27. Saveli CC, Belknap RW, Morgan SJ, et al. The role of prophylactic antibiotics in open fractures in an era of community-acquired methicillin-resistant Staphylococcus aureus. Orthopedics. 2011;34:611-616
28. Bolon MK, Morlote M, Weber SG, et al. Glycopeptides are no more effective than beta-lactam agents for prevention of surgical site infection after cardiac surgery: a meta-analysis. Clin Infect Dis. 2004; 38:1357-1363.