Pharmacokinetics of oseltamivir carboxylate in critically ill patients: Each patient is unique

Intensive Care Medicine

Volumn 39, Issue 5, 2013, Pages 977-978

  Kromdijk, W ^a   Sikma, M A ^b   Van Den Broek, M P H ^b   Beijnen, J H ^a,c   Huitema, A D R ^a   De Lange, D W ^b  

^a SLOTERVAART HOSPITAL   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; OSELTAMIVIR;

2009 H1N1 INFLUENZA; ADULT; AGED; AREA UNDER THE CURVE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTINUOUS HEMOFILTRATION; CRITICALLY ILL PATIENT; DRUG BLOOD LEVEL; EXTRACORPOREAL OXYGENATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTENSIVE CARE UNIT; KIDNEY FAILURE; LETTER; MALE; MAXIMUM PLASMA CONCENTRATION; TANDEM MASS SPECTROMETRY;

ADULT; AGED; ANTIVIRAL AGENTS; AREA UNDER CURVE; CRITICAL ILLNESS; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MALE; MIDDLE AGED; OSELTAMIVIR; PANDEMICS;

EID: 84885022644     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-013-2851-x     Document Type: Letter

References (5)

1. WHO (2009) Guidelines for pharmacological management of pandemic (H1N1) 2009 influenza and other influenza viruses. Available at: http://www.who.int/ csr/resources/publications/swineflu/h1n1-use-antivirals-20090820/en/index.html. Accessed 29 January 2013
2. Ariano RE, Sitar DS, Zelenitsky SA, Zarychanski R, Pisipati A, Ahern S, Kanji S, Rello J, Kumar A (2010) Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza. CMAJ 182(4):357-363
3. Kromdijk W, Rosing H, van den Broek MP, Beijnen JH, Huitema AD (2012) Quantitative determination of oseltamivir and oseltamivir carboxylate in human fluoride EDTA plasma including the ex vivo stability using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 891-892:57-63
4. Widmer N, Meylan P, Ivanyuk A, Aouri M, Decosterd LA, Buclin T (2010) Oseltamivir in seasonal, avian H5N1 and pandemic 2009 A/H1N1 influenza: pharmacokinetic and pharmacodynamic characteristics. Clin Pharmacokinet 49(11):741-765
5. Anderson GD (2005) Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach. Clin Pharmacokinet 44(10):989-1008