Recurrent periprosthetic joint infection: Persistent or new infection?

Journal of Arthroplasty

Volumn 28, Issue 9, 2013, Pages 1486-1489

  Zmistowski, Benjamin ^a   Tetreault, Matthew W ^b   Alijanipour, Pouya ^a   Chen, Antonia F ^c   Della Valle, Craig J ^b   Parvizi, Javad ^a  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Periprosthetic joint infection; Persistent infection; Recurrent infection

Indexed keywords

ADULT; AGED; ARTICLE; BACTERIUM CULTURE; BODY MASS; CHARLSON COMORBIDITY INDEX; COAGULASE NEGATIVE STAPHYLOCOCCUS; COMORBIDITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG TREATMENT FAILURE; ENTEROCOCCUS; FEMALE; FUNGUS; GRAM NEGATIVE BACTERIUM; HEALTH STATUS; HIGH RISK POPULATION; HIP PROSTHESIS; HUMAN; INFECTION RISK; KNEE PROSTHESIS; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MYCOBACTERIUM; NONHUMAN; PATHOGEN CLEARANCE; PERIPROSTHETIC JOINT INFECTION; PERSISTENT INFECTION; RECURRENT INFECTION; REIMPLANTATION; RETROSPECTIVE STUDY; RISK FACTOR; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STREPTOCOCCUS; TREATMENT OUTCOME; VANCOMYCIN RESISTANT ENTEROCOCCUS;

PERIPROSTHETIC JOINT INFECTION; PERSISTENT INFECTION; RECURRENT INFECTION;

ADULT; AGED; AGED, 80 AND OVER; ARTHROPLASTY, REPLACEMENT; FEMALE; HUMANS; MALE; MIDDLE AGED; PROSTHESIS-RELATED INFECTIONS; RECURRENCE; RETROSPECTIVE STUDIES; TREATMENT FAILURE;

EID: 84885019132     PISSN: 08835403     EISSN: 15328406     Source Type: Journal    
DOI: 10.1016/j.arth.2013.02.021     Document Type: Article

References (26)

1. Cram P., Lu X., Kaboli P.J., et al. Clinical characteristics and outcomes of Medicare patients undergoing total hip arthroplasty, 1991-2008. JAMA 2011, 305(15):1560. Available at: [Accessed April 27, 2011].
2. Kurtz S.M., Lau E., Schmier J., et al. Infection burden for hip and knee arthroplasty in the United States. J Arthroplasty 2008, 23(7):984. Available at: [Accessed May 16, 2011].
3. Goldman R.T., Scuderi G.R., Insall J.N. 2-Stage reimplantation for infected total knee replacement. Clin Orthop Relat Res 1996, (331):118. Available at: [Accessed August 20, 2012].
4. Mittal Y., Fehring T.K., Hanssen A., et al. Two-stage reimplantation for periprosthetic knee infection involving resistant organisms. J Bone Joint Surg Am 2007, 89(6):1227. Available at: [Accessed August 20, 2012].
5. Mortazavi S.J., Vegari D., Ho A., et al. Two-stage exchange arthroplasty for infected total knee arthroplasty: predictors of failure. Clin Orthop Relat Res 2011, 469(11):3049.
6. Sherrell J.C., Fehring T.K., Odum S., et al. The Chitranjan Ranawat Award: fate of two-stage reimplantation after failed irrigation and débridement for periprosthetic knee infection. Clin Orthop Relat Res 2011, 469(1):18. Available at: [Accessed July 18, 2011].
7. Deyo R.A., Cherkin D.C., Ciol M.A. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992, 45(6):613. Available at: [Accessed May 2, 2010].
8. Scott I.R., Stockley I., Getty C.J. Exchange arthroplasty for infected knee replacements. A new two-stage method. J Bone Joint Surg Br 1993, 75(1):28. Available at: [Accessed March 29, 2010].
9. Teeny S.M., Dorr L., Murata G., et al. Treatment of infected total knee arthroplasty. Irrigation and debridement versus two-stage reimplantation. J Arthroplasty 1990, 5(1):35. Available at: [Accessed March 29, 2010].
10. Gristina A.G., Costerton J.W. Bacterial adherence to biomaterials and tissue. The significance of its role in clinical sepsis. J Bone Joint Surg Am 1985, 67(2):264. Available at: [Accessed August 30, 2010].
11. Trampuz A., Piper K.E., Jacobson M.J., et al. Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med 2007, 357(7):654. Available at: [Accessed April 11, 2010].
12. Tunney M.M., Patrick S., Gorman S.P., et al. Improved detection of infection in hip replacements. A currently underestimated problem. J Bone Joint Surg Br 1998, 80(4):568. Available at: [Accessed August 30, 2010].
13. Ghanem E., Azzam K., Seeley M., et al. Staged revision for knee arthroplasty infection: what is the role of serologic tests before reimplantation?. Clin Orthop Relat Res 2009, 467(7):1699.
14. Kusuma S.K., Ward J., Jacofsky M., et al. What is the role of serological testing between stages of two-stage reconstruction of the infected prosthetic knee?. Clin Orthop Relat Res 2011, 469(4):1002. Available at: [Accessed August 12, 2011].
15. Lonner J.H., Siliski J.M., Della Valle C., et al. Role of knee aspiration after resection of the infected total knee arthroplasty. Am J Orthop 2001, 30(4):305. Available at: [Accessed March 29, 2010].
16. Kraay M.J., Goldberg V.M., Fitzgerald S.J., et al. Cementless two-staged total hip arthroplasty for deep periprosthetic infection. Clin Orthop Relat Res 2005, 441:243. Available at: [Accessed August 4, 2011].
17. Haddad F.S., Muirhead-Allwood S.K., Manktelow A.R., et al. Two-stage uncemented revision hip arthroplasty for infection. J Bone Joint Surg Br 2000, 82(5):689. Available at: [Accessed August 4, 2011].
18. Parvizi J., Azzam K., Ghanem E., et al. Periprosthetic infection due to resistant staphylococci: serious problems on the horizon. Clin Orthop Relat Res 2009, 467(7):1732. Available at: [Accessed November 30, 2009].
19. Leung F., Richards C.J., Garbuz D.S., et al. Two-stage total hip arthroplasty: how often does it control methicillin-resistant infection?. Clin Orthop Relat Res 2011, 469(4):1009. Available at: [Accessed August 16, 2012].
20. Athanasou N.A., Pandey R., De Steiger R., et al. Diagnosis of infection by frozen section during revision arthroplasty. J Bone Joint Surg Br 1995, 77(1):28. Available at: [Accessed August 30, 2010].
21. Fehring T.K., McAlister J.A. Frozen histologic section as a guide to sepsis in revision joint arthroplasty. Clin Orthop Relat Res 1994, 304:229. Available at: [Accessed August 30, 2010].
22. Feldman D.S., Lonner J.H., Desai P., et al. The role of intraoperative frozen sections in revision total joint arthroplasty. J Bone Joint Surg Am 1995, 77(12):1807. Available at: [Accessed August 30, 2010].
23. Pandey R., Berendt A.R., Athanasou N.A. Histological and microbiological findings in non-infected and infected revision arthroplasty tissues. The OSIRIS Collaborative Study Group. Oxford Skeletal Infection Research and Intervention Service. Arch Orthop Trauma Surg 2000, 120(10):570. Available at: [Accessed August 30, 2010].
24. Sendi P., Rohrbach M., Graber P., et al. Staphylococcus aureus small colony variants in prosthetic joint infection. Clin Infect Dis 2006, 43(8):961. Available at: [Accessed August 15, 2012].
25. Cordero-Ampuero J., Esteban J., García-Rey E. Results after late polymicrobial, gram-negative, and methicillin-resistant infections in knee arthroplasty. Clin Orthop Relat Res 2010, [Accessed March 29, 2010]. http://www.ncbi.nlm.nih.gov.proxy1.lib.tju.edu:2048/pubmed/20087702.
26. Salgado C.D., Dash S., Cantey J.R., et al. Higher risk of failure of methicillin-resistant Staphylococcus aureus prosthetic joint infections. Clin Orthop Relat Res 2007, PAP.