Ethylbenzene-induced hearing loss, neurobehavioral function, and neurotransmitter alterations in petrochemical workers

Journal of Occupational and Environmental Medicine

Volumn 55, Issue 9, 2013, Pages 1001-1006

  Zhang, Ming ^a   Wang, Yanrang ^a   Wang, Qian ^b   Yang, Deyi ^a   Zhang, Jingshu ^a   Wang, Fengshan ^a   Gu, Qing ^a  

^a TIANJIN CENTERS FOR DISEASE CONTROL AND PREVENTION   (China)

^b Tianjin Institute of Medical and Pharmaceutical Science   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; ETHYLBENZENE; NEUROTRANSMITTER;

ADULT; AIR ANALYSIS; ANGER; ANXIETY; ARTICLE; BEHAVIOR; BRAIN FUNCTION; CONFUSION; CONTROLLED STUDY; DEPRESSION; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; FATIGUE; HEARING IMPAIRMENT; HEMATOLOGICAL PARAMETERS; HOSTILITY; HUMAN; INDUSTRIAL WORKER; LEARNING; MAJOR CLINICAL STUDY; MALE; MEMORY; NOISE; PERSONNEL; PETROCHEMICAL INDUSTRY;

ACETYLCHOLINESTERASE; ADULT; AIR POLLUTANTS, OCCUPATIONAL; BENZENE DERIVATIVES; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHINA; CROSS-SECTIONAL STUDIES; EXTRACTION AND PROCESSING INDUSTRY; HEARING LOSS, NOISE-INDUCED; HEARING LOSS, SENSORINEURAL; HUMANS; LEARNING DISORDERS; MALE; MEMORY DISORDERS; NEUROPSYCHOLOGICAL TESTS; NEUROTRANSMITTER AGENTS; NOISE, OCCUPATIONAL; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; ODDS RATIO; PETROLEUM;

EID: 84885018648     PISSN: 10762752     EISSN: 15365948     Source Type: Journal    
DOI: 10.1097/JOM.0b013e31829f3142     Document Type: Article

References (19)

1. Fishbein L. An overview of environmental and toxicological aspects of aromatic hydrocarbons. IV. Ethylbenzene. Sci Total Environ. 1985;44:269-287.
2. Molnar J, Paksy KA, Naray M. Changes in the rat's motor behaviour during 4-hr inhalation exposure to prenarcotic concentrations of benzene and its derivatives. Acta Physiol Hung. 1986;67:349-354.
3. Li AA, Maurissen JP, Barnett JF, et al. Oral gavage subchronic neurotoxicity and inhalation subchronic immunotoxicity studies of ethylbenzene in the rat. Neurotoxicology. 2010;31:247-258.
4. Cappaert NL, Klis SF, Muijser H, et al. The ototoxic effects of ethyl benzene in rats. Hear Res. 1999;137:91-102.
5. Cappaert NL, Klis SF, Baretta AB, et al. Ethyl benzene-induced ototoxicity in rats: a dose-dependent mid-frequency hearing loss. J Assoc Res Otolaryngol. 2000;1:292-299.
6. Cappaert NL, Klis SF, Muijser H, et al. Simultaneous exposure to ethyl benzene and noise: synergistic effects on outer hair cells. Hear Res. 2001;162: 67-79.
7. Ruan GH, Zheng LX, Wu QE, et al. Study on monoamine neurotransmitters in rat serum and brain tissue by high performance liquid chromatography with electrochemical detection. Wei Sheng Yan Jiu. 2006;35:146-148.
8. Zhao XE, Suo YR. Simultaneous determination of monoamine and amino acid neurotransmitters in rat endbrain tissues by pre-column derivatization with high-performance liquid chromatographic fluorescence detection and mass spectrometric identification. Talanta. 2008;76:690-697.
9. Yant WP, Schrenk HH, Waite CP, Patty FA. Acute response of guinea pigs to vapors of some new commercial organic compounds. II. Ethylbenzene. Pub Health Rep. 1930;45:1241-1250.
10. Tegeris JS, Balster RL. A comparison of the acute behavioral effects of alkylbenzenes using a functional observational battery in mice. Fundam Appl Toxicol. 1994;22:240-250.
11. NTP. NTP technical report on the toxicology and carcinogenesis studies of ethylbenzene in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program, U.S. Department of Health and Human Services. 1999;NTPTR 466.
12. Frantik E, Hornychova M, Horvath M. Relative acute neurotoxicity of solvents: isoeffective air concentrations of 48 compounds evaluated in rats and mice. Environ Res. 1994;66:173-185.
13. Gagnaire F, Langlais C, Grossman S, et al. Ototoxicity in rats exposed to ethylbenzene and to two technical xylene vapours for 13 weeks. Arch Toxicol. 2007;81:127-143.
14. Barregard L, Axelsson A. Is there an ototraumatic interaction between noise and solvents? Scand Audiol. 1984;13:151-155.
15. Sliwinska-Kowalska M, Zamyslowska-Szmytke E, Szymczak W, et al. Hearing loss amongworkers exposed to moderate concentrations of solvents. Scand J Work Environ Health. 2001;27:335-342.
16. Kurian MA, Gissen P, Smith M, et al. The monoamine neurotransmitter disorders: an expanding range of neurological syndromes. Lancet Neurol. 2011;10:721-733.
17. OSHA. Ethyl Benzene. Available at: https://www.osha.gov/dts/ chemicalsampling/data/CH-240000.html.
18. ACGIH. Ethylbenzene. Threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 2006;29,104.
19. NIOSH. Ethylbenzene. NIOSH pocket guide to chemical hazards. Atlanta, GA: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention. 2005.