Excretion profile of corticosteroids in bovine urine compared with tissue residues after therapeutic and growth-promoting administration of dexamethasone

Steroids

Volumn 78, Issue 9, 2013, Pages 803-812

  Ferranti, Carolina ^a   Famele, Marco ^a   Palleschi, Luca ^a   Bozzetta, Elena ^b   Pezzolato, Marzia ^b   Draisci, Rosa ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b LIGURIA E VALLE D AOSTA   (Italy)

Author keywords

Cattle; Dexamethasone; LC MS MS; Prednisolone; Tissue distribution; Urinary excretion

Indexed keywords

CORTICOSTEROID; CORTICOSTEROID DERIVATIVE; CORTISONE; DEXAMETHASONE; HYDROCORTISONE; PREDNISONE;

ARTICLE; CALF (BOVINE); EXPERIMENTAL STUDY; KIDNEY PARENCHYMA; LIQUID CHROMATOGRAPHY; LIVER; MALE; MUSCLE TISSUE; NONHUMAN; STEROID URINE LEVEL; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

ANIMALIA; BOS; BOVINAE;

EID: 84885004429     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2013.05.002     Document Type: Article

References (22)

1. EMEA. Dexamethasone summary report (1)-Committee for Veterinary Medicinal Products; November 1997.
2. Kahn CM, Line S. The Merck veterinary manual, anti-inflammatory agents. 9th ed. New Jersey: Merck and Co. Inc.; 2005.
3. Ferguson DC, Hoenig M. Glucocorticoids, mineralcorticoids and steroid synthesis inhibitors. In: Veterinary pharmacology and therapeutics. Ames (IA): Iowa State University Press; 1995. p. 622-37.
4. Courtheyn D, Le Bizec B, Brambilla G, De Brabander HF, Cobbaert E, Van De Wiele M, et al. Recent developments in the use and abuse of growth promoters. Anal Chim Acta 2002;473:71-82. (Pubitemid 35335416)
5. Istasse L, De Haan V, Van Eneaeme C, Buts B, Baldwin P, Gielen M. Effects of dexamethasone injections on performances in a pair of monozygotic cattle twins. J Anim Physiol Anim Nutr 1989;62:150-8.
6. Graham SF, Ruiz-Aracama A, Lommen A, Cannizzo FT, Biolatti B, Elliott CT, et al. Use of NMR metabolomic plasma profiling methodologies to identify illicit growth-promoting administrations. Anal Bioanal Chem 2012;403:573-82.
7. Commission of the European Communities. Commision Decision 2002/657/EC of 12 August 2002, implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. Off J Eur Commun: Legis 2002;L221:8-36.
8. Cannizzo FT, Capra P, Divari S, Ciccotelli V, Biolatti B, Vincenti M. Effects of low-dose dexamethasone and prednisolone long term administration in beef calf: chemical and morphological investigation. Anal Chim Acta 2011;700:95-104.
9. Vanhaecke L, Antignac J, Courtheyn D, Le Bizec B, De Brabander H. Elimination kinetics of dexamethasone in bovine urine, hair and feces following single administration of dexamethasone acetate and phosphate esters. Steroids 2011;76:111-7.
10. Ferranti C, Delli Quadri F, Palleschi L, Marchiafava C, Pezzolato M, Bozzetta E, Caramelli M, Draisci R. Studies on the presence of natural and synthetic corticosteroids in bovine urine. Steroids 2011;76:616-25.
11. Vincenti M, Girolami F, Capra P, Pazzi M, Carletti M, Gardini G, et al. Study of dexamethasone urinary excretion profile in cattle by LC-MS/MS: comparison between therapeutic and growth-promoting administration. J Agric Food Chem 2009;57:1299-306.
12. EMEA. Prednisolone (as free alcohol) summary report-Committee for Veterinary Medicinal Products; EMEA/MRL/629/99-FINAL; July 1999.
13. Bredehöft M, Baginski R, Parr MK, Thevis M, Schänzer W. Investigations of the microbial transformation of cortisol to prednisolone in urine samples. J Steroid Biochem Mol Biol 2012;129:54-60.
14. Pompa G, Arioli F, Casati A, Fidani M, Bertocchi L, Dusi G. Investigation of the origin of prednisolone in cow urine. Steroids 2011;76:104-10.
15. Arioli F, Fidani M, Casati A, Fracchiolla ML, Pompa G. Investigation on possible transformations of cortisol, cortisone and cortisol glucuronide in bovine faecal matter using liquid chromatography-mass spectrometry. Steroids 2010;75(4-5):350-4.
16. Kaklamanos G, Theodoridis G, Dabalis T. Determination of anabolic steroids in muscle tissue by liquid chromatography-tandem mass spectrometry. J Chromatogr A 2009;1216:8072-9.
17. Guidelines for the implementation of Decision 2002/657/EC. SANCO/2004/ 2726-rev 4-December 2008.
18. Soma LR, Uboh CE, Luo Y, Guan F, Moate PJ, Boston RC. Pharmacokinetics of dexamethasone with pharmacokinetic/ farmacodynamic model of the effect of dexamethasone on endogenous hydrocortisone and cortisone in the horse. J Vet Pharmacol Ther 2005;28:71-80. (Pubitemid 40353797)
19. Capolongo F, Tapparo M, Merlanti R, Ravarotto L, Tealdo E, Gallina G, et al. Illicit treatments in cattle and urinary 6beta-hydroxycortisol/cortisol ratio. Anal Chim Acta 2007;586:228-32. (Pubitemid 46240014)
20. Dusi G, Arioli F, Ghidelli V, Casati A, Hathaway T, Pompa G, Bertocchi L. Investigation on the origin of the prednisolone residue in cow urine. In: Proceeding of Euroresidue VII 2012 May 14-16, Egmond aan Zee (NL). p 297-302.
21. De Brandaber HF, Le Bizec B, Pinel G, Antignac JP, Verheyden K, Mortier V, et al. Past, present and future of mass spectrometry in the analysis of residue of banned substances in meat-producing animals. J Mass Spectrom 2007;42:983-98. (Pubitemid 47255451)
22. De Brabander HF, Poemans S, Schilt R, Stephany RW, Le Bizec B, Draisci R, et al. Presence and metabolism of the anabolic steroid boldenone in various animal species: a review. Food Addit Contam 2004;21:515-25. (Pubitemid 38885963)