Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor

Journal of Medicinal Chemistry

Volumn 56, Issue 18, 2013, Pages 7243-7259

  Bartolomé Nebreda, José Manuel ^a   Conde Ceide, Susana ^a   Delgado, Francisca ^a   Iturrino, Laura ^a   Pastor, Joaquín ^a   Pena, Miguel Ángel ^a   Trabanco, Andrés A ^a   Tresadern, Gary ^a   Wassvik, Carola M ^a   Stauffer, Shaun R ^b,c,d   Jadhav, Satyawan ^b   Gogi, Kiran ^b   Vinson, Paige N ^b   Noetzel, Meredith J ^b   Days, Emily ^b   Weaver, C David ^b   Lindsley, Craig W ^b,c,d   Niswender, Colleen M ^b,c   Jones, Carrie K ^b,c   Conn, P Jeffrey ^b,c   Rombouts, Frederik ^a   Lavreysen, Hilde ^a   Macdonald, Gregor J ^a   Mackie, Claire ^a   Steckler, Thomas ^a   more..

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 FLUOROPHENOXYMETHYL) 5 (4 FLUOROPHENYL) 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 2 (3 FLUOROPHENOXYMETHYL) 5 (4 FLUOROPHENYL) 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 2 (4 FLUOROPHENOXYMETHYL) 5 (4 FLUOROPHENYL) 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 2 PHENOXYMETHYL 5 (TETRAHYDROPYRAN 4 YLMETHYL) 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 2 PHENOXYMETHYL 5 PYRIDIN 2 YL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 2 PHENOXYMETHYL 5 PYRIDIN 3 YL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 2 PHENOXYMETHYL 5 PYRIDIN 4 YL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 2 PHENYLETHYNYL THIAZOLO[5,4 C]PYRIDIN 4 ONE 6,7 DIHYDRO 5H; 5 (2 METHOXYETHYL) 2 PHENOXYMETHYL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 5 (2,4 DIFLUOROPHENYL) 2 PHENOXYMETHYL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 5 (3 FLUOROPYRIDIN 2 YL) 2 PHENOXYMETHYL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 5 (4 FLUOROPHENYL) 2 PHENOXYMETHYL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 5 (5 FLUOROPYRIDIN 2 YL) 2 PHENOXYMETHYL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 5 CYCLOPROPYL 2 PHENOXYMETHYL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 5 CYCLOPROPYLMETHYL 2 PHENOXYMETHYL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 5 ETHYL 2 PHENOXYMETHYL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 5 ISOPROPYL 2 PHENOXYMETHYL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 5 METHYL 2 PHENOXYMETHYL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; 5 METHYL 2 PHENYLETHYNYL 6,7 DIHYDRO 5H THIAZOLO[5,4 C]PYRIDIN 4 ONE; DIHYDROTHIAZOLOPYRIDONE DERIVATIVE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR AGONIST; NEUROLEPTIC AGENT; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG; THIAZOLE DERIVATIVE;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; MOTOR COORDINATION; NONHUMAN; PLASMA CLEARANCE; RAT; SONOGASHIRA REACTION; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; ANIMAL BEHAVIOR; CHEMISTRY; DRUG EFFECTS; LOCOMOTION; METABOLISM;

ALLOSTERIC REGULATION; ANIMALS; ANTIPSYCHOTIC AGENTS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LOCOMOTION; MALE; RATS; RECEPTOR, METABOTROPIC GLUTAMATE 5; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84885000221     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400650w     Document Type: Article

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