메뉴 건너뛰기




Volumn 27, Issue 5, 2013, Pages 889-904

Gastrointestinal Stromal Tumors. Risk Assessment and Adjuvant Therapy.

Author keywords

Adjuvant therapy; Gastrointestinal stromal tumor; Imatinib; Prognostic factor; Risk stratification

Indexed keywords

AURORA A KINASE; IMATINIB; PLACEBO; PLATELET DERIVED GROWTH FACTOR A; SUCCINATE DEHYDROGENASE; SUNITINIB;

EID: 84884989340     PISSN: 08898588     EISSN: 15581977     Source Type: Journal    
DOI: 10.1016/j.hoc.2013.07.004     Document Type: Review
Times cited : (10)

References (74)
  • 1
    • 84867300058 scopus 로고    scopus 로고
    • Frequencies of KIT and PDGFRA mutations in the MolecGIST prospective population-based study differ from those of advanced GISTs
    • Emile J.F., Brahini S., Coindre J.M., et al. Frequencies of KIT and PDGFRA mutations in the MolecGIST prospective population-based study differ from those of advanced GISTs. Med Oncol 2012, 29(3):1765-1772.
    • (2012) Med Oncol , vol.29 , Issue.3 , pp. 1765-1772
    • Emile, J.F.1    Brahini, S.2    Coindre, J.M.3
  • 2
    • 67650837935 scopus 로고    scopus 로고
    • An evaluation of 2537 gastrointestinal stromal tumors for a proposed clinical staging system
    • Woodall C.E., Brock G.N., Fan J., et al. An evaluation of 2537 gastrointestinal stromal tumors for a proposed clinical staging system. Arch Surg 2009, 144(7):670-678.
    • (2009) Arch Surg , vol.144 , Issue.7 , pp. 670-678
    • Woodall, C.E.1    Brock, G.N.2    Fan, J.3
  • 3
    • 84857502045 scopus 로고    scopus 로고
    • Risk of gastrointestinal stromal tumour recurrence after surgery: an analysis based on pooled population-based cohorts
    • Joensuu H., Vehtari A., Riihimäki J., et al. Risk of gastrointestinal stromal tumour recurrence after surgery: an analysis based on pooled population-based cohorts. Lancet Oncol 2012, 13(3):265-274.
    • (2012) Lancet Oncol , vol.13 , Issue.3 , pp. 265-274
    • Joensuu, H.1    Vehtari, A.2    Riihimäki, J.3
  • 4
    • 0033984319 scopus 로고    scopus 로고
    • Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival
    • DeMatteo R.P., Lewis J.J., Leung D., et al. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg 2000, 231(1):51-58.
    • (2000) Ann Surg , vol.231 , Issue.1 , pp. 51-58
    • DeMatteo, R.P.1    Lewis, J.J.2    Leung, D.3
  • 5
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Demetri G.D., von Mehren M., Blanke C.D., et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. NEngl J Med 2002, 347(7):472-480.
    • (2002) NEngl J Med , vol.347 , Issue.7 , pp. 472-480
    • Demetri, G.D.1    von Mehren, M.2    Blanke, C.D.3
  • 6
    • 20844433223 scopus 로고    scopus 로고
    • Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial
    • Verweij J., Casali P.G., Zalcberg J., et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet 2004, 364(9440):1127-1134.
    • (2004) Lancet , vol.364 , Issue.9440 , pp. 1127-1134
    • Verweij, J.1    Casali, P.G.2    Zalcberg, J.3
  • 7
    • 39149123549 scopus 로고    scopus 로고
    • Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT
    • Blanke C.D., Demetri G.D., von Mehren M., et al. Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT. JClin Oncol 2008, 26(4):620-625.
    • (2008) JClin Oncol , vol.26 , Issue.4 , pp. 620-625
    • Blanke, C.D.1    Demetri, G.D.2    von Mehren, M.3
  • 8
    • 80355147509 scopus 로고    scopus 로고
    • Follow-up results after 9 years of the ongoing, phase II B2222 trial of imatinib mesylate in patients with metastatic or unresectable KIT+ gastrointestinal stromal tumors (GIST)
    • Von Mehren M. Follow-up results after 9 years of the ongoing, phase II B2222 trial of imatinib mesylate in patients with metastatic or unresectable KIT+ gastrointestinal stromal tumors (GIST). JClin Oncol 2011, 29(Suppl):609s.
    • (2011) JClin Oncol , vol.29 , Issue.SUPPL
    • Von Mehren, M.1
  • 9
    • 0033816156 scopus 로고    scopus 로고
    • Abl protein-tyrosine kinase inhibitor STI571 inhibits invitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
    • Buchdunger E., Cioffi C.L., Law N., et al. Abl protein-tyrosine kinase inhibitor STI571 inhibits invitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. JPharmacol Exp Ther 2000, 295(1):139-145.
    • (2000) JPharmacol Exp Ther , vol.295 , Issue.1 , pp. 139-145
    • Buchdunger, E.1    Cioffi, C.L.2    Law, N.3
  • 10
    • 62849096370 scopus 로고    scopus 로고
    • Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial
    • DeMatteo R.P., Ballman K.V., Antonescu C.R., et al. Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. Lancet 2009, 373(9669):1097-1104.
    • (2009) Lancet , vol.373 , Issue.9669 , pp. 1097-1104
    • DeMatteo, R.P.1    Ballman, K.V.2    Antonescu, C.R.3
  • 11
    • 84859187987 scopus 로고    scopus 로고
    • One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial
    • Joensuu H., Eriksson M., Sundby Hall K., et al. One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial. JAMA 2012, 307(12):1265-1272.
    • (2012) JAMA , vol.307 , Issue.12 , pp. 1265-1272
    • Joensuu, H.1    Eriksson, M.2    Sundby Hall, K.3
  • 12
    • 84859447234 scopus 로고    scopus 로고
    • Response to imatinib rechallenge of GIST that recurs following completion of adjuvant imatinib treatment-the first analysis in the SSGXVIII/AIO trial patient population
    • Reichardt P., Hartmann J., Sundby Hall K., et al. Response to imatinib rechallenge of GIST that recurs following completion of adjuvant imatinib treatment-the first analysis in the SSGXVIII/AIO trial patient population. Eur J Cancer 2011, 47(Suppl 2):15.
    • (2011) Eur J Cancer , vol.47 , Issue.SUPPL 2 , pp. 15
    • Reichardt, P.1    Hartmann, J.2    Sundby Hall, K.3
  • 13
    • 11144284051 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors of the stomach. A clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up
    • Miettinen M., Sobin L.H., Lasota J. Gastrointestinal stromal tumors of the stomach. A clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol 2005, 29(1):52-68.
    • (2005) Am J Surg Pathol , vol.29 , Issue.1 , pp. 52-68
    • Miettinen, M.1    Sobin, L.H.2    Lasota, J.3
  • 14
    • 33646685694 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors of the jejunum and ileum. A clinopathologic, immunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term-follow-up
    • Miettinen M., Makhlouf H., Sobin L.H., et al. Gastrointestinal stromal tumors of the jejunum and ileum. A clinopathologic, immunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term-follow-up. Am J Surg Pathol 2006, 30(4):477-489.
    • (2006) Am J Surg Pathol , vol.30 , Issue.4 , pp. 477-489
    • Miettinen, M.1    Makhlouf, H.2    Sobin, L.H.3
  • 15
    • 38749149936 scopus 로고    scopus 로고
    • Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST)
    • DeMatteo R.P., Gold J.S., Saran L., et al. Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST). Cancer 2008, 112(3):608-615.
    • (2008) Cancer , vol.112 , Issue.3 , pp. 608-615
    • DeMatteo, R.P.1    Gold, J.S.2    Saran, L.3
  • 16
    • 0035122393 scopus 로고    scopus 로고
    • Malignant gastrointestinal stromal tumors of the small intestine: a review of 50 cases from a prospective database
    • Crosby J.A., Catton C.N., Davis A., et al. Malignant gastrointestinal stromal tumors of the small intestine: a review of 50 cases from a prospective database. Ann Surg Oncol 2001, 8(1):50-59.
    • (2001) Ann Surg Oncol , vol.8 , Issue.1 , pp. 50-59
    • Crosby, J.A.1    Catton, C.N.2    Davis, A.3
  • 17
    • 18144376738 scopus 로고    scopus 로고
    • An improved technique for mitosis counting
    • Gal R., Rath-Wolfson L., Rosenblatt Y., et al. An improved technique for mitosis counting. Int J Surg Pathol 2005, 13(2):161-165.
    • (2005) Int J Surg Pathol , vol.13 , Issue.2 , pp. 161-165
    • Gal, R.1    Rath-Wolfson, L.2    Rosenblatt, Y.3
  • 18
    • 84871888257 scopus 로고    scopus 로고
    • Evaluation of malignancy using Ki-67, p53, EGFR and COX-2 expressions in gastrointestinal stromal tumors
    • Jiang J., Jin M.S., Suo J., et al. Evaluation of malignancy using Ki-67, p53, EGFR and COX-2 expressions in gastrointestinal stromal tumors. World J Gastroenterol 2012, 18(20):2569-2575.
    • (2012) World J Gastroenterol , vol.18 , Issue.20 , pp. 2569-2575
    • Jiang, J.1    Jin, M.S.2    Suo, J.3
  • 19
    • 84860002395 scopus 로고    scopus 로고
    • Prognostic significance of PTEN, Ki-67 and CD44s expression patterns in gastrointestinal stromal tumors
    • Liang Y.M., Li X.H., Li W.M., et al. Prognostic significance of PTEN, Ki-67 and CD44s expression patterns in gastrointestinal stromal tumors. World J Gastroenterol 2012, 18(14):1664-1671.
    • (2012) World J Gastroenterol , vol.18 , Issue.14 , pp. 1664-1671
    • Liang, Y.M.1    Li, X.H.2    Li, W.M.3
  • 20
    • 33750618188 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: pathology and prognosis at different sites
    • Miettinen M., Lasota J. Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol 2006, 23(2):70-83.
    • (2006) Semin Diagn Pathol , vol.23 , Issue.2 , pp. 70-83
    • Miettinen, M.1    Lasota, J.2
  • 21
    • 71449088757 scopus 로고    scopus 로고
    • Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis
    • Gold J.S., Gönen M., Gutiérrez A., et al. Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis. Lancet Oncol 2009, 10(11):1045-1052.
    • (2009) Lancet Oncol , vol.10 , Issue.11 , pp. 1045-1052
    • Gold, J.S.1    Gönen, M.2    Gutiérrez, A.3
  • 22
    • 80054971913 scopus 로고    scopus 로고
    • Natural history of imatinib-naive GISTs: a retrospective analysis of 929 cases with long-term follow-up and development of a survival nomogram based on mitotic index and size as continuous variables
    • Rossi S., Miceli R., Messerini L., et al. Natural history of imatinib-naive GISTs: a retrospective analysis of 929 cases with long-term follow-up and development of a survival nomogram based on mitotic index and size as continuous variables. Am J Surg Pathol 2011, 35(11):1646-1656.
    • (2011) Am J Surg Pathol , vol.35 , Issue.11 , pp. 1646-1656
    • Rossi, S.1    Miceli, R.2    Messerini, L.3
  • 23
    • 80052963619 scopus 로고    scopus 로고
    • Validation of the Joensuu risk criteria for primary resectable gastrointestinal stromal tumour-the impact of tumour rupture on patient outcomes
    • Rutkowski P., Bylina E., Wozniak A., et al. Validation of the Joensuu risk criteria for primary resectable gastrointestinal stromal tumour-the impact of tumour rupture on patient outcomes. Eur J Surg Oncol 2011, 37(10):890-896.
    • (2011) Eur J Surg Oncol , vol.37 , Issue.10 , pp. 890-896
    • Rutkowski, P.1    Bylina, E.2    Wozniak, A.3
  • 24
    • 0034883994 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases
    • Miettinen M., Furlong M., Sarlomo-Rikala M., et al. Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases. Am J Surg Pathol 2001, 25(9):1121-1133.
    • (2001) Am J Surg Pathol , vol.25 , Issue.9 , pp. 1121-1133
    • Miettinen, M.1    Furlong, M.2    Sarlomo-Rikala, M.3
  • 25
    • 35348871015 scopus 로고    scopus 로고
    • An enhanced risk-group stratification system for more practical prognostication of clinically malignant gastrointestinal stromal tumors
    • Takahashi T., Nakajima K., Nishitani A., et al. An enhanced risk-group stratification system for more practical prognostication of clinically malignant gastrointestinal stromal tumors. Int J Clin Oncol 2007, 12(5):369-374.
    • (2007) Int J Clin Oncol , vol.12 , Issue.5 , pp. 369-374
    • Takahashi, T.1    Nakajima, K.2    Nishitani, A.3
  • 26
    • 78049483265 scopus 로고    scopus 로고
    • Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour
    • Hohenberger P., Ronellenfitsch U., Oladeji O., et al. Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour. Br J Surg 2010, 97(12):1854-1859.
    • (2010) Br J Surg , vol.97 , Issue.12 , pp. 1854-1859
    • Hohenberger, P.1    Ronellenfitsch, U.2    Oladeji, O.3
  • 27
    • 50649085726 scopus 로고    scopus 로고
    • Risk stratification of patients diagnosed with gastrointestinal stromal tumor
    • Joensuu H. Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol 2008, 39(10):1411-1419.
    • (2008) Hum Pathol , vol.39 , Issue.10 , pp. 1411-1419
    • Joensuu, H.1
  • 28
    • 0036301722 scopus 로고    scopus 로고
    • Diagnosis of gastrointestinal stromal tumors: a consensus approach
    • Fletcher C.D., Berman J.J., Corless C., et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol 2002, 33(5):459-465.
    • (2002) Hum Pathol , vol.33 , Issue.5 , pp. 459-465
    • Fletcher, C.D.1    Berman, J.J.2    Corless, C.3
  • 29
    • 0037407876 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the duodenum: a clinicopathologic, immunohistochemical, and molecular genetic study of 167 cases
    • Miettinen M., Kopczynski J., Makhlouf H.R., et al. Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the duodenum: a clinicopathologic, immunohistochemical, and molecular genetic study of 167 cases. Am J Surg Pathol 2003, 27(5):625-641.
    • (2003) Am J Surg Pathol , vol.27 , Issue.5 , pp. 625-641
    • Miettinen, M.1    Kopczynski, J.2    Makhlouf, H.R.3
  • 30
    • 59449083984 scopus 로고    scopus 로고
    • Lymph node metastasis in gastrointestinal stromal tumours (GIST) occurs preferentially in young patients < or= 40 years: an overview based on our case material and the literature
    • Agaimy A., Wünsch P.H. Lymph node metastasis in gastrointestinal stromal tumours (GIST) occurs preferentially in young patients < or= 40 years: an overview based on our case material and the literature. Langenbecks Arch Surg 2009, 394:375-381.
    • (2009) Langenbecks Arch Surg , vol.394 , pp. 375-381
    • Agaimy, A.1    Wünsch, P.H.2
  • 31
    • 73949152219 scopus 로고    scopus 로고
    • Gastric stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases
    • Zhang L., Smyrk T.C., Young W.F., et al. Gastric stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases. Am J Surg Pathol 2010, 34:53-64.
    • (2010) Am J Surg Pathol , vol.34 , pp. 53-64
    • Zhang, L.1    Smyrk, T.C.2    Young, W.F.3
  • 32
    • 79953183996 scopus 로고    scopus 로고
    • "Pediatric-type" gastrointestinal stromal tumors in adults: distinctive histology predicts genotype and clinical behavior
    • Rege T.A., Wagner A.J., Corless C.L., et al. "Pediatric-type" gastrointestinal stromal tumors in adults: distinctive histology predicts genotype and clinical behavior. Am J Surg Pathol 2011, 35:495-504.
    • (2011) Am J Surg Pathol , vol.35 , pp. 495-504
    • Rege, T.A.1    Wagner, A.J.2    Corless, C.L.3
  • 33
    • 84856513068 scopus 로고    scopus 로고
    • Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors
    • Lagarde P., Pérot G., Kauffmann A., et al. Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors. Clin Cancer Res 2012, 18(3):826-838.
    • (2012) Clin Cancer Res , vol.18 , Issue.3 , pp. 826-838
    • Lagarde, P.1    Pérot, G.2    Kauffmann, A.3
  • 34
    • 0031714080 scopus 로고    scopus 로고
    • Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
    • Zhou H., Kuang J., Zhong L., et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 1998, 20(2):189-193.
    • (1998) Nat Genet , vol.20 , Issue.2 , pp. 189-193
    • Zhou, H.1    Kuang, J.2    Zhong, L.3
  • 35
    • 84868190938 scopus 로고    scopus 로고
    • Integrating bioinformatics and clinicopathological research of gastrointestinal stromal tumors: identification of aurora kinase A as a poor risk marker
    • Yen C.C., Yeh C.N., Cheng C.T., et al. Integrating bioinformatics and clinicopathological research of gastrointestinal stromal tumors: identification of aurora kinase A as a poor risk marker. Ann Surg Oncol 2012, 19(11):3491-3499.
    • (2012) Ann Surg Oncol , vol.19 , Issue.11 , pp. 3491-3499
    • Yen, C.C.1    Yeh, C.N.2    Cheng, C.T.3
  • 36
    • 84867399406 scopus 로고    scopus 로고
    • Genomic Grade Index predicts postoperative clinical outcome of GIST
    • Bertucci F., Finetti P., Ostrowski J., et al. Genomic Grade Index predicts postoperative clinical outcome of GIST. Br J Cancer 2012, 107(8):1433-1441.
    • (2012) Br J Cancer , vol.107 , Issue.8 , pp. 1433-1441
    • Bertucci, F.1    Finetti, P.2    Ostrowski, J.3
  • 37
    • 33144462268 scopus 로고    scopus 로고
    • Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis
    • Sotiriou C., Wirapati P., Loi S., et al. Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. JNatl Cancer Inst 2006, 98(4):262-272.
    • (2006) JNatl Cancer Inst , vol.98 , Issue.4 , pp. 262-272
    • Sotiriou, C.1    Wirapati, P.2    Loi, S.3
  • 38
    • 84884987426 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network. Clinical practice guidelines in oncology. Soft tissue sarcoma. V. 2.2011. Available at: Accessed January 31, 2013.
    • National Comprehensive Cancer Network. Clinical practice guidelines in oncology. Soft tissue sarcoma. V. 2.2011. Available at: Accessed January 31, 2013. http://www.nccn.org/professionals/physician_gls/.
  • 39
    • 84866602260 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • ESMO/European Sarcoma Network Working Group
    • ESMO/European Sarcoma Network Working Group Gastrointestinal stromal tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2012, 23(Suppl 7):vii49-vii55.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL 7 , pp. 749-755
  • 40
    • 84885386346 scopus 로고    scopus 로고
    • Imatinib failure-free survival in patients with localized gastrointestinal stromal tumors (GIST) treated with adjuvant imatinib: The EORTC/AGITG/FSG/GEIS/ISG randomized controlled phase III trial
    • Casali P. Imatinib failure-free survival in patients with localized gastrointestinal stromal tumors (GIST) treated with adjuvant imatinib: The EORTC/AGITG/FSG/GEIS/ISG randomized controlled phase III trial. JClin Oncol 2013, 31(Suppl):632s.
    • (2013) JClin Oncol , vol.31 , Issue.SUPPL
    • Casali, P.1
  • 41
    • 78649888468 scopus 로고    scopus 로고
    • Practical management of tyrosine-kinase inhibitor-associated side effects in GIST
    • Joensuu H., Trent J.C., Reichardt P. Practical management of tyrosine-kinase inhibitor-associated side effects in GIST. Cancer Treat Rev 2011, 37(1):75-88.
    • (2011) Cancer Treat Rev , vol.37 , Issue.1 , pp. 75-88
    • Joensuu, H.1    Trent, J.C.2    Reichardt, P.3
  • 42
    • 84884979397 scopus 로고    scopus 로고
    • Efficacy of adjuvant imatinib mesylate following complete resection of localized, primary gastrointestinal stromal tumor (GIST) at high risk of recurrence: the U.S. Intergroup phase II trial ACOSOG Z9000. Presented at American Society of Clinical Oncology 2008 Gastrointestinal Cancers Symposium. Orlando, January 25-27, 2008 [abstract 8].
    • DeMatteo RP, Owzar K, Antonescu CR, etal. Efficacy of adjuvant imatinib mesylate following complete resection of localized, primary gastrointestinal stromal tumor (GIST) at high risk of recurrence: the U.S. Intergroup phase II trial ACOSOG Z9000. Presented at American Society of Clinical Oncology 2008 Gastrointestinal Cancers Symposium. Orlando, January 25-27, 2008 [abstract 8].
    • DeMatteo, R.P.1    Owzar, K.2    Antonescu, C.R.3
  • 43
    • 84874051023 scopus 로고    scopus 로고
    • Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients
    • Kanda T., Nishida T., Wada N., et al. Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients. Int J Clin Oncol 2013, 18(1):38-45.
    • (2013) Int J Clin Oncol , vol.18 , Issue.1 , pp. 38-45
    • Kanda, T.1    Nishida, T.2    Wada, N.3
  • 44
    • 77952503219 scopus 로고    scopus 로고
    • Aphase II study of imatinib mesylate as adjuvant treatment for curatively resected high-risk localized gastrointestinal stromal tumors
    • Kang B., Lee J., Ryu M., et al. Aphase II study of imatinib mesylate as adjuvant treatment for curatively resected high-risk localized gastrointestinal stromal tumors. JClin Oncol 2009, 27(Suppl):e21515.
    • (2009) JClin Oncol , vol.27 , Issue.SUPPL
    • Kang, B.1    Lee, J.2    Ryu, M.3
  • 45
    • 70349948755 scopus 로고    scopus 로고
    • Efficacy and safety of adjuvant post-surgical therapy with imatinib in patients with high risk of relapsing GIST
    • Zhan W.H. Efficacy and safety of adjuvant post-surgical therapy with imatinib in patients with high risk of relapsing GIST. JClin Oncol 2007, 25(Suppl):556s.
    • (2007) JClin Oncol , vol.25 , Issue.SUPPL
    • Zhan, W.H.1
  • 46
    • 34249791491 scopus 로고    scopus 로고
    • Adjuvant imatinib treatment improves recurrence-free survival in patients with high-risk gastrointestinal stromal tumours (GIST)
    • Nilsson B., Sjölund K., Kindblom L.G., et al. Adjuvant imatinib treatment improves recurrence-free survival in patients with high-risk gastrointestinal stromal tumours (GIST). Br J Cancer 2007, 96(11):1656-1658.
    • (2007) Br J Cancer , vol.96 , Issue.11 , pp. 1656-1658
    • Nilsson, B.1    Sjölund, K.2    Kindblom, L.G.3
  • 47
    • 84866285367 scopus 로고    scopus 로고
    • Surgical outcomes of gastrointestinal stromal tumors of the stomach: a single unit experience in the era of targeted drug therapy
    • Huang H., Liang H., Zhan Z.L., et al. Surgical outcomes of gastrointestinal stromal tumors of the stomach: a single unit experience in the era of targeted drug therapy. Med Oncol 2012, 29(2):941-947.
    • (2012) Med Oncol , vol.29 , Issue.2 , pp. 941-947
    • Huang, H.1    Liang, H.2    Zhan, Z.L.3
  • 48
    • 80255138368 scopus 로고    scopus 로고
    • Adjuvant imatinib treatment after R0 resection for patients with high-risk gastrointestinal stromal tumors: a median follow-up of 44 months
    • Jiang W.Z., Guan G.X., Lu H.S., et al. Adjuvant imatinib treatment after R0 resection for patients with high-risk gastrointestinal stromal tumors: a median follow-up of 44 months. JSurg Oncol 2011, 104(7):760-764.
    • (2011) JSurg Oncol , vol.104 , Issue.7 , pp. 760-764
    • Jiang, W.Z.1    Guan, G.X.2    Lu, H.S.3
  • 49
    • 79952451365 scopus 로고    scopus 로고
    • Post-operative imatinib in patients with intermediate or high risk gastrointestinal stromal tumor
    • Li J., Gong J.F., Wu A.W., et al. Post-operative imatinib in patients with intermediate or high risk gastrointestinal stromal tumor. Eur J Surg Oncol 2011, 37(10):319-324.
    • (2011) Eur J Surg Oncol , vol.37 , Issue.10 , pp. 319-324
    • Li, J.1    Gong, J.F.2    Wu, A.W.3
  • 50
    • 84861759106 scopus 로고    scopus 로고
    • Phase II trial of neoadjuvant/adjuvant imatinib mesylate for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumors: long-term follow-up results of Radiation Therapy Oncology Group 0132
    • Wang D., Zhang Q., Blanke C.D., et al. Phase II trial of neoadjuvant/adjuvant imatinib mesylate for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumors: long-term follow-up results of Radiation Therapy Oncology Group 0132. Ann Surg Oncol 2012, 19(4):1074-1080.
    • (2012) Ann Surg Oncol , vol.19 , Issue.4 , pp. 1074-1080
    • Wang, D.1    Zhang, Q.2    Blanke, C.D.3
  • 51
    • 33845633389 scopus 로고    scopus 로고
    • Surgical resection of gastrointestinal stromal tumors after treatment with imatinib
    • Andtbacka R.H., Ng C.S., Scaife C.L., et al. Surgical resection of gastrointestinal stromal tumors after treatment with imatinib. Ann Surg Oncol 2007, 14(1):14-24.
    • (2007) Ann Surg Oncol , vol.14 , Issue.1 , pp. 14-24
    • Andtbacka, R.H.1    Ng, C.S.2    Scaife, C.L.3
  • 52
    • 62149141753 scopus 로고    scopus 로고
    • Arandomized, phase II study of preoperative plus postoperative imatinib in GIST: evidence of rapid radiographic response and temporal induction of tumor cell apoptosis
    • McAuliffe J.C., Hunt K.K., Lazar J.F., et al. Arandomized, phase II study of preoperative plus postoperative imatinib in GIST: evidence of rapid radiographic response and temporal induction of tumor cell apoptosis. Ann Surg Oncol 2009, 16(4):910-919.
    • (2009) Ann Surg Oncol , vol.16 , Issue.4 , pp. 910-919
    • McAuliffe, J.C.1    Hunt, K.K.2    Lazar, J.F.3
  • 53
    • 77951810587 scopus 로고    scopus 로고
    • Neoadjuvant imatinib and organ preservation in locally advanced gastrointestinal stromal tumors (GIST)
    • Hohenberger P., Oladeji O., Licht T., et al. Neoadjuvant imatinib and organ preservation in locally advanced gastrointestinal stromal tumors (GIST). JClin Oncol 2009, 27(Suppl):548s.
    • (2009) JClin Oncol , vol.27 , Issue.SUPPL
    • Hohenberger, P.1    Oladeji, O.2    Licht, T.3
  • 54
    • 79851508006 scopus 로고    scopus 로고
    • Neoadjuvant imatinib in patients with locally advanced non metastatic GIST in the prospective BRF 14 trial
    • Blesius A., Cassier P.A., Bertucci F., et al. Neoadjuvant imatinib in patients with locally advanced non metastatic GIST in the prospective BRF 14 trial. BMC Cancer 2011, 11:72.
    • (2011) BMC Cancer , vol.11 , pp. 72
    • Blesius, A.1    Cassier, P.A.2    Bertucci, F.3
  • 55
    • 80053296615 scopus 로고    scopus 로고
    • Adjuvant and neoadjuvant imatinib therapy: current role in the management of gastrointestinal stromal tumors
    • Eisenberg B.L., Trent J.C. Adjuvant and neoadjuvant imatinib therapy: current role in the management of gastrointestinal stromal tumors. Int J Cancer 2011, 129(11):2533-2542.
    • (2011) Int J Cancer , vol.129 , Issue.11 , pp. 2533-2542
    • Eisenberg, B.L.1    Trent, J.C.2
  • 56
    • 0042338788 scopus 로고    scopus 로고
    • Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors
    • Wardelmann E., Losen I., Hans V., et al. Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors. Int J Cancer 2003, 106(6):887-895.
    • (2003) Int J Cancer , vol.106 , Issue.6 , pp. 887-895
    • Wardelmann, E.1    Losen, I.2    Hans, V.3
  • 57
    • 24944536236 scopus 로고    scopus 로고
    • Deletions affecting codons 557-558 of the c-KIT gene indicate a poor prognosis in patients with completely resected gastrointestinal stromal tumors: a study by the Spanish Group for Sarcoma Research (GEIS)
    • Martin J., Poveda A., Llombart-Bosch A., et al. Deletions affecting codons 557-558 of the c-KIT gene indicate a poor prognosis in patients with completely resected gastrointestinal stromal tumors: a study by the Spanish Group for Sarcoma Research (GEIS). JClin Oncol 2005, 23(25):6190-6198.
    • (2005) JClin Oncol , vol.23 , Issue.25 , pp. 6190-6198
    • Martin, J.1    Poveda, A.2    Llombart-Bosch, A.3
  • 58
    • 23944476156 scopus 로고    scopus 로고
    • PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and invitro sensitivity to imatinib
    • Corless C.L., Schroeder A., Griffith D., et al. PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and invitro sensitivity to imatinib. JClin Oncol 2005, 23(23):5357-5364.
    • (2005) JClin Oncol , vol.23 , Issue.23 , pp. 5357-5364
    • Corless, C.L.1    Schroeder, A.2    Griffith, D.3
  • 59
    • 33845601781 scopus 로고    scopus 로고
    • Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity
    • Weisberg E., Wright R.D., Jiang J., et al. Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity. Gastroenterology 2006, 131(6):1734-1742.
    • (2006) Gastroenterology , vol.131 , Issue.6 , pp. 1734-1742
    • Weisberg, E.1    Wright, R.D.2    Jiang, J.3
  • 60
    • 84865100068 scopus 로고    scopus 로고
    • Outcome of patients with platelet-derived growth factor receptor alpha-mutated gastrointestinal stromal tumors in the tyrosine kinase inhibitor era
    • Cassier P.A., Fumagilli E., Rutkowski P., et al. Outcome of patients with platelet-derived growth factor receptor alpha-mutated gastrointestinal stromal tumors in the tyrosine kinase inhibitor era. Clin Cancer Res 2012, 18(16):4458-4464.
    • (2012) Clin Cancer Res , vol.18 , Issue.16 , pp. 4458-4464
    • Cassier, P.A.1    Fumagilli, E.2    Rutkowski, P.3
  • 61
    • 84865074356 scopus 로고    scopus 로고
    • Crenolanib inhibits the drug-resistant PDGFRA D842V mutation associated with imatinib-resistant gastrointestinal stromal tumors
    • Heinrich M.C., Griffith D., McKinley A., et al. Crenolanib inhibits the drug-resistant PDGFRA D842V mutation associated with imatinib-resistant gastrointestinal stromal tumors. Clin Cancer Res 2012, 18(16):4375-4384.
    • (2012) Clin Cancer Res , vol.18 , Issue.16 , pp. 4375-4384
    • Heinrich, M.C.1    Griffith, D.2    McKinley, A.3
  • 62
    • 78649673624 scopus 로고    scopus 로고
    • Relation of tumor pathologic and molecular features to outcome after surgical resection of localized primary gastrointestinal stromal tumor (GIST): results of the intergroup phase III trial ACOSOG Z9001
    • Corless C., Ballman K.V., Antonescu C., et al. Relation of tumor pathologic and molecular features to outcome after surgical resection of localized primary gastrointestinal stromal tumor (GIST): results of the intergroup phase III trial ACOSOG Z9001. JClin Oncol 2010, 28(Suppl):699s.
    • (2010) JClin Oncol , vol.28 , Issue.SUPPL
    • Corless, C.1    Ballman, K.V.2    Antonescu, C.3
  • 63
    • 33644752349 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors in patients with neurofibromatosis 1: a clinicopathologic and molecular genetic study of 45 cases
    • Miettinen M., Fetsch J.F., Sobin L.H., et al. Gastrointestinal stromal tumors in patients with neurofibromatosis 1: a clinicopathologic and molecular genetic study of 45 cases. Am J Surg Pathol 2006, 30(1):90-96.
    • (2006) Am J Surg Pathol , vol.30 , Issue.1 , pp. 90-96
    • Miettinen, M.1    Fetsch, J.F.2    Sobin, L.H.3
  • 64
    • 51649112019 scopus 로고    scopus 로고
    • Therapeutic consequences from molecular biology for gastrointestinal stromal tumor patients affected by neurofibromatosis type 1
    • Mussi C., Schildhaus H.U., Gronchi A., et al. Therapeutic consequences from molecular biology for gastrointestinal stromal tumor patients affected by neurofibromatosis type 1. Clin Cancer Res 2008, 14(14):4550-4555.
    • (2008) Clin Cancer Res , vol.14 , Issue.14 , pp. 4550-4555
    • Mussi, C.1    Schildhaus, H.U.2    Gronchi, A.3
  • 65
    • 33746401591 scopus 로고    scopus 로고
    • EORTC Soft Tissue and Bone Sarcoma Group; Italian Sarcoma Group; Australasian GastroIntestinal Trials Group. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours
    • Debiec-Rychter M., Sciot R., Le Cesne A., et al. EORTC Soft Tissue and Bone Sarcoma Group; Italian Sarcoma Group; Australasian GastroIntestinal Trials Group. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer 2006, 42(8):1093-1103.
    • (2006) Eur J Cancer , vol.42 , Issue.8 , pp. 1093-1103
    • Debiec-Rychter, M.1    Sciot, R.2    Le Cesne, A.3
  • 66
    • 67650306170 scopus 로고    scopus 로고
    • Imatinib plasma levels are correlated with clinical benefit in patients with unresectable/metastatic gastrointestinal stromal tumors
    • Demetri G.D., Wang Y., Wehrle E., et al. Imatinib plasma levels are correlated with clinical benefit in patients with unresectable/metastatic gastrointestinal stromal tumors. JClin Oncol 2009, 27(19):3141-3147.
    • (2009) JClin Oncol , vol.27 , Issue.19 , pp. 3141-3147
    • Demetri, G.D.1    Wang, Y.2    Wehrle, E.3
  • 67
    • 84867521054 scopus 로고    scopus 로고
    • Along-term prospective population pharmacokinetic study on imatinib plasma concentrations in GIST patients
    • Eechoute K., Fransson M.N., Reyners A.K., et al. Along-term prospective population pharmacokinetic study on imatinib plasma concentrations in GIST patients. Clin Cancer Res 2012, 18(20):5780-5787.
    • (2012) Clin Cancer Res , vol.18 , Issue.20 , pp. 5780-5787
    • Eechoute, K.1    Fransson, M.N.2    Reyners, A.K.3
  • 68
    • 77951922479 scopus 로고    scopus 로고
    • Cross-sectional study of imatinib plasma trough levels in patients with advanced gastrointestinal stromal tumors: impact of gastrointestinal resection on exposure to imatinib
    • Yoo C., Ryu M.H., Kang B.W., et al. Cross-sectional study of imatinib plasma trough levels in patients with advanced gastrointestinal stromal tumors: impact of gastrointestinal resection on exposure to imatinib. JClin Oncol 2010, 28(9):1554-1559.
    • (2010) JClin Oncol , vol.28 , Issue.9 , pp. 1554-1559
    • Yoo, C.1    Ryu, M.H.2    Kang, B.W.3
  • 69
    • 84867528896 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of imatinib-new data strengthen the case
    • Judson I.R. Therapeutic drug monitoring of imatinib-new data strengthen the case. Clin Cancer Res 2012, 18(20):517-519.
    • (2012) Clin Cancer Res , vol.18 , Issue.20 , pp. 517-519
    • Judson, I.R.1
  • 70
    • 84855330478 scopus 로고    scopus 로고
    • Who are the long responders to imatinib in patients with advanced GIST? Results of the BRF14 prospective French Sarcoma Group randomized phase III trial
    • Blesius A. Who are the long responders to imatinib in patients with advanced GIST? Results of the BRF14 prospective French Sarcoma Group randomized phase III trial. JClin Oncol 2011, 29(Suppl):616s.
    • (2011) JClin Oncol , vol.29 , Issue.SUPPL
    • Blesius, A.1
  • 71
    • 79952515393 scopus 로고    scopus 로고
    • The risks of radiation exposure related to diagnostic imaging and how to minimise them
    • Davies H.E., Wathen C.G., Gleeson F.V. The risks of radiation exposure related to diagnostic imaging and how to minimise them. BMJ 2011, 342:d947.
    • (2011) BMJ , vol.342
    • Davies, H.E.1    Wathen, C.G.2    Gleeson, F.V.3
  • 72
    • 84884975244 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Available at: Accessed January 31, 2013.
    • ClinicalTrials.gov. Available at: Accessed January 31, 2013. http://www.clinicaltrials.gov/.
  • 73
    • 84884976641 scopus 로고    scopus 로고
    • ISRCTN register. Available at: Accessed January 31, 2013.
    • ISRCTN register. Available at: Accessed January 31, 2013. http://isrctn.org/.
  • 74
    • 77956146147 scopus 로고    scopus 로고
    • Kitlow stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors
    • Bardsley M.R., Horváth V.J., Asuzu D.T., et al. Kitlow stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors. Gastroenterology 2010, 139(3):942-952.
    • (2010) Gastroenterology , vol.139 , Issue.3 , pp. 942-952
    • Bardsley, M.R.1    Horváth, V.J.2    Asuzu, D.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.