Targeting the K-Ras/PDEδ protein-protein interaction: The solution for ras-driven cancers or just another therapeutic mirage?

ChemMedChem

Volumn 8, Issue 10, 2013, Pages 1620-1622

  Frett, Brendan ^a   Wang, Yuanxiang ^a   Li, Hong yu ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Anticancer agents; Drug resistance; Protein protein interactions; Ras; Targeted therapeutics

Indexed keywords

B RAF KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; GEMCITABINE; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; VEMURAFENIB; ANTINEOPLASTIC AGENT; KRAS PROTEIN, HUMAN; ONCOPROTEIN; PDE6D PROTEIN, HUMAN; PHOSPHODIESTERASE VI;

ARTICLE; CANCER REGRESSION; CELL SURVIVAL; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; LUNG NON SMALL CELL CANCER; MELANOMA; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TUMOR MICROENVIRONMENT; TUMOR REGRESSION; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG DESIGN; DRUG EFFECTS; DRUG RESISTANCE; METABOLISM; NEOPLASMS; PATHOLOGY; PROTEIN DOMAIN;

ANIMALS; ANTINEOPLASTIC AGENTS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6; DRUG DESIGN; DRUG RESISTANCE, NEOPLASM; HUMANS; NEOPLASMS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTO-ONCOGENE PROTEINS; RAS PROTEINS;

EID: 84884986099     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300311     Document Type: Article

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