The levels of the circulating cellular adhesion molecules ICAM-1, VCAM-1 and endothelin-1 and the flow-mediated vasodilatation values in patients with type 1 diabetes mellitus with early-stage diabetic retinopathy

Internal Medicine

Volumn 52, Issue 19, 2013, Pages 2173-2178

  Uǧurlu, Nagihan ^a   Gerceker, Sidika ^a   Yülek, Fatma ^a   Ugurlu, Burcak ^a   Sari, Cenk ^a   Baran, Pervin ^a   Çaǧil, Nurullah ^a  

^a ATATURK TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Diabetic retinopathy; Endothelial dysfunction; FMD

Indexed keywords

C REACTIVE PROTEIN; ENDOTHELIN 1; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERCELLULAR ADHESION MOLECULE 1; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIABETIC RETINOPATHY; ELECTROCARDIOGRAPHY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; VASODILATATION;

ADULT; BIOLOGICAL MARKERS; BLOOD FLOW VELOCITY; DIABETES MELLITUS, TYPE 1; DIABETIC RETINOPATHY; ENDOTHELIN-1; FEMALE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MALE; VASCULAR CELL ADHESION MOLECULE-1; VASODILATION;

EID: 84884958371     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.52.8572     Document Type: Article

References (33)

1. Mohamed Q, Gillies MC, Wong TY. Management of diabetic ret-inopathy: a systematic review. JAMA 298: 902-916, 2007.
2. Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet 376: 124-136, 2010.
3. Van Hecke MV, Dekker JM, Nijpels G, et al. Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn study. Diabetologia 48: 1300-1306, 2005.
4. Horstman LL, Jy W, Jimenez JJ, Ahn YS. Endothelial microparti-cles as markers of endothelial dysfunction. Front Biosci 9: 1118-1135, 2004.
5. Schalkwijk CG, Stehouwer CD. Vascular complications in diabetes mellitus: the role of endothelial dysfunction. Clin Sci 109: 143-159, 2005.
6. Widlansky ME, Gokce N, Keaney JF Jr, Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol 42: 1149-1160, 2003.
7. Vita JA. Nitric oxide-dependent vasodilation in human subjects. Methods Enzymol 359: 186-200, 2002.
8. Miyamoto K, Khosrof S, Bursell SE, et al. Prevention of leukosta-sis and vascular leakage in streptozotocin-induced diabetic retino-pathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci USA 96: 10836-10841, 1999.
9. Joussen AM, Murata T, Tsujikawa A, Kirchhof B, Bursell SE, Adamis AP. Leukocyte-mediated endothelial cell injury and death in the diabetic retina. Am J Pathol 158: 147-152, 2001.
10. McLeod DS, Lefer DJ, Merges C, Lutty GA. Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. Am J Pathol 147: 642-653, 1995.
11. Pang IH, Yorio T. Ocular actions of endothelins. Proc Soc Exp Biol Med 215: 21-34, 1997.
12. Kohner EM, Patel V, Rassam SM. Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy. Diabetes 44: 603-607, 1995.
13. Chakrabarti S, Gan XT, Merry A, et al. Augmented retinal endothelin-1, endothelin-3, endothelinA and endothelinB gene expression in chronic diabetes. Curr Eye Res 17: 301-307, 1998.
14. Adamiec-Mroczek J, Oficjalska-Mlynczak J. Assessment of selected adhesion molecule and proinflammatory cytokine levels in the vitreous body of patients with type 2 diabetes-role of the inflammatory-immune process in the pathogenesis of proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 246: 1665-1670, 2008.
15. Fasching P, Veitl M, Rohac M, et al. Elevated concentrations of circulating adhesion molecules and their association with microvascular complications in insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 81: 4313-4317, 1996.
16. Soedamah-Muthu SS, Chaturvedi N, Schalkwijk CG, Stehouwer CD, Ebeling P, Fuller JH. Soluble vascular cell adhesion molecule-1 and soluble E-selectin are associated with micro- and macrovascular complications in Type 1 diabetic patients. EURODIAB Prospective Complications Study group. J Diabetes Complications 20: 188-195, 2006.
17. Boulbou MS, Koukoulis GN, Petinaki EA, Germenis A, Gour-goulianis KI. Soluble adhesion molecules are not involved in the development of retinopathy in type 2 diabetic patients. Acta Dia-betol 41: 118-122, 2004.
18. Siemianowicz K, Francuz T, Gminski J, Telega A, Syzdól M. Endothelium dysfunction markers in patients with diabetic retinopathy. Int J Mol Med 15: 459-462, 2005.
19. Sogawa K, Nagaoka T, Tanano I, et al. Association between diabetic retinopathy and flow-mediated vasodilation in Type 2 DM. Curr Eye Res 37: 446-451, 2012.
20. Suetsugu M, Takebayashi K, Aso Y. Association between diabetic microangiopathy and vascular endothelial function evaluated by flow mediated vasodilatation in patients with type 2 diabetes. Int J Clin Pract 61: 920-926, 2007.
21. Van Hecke MV, Dekker JM, Nijpels G, et al. Are retinal microvascular abnormalities associated with large artery endothelial dysfunction and intima-media thickness? The Hoorn Study. Clin Sci 110: 597-604, 2006.
22. Glowinska-Olszewska B, Urban M, Urban B, Tolwinska J, Szadkowska A. The association of early atherosclerosis and retinopathy in adolescents with type 1 diabetes: preliminary report. Acta Diabetol 44: 131-137, 2007.
23. Wilkinson CP, Ferris FL 3rd, Klein RE, et al; Global Diabetic Retinopathy Project Group. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110: 1677-1682, 2003.
24. Corretti MC, Anderson TJ, Benjamin EJ, et al; International Brachial Artery Reactivity Task Force. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 39: 257-265, 2002.
25. Tang S, Le-Ruppert KC, Gabel VP Expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on proliferating vascular endothelial cells in diabetic epiretinal membranes. Br J Ophthalmol 78: 370-376, 1994.
26. Ergul A. Endothelin-1 and diabetic complications: focus on the vasculature. Pharmacol Res 63: 477-482, 2011.
27. Olson JA, Whitelaw CM, McHardy KC, Pearson DW, Forrester JV. Soluble leucocyte adhesion molecules in diabetic retinopathy stimulate retinal capillary endothelial cell migration. Diabetologi 40: 1166-1171, 1997.
28. Gustavsson C, Agardh E, Bengsston B, Agardh CD. TNF is an independent serum marker for proliferative retinopathy in type 1 diabetic patients. J Diabet Complications 22: 309-316, 2008.
29. Lu M, Perez VL, Ma N, et al. VEGF increases retinal vascular ICAM-1 expression in vivo. Invest Ophthalmol Vis Sci 40: 1808-1812, 1999.
30. Zheng L, Szabó C, Kern TS. Poly (ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-KB. Diabetes 53: 2960-2967, 2004.
31. Chen W, Jump DB, Grant MB, Esselman WJ, Busik JV. Dyslipi-demia, but not hyperglycemia, induces inflammatory adhesion molecules in human retinal vascular endothelial cells. Invest Ophthalmol Vis Sci 44: 5016-5022, 2003.
32. Grossman E, Messerli FH. Hypertension and diabetes. Adv Cardiol 45: 82-106, 2008.
33. Ghiadoni L, Magagna A, Versari D, et al. Different effect of antihypertensive drugs on conduit artery endothelial function. Hypertension 41: 1281-1286, 2003.