Chronic activation of the baroreflex and the promise for hypertension therapy

Handbook of Clinical Neurology

Volumn 117, Issue , 2013, Pages 395-406

  Lohmeier, Thomas E ^a   Iliescu, Radu ^b  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^b GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Baroreflex; Hypertension; Kidney; Obesity; Renal nerves; Renin angiotensin system; Resistant hypertension; Sympathetic nervous system

Indexed keywords

ADRENERGIC SYSTEM; ANIMAL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; HUMAN; HYPERTENSION; KIDNEY; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESSORECEPTOR REFLEX; RENAL NERVES; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RESISTANT HYPERTENSION;

BAROREFLEX; HYPERTENSION; KIDNEY; OBESITY; RENAL NERVES; RENIN-ANGIOTENSIN SYSTEM; RESISTANT HYPERTENSION; SYMPATHETIC NERVOUS SYSTEM;

ANIMALS; AUTONOMIC NERVOUS SYSTEM; BAROREFLEX; HUMANS; HYPERTENSION;

EID: 84884933611     PISSN: 00729752     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-444-53491-0.00032-8     Document Type: Chapter

References (54)

1. Bakris G.L., Lindholm L.H., Black H.R., et al. Divergent results using clinic and ambulatory blood pressures. Report of a Darusentan-resistant hypertension trial. Hypertension 2010, 56:824-830.
2. Barrett C.J., Guild S.-J., Ramchandra R., et al. Baroreceptor denervation prevents sympathoinhibition during angiotensin II-induced hypertension. Hypertension 2005, 46:1-5.
3. Bisognano J.D., Bakris G., Nadim M.K., et al. Baroreflex activation therapy lowers blood pressure in patients with resistant hypertension: results from the double-blind, randomized, placebo-controlled Rheos Pivotal trial. J Am Coll Cardiol 2011, 58:765-773.
4. Bisognano J.D., Kaufman C.L., Bach D.S. Improved cardiac structure and function with treatment using an implantable device in resistant hypertension: results from European and United States trials of the Rheos system. J Am Coll Cardiol 2011, 57:1787-1788.
5. Calhoun D.A., Jones D., Textor S., et al. Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension 2008, 117:e510-e526.
6. Carroll R.G., Lohmeier T.E., Brown A.J. Chronic angiotensin II infusion decreases renal norepinephrine overflow in the conscious dog. Hypertension 1984, 6:675-681.
7. Chapleau M.W., Hajduczok G., Abboud F.M. Reflex control of the circulation 1991, 165-194. CRC Press, Boca Raton, FL. I.H. Zucker, J.P. Gilmore (Eds.).
8. Chobanian A.V., Bakris G.L., Black H.R., et al. Seventh report of the National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003, 42:1206-1252.
9. Cowley A.W. Long-term control of arterial pressure. Physiol Rev 1992, 72:231-300.
10. De Champlain J., Karas M., Nguyen P., et al. Different effects of nifedipine and amlodipine on circulating catecholamine levels in essential hypertensive patients. J Hypertens 1998, 16:1357-1369.
11. De la Sierra A., Segura J., Banegas J.R. Clinical features of 8295 patients with resistant hypertension classified on the basis of ambulatory blood pressure monitoring. Hypertension 2011, 57:898-902.
12. DiBona G.F., Kopp U.C. Neural control of renal function. Physiol Rev 1997, 77:75-197.
13. Esler M. The sympathetic system and hypertension. Am J Hypertens 2000, 13:99S-105S.
14. Esler M., Straznicky N., Eikelis N., et al. Mechanisms of sympathetic activation in obesity-related hypertension. Hypertension 2006, 48:1-10.
15. Fu Q., Zhang R., Witkowski S., et al. Persistent sympathetic activation during chronic antihypertensive therapy. A potential mechanism for long-term morbidity?. Hypertension 2005, 45:513-521.
16. Gonzalez E.R., Krieger A.J., Sapru H.N. Central resetting of baroreflex in spontaneously hypertensive rat. Hypertension 1983, 5:346-352.
17. Grassi G., Cattaneo B., Seravalle G., et al. Baroreflex control of sympathetic nerve activity in essential and secondary hypertension. Hypertension 1998, 31:68-72.
18. Grassi G., Seravalle G., Dell'Oro R., et al. Adrenergic and reflex abnormalities in obesity-related hypertension. Hypertension 2000, 36:538-542.
19. Guyton A.C. Arterial Pressure and Hypertension 1980, Saunders, Philadelphia, PA.
20. Hall J.E., Hildebrandt D.A., Kuo J. Obesity hypertension: role of leptin and sympathetic nervous system. Am J Hypertens 2001, 14:103s-115s.
21. Heusser K., Tank J., Engeli S., et al. Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients. Hypertension 2010, 55:619-626.
22. Iliescu R., Lohmeier T.E. Lowering of blood pressure during chronic suppression of central sympathetic outflow: insight from computer simulations. Clin Exp Pharmacol Physiol 2009, 37:e24-e33.
23. Iliescu R., Dwyer T.M., Irwin E.D., et al. Electrical activation of carotid baroreflex enhances the chronic blood pressure lowering effects of calcium channel blockade by abolishing sympathoexcitation (abstract). Hypertension 2010, 56:e71-e72.
24. Kaplan N.M. Resistant hypertension. J Hypertens 2005, 23:1441-1444.
25. Kassab S., Kato T., Wilkins C., et al. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension 1995, 25:893-897.
26. Kirchheim H.R., Finke R., Hackenthal E., et al. Baroreflex sympathetic activation increases threshold pressure for pressure-dependent renin release. Pflugers Arch 1985, 405:127-135.
27. Ligtenberg G., Blankestijn P.J., Oey P.L., et al. Reduction of sympathetic hyperactivity by enalapril in patients with chronic renal failure. N Engl J Med 1999, 340:1321-1328.
28. Lohmeier T.E., Drummond H.A. The baroreflex in the pathogenesis of hypertension. Comprehensive Hypertension 2007, 265-279. Elsevier, Philadelphia, PA. G.Y.H. Lip, J.E. Hall (Eds.).
29. Lohmeier T.E., Lohmeier J.R., Haque A., et al. Baroreflexes prevent neurally-induced sodium retention in angiotensin hypertension. Am J Physiol Regul Integr Comp Physiol 2000, 279:R1437-R1448.
30. Lohmeier T.E., Irwin E.D., Rossing M.A., et al. Prolonged activation of the baroreflex produces sustained hypotension. Hypertension 2004, 43:306-311.
31. Lohmeier T.E., Barrett A.M., Irwin E.D. Prolonged activation of the baroreflex: a viable approach for the treatment of resistant hypertension?. Curr Hypertens Rep 2005, 7:193-198.
32. Lohmeier T.E., Dwyer T.M., Hildebrandt D.A., et al. Influence of prolonged baroreflex activation on arterial pressure in angiotensin hypertension. Hypertension 2005, 46:1194-1200.
33. Lohmeier T.E., Hildebrandt D.A., Warren S., et al. Recent insights into the interactions between the baroreflex and the kidneys in hypertension. Am J Physiol Regul Integr Comp Physiol 2005, 288:R828-R836.
34. Lohmeier T.E., Dwyer T.M., Irwin E.D., et al. Prolonged activation of the baroreflex abolishes obesity-induced hypertension. Hypertension 2007, 49:1307-1314.
35. Lohmeier T.E., Hildebrandt D.A., Dwyer T.M., et al. Renal denervation does not abolish sustained baroreflex-mediated reductions in arterial pressure. Hypertension 2007, 49:373-379.
36. Lohmeier T.E., Hildebrandt D.A., Dwyer, et al. Prolonged activation of the baroreflex decreases arterial pressure even during chronic adrenergic blockade. Hypertension 2009, 53:833-838.
37. Lohmeier T.E., Iliescu R., Dwyer T.M., et al. Sustained suppression of sympathetic activity and arterial pressure during chronic activation of the carotid baroreflex. Am J Physiol Heart Circ Physiol 2010, 299:H402-H409.
38. Malpas S.C. Sympathetic nervous system overactivity and its role in the development of cardiovascular diseases. Physiol Rev 2010, 90:513-557.
39. Martin W.A., Victor R.G. Premise, promise, and potential limitations of invasive devices to treat hypertension. Curr Cardiol Rep 2010, 13:86-92.
40. McCubbin J.W., Green J.H., Page I.H., et al. Baroreceptor function in chronic renal hypertension. Circ Res 1956, 4:205-210.
41. Parati G. Blood pressure variability: its measurement and significance. J Hypertens 2005, 23:s19-s25.
42. Persell S.D. Prevalence of resistant hypertension in the United States, 2003-2008. Hypertension 2011, 57:1076-1080.
43. Rumantir M.S., Vaz M., Jennings G.L., et al. Neural mechanisms in human obesity-related hypertension. J Hypertens 1999, 17:1125-1133.
44. Scheffers I.J.M., Kroon A.A., Schmidli, et al. Novel baroreflex activation therapy in resistant hypertension; results of a European multi-center feasibility study. J Am Coll Cardiol 2010, 56:1254-1258.
45. Schreihofer A.M., Ito S., Sved A.F. Nucleus tractus solitarius and control of blood pressure in chronic sinoaortic denervated rats. Am J Physiol Regul Integr Comp Physiol 1992, 262:R258-R266.
46. Schwartz S.I., Griffith L.S.C., Neistadt A., et al. Chronic carotid sinus nerve stimulation in the treatment of essential hypertension. Am J Surg 1967, 114:5-15.
47. Shibao C., Gamboa A., Diedrich A., et al. Autonomic contribution to blood pressure and metabolism in obesity. Hypertension 2007, 49:17-33.
48. Thrasher T.N. Effects of chronic baroreceptor unloading on blood pressure in the dog. Am J Physiol Regul Integr Comp Physiol 2005, 288:R863-R871.
49. Tuckman J., Reich T., Lyon A.F., et al. Electrical stimulation of the sinus nerves in hypertensive patients. Clinical evaluation and physiological studies. Hypertension 1968, Vol. 16:23-26. American Heart Association, New York, NY. J.E. Wood (Ed.).
50. Vaz M., Jennings G., Turner A., et al. Regional sympathetic nervous activity and oxygen consumption in obese normotensive human subjects. Circulation 1997, 96:3423-3429.
51. Wustmann K., Kucera J.P., Scheffers I., et al. Effects of chronic baroreceptor stimulation on the autonomic cardiovascular regulation in patients with drug-resistant arterial hypertension. Hypertension 2009, 54:530-536.
52. Yang H.M., Lohmeier T.E., Kivlighn S.D., et al. Sustained increases in plasma epinephrine concentration do not modulate renin release. Am J Physiol Endocrinol Metab 1989, 257:E57-E64.
53. Yin M., Sved A.F. Role of γ-aminobutyric acid-B receptors in baroreceptor reflexes in hypertensive rats. Hypertension 1996, 27:1291-1298.
54. Zhang J., Mifflin S.W. Integration of aortic nerve inputs in hypertensive rats. Hypertension 2000, 35:430-436.