TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in behçet's disease patients in two ethnic cohorts

Clinical and Experimental Rheumatology

Volumn 31, Issue SUPPL.77, 2013, Pages

  Turunc, Gorkem ^a   Coskun, Doga ^a   Alibaz Oner, Fatma ^b   Coit, Patrick ^c   Duzgun, Nursen ^d   Alpsoy, Erkan ^e   Yentur, Sibel P ^a   Salvarani, Carlo ^f   Casali, Bruno ^f   Kötter, Ina ^g   Ergun, Tulin ^b   Direskeneli, Haner ^b   Sawalha, Amr H ^c   Saruhan Direskeneli, Güher ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^c UNIVERSITY OF MICHIGAN   (United States)

^d ANKARA UNIVERSITY   (Turkey)

^e AKDENIZ UNIVERSITY   (Turkey)

^f S MARIA NUOVA HOSPITAL   (Italy)

^g UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Beh et's disease; Genetic susceptibility; TIRAP

Indexed keywords

ADULT; ALLELE; ARTICLE; BEHCET DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; ETHNIC DIFFERENCE; FEMALE; GENE; GENE FREQUENCY; GENOTYPE; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TIRAP GENE; TURKEY (REPUBLIC);

ADULT; BEHCET SYNDROME; CHI-SQUARE DISTRIBUTION; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ITALY; MALE; MEMBRANE GLYCOPROTEINS; ODDS RATIO; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-1; RISK FACTORS; TURKEY;

EID: 84884930166     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. AKIRA S, TAKEDA K: Toll-like receptor signalling. Nat Rev Immunol 2004; 4: 499- 511.
2. KHOR CC, CHAPMAN SJ, VANNBERG FO et al.: A mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet 2007; 39: 523-8.
3. THAMES AD, FOLEY JM, WRIGHT MJ, et al.: Basal ganglia structures differentially contribute to verbal fluency: Evidence from Human Immunodeficiency Virus (HIV)- infected adults. Neuropsychologia 2012; 50: 390-5.
4. RAMASAWMY R, CUNHA-NETO E, FAE KC, et al.: Heterozygosity for the S180L variant of MAL/TIRAP, a gene expressing an adaptor protein in the toll-like receptor pathway, is associated with lower risk of developing chronic chagas cardiomyopathy. J Infect Dis 2009; 199: 1838-45.
5. DIRESKENELI H: Autoimmunity vs. autoinflammation in Behçet's disease: do we oversimplify a complex disorder? Rheumatology 2006; 45: 1461-5.
6. KIRINO Y, TAKENO M, WATANABE R, et al.: Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behçet's disease. Arthritis Res Ther 2008; 10: R16.
7. DURRANI O, BANAHAN K, SHEEDY FJ, et al.: TIRAP Ser180Leu polymorphism is associated with Behçet's disease. Rheumatology Oxford 2011; 50: 1760-5.
8. International Study Group for Behçet's Disease: Criteria for diagnosis of Behçet's disesase. Lancet 1990; 335: 1078-80.
9. CANTAERT T, STONE MA, ter BORG M, et al.: A functional polymorphism of TIR-domaincontaining adaptor is not associated with axial spondyloarthritis. Ann Rheum Dis 2008; 67: 720-2.
10. CASTIBLANCO J, VARELA DC, CASTAñORODRIGUEZ N, ROJAS-VILLARRAGA A, HINCAPIé ME, ANAYA JM: TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus. Infect Genet Evol 2008; 8: 4.
11. SHEEDY FJ, MARINOU I, O'NEILL LA, WILSON AG: The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to, or severity of, rheumatoid arthritis. Ann Rheum Dis 2008; 67: 1328-31.
12. COSAN F, USTEK D, OKU B, et al.: Association of familial Mediterranean fever-related MEFV variations with ankylosing spondylitis. Arthritis Rheum 2010; 62: 3232-36.
13. ATAGUNDUZ P, ERGUN T, DIRESKENELI H: MEFV mutations are increased in Behçet's disease (BD) and are associated with vascular involvement. Clin Exp Rheumatol 2003; 21 (Suppl. 30): S35-7.