Residual nodal disease in patients with advanced-stage oropharyngeal squamous cell carcinoma treated with definitive radiation therapy and posttreatment neck dissection: Association with locoregional recurrence, distant metastasis, and decreased survival

Head and Neck

Volumn 35, Issue 10, 2013, Pages 1454-1460

  Sandulache, Vlad C ^a   Ow, Thomas J ^b   Daram, Shiva P ^b   Hamilton, Jackson ^b   Skinner, Heath ^b   Bell, Diana ^b   Rosenthal, David I ^b   Beadle, Beth M ^b   Ang, K Kian ^b   Kies, Merrill S ^b   Johnson, Faye M ^b   El Naggar, Adel K ^b   Myers, Jeffrey N ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

HPV; neck dissection; oropharynx; radiation; recurrence

Indexed keywords

ANTINEOPLASTIC AGENT;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RISK; CANCER STAGING; CHEMORADIOTHERAPY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISTANT METASTASIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MINIMAL RESIDUAL DISEASE; NECK DISSECTION; OROPHARYNGEAL SQUAMOUS CELL CARCINOMA; OROPHARYNX CARCINOMA; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

HPV; NECK DISSECTION; OROPHARYNX; RADIATION; RECURRENCE;

ADULT; AGED; CANCER CARE FACILITIES; CARCINOMA, SQUAMOUS CELL; CHEMORADIOTHERAPY; COHORT STUDIES; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPH NODES; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NECK DISSECTION; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASM, RESIDUAL; OROPHARYNGEAL NEOPLASMS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SURVIVAL ANALYSIS; TEXAS; TREATMENT OUTCOME;

EID: 84884906362     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.23173     Document Type: Article

References (24)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D,. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
2. Dahlstrom KR, Li G, Tortolero-Luna G, Wei Q, Sturgis EM,. Differences in history of sexual behavior between patients with oropharyngeal squamous cell carcinoma and patients with squamous cell carcinoma at other head and neck sites. Head Neck 2011; 33: 847-855.
3. Ang KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010; 363: 24-35.
4. D'Souza G, Kreimer AR, Viscidi R, et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007; 356: 1944-1956.
5. Chaturvedi AK, Engels EA, Pfeiffer RM, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 2011; 29: 4294-4301.
6. Ojiri H, Mendenhall WM, Stringer SP, Johnson PL, Mancuso AA,. Post-RT CT results as a predictive model for the necessity of planned post-RT neck dissection in patients with cervical metastatic disease from squamous cell carcinoma. Int J Radiat Oncol Biol Phys 2002; 52: 420-428.
7. Mendenhall WM, Amdur RJ, Stringer SP, Villaret DB, Cassisi NJ,. Radiation therapy for squamous cell carcinoma of the tonsillar region: a preferred alternative to surgery? J Clin Oncol 2000; 18: 2219-2225.
8. Mendenhall WM, Morris CG, Amdur RJ, et al. Definitive radiotherapy for tonsillar squamous cell carcinoma. Am J Clin Oncol 2006; 29: 290-297.
9. Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006; 354: 567-578.
10. Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 2010; 11: 21-28.
11. Boyd TS, Harari PM, Tannehill SP, et al. Planned postradiotherapy neck dissection in patients with advanced head and neck cancer. Head Neck 1998; 20: 132-137.
12. Clavel S, Charron MP, Bélair M, et al. The role of computed tomography in the management of the neck after chemoradiotherapy in patients with head-and-neck cancer. Int J Radiat Oncol Biol Phys 2012; 82: 567-573.
13. Doweck I, Robbins KT, Mendenhall WM, Hinerman RW, Morris C, Amdur R,. Neck level-specific nodal metastases in oropharyngeal cancer: is there a role for selective neck dissection after definitive radiation therapy? Head Neck 2003; 25: 960-967.
14. Liauw SL, Mancuso AA, Amdur RJ, et al. Postradiotherapy neck dissection for lymph node-positive head and neck cancer: the use of computed tomography to manage the neck. J Clin Oncol 2006; 24: 1421-1427.
15. Narayan K, Crane CH, Kleid S, Hughes PG, Peters LJ,. Planned neck dissection as an adjunct to the management of patients with advanced neck disease treated with definitive radiotherapy: for some or for all? Head Neck 1999; 21: 606-613.
16. Simon C, Goepfert H, Rosenthal DI, et al. Presence of malignant tumor cells in persistent neck disease after radiotherapy for advanced squamous cell carcinoma of the oropharynx is associated with poor survival. Eur Arch Otorhinolaryngol 2006; 263: 313-318.
17. Corry J, Peters L, Fisher R, et al. N2-N3 neck nodal control without planned neck dissection for clinical/radiologic complete responders-results of Trans Tasman Radiation Oncology Group Study 98.02. Head Neck 2008; 30: 737-742.
18. Corry J, Smith JG, Peters LJ,. The concept of a planned neck dissection is obsolete. Cancer J 2001; 7: 472-474.
19. Porceddu SV, Jarmolowski E, Hicks RJ, et al. Utility of positron emission tomography for the detection of disease in residual neck nodes after (chemo)radiotherapy in head and neck cancer. Head Neck 2005; 27: 175-181.
20. de Bree R, van der Putten L, Brouwer J, Castelijns JA, Hoekstra OS, Leemans CR,. Detection of locoregional recurrent head and neck cancer after (chemo)radiotherapy using modern imaging. Oral Oncol 2009; 45: 386-393.
21. 18F]fluorodeoxyglucose positron emission tomography and computed tomography assessment of radiation response in head and neck cancer. J Clin Oncol 2009; 27: 2509-2515.
22. Seixas-Silva JA Jr, Richards T, Khuri FR, et al. Phase 2 bioadjuvant study of interferon alfa-2a, isotretinoin, and vitamin E in locally advanced squamous cell carcinoma of the head and neck: long-term follow-up. Arch Otolaryngol Head Neck Surg 2005; 131: 304-307.
23. Hermans R, Pameijer FA, Mancuso AA, Parsons JT, Mendenhall WM,. Laryngeal or hypopharyngeal squamous cell carcinoma: can follow-up CT after definitive radiation therapy be used to detect local failure earlier than clinical examination alone? Radiology 2000; 214: 683-687.
24. Shoushtari A, Meeneghan M, Sheng K, et al. Intensity-modulated radiotherapy outcomes for oropharyngeal squamous cell carcinoma patients stratified by p16 status. Cancer 2010; 116: 2645-2654.