Tumor Suppressive Function of mir-205 in Breast Cancer Is Linked to HMGB3 Regulation

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Elgamal, Ola A ^a   Park, Jong Kook ^a,d   Gusev, Yuriy ^b   Azevedo Pouly, Ana Clara P ^a   Jiang, Jinmai ^a   Roopra, Avtar ^c   Schmittgen, Thomas D ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; HIGH MOBILITY GROUP B3 PROTEIN; MICRORNA; MICRORNA 205; SMALL INTERFERING RNA; TRICHOSTATIN A; AZACITIDINE; MIRN205 MICRORNA, HUMAN; RE1 SILENCING TRANSCRIPTION FACTOR; RE1-SILENCING TRANSCRIPTION FACTOR; REPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

3' UNTRANSLATED REGION; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; CANCER INHIBITION; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; HMGB3 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN TARGETING; TUMOR INVASION; WESTERN BLOTTING; BASE PAIRING; BREAST TUMOR; CHROMATIN; DRUG EFFECT; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; MORTALITY; PATHOLOGY; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; AZACITIDINE; BASE PAIRING; BASE SEQUENCE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATIN; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HMGB3 PROTEIN; HUMANS; MICRORNAS; NEOPLASM INVASIVENESS; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 84884889399     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076402     Document Type: Article

References (30)

1. Chen C, Frierson HF Jr., Haggerty PF, Theodorescu D, Gregory CW, et al. (2001) An 800-kb region of deletion at 13q14 in human prostate and other carcinomas. Genomics 77: 135-144. doi:10.1006/geno.2001.6631. PubMed: 11597138.
2. DeSantis C, Siegel R, Bandi P, Jemal A, (2011) Breast cancer statistics, 2011. CA Cancer J Clin 61: 409-418. PubMed: 21969133.
3. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, et al. (2002) Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 99: 15524-15529. doi:10.1073/pnas.242606799. PubMed: 12434020.
4. Rodríguez-Pinilla SM, Sarrió D, Honrado E, Hardisson D, Calero F, et al. (2006) Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas. Clin Cancer Res 12: 1533-1539. doi:10.1158/1078-0432.CCR-05-2281. PubMed: 16533778.
5. Liang Y, Ridzon D, Wong L, Chen C, (2007) Characterization of microRNA expression profiles in normal human tissues. BMC Genomics 8: 166. doi:10.1186/1471-2164-8-166. PubMed: 17565689.
6. Chung TK, Cheung TH, Huen NY, Wong KW, Lo KW, et al. (2009) Dysregulated microRNAs and their predicted targets associated with endometrioid endometrial adenocarcinoma in Hong Kong women. Int J Cancer 124: 1358-1365. doi:10.1002/ijc.24071. PubMed: 19065659.
7. Lebanony D, Benjamin H, Gilad S, Ezagouri M, Dov A, et al. (2009) Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma. J Clin Oncol 27: 2030-2037. doi:10.1200/JCO.2008.19.4134. PubMed: 19273703.
8. Markou A, Tsaroucha EG, Kaklamanis L, Fotinou M, Georgoulias V, et al. (2008) Prognostic value of mature microRNA-21 and microRNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR. Clin Chem 54: 1696-1704. doi:10.1373/clinchem.2007.101741. PubMed: 18719201.
9. Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, et al. (2006) Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9: 189-198. doi:10.1016/j.ccr.2006.01.025. PubMed: 16530703.
10. Hulf T, Sibbritt T, Wiklund ED, Bert S, Strbenac D, et al. (2011) Discovery pipeline for epigenetically deregulated miRNAs in cancer: integration of primary miRNA transcription. BMC Genomics 12: 54. doi:10.1186/1471-2164-12-54.
11. Dar AA, Majid S, de Semir D, Nosrati M, Bezrookove V, et al. (2011) miRNA-205 suppresses melanoma cell proliferation and induces senescence via regulation of E2F1 protein. J Biol Chem 286: 16606-16614. doi:10.1074/jbc.M111.227611. PubMed: 21454583.
12. Philippidou D, Schmitt M, Moser D, Margue C, Nazarov PV, et al. (2010) Signatures of microRNAs and selected microRNA target genes in human melanoma. Cancer Res 70: 4163-4173. doi:10.1158/0008-5472.CAN-09-4512. PubMed: 20442294.
13. Xu Y, Brenn T, Brown ER, Doherty V, Melton DW, (2012) Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors. Br J Cancer 106: 553-561. doi:10.1038/bjc.2011.568. PubMed: 22223089.
14. Iorio MV, Casalini P, Piovan C, Di Leva G, Merlo A, et al. (2009) microRNA-205 regulates HER3 in human breast cancer. Cancer Res 69: 2195-2200. doi:10.1158/0008-5472.CAN-08-2920. PubMed: 19276373.
15. Wu H, Zhu S, Mo YY, (2009) Suppression of cell growth and invasion by miR-205 in breast cancer. Cell Res 19: 439-448. doi:10.1038/cr.2009.18. PubMed: 19238171.
16. Greene SB, Herschkowitz JI, Rosen JM, (2010) The ups and downs of miR-205: identifying the roles of miR-205 in mammary gland development and breast cancer. RNA Biol 7: 300-304. doi:10.4161/rna.7.3.11837. PubMed: 20436283.
17. Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, et al. (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10: 593-601. doi:10.1038/ncb1722. PubMed: 18376396.
18. Wu H, Mo YY, (2009) Targeting miR-205 in breast cancer. Expert Opin Ther Targets 13: 1439-1448. doi:10.1517/14728220903338777. PubMed: 19839716.
19. Wagoner MP, Gunsalus KT, Schoenike B, Richardson AL, Friedl A, et al. (2010) The transcription factor REST is lost in aggressive breast cancer. PLOS Genet 6: e1000979.
20. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408. doi:10.1006/meth.2001.1262. PubMed: 11846609.
21. Radojicic J, Zaravinos A, Vrekoussis T, Kafousi M, Spandidos DA, et al. (2011) MicroRNA expression analysis in triple-negative (ER, PR and Her2/neu) breast cancer. Cell Cycle 10: 507-517. doi:10.4161/cc.10.3.14754. PubMed: 21270527.
22. Savad S, Mehdipour P, Miryounesi M, Shirkoohi R, Fereidooni F, et al. (2012) Expression analysis of MiR-21, MiR-205, and MiR-342 in breast cancer in Iran. Asian Pac J Cancer Prev 13: 873-877. doi:10.7314/APJCP.2012.13.3.873. PubMed: 22631664.
23. Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, et al. (2011) Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 121: 2750-2767. doi:10.1172/JCI45014.
24. Hulf T, Sibbritt T, Wiklund ED, Patterson K, Song JZ, et al. (2013) Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer. Oncogene 32: 2891-2899. doi:10.1038/onc.2012.300. PubMed: 22869146.
25. Lange SS, Vasquez KM, (2009) HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic. Mol Carcinog 48: 571-580. doi:10.1002/mc.20544. PubMed: 19360789.
26. Grosschedl R, Giese K, Pagel J, (1994) HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet 10: 94-100. doi:10.1016/0168-9525(94)90232-1. PubMed: 8178371.
27. Ellerman JE, Brown CK, de Vera M, Zeh HJ, Billiar T, et al. (2007) Masquerader: high mobility group box-1 and cancer. Clin Cancer Res 13: 2836-2848. doi:10.1158/1078-0432.CCR-06-1953. PubMed: 17504981.
28. Nemeth MJ, Curtis DJ, Kirby MR, Garrett-Beal LJ, Seidel NE, et al. (2003) Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation. Blood 102: 1298-1306. doi:10.1182/blood-2002-11-3541. PubMed: 12714519.
29. Maciotta S, Meregalli M, Cassinelli L, Parolini D, Farini A, et al. (2012) Hmgb3 is regulated by microRNA-206 during muscle regeneration. PLOS ONE 7: e43464. doi:10.1371/journal.pone.0043464. PubMed: 22912879.
30. Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 40: 499-507. doi:10.1038/ng.127.