Fatigue in myasthenia gravis: Is it more than muscular weakness?

BMC Neurology

Volumn 13, Issue , 2013, Pages

  Elsais, Ahmed ^a,b   Wyller, Vegard B ^c   Loge, Jon H ^b,c   Kerty, Emilia ^a,b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Acetylcholine esterase inhibitors; Autonomic nervous system; Fatigue; Myasthenia gravis; Questionnaire; Self report

Indexed keywords

ADULT; AGED; ARTICLE; AUTONOMIC DYSFUNCTION; CONTROLLED STUDY; DISEASE SEVERITY; DYSTHYMIA; FATIGUE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MUSCLE WEAKNESS; MYASTHENIA GRAVIS; REMISSION; SLEEP DISORDER; STANDING; THERMOREGULATION;

ADULT; AGED; AUTONOMIC NERVOUS SYSTEM DISEASES; CASE-CONTROL STUDIES; CHOLINESTERASE INHIBITORS; FATIGUE; FEMALE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; MUSCLES; MYASTHENIA GRAVIS; NEUROLOGIC EXAMINATION; QUESTIONNAIRES; RETROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 84884886539     PISSN: None     EISSN: 14712377     Source Type: Journal    
DOI: 10.1186/1471-2377-13-132     Document Type: Article

References (28)

1. Stephen SA. Fatigue in older adults with stable heart failure. Heart Lung 2008, 37:122-131.
2. Kalkman JS, Schillings ML, van der Werf SP, Padberg GW, Zwarts MJ, van Engelen BG, Bleijenberg G. Experienced fatigue in facioscapulohumeral dystrophy, myotonic dystrophy, and HMSN-I. J Neurol Neurosurg Psychiatry 2005, 76:1406-1409.
3. Chaudhuri A, Behan PO. Fatigue in neurological disorders. Lancet 2004, 363:978-988.
4. Zwarts MJ, Bleijenberg G, van Engelen BG. Clinical neurophysiology of fatigue. Clin Neurophysiol 2008, 119:2-10.
5. Wessely S. The epidemiology of chronic fatigue syndrome. Epidemiol Rev 1995, 17:139-151.
6. Kittiwatanapaisan W, Gauthier DK, Williams AM, Oh SJ. Fatigue in Myasthenia Gravis patients. J Neurosci Nurs 2003, 35:87-93. 106.
7. Paul RH, Cohen RA, Goldstein JM, Gilchrist JM. Fatigue and its impact on patients with myasthenia gravis. Muscle Nerve 2000, 23:1402-1406.
8. Symonette CJ, Watson BV, Koopman WJ, Nicolle MW, Doherty TJ. Muscle strength and fatigue in patients with generalized myasthenia gravis. Muscle Nerve 2010, 41:362-369.
9. Wyller VB, Saul JP, Walloe L, Thaulow E. Sympathetic cardiovascular control during orthostatic stress and isometric exercise in adolescent chronic fatigue syndrome. Eur J Appl Physiol 2008, 102:623-632.
10. Stewart JM. Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion. Pediatr Res 2000, 48:218-226.
11. Shukla G, Gupta S, Goyal V, Singh S, Srivastava A, Behari M. Abnormal sympathetic hyper-reactivity in patients with myasthenia gravis: A prospective study. Clin Neurol Neurosurg Epub 2012 Jun 5.
12. Stoica E, Enulescu O. Deficiency of sympathetic nervous system function in myasthenia. J Auton Nerv Syst 1992, 38:69-76.
13. Lechin F, van der Dijs B, Pardey-Maldonado B, John E, Jimenez V, Orozco B, Baez S, Lechin ME. Enhancement of noradrenergic neural transmission: an effective therapy of myasthenia gravis: a report on 52 consecutive patients. J Med 2000, 31:333-361.
14. Kimura S, Nezu A. Peripheral nerve involvement in myasthenia gravis. Brain Dev 1989, 11:429-432.
15. Vernino S, Cheshire WP, Lennon VA. Myasthenia gravis with autoimmune autonomic neuropathy. Auton Neurosci 2001, 88:187-192.
16. Loge JH, Ekeberg O, Kaasa S. Fatigue in the general Norwegian population: normative data and associations. J Psychosom Res 1998, 45:53-65.
17. Chalder T, Berelowitz G, Pawlikowska T, Watts L, Wessely S, Wright D, Wallace EP. Development of a fatigue scale. J Psychosom Res 1993, 37:147-153.
18. Padua L, Evoli A, Aprile I, Caliandro P, Batocchi AP, Punzi C, Mazza S, Padua R, Tonali P. Myasthenia gravis outcome measure: development and validation of a disease-specific self-administered questionnaire. Neurol Sci 2002, 23:59-68.
19. Rostedt A, Padua L, Stalberg EV. Validation of the Swedish version of the disease-specific Myasthenia Gravis Questionnaire. Neurol Sci 2006, 27:91-96.
20. Suarez GA, Opfer-Gehrking TL, Offord KP, Atkinson EJ, O'Brien PC, Low PA. The autonomic symptom profile: a new instrument to assess autonomic symptoms. Neurology 1999, 52:523-528.
21. Wyller VB, Godang K, Morkrid L, Saul JP, Thaulow E, Walloe L. Abnormal thermoregulatory responses in adolescents with chronic fatigue syndrome: relation to clinical symptoms. Pediatrics 2007, 120:e129-e137.
22. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A, International Chronic Fatigue Syndrome Study Group The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med 1994, 121:953-959. International Chronic Fatigue Syndrome Study Group.
23. Elsais A, Johansen B, Kerty E. Airway limitation and exercise intolerance in well-regulated myasthenia gravis patients. Acta Neurol Scand 2010, 122:12-17.
24. Martinez de Lapiscina EH, Aguirre ME, Blanco TA, Pascual IJ. Myasthenia gravis: sleep quality, quality of life, and disease severity. Muscle Nerve 2012, 46:174-180.
25. Mennuni G, Morante M, Scoppetta C, Bergonzi P. First REM latency in patients with myasthenia gravis: an observation, an hypothesis. Acta Neurol (Napoli) 1983, 5:253-255.
26. Papazian O. Rapid eye movement sleep alterations in myasthenia gravis. Neurology 1976, 26:311-316.
27. Stepansky R, Weber G, Zeitlhofer J. Sleep apnea and cognitive dysfunction in myasthenia gravis. Acta Med Austriaca 1997, 24:128-131.
28. Quera-Salva MA, Guilleminault C, Chevret S, Troche G, Fromageot C, Crowe MC, Stoos R, de Lattre J, Raphael JC, Gajdos P. Breathing disorders during sleep in myasthenia gravis. Ann Neurol 1992, 31:86-92.