Differences in histopathological evaluation of standard lymph node dissections result in differences in nodal count but not in survival

World Journal of Urology

Volumn 31, Issue 5, 2013, Pages 1297-1302

  Mertens, L S ^a   Meijer, R P ^a   van Werkhoven, E ^a   Bex, A ^a   van der Poel, H G ^a   van Rhijn, B W ^a   Meinhardt, W ^a   Horenblas, S ^a  

^a ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

Author keywords

Lymph node density; Lymph node excision; Lymph nodes; Prognosis; Urinary bladder neoplasms

Indexed keywords

AGED; ARTICLE; BLADDER TUMOR; CANCER STAGING; COMPARATIVE STUDY; EVALUATION STUDY; FOLLOW UP; HISTOLOGY; HUMAN; INCIDENCE; KAPLAN MEIER METHOD; LYMPH NODE; LYMPH NODE DISSECTION; METHODOLOGY; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; PATHOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; STANDARD; SURVIVAL RATE; TUMOR RECURRENCE;

AGED; FOLLOW-UP STUDIES; HISTOLOGICAL TECHNIQUES; HUMANS; INCIDENCE; KAPLAN-MEIER ESTIMATE; LYMPH NODE EXCISION; LYMPH NODES; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PATHOLOGY, CLINICAL; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE; URINARY BLADDER NEOPLASMS;

EID: 84884813421     PISSN: 07244983     EISSN: 14338726     Source Type: Journal    
DOI: 10.1007/s00345-012-0916-z     Document Type: Article

References (22)

1. Dhar NB, Klein EA, Reuther AM, Thalmann GN, Madersbacher S, Studer UE (2008) Outcome after radical cystectomy with limited or extended pelvic lymph node dissection. J Urol 179: 873.
2. Leissner J, Ghoneim MA, Abol-Enein H, Thuroff JW, Franzaring L, Fisch M et al (2004) Extended radical lymphadenectomy in patients with urothelial bladder cancer: results of a prospective multicenter study. J Urol 171: 139.
3. Roth B, Wissmeyer MP, Zehnder P, Birkhauser FD, Thalmann GN, Krause TM et al (2010) A new multimodality technique accurately maps the primary lymphatic landing sites of the bladder. Eur Urol 57: 205.
4. Herr HW, Faulkner JR, Grossman HB, Natale RB, deVere White R, Sarosdy MF et al (2004) Surgical factors influence bladder cancer outcomes: a cooperative group report. J Clin Oncol 22: 2781.
5. Herr HW, Bochner BH, Dalbagni G, Donat SM, Reuter VE, Bajorin DF (2002) Impact of the number of lymph nodes retrieved on outcome in patients with muscle invasive bladder cancer. J Urol 167: 1295.
6. Kassouf W, Svatek RS, Shariat SF, Novara, G, Lerner SP, Fradet Y et al (2011) Critical analysis and validation of lymph node density as prognostic variable in urothelial carcinoma of bladder. Urol Oncol [Epub ahead of print].
7. May M, Herrmann E, Bolenz C, Tiemann A, Brookman-May S, Fritsche HM et al (2011) Lymph node density affects cancer-specific survival in patients with lymph node-positive urothelial bladder cancer following radical cystectomy. Eur Urol 59: 712.
8. Kassouf W, Leibovici D, Munsell MF, Dinney CP, Grossman HB, Kamat AM (2006) Evaluation of the relevance of lymph node density in a contemporary series of patients undergoing radical cystectomy. J Urol 176: 53.
9. Stein JP, Cai J, Groshen S, Skinner DG (2003) Risk factors for patients with pelvic lymph node metastases following radical cystectomy with en bloc pelvic lymphadenectomy: concept of lymph node density. J Urol 170: 35.
10. Jensen JB, Ulhoi BP, Jensen KM (2012) Extended versus limited lymph node dissection in radical cystectomy: impact on recurrence pattern and survival. Int J Urol 19: 39.
11. Meijer RP, Nunnink CJ, Wassenaar AE, Bex A, van der Poel HG, van Rhijn BW et al (2012) Standard lymph node dissection for bladder cancer: significant variability in the number of reported lymph nodes. J Urol 187(2): 446-450.
12. Dorin RP, Daneshmand S, Eisenberg MS, Chandrasoma S, Cai J, Miranda G et al (2011) Lymph node dissection technique is more important than lymph node count in identifying nodal metastases in radical cystectomy patients: a comparative mapping study. Eur Urol 60: 946.
13. Zehnder P, Studer UE, Skinner EC, Dorin RP, Cai J, Roth B et al (2011) Super extended versus extended pelvic lymph node dissection in patients undergoing radical cystectomy for bladder cancer: a comparative study. J Urol 186: 1261.
14. Kassouf W, Agarwal PK, Herr HW, Munsell MF, Spiess PE, Brown GA et al (2008) Lymph node density is superior to TNM nodal status in predicting disease-specific survival after radical cystectomy for bladder cancer: analysis of pooled data from MDACC and MSKCC. J Clin Oncol 26: 121.
15. Quek ML, Flanigan RC (2009) The role of lymph node density in bladder cancer prognostication. World J Urol 27: 27.
16. Bochner BH, Herr HW, Reuter VE (2001) Impact of separate versus en bloc pelvic lymph node dissection on the number of lymph nodes retrieved in cystectomy specimens. J Urol 166: 2295.
17. Stein JP, Penson DF, Cai J, Miranda G, Skinner EC, Dunn MA et al (2007) Radical cystectomy with extended lymphadenectomy: evaluating separate package versus en bloc submission for node positive bladder cancer. J Urol 177: 876.
18. Bennett VS, Varma M, Bailey DM (2008) Guidelines for the macroscopic processing of radical prostatectomy and pelvic lymphadenectomy specimens. J Clin Pathol 61: 713.
19. Winstanley AM, Sandison A, Bott SR, Dogan A, Parkinson MC (2002) Incidental findings in pelvic lymph nodes at radical prostatectomy. J Clin Pathol 55: 623.
20. Fang AC, Ahmad AE, Whitson JM, Ferrell LD, Carroll PR, Konety BR (2010) Effect of a minimum lymph node policy in radical cystectomy and pelvic lymphadenectomy on lymph node yields, lymph node positivity rates, lymph node density, and survivorship in patients with bladder cancer. Cancer 116: 1901.
21. Lopez-Beltran A, Bassi P, Pavone-Macaluso M, Montironi R (2004) Handling and pathology reporting of specimens with carcinoma of the urinary bladder, ureter, and renal pelvis. Eur Urol 45: 257.
22. Herr H, Lee C, Chang S, Lerner S (2004) Standardization of radical cystectomy and pelvic lymph node dissection for bladder cancer: a collaborative group report. J Urol 171: 1823.