Faces of a changing climate: Semi-quantitative multi-mycotoxin analysis of grain grown in exceptional climatic conditions in Norway

Toxins

Volumn 5, Issue 10, 2013, Pages 1682-1697

  Uhlig, Silvio ^a   Eriksen, Gunnar Sundstøl ^a   Hofgaard, Ingerd Skow ^b   Krska, Rudolf ^c   Beltrán, Eduardo ^d   Sulyok, Michael ^c  

^a NORWEGIAN VETERINARY INSTITUTE   (Norway)

^b NORWEGIAN INSTITUTE OF BIOECONOMY RESEARCH   (Norway)

^c UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^d UNIVERSITAT JAUME I   (Spain)

Author keywords

Climate change; Fungi; LC MS; Multiplexing; Mycotoxin

Indexed keywords

AFLATOXIN; ALTERNARIOL; ERGOT ALKALOID; FUMONISIN; MYCOTOXIN; OCHRATOXIN; STERIGMATOCYSTIN; TRICHOTHECENE; TRICHOTHECENE A; TRICHOTHECENE B; TRICHOTHECENE DERIVATIVE; UNCLASSIFIED DRUG; ZEARALENONE;

ALTERNARIA; ARTICLE; ASPERGILLUS; BARLEY; CEREAL; CLIMATE CHANGE; ETHNIC GROUP; FUSARIUM; GRAIN; GREENHOUSE EFFECT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; NONHUMAN; NORWAY; NORWEGIAN; OAT; PENICILLIUM; PILOT STUDY; PLANT GROWTH; PREVALENCE; SEASONAL VARIATION; WHEAT;

ALTERNARIA; ASPERGILLUS; CEREALS; CLIMATE CHANGE; ENVIRONMENTAL MONITORING; ERGOT ALKALOIDS; FOOD CONTAMINATION; FUSARIUM; MYCOTOXINS; NORWAY; PENICILLIUM;

EID: 84884811707     PISSN: 20726651     EISSN: None     Source Type: Journal    
DOI: 10.3390/toxins5101682     Document Type: Article

References (45)

1. Været i Norge Klimatologisk oversikt Året 2011. Available online: http://met.no/Klima/Klimastatistikk/Varet_i_Norge/2011/Aret_2011/filestore/20112.pdf (accessed on 20 August 2013).
2. Bernhoft, A.; Eriksen, G.S.; Sundheim, L.; Berntssen, M.; Brantsæter, A.L.; Brodal, G.; Fæste, C.K.; Hofgaard, I.S.; Rafoss, T.; Sivertsen, T.; et al. Risk Assessment of Mycotoxins in Cereal Grain in Norway; Opinion of the Scientific Steering Committee of the Norwegian Scientific Committee for Food Safety: Oslo, Norway, 2013.
3. Brodal, G.; Rafoss, T.; Elen, O.; Tangerås, H. Trends and variations in the occurrence of Fusarium in cereal seeds in Norway 1970-2010. Seed Sci. Technol. 2013, submitted for publication.
4. Abia, W.A.; Warth, B.; Sulyok, M.; Krska, R.; Tchana, A.N.; Njobeh, P.B.; Dutton, M.F.; Moundipa, P.F. Determination of multi-mycotoxin occurrence in cereals, nuts and their products in Cameroon by liquid chromatography tandem mass spectrometry (LC-MS/MS). Food Control 2013, 31, 438-453.
5. Sulyok, M.; Berthiller, F.; Krska, R.; Schumacher, R. Development and validation of a liquid chromatography/tandem mass spectrometric method for the determination of 39 mycotoxins in wheat and maize. Rapid Commun. Mass Spectrom. 2006, 20, 2649-2659.
6. Sulyok, M.; Krska, R.; Schuhmacher, R. Application of an LC-MS/MS based multi-mycotoxin method for the semi-quantitative determination of mycotoxins occurring in different types of food infected by moulds. Food Chem. 2010, 119, 408-416.
7. Vishwanath, V.; Sulyok, M.; Labuda, R.; Bicker, W.; Krska, R. Simultaneous determination of 186 fungal and bacterial metabolites in indoor matrices by liquid chromatography/tandem mass spectrometry. Anal. Bioanal. Chem. 2009, 395, 1355-1372.
8. Bernhoft, A.; Clasen, P.E.; Kristoffersen, A.B.; Torp, M. Less Fusarium infestation and mycotoxin contamination in organic than in conventional cereals. Food Addit. Contam. Part A 2010, 27, 842-852.
9. Uhlig, S.; Jestoi, M.; Parikka, P. Fusarium avenaceum-The North European situation. Int. J. Food Microbiol. 2007, 119, 17-24.
10. Chandelier, A.; Nimal, C.; Andre, F.; Planchon, V.; Oger, R. Fusarium species and DON contamination associated with head blight in winter wheat over a 7-year period (2003-2009) in Belgium. Eur. J. Plant Pathol. 2011, 130, 403-414.
11. Nielsen, L.K.; Jensen, J.D.; Rodriguez, A.; Jorgensen, L.N.; Justesen, A.F. TRI12 based quantitative real-time PCR assays reveal the distribution of trichothecene genotypes of F. graminearum and F. culmorum isolates in Danish small grain cereals. Int. J. Food Microbiol. 2012, 157, 384-392.
12. Waalwijk, C.; Kastelein, P.; de Vries, I.; Kerenyi, Z.; van der Lee, T.; Hesselink, T.; Kohl, J.; Kema, G. Major changes in Fusarium spp. in wheat in the Netherlands. Eur. J. Plant Pathol. 2003, 109, 743-754.
13. Streit, E.; Naehrer, K.; Rodrigues, I.; Schatzmayr, G. Mycotoxin occurrence in feed and feed raw materials worldwide: Long-term analysis with special focus on Europe and Asia. J. Sci. Food Agric. 2013, 93, 2892-2899.
14. Van der Fels-Klerx, H.J.; Klemsdal, S.; Hietaniemi, V.; Lindblad, M.; Ioannou-Kakouri, E.; van Asselt, E.D. Mycotoxin contamination of cereal grain commodities in relation to climate in North West Europe. Food Addit. Contam. Part A 2012, 29, 1581-1592.
15. Brandfass, C. Establishment and Application of Real-Time PCR-Based Methods to Study the Epidemiology of Fusarium Head Blight. Ph.D. thesis, Georg-August-University Göttingen, Göttingen, Germany, 2006.
16. Rodrigues, I.; Naehrer, K. A three-year survey on the worldwide occurrence of mycotoxins in feedstuffs and feed. Toxins 2012, 4, 663-675.
17. Fredlund, E.; Gidlund, A.; Sulyok, M.; Börjesson, T.; Krska, R.; Olsen, M.; Lindblad, M. Deoxynivalenol and other selected Fusarium toxins in Swedish oats-Occurrence and correlation to specific Fusarium species. Int. J. Food Microbiol. 2013, doi:10.1016/j.ijfoodmicro.2013.06.026.
18. Berthiller, F.; Crews, C.; Dall'Asta, C.; de Saeger, S.; Haesaert, G.; Karlovsky, P.; Oswald, I.P.; Seefelder, W.; Speijers, G.; Stroka, J. Masked mycotoxins: A review. Mol. Nutr. Food Res. 2013, 57, 165-186.
19. Edwards, S.G. Fusarium mycotoxin content of UK organic and conventional barley. Food Addit. Contam. Part A 2009, 26, 1185-1190.
20. Ghebremeskel, M.; Langseth, W. The occurrence of culmorin and hydroxy-culmorins in cereals. Mycopathologia 2001, 152, 103-108.
21. Santini, A.; Meca, G.; Uhlig, S.; Ritieni, A. Fusaproliferin, beauvericin and enniatins: Occurrence in food-A review. World Mycotoxin J. 2012, 5, 71-81.
22. Jestoi, M.; Rokka, M.; Yli-Mattila, T.; Parikka, P.; Rizzo, A.; Peltonen, K. Presence and concentrations of the Fusarium-related mycotoxins beauvericin, enniatins and moniliformin in Finnish grain samples. Food Addit. Contam. 2004, 21, 794-802.
23. Uhlig, S.; Torp, M.; Heier, B.T. Beauvericin and enniatins A, A1, B and B1 in Norwegian grain: A survey. Food Chem. 2006, 94, 193-201.
24. Uhlig, S.; Petersen, D.; Flåøyen, A.; Wilkins, A. 2-Amino-14,16-dimethyloctadecan-3-ol, a new sphingosine analogue toxin in the fungal genus Fusarium. Toxicon 2005, 46, 513-522.
25. EFSA panel on contaminants in the food chain. Scientific opinion on the risks for animal and public health related to the presence of Alternaria toxins in feed and food. EFSA J. 2011, 9, 2407-2505.
26. Häggblom, P.; Stepinska, A.; Solyakov, A. Alternaria Mycotoxins in Swedish Feed Grain. In Proceedings of the 29th Mycotoxin-Workshop of the Society of Mycotoxin Research, Fellbach, Germany, May 2007; p. 35.
27. Müller, M.E.H.; Steier, I.; Koppen, R.; Siegel, D.; Proske, M.; Korn, U.; Koch, M. Cocultivation of phytopathogenic Fusarium and Alternaria strains affects fungal growth and mycotoxin production. J. Appl. Microbiol. 2012, 113, 874-887.
28. Flieger, M.; Wurst, M.; Shelby, R. Ergot alkaloids-Sources, structures and analytical methods. Folia Microbiol. 1997, 42, 3-30.
29. Kawai, K.; Nozawa, Y.; Maebayashi, Y.; Yamazaki, M.; Hamasaki, T. Averufin, an anthraquinone mycotoxin possessing a potent uncoupling effect on mitochondrial respiration. Appl. Environ. Microbiol. 1984, 47, 481-483.
30. Udagawa, T.; Yuan, J.; Panigrahy, D.; Chang, Y.H.; Shah, J.; D'Amato, R.J. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. J. Pharmacol. Exp. Ther. 2000, 294, 421-427.
31. Regueira, T.B.; Kildegaard, K.R.; Hansen, B.G.; Mortensen, U.H.; Hertweck, C.; Nielsen, J. Molecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactum. Appl. Environ. Microbiol. 2011, 77, 3035-3043.
32. EFSA panel on contaminants in the food chain. Opinion of the scientific panel on contaminants in the food chain related to deoxynivalenol (DON) as undesirable substance in animal feed. EFSA J. 2004, 73, 1-43.
33. Berthiller, F.; Schuhmacher, R.; Adam, G.; Krska, R. Formation, determination and significance of masked and other conjugated mycotoxins. Anal. Bioanal. Chem. 2009, 395,1243-1252.
34. World Health Organization; Food and Agriculture Organization. Deoxynivalenol. WHO Tech. Rep. Ser. 2010, 959, 37-48.
35. Nagl, V.; Schwartz, H.; Krska, R.; Moll, W.D.; Knasmüller, S.; Ritzmann, M.; Adam, G.; Berthiller, F. Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats. Toxicol. Lett. 2012, 213, 367-373.
36. Berthiller, F.; Krska, R.; Domig, K.J.; Kneifel, W.; Juge, N.; Schuhmacher, R.; Adam, G. Hydrolytic fate of deoxynivalenol-3-glucoside during digestion. Toxicol. Lett. 2011, 206, 264-267.
37. Tran, S.T.; Smith, T.K. Determination of optimal conditions for hydrolysis of conjugated deoxynivalenol in corn and wheat with trifluoromethanesulfonic acid. Anim. Feed Sci. Technol. 2011, 163, 84-92.
38. Ivanova, L.; Egge-Jacobsen, W.M.; Solhaug, A.; Thoen, E.; Fæste, C.K. Lysosomes as a possible target of enniatin B-induced toxicity in Caco-2 cells. Chem. Res. Toxicol. 2012, 25, 1662-1674.
39. Gammelsrud, A.; Solhaug, A.; Dendele, B.; Sandberg, W.J.; Ivanova, L.; Kocbach Bolling, A.; Lagadic-Gossman, D.; Refsnes, M.; Becher, R.; Eriksen, G.S.; et al. Enniatin B-induced cell death and inflammatory responses in RAW 267.4 murine macrophages. Toxicol. Appl. Pharmacol. 2012, 261, 74-87.
40. Müller, M.E.H.; Korn, U. Alternaria mycotoxins in wheat-A 10 years survey in the Northeast of Germany. Food Control 2013, 34, 197-198.
41. Jaksic, D.; Puel, O.; Canlet, C.; Kopjar, N.; Kosalec, I.; Klaric, M.S. Cytotoxicity and genotoxicity of versicolorins and 5-methoxysterigmatocystin in A549 cells. Arch. Toxicol. 2012, 86, 1583-1591.
42. Fehr, M.; Pahlke, G.; Fritz, J.; Christensen, M.O.; Boege, F.; Altemoller, M.; Podlech, J.; Marko, D. Alternariol acts as a topoisomerase poison, preferentially affecting the IIalpha isoform. Mol. Nutr. Food Res. 2009, 53, 441-451.
43. Solhaug, A.; Holme, J.A.; Haglund, K.; Dendele, B.; Sergent, O.; Pestka, J.; Lagadic-Gossmann, D.; Eriksen, G.S. Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages. Toxicol. Lett. 2013, 219, 8-17.
44. Solhaug, A.; Vines, L.L.; Ivanova, L.; Spilsberg, B.; Holme, J.A.; Pestka, J.; Collins, A.; Eriksen, G.S. Mechanisms involved in alternariol-induced cell cycle arrest. Mutat. Res. 2012, 738/739, 1-11.
45. Instructions for Sampling of Feedstuffs; Norwegian Food Safety Authority: Oslo, Norway, 2005.