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Volumn 17, Issue SUPPL.1, 2013, Pages 8-14

Effects of Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: Review of recently completed randomised, controlled trials

Author keywords

Clinical trials; Dementia; Efficacy; Ginkgo biloba extract EGb 761 ; Review

Indexed keywords

DONEPEZIL; GINKGO BILOBA EXTRACT; PLACEBO;

EID: 84884785510     PISSN: 13651501     EISSN: 14711788     Source Type: Journal    
DOI: 10.3109/13651501.2013.814796     Document Type: Review
Times cited : (46)

References (47)
  • 2
    • 0034121829 scopus 로고    scopus 로고
    • The ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by β-amyloid
    • DOI 10.1046/j.1460-9568.2000.00069.x
    • Bastianetto S, Ramassamy C, Dore S, Christen Y, Poirier J, Quirion R. 2000a. Th e Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid. Eur J Neurosci 12 : 1882-1890. (Pubitemid 30348827)
    • (2000) European Journal of Neuroscience , vol.12 , Issue.6 , pp. 1882-1890
    • Bastianetto, S.1    Ramassamy, C.2    Dore, S.3    Christen, Y.4    Poirier, J.5    Quirion, R.6
  • 3
    • 0034122940 scopus 로고    scopus 로고
    • The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: Involvement of its flavonoid constituents and protein kinase C
    • DOI 10.1046/j.1471-4159.2000.0742268.x
    • Bastianetto S, Zheng WH, Quirion R. 2000b. Th e Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its fl avonoid constituents and protein kinase C. J Neurochem 74 : 2268-2277. (Pubitemid 30314201)
    • (2000) Journal of Neurochemistry , vol.74 , Issue.6 , pp. 2268-2277
    • Bastianetto, S.1    Zheng, W.-H.2    Quirion, R.3
  • 4
    • 19844368517 scopus 로고    scopus 로고
    • Prevalence of dementia in the elderly in Europe
    • DOI 10.1016/j.euroneuro.2005.04.003, PII S0924977X05000660, Size and Burden of Mental Disorders in Europe
    • Berr C, Wancata J, Ritchie K. 2005. Prevalence of dementia in the elderly in Europe. Eur Neuropsychopharmacol 15: 463-471. (Pubitemid 40943549)
    • (2005) European Neuropsychopharmacology , vol.15 , Issue.4 , pp. 463-471
    • Berr, C.1    Wancata, J.2    Ritchie, K.3
  • 6
    • 33846608309 scopus 로고    scopus 로고
    • Checklist for the qualitative evaluation of clinical studies with particular focus on external validity and model validity
    • Bornh ö ft G, Maxion-Bergemann S, Wolf U, Kienle GS, Michalsen A, Vollmar HC, et al. 2006, Checklist for the qualitative evaluation of clinical studies with particular focus on external validity and model validity. BMC Med Res Methodol, 6, 56.
    • (2006) BMC Med Res Methodol , vol.6 , pp. 56
    • Bornhö Ft, G.1    Maxion-Bergemann, S.2    Wolf, U.3    Kienle, G.S.4    Michalsen, A.5    Vollmar, H.C.6
  • 7
    • 0035178626 scopus 로고    scopus 로고
    • The Gottfries-Brane-Steen scale: Validity, reliability and application in anti-dementia drug trials
    • DOI 10.1159/000051230
    • Br å ne G, Gottfries CG, Winblad B. 2001. Th e GBS scale: validity, reliability and application in anti-dementia drug trials. Dement Geriatr Cogn Disord 12: 1-14. (Pubitemid 32010737)
    • (2001) Dementia and Geriatric Cognitive Disorders , vol.12 , Issue.1 , pp. 1-14
    • Brane, G.1    Gottfries, C.G.2    Winblad, B.3
  • 8
    • 84863740171 scopus 로고    scopus 로고
    • Why (not) go east Comparison of fi ndings from FDA Investigational New Drug study site inspections performed in Central and Eastern Europe with results from the USA Western Europe and other parts of the world
    • Caldron PH, Gavrilova SI, Kropf S. 2012. Why (not) go east Comparison of fi ndings from FDA Investigational New Drug study site inspections performed in Central and Eastern Europe with results from the USA, Western Europe, and other parts of the world. Drug Des Devel Th er 6 : 53-60.
    • (2012) Drug des Devel Ther , vol.6 , pp. 53-60
    • Caldron, P.H.1    Gavrilova, S.I.2    Kropf, S.3
  • 9
    • 0030958347 scopus 로고    scopus 로고
    • The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients
    • Cummings JL. 1997. Th e Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology 48: S10-S16. (Pubitemid 27232698)
    • (1997) Neurology , vol.48 , Issue.5 SUPPL. 6
    • Cummings, J.L.1
  • 10
    • 77955487508 scopus 로고    scopus 로고
    • National Institutes of Health State-of-The-Science Conference statement: Preventing alzheimer disease and cognitive decline
    • Daviglus ML, Bell CC, Berrettini W, Bowen PE, Connolly ES Jr, Cox NJ, et al. 2010. National Institutes of Health State-of-the-Science Conference statement: preventing alzheimer disease and cognitive decline. Ann Intern Med 153: 176-181.
    • (2010) Ann Intern Med , vol.153 , pp. 176-181
    • Daviglus, M.L.1    Bell, C.C.2    Berrettini, W.3    Bowen, P.E.4    Cox, N.J.5
  • 12
    • 30844458398 scopus 로고    scopus 로고
    • Ginkgo biloba for vascular dementia and Alzheimer's disease: Updated systematic review of double-blind, placebo-controlled, randomized trials
    • Ernst E, Pittler MH. 2005. Ginkgo biloba for vascular dementia and Alzheimer ' s disease: updated systematic review of doubleblind, placebo-controlled, randomized trials. Perfusion 18: 388-392. (Pubitemid 43104438)
    • (2005) Perfusion , vol.18 , Issue.12 , pp. 388-392
    • Ernst, E.1    Pittler, M.H.2
  • 13
    • 0014186152 scopus 로고
    • Development of a rating scale for primary depressive illness
    • Hamilton M. 1967. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 6: 278-296.
    • (1967) Br J Soc Clin Psychol , vol.6 , pp. 278-296
    • Hamilton, M.1
  • 14
    • 84861223275 scopus 로고    scopus 로고
    • Ginkgo biloba extract EGb 761in dementia with neuropsychiatric features: A randomised, placebo-controlled trial to confi rm the effi cacy and safety of a daily dose of 240 mg
    • Herrschaft H, Nacu A, Likhachev S, Sholomov I, Hoerr R, Schlaefk e S. 2012. Ginkgo biloba extract EGb 761in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confi rm the effi cacy and safety of a daily dose of 240 mg. J Psychiatr Res 46: 716-723.
    • (2012) J Psychiatr Res , vol.46 , pp. 716-723
    • Herrschaft, H.1    Nacu, A.2    Likhachev, S.3    Sholomov, I.4    Hoerr, R.5    Schlaefke, S.6
  • 15
    • 0042827349 scopus 로고    scopus 로고
    • Behavioural and psychological symptoms of dementia (BPSD): Effects of EGb 761®
    • Hoerr R. 2003. Behavioural and psychological symptoms of dementia (BPSD): eff ects of EGb 761. Pharmacopsychiatry 36: S56-S61. (Pubitemid 37047010)
    • (2003) Pharmacopsychiatry , vol.36 , Issue.SUPPL. 1
    • Hoerr, R.1
  • 16
    • 80055006038 scopus 로고    scopus 로고
    • Effi cacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: A randomized controlled trial
    • on behalf of the GSG.
    • Ihl R, Bachinskaya N, Korczyn AD, Vakhapova V, Tribanek M, Hoerr R, Napryeyenko O ; on behalf of the GSG. 2010. Effi cacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: a randomized controlled trial. Int J Geriatr Psychiatry 26 : 1186-1194.
    • (2010) Int J Geriatr Psychiatry , vol.26 , pp. 1186-1194
    • Ihl, R.1    Bachinskaya, N.2    Korczyn, A.D.3    Vakhapova, V.4    Tribanek, M.5    Hoerr, R.6    Napryeyenko, O.7
  • 17
    • 0032735883 scopus 로고    scopus 로고
    • Neuropsychometric tests in cross sectional and longitudinal studies-A regression analysis of ADAS-cog, SKT and MMSE
    • Ihl R, Grass-Kapanke B, Janner M, Weyer G. 1999. Neuropsychometric tests in cross sectional and longitudinal studies-a regression analysis of ADAS-cog, SKT and MMSE. Pharmacopsychiatry 32 : 248-254.
    • (1999) Pharmacopsychiatry , vol.32 , pp. 248-254
    • Ihl, R.1    Grass-Kapanke, B.2    Janner, M.3    Weyer, G.4
  • 19
    • 79551613305 scopus 로고    scopus 로고
    • World federation of societies of biological psychiatry (wfsbp) guidelines for the biological treatment of alzheimer's disease and other dementias
    • Ihl R, Frölich L, Winblad B, Schneider L, Burns A, Möller H-J, et al. 2011. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Alzheimer's disease and other dementias. World J Biol Psychiatry 12: 2-32.
    • (2011) World J Biol Psychiatry , vol.12 , pp. 2-32
    • Ihl, R.1    Frölich, L.2    Winblad, B.3    Schneider, L.4    Burns, A.5    Möller, H.-J.6
  • 23
    • 0029152190 scopus 로고
    • Dose-dependent hemorheological eff ects and microcirulatory modifi cations following intravenous administration of Ginkgo biloba special extract EGb 761
    • Kö ltringer P, Langsteger W, Eber O 1995, Dose-dependent hemorheological eff ects and microcirulatory modifi cations following intravenous administration of Ginkgo biloba special extract EGb 761. Clin Hemorheol 15, 649-656.
    • (1995) Clin Hemorheol , vol.15 , pp. 649-656
    • Kö Ltringer, P.1    Langsteger, W.2    Eber, O.3
  • 26
    • 23844522541 scopus 로고    scopus 로고
    • Aggregation of vascular risk factors and risk of incident Alzheimer disease
    • DOI 10.1212/01.wnl.0000172914.08967.dc
    • Luchsinger JA, Reitz C, Honig LS, Tang MX, Shea S, Mayeux R. 2005. Aggregation of vascular risk factors and risk of incident Alzheimer disease. Neurology 65: 545-551. (Pubitemid 41170713)
    • (2005) Neurology , vol.65 , Issue.4 , pp. 545-551
    • Luchsinger, J.A.1    Reitz, C.2    Honig, L.S.3    Tang, M.-X.4    Shea, S.5    Mayeux, R.6
  • 27
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. 1984. Clinical diagnosis of Alzheimer ' s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer ' s Disease. Neurology 34: 939-944. (Pubitemid 14076461)
    • (1984) Neurology , vol.34 , Issue.7 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3
  • 28
    • 0032709113 scopus 로고    scopus 로고
    • The spectrum of behavioral responses to cholinesterase inhibitor therapy in Alzheimer disease
    • DOI 10.1001/archneur.56.11.1388
    • Mega MS, Masterman DM, O ' Connor SM, Barclay TR, Cummings JL. 1999. Th e spectrum of behavioral responses to cholinesterase inhibitor therapy in Alzheimer disease. Arch Neurol 56 : 1388-1393. (Pubitemid 29519856)
    • (1999) Archives of Neurology , vol.56 , Issue.11 , pp. 1388-1393
    • Mega, M.S.1    Mastennan, D.M.2    O'Connor, S.M.3    Barclay, T.R.4    Cummings, J.L.5
  • 29
    • 33846820304 scopus 로고    scopus 로고
    • Ginkgo biloba special extract in dementia with neuropsychiatric features: A randomised, placebo-controlled, double-blind clinical trial
    • Napryeyenko O, Borzenko I, Group G-NS. 2007. Ginkgo biloba special extract in dementia with neuropsychiatric features. A randomised, placebo-controlled, double-blind clinical trial. Arzneimittelforschung 57: 4-11. (Pubitemid 46212982)
    • (2007) Arzneimittel-Forschung/Drug Research , vol.57 , Issue.1 , pp. 4-11
    • Napryeyenko, O.1    Borzenko, I.2
  • 30
    • 34347370406 scopus 로고    scopus 로고
    • Ginkgo biloba extract (EGb 761) in Alzheimer's disease: Is there any evidence?
    • DOI 10.2174/156720507781077304
    • Ramassamy C, Longpre F, Christen Y. 2007. Ginkgo biloba extract (EGb 761) in Alzheimer ' s disease: is there any evidence Curr Alzheimer Res 4: 253-262. (Pubitemid 47025423)
    • (2007) Current Alzheimer Research , vol.4 , Issue.3 , pp. 253-262
    • Ramassamy, C.1    Longpre, F.2    Christen, Y.3
  • 33
    • 0019157340 scopus 로고
    • Verbal fl uency in aging and dementia
    • Rosen WG. 1980. Verbal fl uency in aging and dementia. J Clin Neuropsychol 2: 135-146.
    • (1980) J Clin Neuropsychol , vol.2 , pp. 135-146
    • Rosen, W.G.1
  • 34
    • 35748959415 scopus 로고    scopus 로고
    • Mixed brain pathologies account for most dementia cases in community-dwelling older persons
    • DOI 10.1212/01.wnl.0000271090.28148.24, PII 0000611420071211000005
    • Schneider JA, Arvanitakis Z, Bang W, Bennett DA. 2007. Mixed brain pathologies account for most dementia cases in communitydwelling older persons. Neurology 69: 2197-2204. (Pubitemid 350294674)
    • (2007) Neurology , vol.69 , Issue.24 , pp. 2197-2204
    • Schneider, J.A.1    Arvanitakis, Z.2    Bang, W.3    Bennett, D.A.4
  • 35
    • 28244446721 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type
    • Schneider LS, DeKosky ST, Farlow MR, Tariot PN, Hoerr R, Kieser M. 2005. A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer ' s type. Curr Alzheimer Res 2: 541-551. (Pubitemid 41703672)
    • (2005) Current Alzheimer Research , vol.2 , Issue.5 , pp. 541-551
    • Schneider, L.S.1    DeKosky, S.T.2    Farlow, M.R.3    Tariot, P.N.4    Hoerr, R.5    Kieser, M.6
  • 36
    • 18144388713 scopus 로고    scopus 로고
    • Measurement of health-related quality of life for people with dementia: Development of a new instrument (DEMQOL) and an evaluation of current methodology
    • iii-iv
    • Smith SC, Lamping DL, Banerjee S, Harwood R, Foley B, Smith P, et al. 2005. Measurement of health-related quality of life for people with dementia: development of a new instrument (DEMQOL) and an evaluation of current methodology. Health Technol Assess 9 : 1-93, iii-iv.
    • (2005) Health Technol Assess , vol.9 , pp. 1-93
    • Smith, S.C.1    Lamping, D.L.2    Banerjee, S.3    Harwood, R.4    Foley, B.5    Smith, P.6
  • 40
    • 34547824397 scopus 로고    scopus 로고
    • EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's disease
    • DOI 10.1096/fj.06-7649com
    • Tchantchou F, Xu Y, Wu Y, Christen Y, Luo Y. 2007. EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer ' s disease. FASEB J 21 : 2400-2408. (Pubitemid 47230670)
    • (2007) FASEB Journal , vol.21 , Issue.10 , pp. 2400-2408
    • Tchantchou, F.1    Xu, Y.2    Wu, Y.3    Christen, Y.4    Luo, Y.5
  • 42
    • 77950278582 scopus 로고    scopus 로고
    • Eff ects of Ginkgo biloba in dementia: Systematic review and metaanalysis
    • Weinmann S, Roll S, Schwarzbach C, Vauth C, Willich SN. 2010. Eff ects of Ginkgo biloba in dementia: systematic review and metaanalysis. BMC Geriatr 10 : 14.
    • (2010) BMC Geriatr , vol.10 , pp. 14
    • Weinmann, S.1    Roll, S.2    Schwarzbach, C.3    Vauth, C.4    Willich, S.N.5
  • 43
  • 45
    • 33845613251 scopus 로고    scopus 로고
    • Amyloid-β-induced pathological behaviors are suppressed by Ginkgo biloba extract EGB 761 and ginkgolides in transgenic Caenorhabditis elegans
    • DOI 10.1523/JNEUROSCI.3448-06.2006
    • Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, et al. 2006. Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci 26: 13102-13113. (Pubitemid 44954628)
    • (2006) Journal of Neuroscience , vol.26 , Issue.50 , pp. 13102-13113
    • Wu, Y.1    Wu, Z.2    Butko, P.3    Christen, Y.4    Lambert, M.P.5    Klein, W.L.6    Link, C.D.7    Luo, Y.8
  • 46
    • 67949102170 scopus 로고    scopus 로고
    • Ginkgo biloba extract EGb 761, donepezil or both combined in the treatment of Alzheimer ' s disease with neuropsychiatric features: A randomised, double-blind, exploratory trial
    • Yancheva S, Ihl R, Nikolova G, Panayotov P, Schlaefk e S, Hoerr R, Group GS. 2009. Ginkgo biloba extract EGb 761, donepezil or both combined in the treatment of Alzheimer ' s disease with neuropsychiatric features: a randomised, double-blind, exploratory trial. Aging Ment Health 13 : 183-190.
    • (2009) Aging Ment Health , vol.13 , pp. 183-190
    • Yancheva, S.1    Ihl, R.2    Nikolova, G.3    Panayotov, P.4    Schlaefke, S.5    Hoerr, R.6
  • 47
    • 76449091140 scopus 로고    scopus 로고
    • The Ginkgo biloba extract EGb 761and its main constituent fl avonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex
    • Yoshitake T, Yoshitake S, Kehr J. 2010. Th e Ginkgo biloba extract EGb 761and its main constituent fl avonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex. Br J Pharmacol 159: 659-668.
    • (2010) Br J Pharmacol , vol.159 , pp. 659-668
    • Yoshitake, T.1    Yoshitake, S.2    Kehr, J.3


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