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Volumn 39, Issue , 2013, Pages 114-123

Neuroprotective effects of liquiritigenin isolated from licorice roots on glutamate-induced apoptosis in hippocampal neuronal cells

Author keywords

Apoptosis; Glutamate; HT22; Licorice roots; Liquiritigenin; Neuroprotection

Indexed keywords

APOPTOSIS INDUCING FACTOR; CALCIUM ION; GLUTAMIC ACID; LIQUIRITIGENIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

EID: 84884722306     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2013.08.012     Document Type: Article
Times cited : (61)

References (41)
  • 1
    • 36849028692 scopus 로고    scopus 로고
    • AIF-mediated programmed necrosis: a highly regulated way to die
    • Boujrad H., Gubkina O., Robert N., Krantic S., Susin S.A. AIF-mediated programmed necrosis: a highly regulated way to die. Cell Cycle 2007, 6:2612-2619.
    • (2007) Cell Cycle , vol.6 , pp. 2612-2619
    • Boujrad, H.1    Gubkina, O.2    Robert, N.3    Krantic, S.4    Susin, S.A.5
  • 2
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitatuib if microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitatuib if microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 3
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signaling cascades
    • Chang L., Karin M. Mammalian MAP kinase signaling cascades. Nature 2001, 410:37-40.
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 4
    • 84866998904 scopus 로고    scopus 로고
    • Mitochondrial in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies
    • Cheng G., Kong R.H., Zhang L.M., Zhang J.N. Mitochondrial in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies. Br J Pharmacol 2012, 167:699-719.
    • (2012) Br J Pharmacol , vol.167 , pp. 699-719
    • Cheng, G.1    Kong, R.H.2    Zhang, L.M.3    Zhang, J.N.4
  • 5
    • 84860132077 scopus 로고    scopus 로고
    • Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines
    • Cho N., Choi J.H., Yang H., Jeong E.J., Lee K.Y., Kim Y.C., et al. Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines. Food Chem Toxicol 2012, 50:1940-1945.
    • (2012) Food Chem Toxicol , vol.50 , pp. 1940-1945
    • Cho, N.1    Choi, J.H.2    Yang, H.3    Jeong, E.J.4    Lee, K.Y.5    Kim, Y.C.6
  • 6
    • 4544291755 scopus 로고    scopus 로고
    • An overview of the current and novel drugs for Alzheimer's disease with particular reference to anti-cholinesterase compounds
    • Colombres M., Sagal J.P., Inestrosa N.C. An overview of the current and novel drugs for Alzheimer's disease with particular reference to anti-cholinesterase compounds. Curr Pharm Des 2004, 10:3121-3130.
    • (2004) Curr Pharm Des , vol.10 , pp. 3121-3130
    • Colombres, M.1    Sagal, J.P.2    Inestrosa, N.C.3
  • 7
    • 79954520766 scopus 로고    scopus 로고
    • AIF-mediated caspase-independent necrotosis: a new chance for targeted therapeutics
    • Dellavallee L., Cabon L., Galan-Malo P., Lorenzo H.K., Susin S.A. AIF-mediated caspase-independent necrotosis: a new chance for targeted therapeutics. IUBMB Life 2011, 63:221-232.
    • (2011) IUBMB Life , vol.63 , pp. 221-232
    • Dellavallee, L.1    Cabon, L.2    Galan-Malo, P.3    Lorenzo, H.K.4    Susin, S.A.5
  • 8
    • 0029768088 scopus 로고    scopus 로고
    • Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade
    • Enslen H., Tokumitsu H., Stork P.J., Davis R.J., Soderling T.R. Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. Proc Natl Acad Sci USA 1996, 93:10803-10808.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10803-10808
    • Enslen, H.1    Tokumitsu, H.2    Stork, P.J.3    Davis, R.J.4    Soderling, T.R.5
  • 9
    • 79952825980 scopus 로고    scopus 로고
    • Redox regulation of the intrinsic pathway in neuronal apoptosis
    • Franklin J.L. Redox regulation of the intrinsic pathway in neuronal apoptosis. Antioxid Redox Signal 2011, 14:1437-1448.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1437-1448
    • Franklin, J.L.1
  • 10
    • 79952405292 scopus 로고    scopus 로고
    • Neuronal calcium homeostasis and dysregulation
    • Gleichmann M., Mattson M.P. Neuronal calcium homeostasis and dysregulation. Antioxid Redox Signal 2011, 14:1261-1273.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1261-1273
    • Gleichmann, M.1    Mattson, M.P.2
  • 11
    • 36248976639 scopus 로고    scopus 로고
    • Dendritic and mitochondrial changes during glutamate toxicity
    • Greenwood S.M., Connolly C.N. Dendritic and mitochondrial changes during glutamate toxicity. Neuropharmacology 2007, 53:891-898.
    • (2007) Neuropharmacology , vol.53 , pp. 891-898
    • Greenwood, S.M.1    Connolly, C.N.2
  • 12
    • 29244462502 scopus 로고    scopus 로고
    • Glutamate-induced oxidative stress, but not cell death, is largely dependent upon extracellular calcium in mouse neuronal HT22 cells
    • Ha J.S., Park S.S. Glutamate-induced oxidative stress, but not cell death, is largely dependent upon extracellular calcium in mouse neuronal HT22 cells. Neurosci Lett 2006, 393:165-169.
    • (2006) Neurosci Lett , vol.393 , pp. 165-169
    • Ha, J.S.1    Park, S.S.2
  • 13
    • 0034646936 scopus 로고    scopus 로고
    • Differential activation of MAPK/ERK and p38/SAPK in neurons and glia following focal cerebral ischemia in the rat
    • Irving E.A., Barone F.C., Reith A.D., Hadingham S.J., Parsons A.A. Differential activation of MAPK/ERK and p38/SAPK in neurons and glia following focal cerebral ischemia in the rat. Mol Brain Res 2000, 77:65-75.
    • (2000) Mol Brain Res , vol.77 , pp. 65-75
    • Irving, E.A.1    Barone, F.C.2    Reith, A.D.3    Hadingham, S.J.4    Parsons, A.A.5
  • 14
    • 57049108624 scopus 로고    scopus 로고
    • Evaluation of chalcones - a flavonoid subclass, for their anxiolytic effects in rats using elevated plus maze and open field behavior tests
    • Jamal H., Ansari W.H., Rizvi S.J. Evaluation of chalcones - a flavonoid subclass, for their anxiolytic effects in rats using elevated plus maze and open field behavior tests. Fundam Clin Pharmacol 2008, 22:673-681.
    • (2008) Fundam Clin Pharmacol , vol.22 , pp. 673-681
    • Jamal, H.1    Ansari, W.H.2    Rizvi, S.J.3
  • 15
    • 0036053954 scopus 로고    scopus 로고
    • An analysis of the frequency of formulations and crude drugs described in Shan-Han-Lun
    • Katakai M., Akamaru T., Tani T. An analysis of the frequency of formulations and crude drugs described in Shan-Han-Lun. Takushigaku Zasshi 2002, 37:28-35.
    • (2002) Takushigaku Zasshi , vol.37 , pp. 28-35
    • Katakai, M.1    Akamaru, T.2    Tani, T.3
  • 16
    • 42949164997 scopus 로고    scopus 로고
    • Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-kappaB-dependent iNOS and proinflammatory cytokines production
    • Kim Y.W., Zhao R.J., Park S.J., Lee J.R., Cho I.J., Yang C.H., et al. Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-kappaB-dependent iNOS and proinflammatory cytokines production. Br J Pharmacol 2008, 154:165-173.
    • (2008) Br J Pharmacol , vol.154 , pp. 165-173
    • Kim, Y.W.1    Zhao, R.J.2    Park, S.J.3    Lee, J.R.4    Cho, I.J.5    Yang, C.H.6
  • 17
    • 84862549609 scopus 로고    scopus 로고
    • Glutamate induces mitochondrial dynamic imbalance and autophagy activation: preventive effects of selenium
    • Kumari S., Mehta S.L., Li P.A. Glutamate induces mitochondrial dynamic imbalance and autophagy activation: preventive effects of selenium. PLoS ONE 2012, 7:e39382.
    • (2012) PLoS ONE , vol.7
    • Kumari, S.1    Mehta, S.L.2    Li, P.A.3
  • 18
    • 84862851692 scopus 로고    scopus 로고
    • Inhibitory effects of Glycyrrhizae Radix and its active component, isoliquiritigenin, on Aβ(25-35)-induced neurotoxicity in cultured rat cortical neurons
    • Lee H.K., Yang E.J., Kim J.Y., Song K.S., Seong Y.H. Inhibitory effects of Glycyrrhizae Radix and its active component, isoliquiritigenin, on Aβ(25-35)-induced neurotoxicity in cultured rat cortical neurons. Arch Pharm Res 2012, 35:897-904.
    • (2012) Arch Pharm Res , vol.35 , pp. 897-904
    • Lee, H.K.1    Yang, E.J.2    Kim, J.Y.3    Song, K.S.4    Seong, Y.H.5
  • 19
    • 63649105581 scopus 로고    scopus 로고
    • Liquiritigenin, a licorice flavonoid, helps mice resist disseminated candidiasis due to Candida albicans by Th1 immune response, whereas liquiritin, its glycoside form, doses not
    • Lee J.Y., Lee J.H., Park J.H., Kim S.Y., Choi J.Y., Lee S.H., et al. Liquiritigenin, a licorice flavonoid, helps mice resist disseminated candidiasis due to Candida albicans by Th1 immune response, whereas liquiritin, its glycoside form, doses not. Int Immonopharmacol 2009, 9:632-638.
    • (2009) Int Immonopharmacol , vol.9 , pp. 632-638
    • Lee, J.Y.1    Lee, J.H.2    Park, J.H.3    Kim, S.Y.4    Choi, J.Y.5    Lee, S.H.6
  • 20
    • 79551669602 scopus 로고    scopus 로고
    • Liquiritigenin induces mitochondria-mediated apoptosis via cytochrome c release and caspases activation in HeLa cells
    • Liu C., Wang Y., Xie S., Zhou Y., Ren X., Li X., et al. Liquiritigenin induces mitochondria-mediated apoptosis via cytochrome c release and caspases activation in HeLa cells. Phytother Res 2011, 25:277-283.
    • (2011) Phytother Res , vol.25 , pp. 277-283
    • Liu, C.1    Wang, Y.2    Xie, S.3    Zhou, Y.4    Ren, X.5    Li, X.6
  • 21
    • 77949567251 scopus 로고    scopus 로고
    • Effects of liquiritigenin treatment on the learning and memory deficits induced by beta-peptide (25-35) in rats
    • Liu R.T., Zou L.B., Fu J.Y., Lu Q.J. Effects of liquiritigenin treatment on the learning and memory deficits induced by beta-peptide (25-35) in rats. Behav Brain Res 2010, 210:24-31.
    • (2010) Behav Brain Res , vol.210 , pp. 24-31
    • Liu, R.T.1    Zou, L.B.2    Fu, J.Y.3    Lu, Q.J.4
  • 22
    • 67651152791 scopus 로고    scopus 로고
    • Liquiritigenin inhibits Abeta(25-35)-induced neurotoxicity and secretion of Abeta(1-40) in rat hippocampal neurons
    • Liu R.T., Zou L.B., Lu Q.J. Liquiritigenin inhibits Abeta(25-35)-induced neurotoxicity and secretion of Abeta(1-40) in rat hippocampal neurons. Acta Pharmacol Sin 2009, 30:899-906.
    • (2009) Acta Pharmacol Sin , vol.30 , pp. 899-906
    • Liu, R.T.1    Zou, L.B.2    Lu, Q.J.3
  • 23
    • 20444489204 scopus 로고    scopus 로고
    • One step isolation and purification of liquiritigenin and isoliquiritigenin from Glycyrrhiza uralensis Risch. using high-speed counter-current chromatography
    • Ma C.J., Li G.S., Zhang D.L., Liu K., Fan X. One step isolation and purification of liquiritigenin and isoliquiritigenin from Glycyrrhiza uralensis Risch. using high-speed counter-current chromatography. J. Chromatogr. A 2005, 1078:188-192.
    • (2005) J. Chromatogr. A , vol.1078 , pp. 188-192
    • Ma, C.J.1    Li, G.S.2    Zhang, D.L.3    Liu, K.4    Fan, X.5
  • 24
    • 0033836908 scopus 로고    scopus 로고
    • Signaling by reactive oxygen species in the nervous system
    • Maher P., Schubert D. Signaling by reactive oxygen species in the nervous system. Cell Mol Life Sci 2000, 57:1287-1305.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 1287-1305
    • Maher, P.1    Schubert, D.2
  • 25
    • 42049112734 scopus 로고    scopus 로고
    • MAPKs mediators of cell fate determination: an approach to neurodegenerative disease
    • Miloso M., Scuteri A., Foudah D., Tredici G. MAPKs mediators of cell fate determination: an approach to neurodegenerative disease. Curr Med Chem 2008, 15:538-548.
    • (2008) Curr Med Chem , vol.15 , pp. 538-548
    • Miloso, M.1    Scuteri, A.2    Foudah, D.3    Tredici, G.4
  • 27
    • 34347344991 scopus 로고    scopus 로고
    • Sequencial activation of Poly(ADP-Ribose) polymerase 1, Calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis
    • Moubarak R.S., Yuste V.J., Artus C., Bouharrour A., Greer P.A., Menissier-de Murcia J., et al. Sequencial activation of Poly(ADP-Ribose) polymerase 1, Calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol Cell Biol 2007, 27:4844-4862.
    • (2007) Mol Cell Biol , vol.27 , pp. 4844-4862
    • Moubarak, R.S.1    Yuste, V.J.2    Artus, C.3    Bouharrour, A.4    Greer, P.A.5    Menissier-de Murcia, J.6
  • 28
    • 0032578510 scopus 로고    scopus 로고
    • Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity
    • Murray B., Alessandrini A., Cole A.J., Yee A.G., Furshpan E.J. Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity. Proc Natl Acad Sci USA 1998, 95:11975-11980.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11975-11980
    • Murray, B.1    Alessandrini, A.2    Cole, A.J.3    Yee, A.G.4    Furshpan, E.J.5
  • 29
    • 33846603289 scopus 로고    scopus 로고
    • Pathophysiological roles of ASK1-MAP kinase signaling pathways
    • Nagai H., Noguchi T., Takeda K., Ichijo H. Pathophysiological roles of ASK1-MAP kinase signaling pathways. J Biochem Mol Biol 2007, 40:1-6.
    • (2007) J Biochem Mol Biol , vol.40 , pp. 1-6
    • Nagai, H.1    Noguchi, T.2    Takeda, K.3    Ichijo, H.4
  • 30
    • 0034997845 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase pathway: regulation and physiological functions
    • Pearson G., Robinson F., Gibson T.B., Xu B., Karandikar M., Berman K., et al. Mitogen-activated protein (MAP) kinase pathway: regulation and physiological functions. Endocr Rev 2001, 22:153-158.
    • (2001) Endocr Rev , vol.22 , pp. 153-158
    • Pearson, G.1    Robinson, F.2    Gibson, T.B.3    Xu, B.4    Karandikar, M.5    Berman, K.6
  • 31
    • 44249116000 scopus 로고    scopus 로고
    • Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice
    • Rezai-Zadeh K., Arendash G.W., Hou H., Fernandez F., Jensen M., Runfeldt M., et al. Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain Res 2008, 1214:177-187.
    • (2008) Brain Res , vol.1214 , pp. 177-187
    • Rezai-Zadeh, K.1    Arendash, G.W.2    Hou, H.3    Fernandez, F.4    Jensen, M.5    Runfeldt, M.6
  • 32
    • 78650137389 scopus 로고    scopus 로고
    • Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties
    • Sun Y.X., Tang Y., Wu A.L., Liu T., Dai X.L., Zheng Q.S., et al. Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties. J Asian Nat Prod Res 2010, 12:1051-1060.
    • (2010) J Asian Nat Prod Res , vol.12 , pp. 1051-1060
    • Sun, Y.X.1    Tang, Y.2    Wu, A.L.3    Liu, T.4    Dai, X.L.5    Zheng, Q.S.6
  • 33
    • 78651306433 scopus 로고    scopus 로고
    • Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons
    • Tobaben S., Grohm J., Seiler A., Conrad M., Plesnila N., Culmsee C. Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death Differ 2011, 18:282-292.
    • (2011) Cell Death Differ , vol.18 , pp. 282-292
    • Tobaben, S.1    Grohm, J.2    Seiler, A.3    Conrad, M.4    Plesnila, N.5    Culmsee, C.6
  • 34
    • 84863714863 scopus 로고    scopus 로고
    • Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects
    • Vauzour D. Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxid Med Cell Longev 2012, 2012:914273.
    • (2012) Oxid Med Cell Longev , vol.2012 , pp. 914273
    • Vauzour, D.1
  • 35
    • 0032527705 scopus 로고    scopus 로고
    • The cellular response to oxidative stress: influences of mitogen-activated protein kinase signaling pathways on cell survival
    • Wang X., Martindale J.L., Liu Y., Holbrook N.J. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signaling pathways on cell survival. Biochem J 1998, 333:291-300.
    • (1998) Biochem J , vol.333 , pp. 291-300
    • Wang, X.1    Martindale, J.L.2    Liu, Y.3    Holbrook, N.J.4
  • 36
    • 0031972678 scopus 로고    scopus 로고
    • Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons
    • Watson A., Eilers A., Lallemand D., Kyriakis J., Rubin L.L., Ham J. Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons. J Neurosci 1998, 18:751-762.
    • (1998) J Neurosci , vol.18 , pp. 751-762
    • Watson, A.1    Eilers, A.2    Lallemand, D.3    Kyriakis, J.4    Rubin, L.L.5    Ham, J.6
  • 37
    • 84870417658 scopus 로고    scopus 로고
    • L-type voltage-dependent calcium channels as therapeutic targets for neurodegenerative disease
    • Yagami T., Kohma H., Yamamoto Y. L-type voltage-dependent calcium channels as therapeutic targets for neurodegenerative disease. Curr Med Chem 2012, 19:4816-4827.
    • (2012) Curr Med Chem , vol.19 , pp. 4816-4827
    • Yagami, T.1    Kohma, H.2    Yamamoto, Y.3
  • 38
    • 84861225244 scopus 로고    scopus 로고
    • Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction
    • Yang E.J., Min J.S., Ku H.Y., Choi H.S., Park M.K., Kim M.K., et al. Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction. Biochem Biophys Res Commun 2012, 421:658-664.
    • (2012) Biochem Biophys Res Commun , vol.421 , pp. 658-664
    • Yang, E.J.1    Min, J.S.2    Ku, H.Y.3    Choi, H.S.4    Park, M.K.5    Kim, M.K.6
  • 39
    • 84860197018 scopus 로고    scopus 로고
    • Fermentation enhances the in vitro antioxidative effect of onion (Allium cepa) via an increase in quercetin content
    • Yang E.J., Kim S.I., Park S.Y., Bang H.Y., Jeong J.H., So J.H., et al. Fermentation enhances the in vitro antioxidative effect of onion (Allium cepa) via an increase in quercetin content. Food Chem Toxicol 2012, 50:2042-2048.
    • (2012) Food Chem Toxicol , vol.50 , pp. 2042-2048
    • Yang, E.J.1    Kim, S.I.2    Park, S.Y.3    Bang, H.Y.4    Jeong, J.H.5    So, J.H.6
  • 40
    • 84870845880 scopus 로고    scopus 로고
    • Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phosphor-JNK/Bax pathway
    • Zhai C., Zhang M., Zhang Y., Xu H., Wang J., An G., et al. Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phosphor-JNK/Bax pathway. Acta Pharmacol Sin 2012, 33:1477-1487.
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 1477-1487
    • Zhai, C.1    Zhang, M.2    Zhang, Y.3    Xu, H.4    Wang, J.5    An, G.6
  • 41
    • 84871967742 scopus 로고    scopus 로고
    • Liquiritin attenuates advanced glycation end products-induced endothelial dysfunction via RAGE/NF-κB pathway in human umbilical vein endothelial cells
    • Zhang X., Song Y., Han X., Feng L., Wang R., Zhang M., et al. Liquiritin attenuates advanced glycation end products-induced endothelial dysfunction via RAGE/NF-κB pathway in human umbilical vein endothelial cells. Mol Cell Biochem 2012, 374:191-201.
    • (2012) Mol Cell Biochem , vol.374 , pp. 191-201
    • Zhang, X.1    Song, Y.2    Han, X.3    Feng, L.4    Wang, R.5    Zhang, M.6


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