메뉴 건너뛰기




Volumn 28, Issue 10, 2013, Pages 1321-1324

The pridopidine paradox in Huntington's disease

Author keywords

[No Author keywords available]

Indexed keywords

PRIDOPIDINE; TETRABENAZINE;

EID: 84884720110     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.25559     Document Type: Editorial
Times cited : (11)

References (30)
  • 1
    • 84884724757 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of pridopidine in Huntington's disease
    • The Huntington Study Group HART Investigators
    • The Huntington Study Group HART Investigators. A randomized, double-blind, placebo-controlled trial of pridopidine in Huntington's disease. Mov Disord 2013;28:1407-1415.
    • (2013) Mov Disord , vol.28 , pp. 1407-1415
  • 2
    • 85009332113 scopus 로고    scopus 로고
    • Unified Huntington's Disease Rating Scale: reliability and consistency
    • Huntington Study Group
    • Huntington Study Group. Unified Huntington's Disease Rating Scale: reliability and consistency. Mov Disord 1996;11:136-142.
    • (1996) Mov Disord , vol.11 , pp. 136-142
  • 3
    • 77957986360 scopus 로고    scopus 로고
    • Efficacy and safety of the dopaminergic stabilizer pridopidine (ACR16) in patients with Huntington's disease
    • Lundin A, Dietrichs E, Haghighi S, et al. Efficacy and safety of the dopaminergic stabilizer pridopidine (ACR16) in patients with Huntington's disease. Clin Neuropharmacol 2010;33:260-264.
    • (2010) Clin Neuropharmacol , vol.33 , pp. 260-264
    • Lundin, A.1    Dietrichs, E.2    Haghighi, S.3
  • 4
    • 81255195330 scopus 로고    scopus 로고
    • Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial
    • de Yebenes JG, Landwehrmeyer B, Squitieri F, et al. Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet Neurol 2011;10:1049-1057.
    • (2011) Lancet Neurol , vol.10 , pp. 1049-1057
    • de Yebenes, J.G.1    Landwehrmeyer, B.2    Squitieri, F.3
  • 5
    • 84993669040 scopus 로고    scopus 로고
    • A teaching film, video library and online certification for the Unified Huntington's Disease Rating Scale Total Motor Score (UHDRS-TMS) [Abstract]
    • Reilmann R, Roos RA, Rosser A, et al. A teaching film, video library and online certification for the Unified Huntington's Disease Rating Scale Total Motor Score (UHDRS-TMS) [Abstract]. Akt Neurol 2009;36(Suppl 2):116-117.
    • (2009) Akt Neurol , vol.36 , Issue.SUPPL. 2 , pp. 116-117
    • Reilmann, R.1    Roos, R.A.2    Rosser, A.3
  • 6
    • 84879134175 scopus 로고    scopus 로고
    • Huntington's disease: towards disease modification-gaps and bridges, facts and opinions
    • Reilmann R. Huntington's disease: towards disease modification-gaps and bridges, facts and opinions. Basal Ganglia 2012;2:241-248.
    • (2012) Basal Ganglia , vol.2 , pp. 241-248
    • Reilmann, R.1
  • 7
    • 81255150234 scopus 로고    scopus 로고
    • Pridopidine in treatment of Huntington's disease: beyond chorea?
    • Feigin A. Pridopidine in treatment of Huntington's disease: beyond chorea? Lancet Neurol 2011;10:1036-1037.
    • (2011) Lancet Neurol , vol.10 , pp. 1036-1037
    • Feigin, A.1
  • 8
    • 84871927602 scopus 로고    scopus 로고
    • Effects of the dopaminergic stabilizer pridopidine on motor symptoms in Huntington's disease: a meta-analysis [Abstract]
    • Landwehrmeyer GB, Marder K, Biilmann-Ronn B, et al. Effects of the dopaminergic stabilizer pridopidine on motor symptoms in Huntington's disease: a meta-analysis [Abstract]. Clin Genet 2011;80(Suppl 1):48.
    • (2011) Clin Genet , vol.80 , Issue.SUPPL. 1 , pp. 48
    • Landwehrmeyer, G.B.1    Marder, K.2    Biilmann-Ronn, B.3
  • 9
    • 73649139180 scopus 로고    scopus 로고
    • The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties
    • Dyhring T, Nielsen EO, Sonesson C, et al. The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties. Eur J Pharmacol 2010;628:19-26.
    • (2010) Eur J Pharmacol , vol.628 , pp. 19-26
    • Dyhring, T.1    Nielsen, E.O.2    Sonesson, C.3
  • 10
    • 77955772400 scopus 로고    scopus 로고
    • In vivo pharmacology of the dopaminergic stabilizer pridopidine
    • Ponten H, Kullingsjo J, Lagerkvist S, et al. In vivo pharmacology of the dopaminergic stabilizer pridopidine. Eur J Pharmacol 2010;644:88-95.
    • (2010) Eur J Pharmacol , vol.644 , pp. 88-95
    • Ponten, H.1    Kullingsjo, J.2    Lagerkvist, S.3
  • 11
    • 21244483198 scopus 로고    scopus 로고
    • The dopaminergic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats
    • Rung JP, Carlsson A, Markinhuhta KR, et al. The dopaminergic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:833-839.
    • (2005) Prog Neuropsychopharmacol Biol Psychiatry , vol.29 , pp. 833-839
    • Rung, J.P.1    Carlsson, A.2    Markinhuhta, K.R.3
  • 12
    • 0031913840 scopus 로고    scopus 로고
    • Effects of the substituted (S)-3-phenylpiperidine (-)-OSU6162 on PET measurements in subhuman primates: evidence for tone-dependent normalization of striatal dopaminergic activity
    • Tedroff J, Torstenson R, Hartvig P, et al. Effects of the substituted (S)-3-phenylpiperidine (-)-OSU6162 on PET measurements in subhuman primates: evidence for tone-dependent normalization of striatal dopaminergic activity. Synapse 1998;28:280-287.
    • (1998) Synapse , vol.28 , pp. 280-287
    • Tedroff, J.1    Torstenson, R.2    Hartvig, P.3
  • 13
    • 33745933839 scopus 로고    scopus 로고
    • The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor side effects in the rat
    • Natesan S, Svensson KA, Reckless GE, et al. The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor side effects in the rat. J Pharmacol Exp Ther 2006;318:810-818.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 810-818
    • Natesan, S.1    Svensson, K.A.2    Reckless, G.E.3
  • 14
    • 78049392648 scopus 로고    scopus 로고
    • Analysis of the actions of the novel dopamine receptor-directed compounds (S)-OSU6162 and ACR16 at the D2 dopamine receptor
    • Kara E, Lin H, Svensson K, et al. Analysis of the actions of the novel dopamine receptor-directed compounds (S)-OSU6162 and ACR16 at the D2 dopamine receptor. Br J Pharmacol 2010;161:1343-1350.
    • (2010) Br J Pharmacol , vol.161 , pp. 1343-1350
    • Kara, E.1    Lin, H.2    Svensson, K.3
  • 15
    • 70349112311 scopus 로고    scopus 로고
    • The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2(High) receptors
    • Seeman P, Tokita K, Matsumoto M, et al. The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2(High) receptors. Synapse 2009;63:930-934.
    • (2009) Synapse , vol.63 , pp. 930-934
    • Seeman, P.1    Tokita, K.2    Matsumoto, M.3
  • 16
    • 84855922033 scopus 로고    scopus 로고
    • Pharmacologic approaches to the treatment of Huntington's disease
    • Venuto CS, McGarry A, Ma Q, et al. Pharmacologic approaches to the treatment of Huntington's disease. Mov Disord 2012;27:31-41.
    • (2012) Mov Disord , vol.27 , pp. 31-41
    • Venuto, C.S.1    McGarry, A.2    Ma, Q.3
  • 17
    • 35348854954 scopus 로고    scopus 로고
    • Differences in agonist/antagonist properties at human dopamine D(2) receptors between aripiprazole, bifeprunox and SDZ 208-912
    • Tadori Y, Kitagawa H, Forbes RA, et al. Differences in agonist/antagonist properties at human dopamine D(2) receptors between aripiprazole, bifeprunox and SDZ 208-912. Eur J Pharmacol 2007;574:103-111.
    • (2007) Eur J Pharmacol , vol.574 , pp. 103-111
    • Tadori, Y.1    Kitagawa, H.2    Forbes, R.A.3
  • 18
    • 84871295100 scopus 로고    scopus 로고
    • The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the sigma-1 receptor
    • Sahlholm K, Arhem P, Fuxe K, et al. The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the sigma-1 receptor. Mol Psychiatry 2013;18:12-14.
    • (2013) Mol Psychiatry , vol.18 , pp. 12-14
    • Sahlholm, K.1    Arhem, P.2    Fuxe, K.3
  • 19
    • 84885854116 scopus 로고    scopus 로고
    • A single center, randomized, placebo-controlled, double-blind study to evaluate the safety, tolerability, and pharmacokinetics of multiple-ascending doses of pridopidine in healthy volunteers [Abstract]. Sixth Annual Huntington Disease Clinical Research Symposium
    • Osterberg O, Ivkovic J, Sundgreen C, et al. A single center, randomized, placebo-controlled, double-blind study to evaluate the safety, tolerability, and pharmacokinetics of multiple-ascending doses of pridopidine in healthy volunteers [Abstract]. Sixth Annual Huntington Disease Clinical Research Symposium. Neurotherapeutics 2012;9:1-17.
    • (2012) Neurotherapeutics , vol.9 , pp. 1-17
    • Osterberg, O.1    Ivkovic, J.2    Sundgreen, C.3
  • 20
    • 33645798913 scopus 로고    scopus 로고
    • Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial
    • Huntington Study Group
    • Huntington Study Group. Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial. Neurology 2006;66:366-372.
    • (2006) Neurology , vol.66 , pp. 366-372
  • 21
    • 84872393372 scopus 로고    scopus 로고
    • Physical therapy in Huntington's disease-toward objective assessments?
    • Bohlen S, Ekwall C, Hellström K, et al. Physical therapy in Huntington's disease-toward objective assessments? Eur J Neurol 2013;20:389-393.
    • (2013) Eur J Neurol , vol.20 , pp. 389-393
    • Bohlen, S.1    Ekwall, C.2    Hellström, K.3
  • 22
    • 78650196560 scopus 로고    scopus 로고
    • Fall risk assessment using the Tinetti mobility test in individuals with Huntington's disease
    • Kloos AD, Kegelmeyer DA, Young GS, et al. Fall risk assessment using the Tinetti mobility test in individuals with Huntington's disease. Mov Disord 2010;25:2838-2844.
    • (2010) Mov Disord , vol.25 , pp. 2838-2844
    • Kloos, A.D.1    Kegelmeyer, D.A.2    Young, G.S.3
  • 24
    • 78650850960 scopus 로고    scopus 로고
    • Tapping linked to function and structure in premanifest and symptomatic Huntington disease
    • Bechtel N, Scahill RI, Rosas HD, et al. Tapping linked to function and structure in premanifest and symptomatic Huntington disease. Neurology 2010;75:2150-2160.
    • (2010) Neurology , vol.75 , pp. 2150-2160
    • Bechtel, N.1    Scahill, R.I.2    Rosas, H.D.3
  • 25
    • 78650205712 scopus 로고    scopus 로고
    • Grasping premanifest Huntington's disease-shaping new endpoints for new trials
    • Reilmann R, Bohlen S, Klopstock T, et al. Grasping premanifest Huntington's disease-shaping new endpoints for new trials. Mov Disord 2010;25:2858-2862.
    • (2010) Mov Disord , vol.25 , pp. 2858-2862
    • Reilmann, R.1    Bohlen, S.2    Klopstock, T.3
  • 26
    • 0035845618 scopus 로고    scopus 로고
    • Objective assessment of progression in Huntington's disease: a 3-year follow-up study
    • Reilmann R, Kirsten F, Quinn L, et al. Objective assessment of progression in Huntington's disease: a 3-year follow-up study. Neurology 2001;57:920-924.
    • (2001) Neurology , vol.57 , pp. 920-924
    • Reilmann, R.1    Kirsten, F.2    Quinn, L.3
  • 27
    • 84859422752 scopus 로고    scopus 로고
    • Huntington's disease: objective assessment of posture-a link between motor and functional deficits
    • Reilmann R, Rumpf S, Beckmann H, et al. Huntington's disease: objective assessment of posture-a link between motor and functional deficits. Mov Disord 2012;27:555-559.
    • (2012) Mov Disord , vol.27 , pp. 555-559
    • Reilmann, R.1    Rumpf, S.2    Beckmann, H.3
  • 28
    • 68249113963 scopus 로고    scopus 로고
    • Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data
    • Tabrizi SJ, Langbehn DR, Leavitt BR, et al. Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. Lancet Neurol 2009;8:791-801.
    • (2009) Lancet Neurol , vol.8 , pp. 791-801
    • Tabrizi, S.J.1    Langbehn, D.R.2    Leavitt, B.R.3
  • 29
    • 83555173501 scopus 로고    scopus 로고
    • Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data
    • Tabrizi SJ, Reilmann R, Roos RA, et al. Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data. Lancet Neurol 2012;11:42-53.
    • (2012) Lancet Neurol , vol.11 , pp. 42-53
    • Tabrizi, S.J.1    Reilmann, R.2    Roos, R.A.3
  • 30
    • 79952118771 scopus 로고    scopus 로고
    • Tapping in Huntington disease: a path forward to preventive therapies?
    • Biglan KM. Tapping in Huntington disease: a path forward to preventive therapies? Neurology 2010;75:2142-2143.
    • (2010) Neurology , vol.75 , pp. 2142-2143
    • Biglan, K.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.