Restoring impaired protein metabolism in Parkinson's disease - TFEB-mediated autophagy as a novel therapeutic target

Movement Disorders

Volumn 28, Issue 10, 2013, Pages 1346-1346

  Ebrahimi Fakhari, Darius ^a   Wahlster, Lara ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; CELL PROTEIN; MICRORNA; TEMSIROLIMUS; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG;

ADENO ASSOCIATED VIRUS; ARTICLE; AUTOPHAGY; BIOGENESIS; DIFFUSE LEWY BODY DISEASE; GENE OVEREXPRESSION; NERVE DEGENERATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN METABOLISM;

ALPHA-SYNUCLEIN; ANIMALS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; FEMALE; HUMANS; MESENCEPHALON; NEURONS;

EID: 84884714890     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.25601     Document Type: Article

References (5)

1. Ebrahimi-Fakhari D, Wahlster L, McLean PJ. Molecular chaperones in Parkinson's disease-present and future. J Parkinsons Dis 2011;1:299-320.
2. Ebrahimi-Fakhari D, Wahlster L, McLean PJ. Protein degradation pathways in Parkinson's disease: curse or blessing. Acta Neuropathol 2012;124:153-172.
3. Dehay B, Martinez-Vicente M, Caldwell GA, et al. Lysosomal impairment in Parkinson's disease. Mov Disord 2013;28:725-732.
4. Decressac M, Mattsson B, Weikop P, Lundblad M, Jakobsson J, Bjorklund A. TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity. Proc Natl Acad Sci U S A 2013;110:E1817-E1826.
5. Settembre C, Fraldi A, Medina DL, Ballabio A. Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol 2013;14:283-296.