Amutation in tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse

Human Molecular Genetics

Volumn 22, Issue 20, 2013, Pages 4053-4063

  Stottmann, R W ^a,b   Donlin, M ^b   Hafner, A ^c   Bernard, A ^d   Sinclair, D A ^c   Beier, D R ^a,e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d ALLEN INSTITUTE FOR BRAIN SCIENCE   (United States)

^e SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TUBULIN; TUBULIN BETA 2B; UNCLASSIFIED DRUG; TUBB2B PROTEIN, HUMAN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASAL GANGLION; BRAIN CORTEX; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CHOROID PLEXUS; CONTROLLED STUDY; EMBRYO; HISTOPATHOLOGY; MICROGYRIA; MISSENSE MUTATION; MOUSE; MUTANT; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEUROEPITHELIUM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RHINENCEPHALON; ANIMAL; BRAIN; CELL STRAIN 3T3; CHEMICAL STRUCTURE; CHEMISTRY; CONGENITAL MALFORMATION; CORTICAL DYSPLASIA; FEMALE; GENETICS; HUMAN; LETHAL GENE; MALE; METABOLISM; MOLECULAR CLONING; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NERVE CELL; PATHOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; 3T3 CELL LINE;

ANIMALS; BRAIN; CELL PROLIFERATION; CELL SURVIVAL; CEREBRAL CORTEX; CLONING, MOLECULAR; EVOLUTION, MOLECULAR; FEMALE; GENES, LETHAL; HUMANS; MALE; MALFORMATIONS OF CORTICAL DEVELOPMENT; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NEURONS; NIH 3T3 CELLS; PHENOTYPE; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; TUBULIN;

EID: 84884706542     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt255     Document Type: Article

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