Risk stratification and transplant benefit in children listed for heart transplant in the United States

Circulation: Heart Failure

Volumn 6, Issue 4, 2013, Pages 800-808

  Singh, Tajinder P ^a,b   Almond, Christopher S ^a,b   Piercey, Gary ^a,c   Gauvreau, Kimberlee ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Heart failure; Pediatrics; Risk factors; Survival; Transplantation

Indexed keywords

ADOLESCENT; ARTICLE; CARDIOMYOPATHY; CHILD; CONGENITAL HEART DISEASE; CONTROLLED STUDY; FEMALE; GRAFT RECIPIENT; HEART GRAFT; HIGH RISK POPULATION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; SCHOOL CHILD; SURGICAL MORTALITY; UNITED STATES; CONGENITAL HEART MALFORMATION; HEART FAILURE; HEART TRANSPLANTATION; HOSPITAL ADMISSION; MULTIVARIATE ANALYSIS; PEDIATRICS; RISK FACTOR; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL; SURVIVAL; TRANSPLANTATION; TREATMENT OUTCOME;

HEART FAILURE; PEDIATRICS; RISK FACTORS; SURVIVAL; TRANSPLANTATION;

CARDIOMYOPATHIES; CHILD; CHILD, PRESCHOOL; FEMALE; HEART DEFECTS, CONGENITAL; HEART TRANSPLANTATION; HUMANS; INFANT; MALE; MODELS, STATISTICAL; MULTIVARIATE ANALYSIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; UNITED STATES; WAITING LISTS;

EID: 84884706366     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.112.000280     Document Type: Article

References (23)

1. Johnson MR, Meyer KH, Haft J, Kinder D, Webber SA, Dyke DB. Heart transplantation in the United States, 1999-2008. Am J Transplant. 2010;10(4 Pt 2):1035-1046.
2. Kirk R, Edwards LB, Kucheryavaya AY, Benden C, Christie JD, Dobbels F, Rahmel AO, Stehlik J, Hertz MI. The Registry of the International Society for Heart and Lung Transplantation: Fourteenth Pediatric Heart Transplantation Report-2011. J Heart Lung Transplant. 2011;30:1095-1103.
3. Canter CE, Shaddy RE, Bernstein D, Hsu DT, Chrisant MR, Kirklin JK, Kanter KR, Higgins RS, Blume ED, Rosenthal DN, Boucek MM, Uzark KC, Friedman AH, Young JK. Indications for heart transplantation in pediatric heart disease: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young; The Councils on Clinical Cardiology, Cardiovascular Nursing, and Cardiovascular Surgery and Anesthesia; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007;115:658-676.
4. Checchia PA, Larsen R, Sehra R, Daher N, Gundry SR, Razzouk AJ, Bailey LL. Effect of a selection and postoperative care protocol on survival of infants with hypoplastic left heart syndrome. Ann Thorac Surg. 2004;77:477-483.
5. Almond CS, Thiagarajan RR, Piercey GE, Gauvreau K, Blume ED, Bastardi HJ, Fynn-Thompson F, Singh TP. Waiting list mortality among children listed for heart transplantation in the United States. Circulation. 2009;119:717-727.
6. Almond CS, Gauvreau K, Canter CE, Rajagopal SK, Piercey GE, Singh TP. A risk-prediction model for in-hospital mortality after heart transplantation in US children. Am J Transplant. 2012. http://www.ncbi.nlm. nih.gov.ezp-prod1.hul. harvard.edu/pubmed/22300640.
7. Mah D, Singh TP, Thiagarajan RR, Gauvreau K, Piercey GE, Blume ED, Fynn-Thompson F, Almond CS. Incidence and risk factors for mortality in infants awaiting heart transplantation in the USA. J Heart Lung Transplant. 2009;28:1292-1298.
8. Gandhi R, Almond C, Singh TP, Gauvreau K, Piercey G, Thiagarajan RR. Factors associated with in-hospital mortality in infants undergoing heart transplantation in the United States. J Thorac Cardiovasc Surg. 2011;141:531-536; 536.e1.
9. Schwartz GJ, Muñoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009;20:629-637.
10. Hogg RJ, Furth S, Lemley KV, Portman R, Schwartz GJ, Coresh J, Balk E, Lau J, Levin A, Kausz AT, Eknoyan G, Levey AS. National kidney foundation's kidney disease outcomes quality initiative clinical practice guidelines for chronic kidney disease in children and adolescents: Evaluation, classification, and stratification. Pediatrics. 2003;111:1416-1421.
11. McGiffin DC, Naftel DC, Kirklin JK, Morrow WR, Towbin J, Shaddy R, Alejos J, Rossi A. Predicting outcome after listing for heart transplantation in children: comparison of Kaplan-Meier and parametric competing risk analysis. Pediatric Heart Transplant Study Group. J Heart Lung Transplant. 1997;16:713-722.
12. Gooley TA, Leisenring W, Crowley J, Storer BE. Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med. 1999;18:695-706.
13. UNOS board of directors:Policy 3.7. Organ distribution:Allocation of thoracic organs. http://optn.Transplant.Hrsa.Gov/policiesandbylaws2/ policies/pdfs/policy-9.Pdf. Accessed February 20, 2013.
14. Egan TM, Murray S, Bustami RT, Shearon TH, McCullough KP, Edwards LB, Coke MA, Garrity ER, Sweet SC, Heiney DA, Grover FL. Development of the new lung allocation system in the United States. Am J Transplant. 2006;6(5 Pt 2):1212-1227.
15. Davis SQ, Garrity ER Jr. Organ allocation in lung transplant. Chest. 2007;132:1646-1651.
16. Krakauer H, Lin MJ, Bailey RC. Projected survival benefit as criterion for listing and organ allocation in heart transplantation. J Heart Lung Transplant. 2005;24:680-689.
17. Freeman RB Jr, Wiesner RH, Roberts JP, McDiarmid S, Dykstra DM, Merion RM. Improving liver allocation: MELD and PELD. Am J Transplant. 2004;(4 suppl 9):114-131.
18. Austin MT, Poulose BK, Ray WA, Arbogast PG, Feurer ID, Pinson CW. Model for end-stage liver disease: did the new liver allocation policy affect waiting list mortality? Arch Surg. 2007;142:1079-1085.
19. Russo MJ, Iribarne A, Hong KN, Davies RR, Xydas S, Takayama H, Ibrahimiye A, Gelijns AC, Bacchetta MD, D'Ovidio F, Arcasoy S, Sonett JR. High lung allocation score is associated with increased morbidity and mortality following transplantation. Chest. 2010;137: 651-657.
20. Final rule: A regulatory framework for the structure and operations of the optn. http://optn.Transplant.Hrsa.Gov/policiesandbylaws/final-rule.Asp. Accessed April 10, 2012.
21. US department of health and human services. Organ procurement and transplant network:Final rule, 42 cfr part 121 63, Fed. Reg. 1998.
22. Singh TP, Almond CS, Semigran MJ, Piercey G, Gauvreau K. Risk prediction for early in-hospital mortality following heart transplantation in the United States. Circ Heart Fail. 2012;5:259-266.
23. Weiss ES, Allen JG, Arnaoutakis GJ, George TJ, Russell SD, Shah AS, Conte JV. Creation of a quantitative recipient risk index for mortality prediction after cardiac transplantation (impact). Ann Thorac Surg. 2011;92:914-921.