Methionine Biosynthesis in Staphylococcus aureus Is Tightly Controlled by a Hierarchical Network Involving an Initiator tRNA-Specific T-box Riboswitch

PLoS Pathogens

Volumn 9, Issue 9, 2013, Pages

  Schoenfelder, Sonja M K ^a,b   Marincola, Gabriella ^c   Geiger, Tobias ^c   Goerke, Christiane ^c   Wolz, Christiane ^c   Ziebuhr, Wilma ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

METHIONINE; RIBONUCLEASE III; RIFAMPICIN; SPACER DNA; SPLICED LEADER RNA; T BOX TRANSCRIPTION FACTOR; TRANSFER RNA; 5' UNTRANSLATED REGION; BACTERIAL DNA; BACTERIAL PROTEIN; BACTERIAL RNA; CODY PROTEIN, STAPHYLOCOCCUS AUREUS; FMET-TRNA(FMET); ISOENZYME; METHIONINE TRANSFER RNA; REPRESSOR PROTEIN; RIBONUCLEASE; RIBOSWITCH;

AMINO ACID METABOLISM; ARTICLE; BACTERIUM CULTURE; BIOSYNTHESIS; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSCRIPTION; GROWTH; HYBRIDIZATION; IN VITRO STUDY; NONHUMAN; NORTHERN BLOTTING; OPTICAL DENSITY; POLYMERASE CHAIN REACTION; RIBOSWITCH; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; STAPHYLOCOCCUS AUREUS; 5' UNTRANSLATED REGION; BIOLOGICAL MODEL; DOWN REGULATION; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION; PROMOTER REGION; RNA STABILITY; RNA TRANSLATION; UPREGULATION;

5' UNTRANSLATED REGIONS; BACTERIAL PROTEINS; DNA, BACTERIAL; DOWN-REGULATION; ISOENZYMES; METHIONINE; MODELS, BIOLOGICAL; MUTATION; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; RIBONUCLEASES; RIBOSWITCH; RNA STABILITY; RNA, BACTERIAL; RNA, SPLICED LEADER; RNA, TRANSFER, MET; STAPHYLOCOCCUS AUREUS; T-BOX DOMAIN PROTEINS; UP-REGULATION;

EID: 84884698380     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003606     Document Type: Article

References (31)

1. Hidron AI, Edwards JR, Patel J, Horan TC, Sievert DM, et al. (2008) NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 29: 996-1011.
2. Chambers HF, Deleo FR, (2009) Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol 7: 629-641.
3. Somerville GA, Proctor RA, (2009) At the crossroads of bacterial metabolism and virulence factor synthesis in Staphylococci. Microbiol Mol Biol Rev 73: 233-248.
4. Parveen N, Cornell KA, (2011) Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism. Mol Microbiol 79: 7-20.
5. Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS, (2004) Comparative genomics of the methionine metabolism in Gram-positive bacteria: a variety of regulatory systems. Nucleic Acids Res 32: 3340-3353.
6. Gutierrez-Preciado A, Henkin TM, Grundy FJ, Yanofsky C, Merino E, (2009) Biochemical features and functional implications of the RNA-based T-box regulatory mechanism. Microbiol Mol Biol Rev 73: 36-61.
7. Grundy FJ, Henkin TM, (1998) The S box regulon: a new global transcription termination control system for methionine and cysteine biosynthesis genes in Gram-positive bacteria. Mol Microbiol 30: 737-749.
8. Vitreschak AG, Mironov AA, Lyubetsky VA, Gelfand MS, (2008) Comparative genomic analysis of T-box regulatory systems in bacteria. RNA 14: 717-735.
9. Green NJ, Grundy FJ, Henkin TM, (2010) The T box mechanism: tRNA as a regulatory molecule. FEBS Lett 584: 318-324.
10. Majerczyk CD, Dunman PM, Luong TT, Lee CY, Sadykov MR, et al. (2010) Direct targets of CodY in Staphylococcus aureus. J Bacteriol 192: 2861-2877.
11. Pohl K, Francois P, Stenz L, Schlink F, Geiger T, et al. (2009) CodY in Staphylococcus aureus: a regulatory link between metabolism and virulence gene expression. J Bacteriol 191: 2953-2963.
12. Geiger T, Goerke C, Fritz M, Schäfer T, Ohlsen K, et al. (2010) Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus. Infect Immun 78: 1873-1883.
13. Ratnayake-Lecamwasam M, Serror P, Wong KW, Sonenshein AL, (2001) Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels. Genes Dev 15: 1093-1103.
14. Shivers RP, Sonenshein AL, (2004) Activation of the Bacillus subtilis global regulator CodY by direct interaction with branched-chain amino acids. Mol Microbiol 53: 599-611.
15. Novichkov PS, Laikova ON, Novichkova ES, Gelfand MS, Arkin AP, et al. (2010) RegPrecise: a database of curated genomic inferences of transcriptional regulatory interactions in prokaryotes. Nucleic Acids Res 38: D111-118.
16. Brinsmade SR, Kleijn RJ, Sauer U, Sonenshein AL, (2010) Regulation of CodY activity through modulation of intracellular branched-chain amino acid pools. J Bacteriol 192: 6357-6368.
17. Serganov A, Patel DJ, (2007) Ribozymes, riboswitches and beyond: regulation of gene expression without proteins. Nat Rev Genet 8: 776-790.
18. Mäder U, Zig L, Kretschmer J, Homuth G, Putzer H, (2008) mRNA processing by RNases J1 and J2 affects Bacillus subtilis gene expression on a global scale. Mol Microbiol 70: 183-196.
19. Lioliou E, Sharma CM, Caldelari I, Helfer AC, Fechter P, et al. (2012) Global regulatory functions of the Staphylococcus aureus endoribonuclease III in gene expression. PLoS Genet 8: e1002782.
20. Joshi GS, Spontak JS, Klapper DG, Richardson AR, (2011) Arginine catabolic mobile element encoded speG abrogates the unique hypersensitivity of Staphylococcus aureus to exogenous polyamines. Mol Microbiol 82: 9-20.
21. Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, et al. (2004) Bacterial variations on the methionine salvage pathway. BMC Microbiol 4: 9.
22. Hullo MF, Auger S, Soutourina O, Barzu O, Yvon M, et al. (2007) Conversion of methionine to cysteine in Bacillus subtilis and its regulation. J Bacteriol 189: 187-197.
23. Chaffin DO, Taylor D, Skerrett SJ, Rubens CE, (2012) Changes in the Staphylococcus aureus transcriptome during early adaptation to the lung. PLoS One 7: e41329.
24. Pietiainen M, Francois P, Hyyrylainen HL, Tangomo M, Sass V, et al. (2009) Transcriptome analysis of the responses of Staphylococcus aureus to antimicrobial peptides and characterization of the roles of vraDE and vraSR in antimicrobial resistance. BMC Genomics 10: 429.
25. Nagarajan V, Elasri MO, (2007) SAMMD: Staphylococcus aureus microarray meta-database. BMC Genomics 8: 351.
26. Ochsner UA, Young CL, Stone KC, Dean FB, Janjic N, et al. (2005) Mode of action and biochemical characterization of REP8839, a novel inhibitor of methionyl-tRNA synthetase. Antimicrob Agents Chemother 49: 4253-4262.
27. Anupam R, Nayek A, Green NJ, Grundy FJ, Henkin TM, et al. (2008) 4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function. Bioorg Med Chem Lett 18: 3541-3544.
28. Anupam R, Denapoli L, Muchenditsi A, Hines JV, (2008) Identification of neomycin B-binding site in T box antiterminator model RNA. Bioorg Med Chem 16: 4466-4470.
29. Lagoja IM, Herdewijn P, (2007) Use of RNA in drug design. Expert Opin Drug Discov 2: 889-903.
30. Sampson JR, Uhlenbeck OC, (1988) Biochemical and physical characterization of an unmodified yeast phenylalanine transfer RNA transcribed in vitro. Proc Natl Acad Sci U S A 85: 1033-1037.
31. Yousef MR, Grundy FJ, Henkin TM, (2003) tRNA requirements for glyQS antitermination: a new twist on tRNA. RNA 9: 1148-1156.