Oxytocin and socioemotional aging: Current knowledge and future trends

Frontiers in Human Neuroscience

Volumn , Issue AUG, 2013, Pages

  Ebner, Natalie C ^a   Maura, Gabriela M ^a   MacDonald, Kai ^b   Westberg, Lars ^c   Fischer, Håkan ^d,e  

^a Department of Psychology University of Florida ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d STOCKHOLM UNIVERSITY   (Sweden)

^e AGING RESEARCH CENTER   (Sweden)

Author keywords

Aging; Amygdala; Anterior cingulate; Oxytocin; Socioemotional functioning

Indexed keywords

OXYTOCIN; OXYTOCIN RECEPTOR;

AGING; ANXIETY; AVOIDANCE BEHAVIOR; DEPRESSION; EMOTIONALITY; EVIDENCE BASED MEDICINE; EXECUTIVE FUNCTION; FACIAL EXPRESSION; GENETIC VARIABILITY; HUMAN; LIFESPAN; OXYTOCIN RECEPTOR GENE; RECEPTOR GENE; REVIEW; SOCIAL BEHAVIOR; SOCIAL COGNITION; SOCIAL INTERACTION; SOCIAL ISOLATION; SOCIAL NETWORK; SOCIAL STATUS; SOCIAL STRESS; WELLBEING;

EID: 84884698125     PISSN: 16625161     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnhum.2013.00487     Document Type: Review

References (185)

1. Adolphs, R. (2003). Cognitive neuroscience of human social behaviour. Nat. Rev. Neurosci. 4, 165-178. doi: 10.1038/nrn1056
2. Amodio, D. M., and Frith, C. D. (2006). Meeting of the minds: the medial frontal cortex and social cognition. Nat. Rev. Neurosci. 7, 268-277. doi: 10.1038/nrn1884
3. Andari, E., Duhamel, J., Zalla, T., Herbrecht, E., Leboyer, M., and Sirigu, A. (2010). Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc. Natl. Acad. Sci. U.S.A. 107, 4389-4394. doi: 10.1073/pnas.0910249107
4. Anderson, G. M. (2006). Report of altered urinary oxytocin and AVP excretion in neglected orphans should be reconsidered. J. Autism Dev. Disord. 36, 829-830. doi: 10.1007/s10803-006-0153-7
5. Apicella, C. L., Cesarini, D., Johannesson, M., Dawes, C. T., Lichtenstein, P., and Wallace, B. (2010). No association between oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences. PLoS ONE 5:e11153. doi: 10.1371/journal.pone.0011153
6. Arletti, R., Benelli, A., Poggioli, R., Luppi, P., Menozzi, B., and Bertolini, A. (1995). Aged rats are still responsive to the antidepressant and memory-improving effects of oxytocin. Neuropeptides 29, 177-182. doi: 10.1016/0143-4179(95)90021-7
7. Arletti, R., and Bertolini, A. (1987). Oxytocin acts as an antidepressant in two animal models of depression. Life Sci. 41, 1725-1730. doi: 10.1016/0024-3205(87)90600-X
8. Arsenijevic, Y., Dreifuss, J. J., Vallet, P., Marguerat, A., and Tribollet, E. (1995). Reduced binding of oxytocin in the rat brain during aging. Brain Res. 698, 275-279. doi: 10.1016/0006-8993(95)01020-V
9. Averbeck, B. B. (2010). Oxytocin and the salience of social cues. Proc. Natl. Acad. Sci. U.S.A. 107, 9033-9034. doi: 10.1073/pnas.1004892107
10. Bakermans-Kranenburg, M. J., and van I, Jzendoorn, M. H. (2008). Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Soc. Cogn. Affect. Neurosci. 3, 128-134. doi: 10.1093/scan/nsn004
11. Bakermans-Kranenburg, M. J., and van I, Jzendoorn, M. H. (2013). Sniffing around oxytocin: review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy. Transl. Psychiatry 3, e258. doi: 10.1038/tp.2013.34
12. Balleine, B. W., Delgado, M. R., and Hikosaka, O. (2007). The role of the dorsal striatum in reward and decision-making. J. Neurosci. 27, 8161-8165. doi: 10.1523/JNEUROSCI.1554-07.2007
13. Baron-Cohen, S. E., Tager-Flusberg, H. E., and Cohen, D. J. (eds.). (2000). Understanding Other Minds: Perspectives from Developmental Cognitive Neuroscience. New York, NY: Oxford University Press.
14. Barraza, J., Grewal, N., Ropacki, S., Perez, P., Gonzalez, A., and Zak, P. (2013). Effects of a 10-day oxytocin trial in older adults on health and well-being. Exp. Clin. Psychopharmacol. 21, 85-92. doi: 10.1037/a0031581
15. Bartlett, J. C., Leslie, J. E., Tubbs, A., and Fulton, A. (1989). Aging and memory for pictures of faces. Psychol. Aging 4, 276-283. doi: 10.1037/0882-7974.4.3.276
16. Bartz, J. A., Zaki, J., Bolger, N., Hollander, E., Ludwig, N. N., Kolevzon, A., et al. (2010). Oxytocin selectively improves empathic accuracy. Psychol. Sci. 21, 1426-1428. doi: 10.1177/0956797610383439
17. Bartz, J. A., Zaki, J., Bolger, N., and Ochsner, K. N. (2011). Social effects of oxytocin in humans: context and person matter. Trends Cogn. Sci. 15, 301-309. doi: 10.1016/j.tics.2011.05.002
18. Baumeister, R. F., and Leary, M. R. (1995). The need to belong: desire for interpersonal attachments as a fundamental human motivation. Psychol. Bull. 117, 497. doi: 10.1037/0033-2909.117.3.497
19. Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., and Fehr, E. (2008). Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron 58, 639-650. doi:10.1016/j.neuron.2008.04.009
20. Blanchard-Fields, F., Mienaltowski, A., and Seay, R. B. (2007). Age differences in everyday problem-solving effectiveness: older adults select more effective strategies for interpersonal problems. J. Gerontol. B Psychol. Sci. Soc. Sci. 62, P61-P64. doi: 10.1093/geronb/62.1.P61
21. Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., and Fehm, H. L. (2002). Sniffing neuropeptides: a transnasal approach to the human brain. Nat. Neurosci. 5, 514-516. doi: 10.1038/nn0602-849
22. Brink, T. L., Yesavage, J. A., Lum, O., Heersema, P. H., Adey, M., and Rose, T. L. (1982). Screening tests for geriatric depression. Clin. Gerontol. 1, 37-43. doi: 10.1300/J018v01n01_06
23. Bush, G., Luu, P., and Posner, M. (2000). Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn. Sci. 4, 215-222. doi: 10.1016/S1364-6613(00)01483-2
24. Cacioppo, J. T., Norris, C. J., Decety, J., Monteleone, G., and Nusbaum, H. (2009). In the eye of the beholder: individual differences in perceived social isolation predict regional brain activation to social stimuli. J. Cogn. Neurosci. 21, 83-92. doi: 10.1162/jocn.2009.21007
25. Calder, A. J., Young, A. W., Keane, J., and Dean, M. (2000). Configural information in facial expression perception. J. Exp. Psychol. Hum. Percept. Perform. 26, 527-551. doi: 10.1037/0096-1523.26.2.527
26. Carstensen, L. L. (2006). The influence of a sense of time on human development. Science 312, 1913-1915. doi: 10.1126/science.1127488
27. Carstensen, L. L., Pasupathi, M., Mayr, U., and Nesselroade, J. R. (2000). Emotional experience in everyday life across the adult life span. J. Pers. Soc. Psychol. 79, 644. doi: 10.1037/0022-3514.79.4.644
28. Carstensen, L. L., Turan, B., Scheibe, S., Ram, N., Ersner-Hershfield, H., Samanez-Larkin, G. R., et al. (2011). Emotional experience improves with age: evidence based on over 10 years of experience sampling. Psychol. Aging 26, 21-33. doi: 10.1037/a0021285
29. Carter, C. S., and Altemus, M. (1997). Integrative functions of lactational hormones in social behavior and stress management. Ann. N.Y. Acad. Sci. 807, 164-174. doi: 10.1111/j.1749-6632.1997.tb51918.x
30. Castle, E., Eisenberger, N. I., Seeman, T. E., Moons, W. G., Boggero, I. A., Grinblatt, M. S., et al. (2012). Neural and behavioral bases of age differences in perceptions of trust. Proc. Natl. Acad. Sci. U.S.A. 109, 20848-20852. doi: 10.1073/pnas.1218518109
31. Charles, S. T., Reynolds, C. A., and Gatz, M. (2001). Age-related differences and change in positive and negative affect over 23 years. J. Pers. Soc. Psychol. 80, 136-151. doi: 10.1037/0022-3514.80.1.136
32. Choleris, E., Clipperton-Allen, A. E., Phan, A., and Kavaliers, M. (2009). Neuroendocrinology of social information processing in rats and mice. Front. Neuroendocrinol. 30, 442-459. doi: 10.1016/j.yfrne.2009.05.003
33. Cornwell, E. Y., and Waite, L. J. (2009). Social disconnectedness, perceived isolation, and health among older adults. J. Health Soc. Behav. 50, 31-48. doi: 10.1177/002214650905000103
34. Crook, T. H., Lebowitz, B. D., Pirozzolo, F. J., Zappalà, G., Cavarzeran, F., Measso, G., et al. (1993). Recalling names after introduction: changes across the adult life span in two cultures. Dev. Neuropsychol. 9, 103-113. doi: 10.1080/87565649109540547
35. Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., and Heinrichs, M. (2009). Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biol. Psychiatry 65, 728-731. doi: 10.1016/j.biopsych.2008.10.011
36. Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., and Herpertz, S. C. (2007a). Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Biol. Psychiatry 62, 1187-1190. doi: 10.1016/j.biopsych.2007.03.025
37. Domes, G., Heinrichs, M., Michel, A., Berger, C., and Herpertz, S. C. (2007b). Oxytocin improves "mind-reading" in humans. Biol. Psychiatry 61, 731-733. doi: 10.1016/j.biopsych.2006.07.015
38. Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., et al. (2010). Effects of intranasal oxytocin on emotional face processing in women. Psychoneuroendocrinology 35, 83-93. doi: 10.1016/j.psyneuen.2009.06.016
39. Donaldson, Z. R., and Young, L. J. (2008). Oxytocin, vasopressin, and the neurogenetics of sociality. Science 322, 900-904. doi: 10.1126/science.1158668
40. Ebner, N. C., Freund, A. M., and Baltes, P. B. (2006). Developmental changes in personal goal orientation from young to late adulthood: from striving for gains to maintenance and prevention of losses. Psychol. Aging 21, 664-678. doi: 10.1037/0882-7974.21.4.664
41. Ebner, N. C., Riediger, M., and Lindenberger, U. (2010). FACES-A database of facial expressions in young, middle-aged, and older women and men. Development and validation. Behav. Res. Methods. 42, 351-362. doi: 10.3758/BRM.42.1.351
42. Ebner, N. C., He, Y., and Johnson, M. K. (2011). Age and emotion affect how we look at a face: visual scan patterns differ for own-age versus other-age emotional faces. Cogn. Emot. 25, 983-997. doi: 10.1080/02699931.2010.540817
43. Ebner, N. C., and Johnson, M. K. (2009). Young and older emotional faces: are there age group differences in expression identification and memory? Emotion 9, 329-339. doi: 10.1037/a0015179
44. Ebner, N. C., and Johnson, M. K. (2010). Age-group differences in interference from young and older emotional faces. Cogn. Emot. 24, 1095-1116. doi: 10.1080/02699930903128395
45. Ebner, N. C., Johnson, M. K., and Fischer, H. (2012). Neural mechanisms of reading facial emotions in young and older adults. Front. Psychol. 3:223. doi: 10.3389/fpsyg.2012.00223
46. Ebner, N. C., Johnson, M. R., Rieckmann, A., Durbin, K. A., Johnson, M. K., and Fischer, H. (2013). Processing own-age vs. other-age faces: neuro-behavioral correlates and effects of emotion. Neuroimage 78, 363-371. doi: 10.1016/j.neuroimage.2013.04.029
47. Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., and Lai, P. S. (2012). The contributions of oxytocin and vasopressin pathway genes to human behavior. Horm. Behav. 61, 359-379. doi: 10.1016/j.yhbeh.2011.12.014
48. Egawa, J., Watanabe, Y., Endo, T., Tamura, R., Masuzawa, N., and Someya, T. (2012). Association between OXTR and clinical phenotypes of autism spectrum disorders. Psychiatry Res. 208, 99-100. doi: 10.1016/j.psychres.2012.11.007
49. Feifel, D., MacDonald, K., Cobb, P., and Minassian, A. (2012). Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia. Schizophr. Res. 139, 207-210. doi: 10.1016/j.schres.2012.05.018
50. Fekete, E. M., Seay, J., Antoni, M. H., Mendez, A. J., Fletcher, M. A., Szeto, A., et al. (2013). Oxytocin, social support, and sleep quality in low-income minority women living with HIV. Behav. Sleep Med. 11, 1-15. doi: 10.1080/15402002.2013.791297
51. Feldman, R., Gordon, I., and Zagoory-Sharon, O. (2011). Maternal and paternal plasma, salivary, and urinary oxytocin and parent-infant synchrony: considering stress and affiliation components of human bonding. Dev. Sci. 14, 752-761. doi: 10.1111/j.1467-7687.2010.01021.x
52. Ferrier, B. M., Kennet, D. J., and Devlin, M. C. (1980). Influence of oxytocin on human memory processes. Life Sci. 27, 2311-2317. doi: 10.1016/0024-3205(80)90499-3
53. Firestone, A. A., Turk-Browne, N. B., and Ryan, J. D. (2007). Age-related deficits in face recognition are related to underlying changes in scanning behavior. Neuropsychol. Dev. Cogn. B Aging Neuropsychol. Cogn. 14, 594-607. doi: 10.1080/13825580600899717
54. Fischer, H., Nyberg, L., and Bäckman, L. (2010). Age-related differences in brain regions supporting successful encoding of emotional faces. Cortex 46, 490-497. doi: 10.1016/j.cortex.2009.05.011
55. Fischer, H., Sandblom, J., Gavazzeni, J., Fransson, P., Wright, C. I., and Bäckman, L. (2005). Age-differential patterns of brain activation during perception of angry faces. Neurosci. Lett. 386, 99-104. doi: 10.1016/j.neulet.2005.06.002
56. Fliers, E., De Vries, G. J., and Swaab, D. F. (1985). Changes with aging in the vasopressin and oxytocin innervation of the rat brain. Brain Res. 348, 1-8. doi: 10.1016/0006-8993(85)90351-8
57. Fliers, E., and Swaab, D. F. (1983). Activation of vasopressinergic and oxytocinergic neurons during aging in the wistar rat. Peptides 4, 165-170. doi: 10.1016/0196-9781(83)90108-0
58. Folstein, M. F., Folstein, S. E., and McHugh, P. R. (1975). Mini-Mental State: A Practical Method for Grading the Cognitive State of Patients for the Clinician. New York, NY: Pergamon Press.
59. Freund, A. M. (2006). Age-differential motivational consequences of optimization versus compensation focus in younger and older adults. Psychol. Aging 21, 240-252. doi: 10.1037/0882-7974.21.2.240
60. Fries, A. B. W., Ziegler, T. E., Kurian, J. R., Jacoris, S., and Pollak, S. D. (2005). Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior. Proc. Natl. Acad. Sci. U.S.A. 102, 17237-17240. doi: 10.1073/pnas.0504767102
61. Gabor, C. S., Phan, A., Clipperton-Allen, A., Kavaliers, M., and Choleris, E. (2012). Interplay of oxytocin, vasopressin, and sex hormones in the regulation of social recognition. Behav. Neurosci. 126, 97-109. doi: 10.1037/a0026464
62. Gamer, M., Zurowski, B., and Büchel, C. (2010). Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans. Proc. Natl. Acad. Sci. U.S.A. 107, 9400-9405. doi: 10.1073/pnas.1000985107
63. Gimpl, G., and Fahrenholz, F. (2001). The oxytocin receptor system: structure, function, and regulation. Physiol. Rev. 81, 629-683.
64. Gottfries, C. G. (1997). Recognition and management of depression in the elderly. Int. Clin. Psychopharmacol. 12, S31-S36. doi: 10.1097/00004850-199712007-00006
65. Gouin, J., Carter, C. S., Pournajafi-Nazarloo, H., Glaser, R., Malarkey, W. B., Loving, T. J., et al. (2010). Marital behavior, oxytocin, vasopressin, and wound healing. Psychoneuroendocrinology 35, 1082-1090. doi: 10.1016/j.psyneuen.2010.01.009
66. Grady, C. L. (2008). Cognitive neuroscience of aging. Ann. N.Y. Acad. Sci. 1124, 127-144. doi: 10.1196/annals.1440.009
67. Grady, C. L., and Keightley, M. L. (2002). Studies of altered social cognition in neuropsychiatric disorders using functional neuroimaging. Can. J. Psychiatry 47, 327-336.
68. Grady, C. L., McIntosh, A. R., Horwitz, B., Maisog, J. M., Ungerleider, L. G., Mentis, M. J., et al. (1995). Age-related reductions in human recognition memory due to impaired encoding. Science 269, 218-221. doi: 10.1126/science.7618082
69. Groppe, S. E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Gründer, G., et al. (2013). Oxytocin influences processing of socially relevant cues in the ventral tegmental area of the human brain. Biol. Psychiatry 74, 172-179. doi: 10.1016/j.biopsych.2012.12.023
70. Gross, J. J., and Levenson, R. W. (1997). Hiding feelings: the acute effects of inhibiting negative and positive emotion. J. Abnorm. Psychol. 106, 95-103. doi: 10.1037/0021-843X.106.1.95
71. Guastella, A., Alvares, G., Hickie, I., Chan, H., Chen, T., and Banati, R. (2013). Unitary hormonal models, peripheral markers, and evaluation of response to drug: a response to Weisman and Feldman. Psychoneuroendocrinology 38, 627-628. doi: 10.1016/j.psyneuen.2013.03.005
72. Guastella, A. J., Carson, D. S., Dadds, M. R., Mitchell, P. B., and Cox, R. E. (2009). Does oxytocin influence the early detection of angry and happy faces? Psychoneuroendocrinology 34, 220-225. doi: 10.1016/j.psyneuen.2008.09.001
73. Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., et al. (2010). Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biol. Psychiatry 67, 692-694. doi: 10.1016/j.biopsych.2009.09.020
74. Guastella, A. J., Mitchell, P. B., and Dadds, M. R. (2008). Oxytocin increases gaze to the eye region of human faces. Biol. Psychiatry 63, 3-5. doi: 10.1016/j.biopsych.2007.06.026
75. Gunning-Dixon, F., Gur, R. C., Perkins, A. C., Schroeder, L., Turner, T., Turetsky, B. I., et al. (2003). Aged-related differences in brain activation during emotional face processing. Neurobiol. Aging 24, 285-295. doi: 10.1016/S0197-4580(02)00099-4
76. Haxby, J. V., Hoffman, E. A., and Gobbini, M. I. (2000). The distributed human neural system for face perception. Trends Cogn. Sci. 4, 223-233. doi: 10.1016/S1364-6613(00)01482-0
77. Haxby, J. V., Hoffman, E. A., and Gobbini, M. I. (2002). Human neural systems for face recognition and social communication. Biol. Psychiatry 51, 59-67. doi: 10.1016/S0006-3223(01)01330-0
78. Heim, C., Young, L. J., Newport, D. J., Mletzko, T., Miller, A. H., and Nemeroff, C. B. (2008). Lower CSF oxytocin concentrations in women with a history of childhood abuse. Mol. Psychiatry 14, 954-958. doi: 10.1038/mp.2008.112
79. Heinrichs, M., Baumgartner, T., Kirschbaum, C., and Ehlert, U. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol. Psychiatry 54, 1389-1398. doi: 10.1016/S0006-3223(03)00465-7
80. Heinrichs, M., Meinlschmidt, G., Wippich, W., Ehlert, U., and Hellhammer, D. H. (2004). Selective amnesic effects of oxytocin on human memory. Physiol. Behav. 83, 31-38. doi: 10.1016/j.physbeh.2004.07.020
81. Huber, D., Veinante, P., and Stoop, R. (2005). Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 308, 245-248. doi: 10.1126/science.1105636
82. Huffmeijer, R., van I, Jzendoorn, M. H., and Bakermans-Kranenburg, M. J. (2012). Ageing and oxytocin: a call for extending human oxytocin research to ageing populations-a mini-review. Gerontology 59, 32-39. doi: 10.1159/000341333
83. Iidaka, T., Okada, T., Murata, T., Omori, M., Kosaka, H., Sadato, N., et al. (2002). Age-related differences in the medial temporal lobe responses to emotional faces as revealed by fMRI. Hippocampus 12, 352-362. doi: 10.1002/hipo.1113
84. Insel, T. R. (2010). The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior. Neuron 65, 768-779. doi: 10.1016/j.neuron.2010.03.005
85. Insel, T. R., and Fernald, R. D. (2004). How the brain processes social information: searching for the social brain. Annu. Rev. Neurosci. 27, 697-722. doi: 10.1146/annurev.neuro.27.070203.144148
86. Isaacowitz, D. M., Löckenhoff, C. E., Lane, R. D., Wright, R., Sechrest, L., Riedel, R., et al. (2007). Age differences in recognition of emotion in lexical stimuli and facial expressions. Psychol. Aging 22, 147-159. doi: 10.1037/0882-7974.22.1.147
87. Isaacowitz, D. M., Wadlinger, H. A., Goren, D., and Wilson, H. R. (2006). Selective preference in visual fixation away from negative images in old age? An eye-tracking study. Psychol. Aging 21, 40-48. doi: 10.1037/0882-7974.21.1.40
88. Israel, S., Knafo, A., Ebstein, R. P., Lerer, E., Shalev, I., and Uzefovsky, F. (2009). The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. PLoS ONE 4:e5535. doi: 10.1371/journal.pone.0005535
89. Keck, M. E., Hatzinger, M., Wotjak, C. T., Landgraf, R., Holsboer, F., and Neumann, I. D. (2000). Ageing alters intrahypothalamic release patterns of vasopressin and oxytocin in rats. Eur. J. Neurosci. 12, 1487-1494.
90. Keightley, M. L., Chiew, K. S., Winocur, G., and Grady, C. L. (2007). Age-related differences in brain activity underlying identification of emotional expressions in faces. Soc. Cogn. Affect. Neurosci. 2, 292-302. doi: 10.1093/scan/nsm024
91. Kemp, A. H., and Guastella, A. J. (2010). Oxytocin: prosocial behavior, social salience, or approach-related behavior? Biol. Psychiatry 67, e33-e34. doi: 10.1016/j.biopsych.2009.11.019
92. Kéri, S., and Kiss, I. (2011). Oxytocin response in a trust game and habituation of arousal. Physiol. Behav. 102, 221-224. doi: 10.1016/j.physbeh.2010.11.011
93. Kessler, E., and Staudinger, U. (2009). Affective experience in adulthood and old age: the role of affective arousal and perceived affect regulation. Psychol. Aging 24, 349-362. doi: 10.1037/a0015352
94. Kimura, T., Tanizawa, O., Mori, K., Brownstein, M. J., and Okayama, H. (1992). Structure and expression of a human oxytocin receptor. Nature 356, 526-529. doi: 10.1038/356526a0
95. Kirchner, W. K. (1958). Age differences in short-term retention of rapidly changing information. J. Exp. Psychol. 55, 352-358. doi: 10.1037/h0043688
96. Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., et al. (2005). Oxytocin modulates neural circuitry for social cognition and fear in humans. J. Neurosci. 25, 11489-11493. doi: 10.1523/JNEUROSCI.3984-05.2005
97. Kiss, I., Levy-Gigi, E., and Kéri, S. (2011). CD 38 expression, attachment style and habituation of arousal in relation to trust-related oxytocin release. Biol. Psychol. 88, 223-226. doi: 10.1016/j.biopsycho.2011.08.005
98. Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., et al. (2012). Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron 73, 553-566. doi: 10.1016/j.neuron.2011.11.030
99. Kogan, A., Saslow, L. R., Impett, E. A., Oveis, C., Keltner, D., and Saturn, S. R. (2011). Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition. Proc. Natl. Acad. Sci. U.S.A. 108, 19189-19192. doi: 10.1073/pnas.1112658108
100. Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., and Fehr, E. (2005). Oxytocin increases trust in humans. Nature 435, 673-676. doi: 10.1038/nature03701
101. Kumsta, R., Chen, F. S., Pape, H., and Heinrichs, M. (2013). Neuropeptide S receptor gene is associated with cortisol responses to social stress in humans. Biol. Psychol. 93, 304-307. doi: 10.1016/j.biopsycho.2013.02.018
102. Kunzmann, U., Kupperbusch, C. S., and Levenson, R. W. (2005). Behavioral inhibition and amplification during emotional arousal: a comparison of two age groups. Psychol. Aging 20, 144-158. doi: 10.1037/0882-7974.20.1.144
103. Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., and Heinrichs, M. (2010). Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology 35, 2403-2413. doi: 10.1038/npp.2010.123
104. Landgraf, R., and Neumann, I. D. (2004). Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. Front. Neuroendocrinol. 25, 150-176. doi: 10.1016/j.yfrne.2004.05.001
105. Lawton, M., Kleban, M., Rajagopal, D., and Dean, J. (1992). Dimensions of affective experience in three age groups. Psychol. Aging 7, 171-184. doi: 10.1037//0882-7974.7.2.171
106. Leng, G., and Ludwig, M. (2006). Information processing in the hypothalamus: peptides and analogue computation. J. Neuroendocrinol. 18, 379-392. doi: 10.1111/j.1365-2826.2006.01428.x
107. Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., and Ebstein, R. P. (2008). Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland adaptive behavior scales and cognition. Mol. Psychiatry 13, 980-988. doi: 10.1038/sj.mp.4002087
108. Lezak, M. D. (1995). Neuropsychological Assessment, 3rd Edn. New York, NY: Oxford University Press.
109. Lischke, A., Berger, C., Prehn, K., Heinrichs, M., Herpertz, S. C., and Domes, G. (2011). Intranasal oxytocin enhances emotion recognition from dynamic facial expressions and leaves eye-gaze unaffected. Psychoneuroendocrinology 37, 475-481. doi: 10.1016/j.psyneuen.2011.07.015
110. List, J. A. (2004). Young, selfish and male: field evidence of social preferences. Econ. J. 114, 121-149. doi: 10.1046/j.0013-0133.2003.00180.x
111. Liu, X., Kawamura, Y., Shimada, T., Otowa, T., Koishi, S., Sugiyama, T., et al. (2010). Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population. J. Hum. Genet. 55, 137-141. doi: 10.1038/jhg.2009.140
112. Lori, A., Lee, I., Cubells, J. F., Binder, E. B., Lehtimäki, T., Puura, K., et al. (2012). "Single nucleotide polymorphism (SNP) fine mapping of the AVPR1A and OXTR loci reveals an OXTR association with a social memory endophenotype in probands with autism and their family members, " in Conference Presentation at American Society of Human Genetics (San Fransisco, CA).
113. Loup, F., Tribollet, E., Dubois-Dauphin, M., and Dreifuss, J. J. (1991). Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain: an autoradiographic study. Brain Res. 555, 220-232. doi: 10.1016/0006-8993(91)90345-V
114. Lucht, M. J., Barnow, S., Sonnenfeld, C., Rosenberger, A., Grabe, H. J., Schroeder, W., et al. (2009). Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 860-866. doi: 10.1016/j.pnpbp.2009.04.004
115. MacDonald, K. (2012). Sex, receptors, and attachment: a review of individual factors influencing response to oxytocin. Front. Neurosci. 6:194. doi: 10.3389/fnins.2012.00194
116. MacDonald, K., and Feifel, D. (2012). Oxytocin in schizophrenia: a review of evidence for its therapeutic effects. Acta Neuropsychiatr. 24, 130-146. doi: 10.1111/j.1601-5215.2011.00634.x
117. MacDonald, K., and Feifel, D. (2013). Helping oxytocin deliver: considerations in the development of oxytocin-based therapeutics for brain disorders. Front. Neurosci. 7, 1-20. doi: 10.3389/fnins.2013.00035
118. Magai, C., Consedine, N., Krivoshekova, Y., Kudadjie-Gyamfi, E., and McPherson, R. (2006). Emotion experience and expression across the adult life span: insights from a multimodal assessment study. Psychol. Aging 21, 303-317. doi: 10.1037/0882-7974.21.2.303
119. Marsh, A., Yu, H., Pine, D., and Blair, R. (2010). Oxytocin improves specific recognition of positive facial expressions. Psychopharmacology 209, 225-232. doi: 10.1007/s00213-010-1780-4
120. Mather, M., and Carstensen, L. L. (2005). Aging and motivated cognition: the positivity effect in attention and memory. Trends Cogn. Sci. 9, 496-502. doi: 10.1016/j.tics.2005.08.005
121. Meinlschmidt, G., and Heim, C. (2007). Sensitivity to intranasal oxytocin in adult men with early parental separation. Biol. Psychiatry 61, 1109-1111. doi: 10.1016/j.biopsych.2006.09.007
122. Melis, M. R., Mauri, A., and Argiolas, A. (1995). Opposite changes in the content of oxytocin-and vasopressin-like immunoreactive peptides in the rat thymus during aging. Regul. Pept. 59, 335-340. doi: 10.1016/0167-0115(95)00088-S
123. Melis, M. R., Spano, M. S., Succu, S., and Argiolas, A. (1999). The oxytocin antagonist d(CH2)5Tyr(Me)2-Orn8-vasotocin reduces non-contact penile erections in male rats. Neurosci. Lett. 265, 171-174. doi: 10.1016/S0304-3940(99)00236-0
124. Melis, M. R., Stancampiano, R., Fratta, W., and Argiolas, A. (1992). Oxytocin concentration changes in different rat brain areas but not in plasma during aging. Neurobiol. Aging 13, 783-786. doi: 10.1016/0197-4580(92)90102-4
125. Meyer-Lindenberg, A., Domes, G., Kirsch, P., and Heinrichs, M. (2011). Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat. Rev. Neurosci. 12, 524-538. doi: 10.1038/nrn3044
126. Mikolajczak, M., Pinon, N., Lane, A., de Timary, P., and Luminet, O. (2010). Oxytocin not only increases trust when money is at stake, but also when confidential information is in the balance. Biol. Psychol. 85, 182-184. doi: 10.1016/j.biopsycho.2010.05.010
127. Nielsen, L., and Mather, M. (2011). Emerging perspectives in social neuroscience and neuroeconomics of aging. Soc. Cogn. Affect. Neurosci. 6, 149-164. doi: 10.1093/scan/nsr019
128. Norman, G. J., Cacioppo, J. T., Morris, J. S., Karelina, K., Malarkey, W. B., DeVries, A. C., et al. (2011). Selective influences of oxytocin on the evaluative processing of social stimuli. J. Psychopharmacol. 25, 1313-1319. doi: 10.1177/0269881110367452
129. Parker, K. J., Hoffman, C. L., Hyde, S. A., Cummings, C. S., and Maestripieri, D. (2010). Effects of age on cerebrospinal fluid oxytocin levels in free-ranging adult female and infant rhesus macaques. Behav. Neurosci. 124, 428-433. doi: 10.1037/a0019576
130. Pedersen, C. A., Caldwell, J. D., Walker, C., Ayers, G., and Mason, G. A. (1994). Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial preoptic areas. Behav. Neurosci. 108, 1163. doi: 10.1037/0735-7044.108.6.1163
131. Pessoa, L., and Adolphs, R. (2010). Emotion processing and the amygdala: from a 'low road' to 'many roads' of evaluating biological significance. Nat. Rev. Neurosci. 11, 773-783. doi: 10.1038/nrn2920
132. Petrovic, P., Kalisch, R., Singer, T., and Dolan, R. J. (2008). Oxytocin attenuates affective evaluations of conditioned faces and amygdala activity. J. Neurosci. 28, 6607-6615. doi: 10.1523/JNEUROSCI.4572-07.2008
133. Phan, K. L., Sripada, C. S., Angstadt, M., and McCabe, K. (2010). Reputation for reciprocity engages the brain reward center. Proc. Natl. Acad. Sci. U.S.A. 107, 13099-13104. doi: 10.1073/pnas.1008137107
134. Phillips, L. H., Henry, J. D., Hosie, J. A., and Milne, A. B. (2008). Effective regulation of the experience and expression of negative affect in old age. J. Gerontol. Series B Psychol. Sci. Soc. Sci. 63, P138-P145. doi: 10.1093/geronb/63.3.P138
135. Quinn, R. (2005). Comparing rat's to human's age: how old is my rat in people years? Nutrition 21, 775-777. doi: 10.1016/j.nut.2005.04.002
136. Raz, N. (2005). "The aging brain observed in vivo: differential changes and their modifiers, " in Cognitive Neuroscience of Aging: Linking Cognitive and Cerebral Aging, eds R. Cabeza, L. Nyberg, and D. Park (New York, NY: Oxford University Press), 19-57.
137. Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., et al. (2005). Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb. Cortex 15, 1676-1689. doi: 10.1093/cercor/bhi044
138. Riediger, M., Schmiedek, F., Wagner, G. G., and Lindenberger, U. (2009). Seeking pleasure and seeking pain: differences in prohedonic and contra-hedonic motivation from adolescence to old age. Psychol. Sci. 20, 1529-1535. doi: 10.1111/j.1467-9280.2009.02473.x
139. Riedl, R., and Javor, A. (2011). The biology of trust: integrating evidence from genetics, endocrinology, and functional brain imaging. J. Neurosci. Psychol. Econ. 5, 63-91. doi: 10.1037/a0026318
140. Riem, M. M., Bakermans-Kranenburg, M. J., Pieper, S., Tops, M., Boksem, M. A., Vermeiren, R. R., et al. (2011). Oxytocin modulates amygdala, insula, and inferior frontal gyrus responses to infant crying: a randomized controlled trial. Biol. Psychiatry 70, 291-297. doi: 10.1016/j.biopsych.2011.02.006
141. Rimmele, U., Hediger, K., Heinrichs, M., and Klaver, P. (2009). Oxytocin makes a face in memory familiar. J. Neurosci. 29, 38-42. doi: 10.1523/JNEUROSCI.4260-08.2009
142. Rockliff, H., Karl, A., McEwan, K., Gilbert, J., Matos, M., and Gilbert, P. (2011). Effects of intranasal oxytocin on 'compassion focused imagery'. Emotion 11, 1388-1396. doi: 10.1037/a0023861
143. Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., and Keltner, D. (2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc. Natl. Acad. Sci. U.S.A. 106, 21437-21341. doi: 10.1073/pnas.0909579106
144. Ruffman, T., Henry, J. D., Livingstone, V., and Phillips, L. H. (2008). A meta-analytic review of emotion recognition and aging: implications for neuropsychological models of aging. Neurosci. Biobehav. Rev. 32, 863-881. doi: 10.1016/j.neubiorev.2008.01.001
145. Ruffman, T., Murray, J., Halberstadt, J., and Vater, T. (2012). Age-related differences in deception. Psychol. Aging 27, 543-549. doi: 10.1037/a0023380
146. Samanez-Larkin, G. R., and Carstensen, L. L. (2011). "Socioemotional functioning and the aging brain, " in The Handbook of Social Neuroscience, eds J. Decety and J. T. Cacioppo (New York, NY: Oxford University Press), 507-523.
147. Sauer, C., Montag, C., Reuter, M., and Kirsch, P. (2013). Imaging oxytocin x dopamine interactions: an epistasis effect of CD38 and COMT gene variants influences the impact of oxytocin on amygdala activation to social stimuli. Front. Neurosci. 7:45. doi: 10.3389/fnins.2013.00045
148. Sauer, C., Montag, C., Worner, C., Kirsch, P., and Reuter, M. (2012). Effects of a common variant in the CD38 gene on social processing in an oxytocin challenge study: possible links to autism. Neuropsychopharmacology 37, 1474-1482. doi: 10.1038/npp.2011.333
149. Savaskan, E., Ehrhardt, R., Schulz, A., Walter, M., and Schächinger, H. (2008). Post-learning intranasal oxytocin modulates human memory for facial identity. Psychoneuroendocrinology 33, 368-374. doi: 10.1016/j.psyneuen.2007.12.004
150. Scheele, D., Striepens, N., Güntürkün, O., Deutschländer, S., Maier, W., Kendrick, K. M., et al. (2012). Oxytocin modulates social distance between males and females. J. Neurosci. 32, 16074-16079. doi: 10.1523/JNEUROSCI.2755-12.2012
151. Scheele, D. A., Scheele, D., Wille, A., Kendrick, K. M., Becker, B., Güntürkün, O., et al. (2013). Oxytocin alters the human reward system to maintain romantic love [Abstract]. Biol. Psychiatry 73, 95S-95S.
152. Scheibe, S., and Blanchard-Fields, F. (2009). Effects of regulating emotions on cognitive performance: what is costly for young adults is not so costly for older adults. Psychol. Aging 24, 217-223. doi: 10.1037/a0013807
153. Scheibe, S., and Carstensen, L. L. (2010). Emotional aging: recent findings and future trends. J. Gerontol. Series B Psychol. Sci. Soc. Sci. 65B, 135-144. doi: 10.1093/geronb/gbp132
154. Schneiderman, I., Zagoory-Sharon, O., Leckman, J. F., and Feldman, R. (2012). Oxytocin during the initial stages of romantic attachment: relations to couples' interactive reciprocity. Psychoneuroendocrinology 37, 1277-1285. doi: 10.1016/j.psyneuen.2011.12.021
155. Shahrestani, S., Kemp, A. H., and Guastella, A. J. (2013). The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: a meta-analysis. Neuropsychopharmacology. doi: 10.1038/npp.2013.86. [Epub ahead of print].
156. Shamay-Tsoory, S. G. (2010). One hormonal system for love and envy: a reply to tops. Biol. Psychiatry 67, e7. doi: 10.1016/j.biopsych.2009.09.002
157. Shamay-Tsoory, S. G., Fischer, M., Dvash, J., Harari, H., Perach-Bloom, N., and Levkovitz, Y. (2009). Intranasal administration of oxytocin increases envy and schadenfreude (gloating). Biol. Psychiatry 66, 864-870. doi: 10.1016/j.biopsych.2009.06.009
158. Singer, T., Snozzi, R., Bird, G., Petrovic, P., Silani, G., Heinrichs, M., et al. (2008). Effects of oxytocin and prosocial behavior on brain responses to direct and vicariously experienced pain. Emotion 8, 781-791. doi: 10.1037/a0014195
159. Spielberger, C. D., Gorsuch, R. L., and Lushene, R. F. (1970). Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologist Press.
160. St. Jaques, P. L., Winecoff, A., and Cabeza, R. (2013). "Emotion and aging, " in The Cambridge Handbook of Human Affective Neuroscience, eds J. Armony and P. Vuilleumier (Cambridge, MA: Cambridge University Press), 635-661.
161. Tansey, K. E., Brookes, K. J., Hill, M. J., Cochrane, L. E., Gill, M., Skuse, D., et al. (2010). Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: genetic and molecular studies. Neurosci. Lett. 474, 163-167. doi: 10.1016/j.neulet.s2010.03.035
162. Taylor, S. E., Gonzaga, G. C., Klein, L. C., Hu, P., Greendale, G. A., and Seeman, T. E. (2006). Relation of oxytocin to psychological stress responses and hypothalamic-pituitary-adrenocortical axis activity in older women. Psychosom. Med. 68, 238-245. doi: 10.1097/01.psy.0000203242.95990.74
163. Teachman, B. A. (2006). Aging and negative affect: the rise and fall and rise of anxiety and depression symptoms. Psychol. Aging 21, 201. doi: 10.1037/0882-7974.21.1.201
164. Tessitore, A., Hariri, A. R., Fera, F., Smith, W. G., Das, S., Weinberger, D. R., et al. (2005). Functional changes in the activity of brain regions underlying emotion processing in the elderly. Psychiatry Res. Neuroimaging 139, 9-18. doi: 10.1016/j.pscychresns.2005.02.009
165. Theodoridou, A., Rowe, A. C., Penton-Voak, I. S., and Rogers, P. J. (2009). Oxytocin and social perception: oxytocin increases perceived facial trustworthiness and attractiveness. Horm. Behav. 56, 128-132. doi: 10.1016/j.yhbeh.2009.03.019
166. Tops, M. (2009). Oxytocin: envy or engagement in others? Biol. Psychiatry 67, e5-e6. doi: 10.1016/j.biopsych.2009.08.032
167. Van Anders, S. M., Goldey, K. L., and Kuo, P. X. (2011). The steroid/peptide theory of social bonds: integrating testosterone and peptide responses for classifying social behavioral contexts. Psychoneuroendocrinology 36, 1265-1275. doi: 10.1016/j.psyneuen.2011.06.001
168. Van I, Jzendoorn, M. H., and Bakermans-Kranenburg, M. J. (2012). A sniff of trust: meta-analysis of the effects of intranasal oxytocin administration on face recognition, trust to in-group, and trust to out-group. Psychoneuroendocrinology 37, 438-443. doi: 10.1016/j.psyneuen.2011.07.008
169. Verhaeghen, P., and Salthouse, T. (1997). Meta-analyses of age-cognition relations in adulthood: estimates of linear and nonlinear age effects and structural models. Psychol. Bull. 122, 231-249. doi: 10.1037/0033-2909.122.3.231
170. Viviani, D., Charlet, A., van den Burg, E., Robinet, C., Hurni, N., Abatis, M., et al. (2011). Oxytocin selectively gates fear responses through distinct outputs from the central amygdala. Science 333, 104-107. doi: 10.1126/science.1201043
171. Voelkle, M., Ebner, N., Lindenberger, U., and Riediger, M. (2013). Here we go again: anticipatory and reactive mood responses to recurring unpleasant situations throughout adulthood. Emotion 13, 424-433. doi: 10.1037/a0031351
172. Walum, H., Lichtenstein, P., Neiderhiser, J. M., Reiss, D., Ganiban, J. M., Spotts, E. L., et al. (2012). Variation in the oxytocin receptor gene is associated with pair-bonding and social behavior. Biol. Psychiatry 71, 419-426. doi: 10.1016/j.biopsych.2011.09.002
173. Weisman, O., and Feldman, R. (2013). Oxytocin administration affects the production of multiple hormones. Psychoneuroendocrinology 38, 626-627. doi: 10.1016/j.psyneuen.2013.03.004
174. Westberg, L., and Walum, H. (2013). "Oxytocin and vasopressin gene variation and the neural basis of prosocial behavior, " in The Oxford Handbook of Molecular Psychology, ed T. Canli (New York, NY: Oxford University Press).
175. Wierda, M., Goudsmit, E., van der Woude, P., Purba, J., Hofman, M., Bogte, H., et al. (1991). Oxytocin cell number in the human paraventricular nucleus remains constant with aging and in Alzheimer's disease. Neurobiol. Aging 12, 511-516. doi: 10.1016/0197-4580(91)90081-T
176. Williams, L. M., Brown, K. J., Palmer, D., Liddell, B. J., Kemp, A. H., Olivieri, G., et al. (2006). The mellow years?: neural basis of improving emotional stability over age. J. Neurosci. 26, 6422-6430. doi: 10.1523/JNEUROSCI.0022-06.2006
177. Winslow, J., Noble, P., Lyons, C., Sterk, S., and Insel, T. (2003). Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys. Neuropsychopharmacology 28, 910-918. doi: 10.1038/sj.npp.1300128
178. Wittfoth-Schardt, D., Grunding, J., Wittfoth, M., Lanfermann, H., Heinrichs, M., Domes, G., et al. (2012). Oxytocin modulates neural reactivity to children's faces as a function of social salience. Neuropsychopharmacology 37, 1799-1807. doi: 10.1038/npp.2012.47
179. Wright, C. I., Wedig, M. M., Williams, D., Rauch, S. L., and Albert, M. S. (2006). Novel fearful faces activate the amygdala in healthy young and elderly adults. Neurobiol. Aging 27, 361-374. doi: 10.1016/j.neurobiolaging.2005.01.014
180. Yoshida, M., Takayanagi, Y., Inoue, K., Kimura, T., Young, L. J., Onaka, T., et al. (2009). Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J. Neurosci. 29, 2259-2271. doi: 10.1523/JNEUROSCI.5593-08.2009
181. Yu, K.-L., Tamada, Y., Suwa, F., Fang, Y.-R., and Tang, C.-S. (2006). Age-related changes in oxytocin-, arginine vasopressin-and nitric oxide synthase-expressing neurons in the supraoptic nucleus of the rat. Life Sci. 78, 1143-1148.
182. Zak, P. J., Kurzban, R., and Matzner, W. T. (2005). Oxytocin is associated with human trustworthiness. Horm. Behav. 48, 522-527. doi: 10.1016/j.yhbeh.2005.07.009
183. Zbuzek, V., Fuchs, A., Zbuzek, V. K., and Wu, W. (1988). Neurohypophyseal aging: differential changes in oxytocin and vasopressin release, studied in Fischer 344 and Sprague-Dawley rats. Neuroendocrinology 48, 619-626. doi: 10.1159/000125072
184. Zetzsche, T., Frasch, A., Jirikowski, G., Murck, H., and Steiger, A. (1996). Nocturnal oxytocin secretion is reduced in major depression. Biol. Psychiatry 39, 584. doi: 10.1016/0006-3223(96)84235-1
185. Zink, C. F., and Meyer-Lindenberg, A. (2012). Human neuroimaging of oxytocin and vasopressin in social cognition. Horm. Behav. 61, 400-409. doi: 10.1016/j.yhbeh.2012.01.016