A review of warfarin dosing with concurrent acetaminophen therapy

Journal of Pharmacy Practice

Volumn 26, Issue 5, 2013, Pages 518-521

  Pinson, G Michelle ^a   Beall, Jennifer W ^a   Kyle, Jeffrey A ^a  

^a SAMFORD UNIVERSITY   (United States)

Author keywords

acetaminophen; interaction; warfarin

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; COUMARIN DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; PARACETAMOL; PROTHROMBIN; WARFARIN;

ANTICOAGULANT THERAPY; DRUG DOSE REDUCTION; GLUCURONIDATION; HUMAN; INTERNATIONAL NORMALIZED RATIO; LIVER FUNCTION TEST; MAXIMUM PLASMA CONCENTRATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SHOULDER PAIN; SYSTEMATIC REVIEW; THROMBOTEST; TIME TO MAXIMUM PLASMA CONCENTRATION;

ACETAMINOPHEN; INTERACTION; WARFARIN;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANTICOAGULANTS; DRUG INTERACTIONS; DRUG MONITORING; HUMANS; INTERNATIONAL NORMALIZED RATIO; PRACTICE GUIDELINES AS TOPIC; THROMBOEMBOLISM; WARFARIN;

EID: 84884685080     PISSN: 08971900     EISSN: 15311937     Source Type: Journal    
DOI: 10.1177/0897190013488802     Document Type: Review

References (10)

1. Ansell J, Hirsh J, Hylek E, et al. Pharmacology and management of the vitamin K antagonists: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2008 ; 133 (suppl 6). 160S - 198S
2. Boeijinga JJ, Boerstra EE, Ris P, et al. Interaction between paracetamol and coumarin anticoagulants. Lancet. 1982 ; 1 (8270). 506
3. Hylek EM, Heiman H, Skates SJ, et al. Acetaminophen and other risk factors for excessive warfarin anticoagulation. JAMA. 1998 ; 279 (9). 657-662
4. Kwan D, Bartle WR, Walker SE. The effects of acetaminophen on pharmacokinetics and pharmacodynamics of warfarin. J Clin Pharmacol. 1999 ; 39 (1). 68-75
5. Lehmann DF. Enzymatic shunting: resolving the acetaminophen-warfarin controversy. Pharmacotherapy. 2000 ; 20 (12). 1464-1468
6. Mahe L, Bertrand N, Drouet L, et al. Paracetamol: a haemorrhagic risk factor in patients on warfarin. Br J Clin Pharmacol. 2004 ; 59 (3). 371-374
7. Mahe L, Bertrand N, Drouet L, et al. Interaction between paracetamol and warfarin in patients: a double-blind, placebo-controlled, randomized study. Haematologica. 2006 ; 91 (12). 1621-1627
8. Parra D, Beckey NP, Stevens GR. The effect of acetaminophen on the international normalized ratio in patients stabilized on warfarin therapy. Pharmacotherapy. 2007 ; 27 (5). 675-683
9. Andrews FJ. Retroperitoneal haematoma after paracetamol increased anticoagulation. Emerg Med J. 2002 ; 19 (1). 84-85
10. Gebauer MG, Nyfort-Hansen K, Henschke PJ, et al. Warfarin and acetaminophen interactions. Pharmacotherapy. 2003 ; 23 (1). 109-112