Overexpression of galectin-3 enhances migration of colon cancer cells related to activation of the K-Ras-Raf-Erk1/2 pathway

Journal of Gastroenterology

Volumn 48, Issue 3, 2013, Pages 350-359

  Wu, Keng Liang ^a,b   Huang, Eng Yen ^a,b   Jhu, En Wei ^a   Huang, Ya Hui ^a   Su, Wen Hong ^a   Chuang, Pei Chin ^a   Yang, Kuender D ^c  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c SHOW CHWAN MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Cell migration; Colorectal carcinoma; Erk1 2; Galectin 3; K Ras; P38

Indexed keywords

GALECTIN 3; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RAF PROTEIN; SHORT HAIRPIN RNA; PROTEIN P21; RAS PROTEIN; SMALL INTERFERING RNA; TUMOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CELL MIGRATION; CELL STRAIN CACO 2; COLON CANCER; CONTROLLED STUDY; FEMALE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTRACELLULAR SIGNALING; LUNG METASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WOUND HEALING; ANIMAL; BIOSYNTHESIS; CANCER TRANSPLANTATION; CELL MOTION; COLON TUMOR; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN; LIVER TUMOR; LUNG TUMOR; METABOLISM; METASTASIS; PATHOLOGY; PHYSIOLOGY; SCID MOUSE; TUMOR CELL CULTURE; XENOGRAFT;

ANIMALS; CACO-2 CELLS; CELL MOVEMENT; COLONIC NEOPLASMS; FEMALE; GALECTIN 3; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; LIVER NEOPLASMS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, SCID; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; PROTO-ONCOGENE PROTEINS P21(RAS); RAF KINASES; RAS PROTEINS; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 84884614538     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-012-0663-3     Document Type: Article

References (22)

1. Schoeppner HL, Raz A, Ho SB, Bresalier RS. Expression of an endogenous galactose-binding lectin correlates with neoplastic progression in the colon. Cancer. 1995;75: 2818-26.
2. Sanjuán X, Fernández PL, Castells A, Castronovo V, van der Brule F, Liu FT, et al. Differential expression of galectin 3 and galectin 1 in colorectal cancer progression. Gastroenterology. 1997;113: 1906-15.
3. Nagy N, Legendre H, Engels O, André S, Kaltner H, Wasano K, et al. Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin finger-printing. Cancer. 2003;97: 1849-58.
4. Glinsky VV, Glinsky GV, Glinskii OV, Huxley VH, Turk JR, Mossine VV, et al. Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium. Cancer Res. 2003;63: 3805-11.
5. Ellerhorst J, Nguyen T, Cooper DN, Lotan D, Lotan R. Differential expression of endogenous galectin-1 and galectin-3 in human prostate cancer cell lines and effects of overexpressing galectin-1 on cell phenotype. Int J Oncol. 1999;14: 217-24.
6. Van den Brule F, Califice S, Garnier F, Fernandez PL, Berchuck A, Castronovo V. Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin. Lab Invest. 2003;83: 377-86.
7. Su WH, Chen HI, Jen CJ. Polymorphonuclear leukocyte transverse migration induces rapid alterations in endothelial focal contacts. J Leukoc Biol. 2007;82: 542-50.
8. Chuang PC, Sun HS, Chen TM, Tsai SJ. Prostaglandin E2 induces fibroblast growth factor 9 via EP3-dependent protein kinase C delta and Elk-1 signaling. Mol Cell Biol. 2006;26: 8281-92.
9. Raz A, Lotan R. Endogenous galactoside-binding lectins: a new class of functional tumor cell surface molecules related to metastasis. Cancer Metastasis Rev. 1987;6: 433-52.
10. Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, et al. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature. 2009;457: 102-6.
11. Endo K, Kohnoe S, Tsujita E, Watanabe A, Nakashima H, Baba H, et al. Galectin-3 expression is a potent prognostic marker in colorectal cancer. Anticancer Res. 2005;25: 3117-21.
12. Bresalier RS, Mazurek N, Sternberg LR, Byrd JC, Yunker CK, Nangia-Makker P, et al. Metastasis of human colon cancer is altered by modifying expression of the beta-galactoside-binding protein galectin 3. Gastroenterology. 1998;115: 287-96.
13. Dudas SP, Yunker CK, Sternberg LR, Byrd JC, Bresalier RS. Expression of human intestinal mucin is modulated by the bgalactoside binding protein galectin-3 in colon cancer. Gastroenterology. 2002;123: 817-26.
14. Saravanan C, Liu FT, Gipson IK, Panjwani N. Galectin-3 promotes lamellipodia formation in epithelial cells by interacting with complex N-glycans on alpha3beta1 integrin. J Cell Sci. 2009;122: 3684-93.
15. Hsu DK, Chernyavsky AI, Chen HY, Yu L, Grando SA, Liu FT. Endogenous galectin-3 is localized in membrane lipid rafts and regulatesmigration of dendritic cells. J Invest Dermatol. 2009;129: 573-83.
16. Wang Y, Nangia-Makker P, Tait L, Balan V, Hogan V, Pienta KJ, et al. Regulation of prostate cancer progression by galectin-3. Am J Pathol. 2009;174: 1515-23.
17. Hittelet A, Legendre H, Nagy N, Bronckart Y, Pector JC, Salmon I, et al. Upregulation of galectins-1 and -3 in human colon cancer and their role in regulating cell migration. Int J Cancer. 2003;103: 370-9.
18. Inder KL, Lau C, Loo D, Chaudhary N, Goodall A, Martin S, et al. Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction. J Biol Chem. 2009;284: 28410-9.
19. Hoogwater FJ, Nijkamp MW, Smakman N, Steller EJ, Emmink BL, Westendorp BF, et al. Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells. Gastroenterology. 2010;138: 2357-67.
20. Dreissigacker U, Mueller MS, Unger M, Siegert P, Genze F, Gierschik P, et al. Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38. Cell Signal. 2006;18: 1156-68.
21. Woods D, Cherwinski H, Venetsanakos E, Bhat A, Gysin S, Humbert M, et al. Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway. Mol Cell Biol. 2001;21: 3192-205.
22. Shalom-Feuerstein R, Plowman SJ, Rotblat B, Ariotti N, Tian T, Hancock JF, et al. K-ras nanoclustering is subverted by overexpression of the scaffold protein galectin-3. Cancer Res. 2008; 68(16): 6608-16.