Benefits and drawbacks of preimplantation genetic diagnosis (PGD) for reciprocal translocations: Lessons from a prospective cohort study

European Journal of Human Genetics

Volumn 21, Issue 10, 2013, Pages 1035-1041

  Scriven, Paul N ^a,b   Flinter, Frances A ^a   Khalaf, Yakoub ^a   Lashwood, Alison ^a   Mackie Ogilvie, Caroline ^a  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

diagnostic accuracy; FISH; meiotic segregation; PGD; reciprocal translocation

Indexed keywords

ARTICLE; CHROMOSOME REARRANGEMENT; COHORT ANALYSIS; CONCEPTION; DIAGNOSTIC ACCURACY; EMBRYO; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HETEROZYGOTE; HUMAN; HUMAN TISSUE; INFERTILITY THERAPY; LIVE BIRTH; MAJOR CLINICAL STUDY; MALE; MEIOSIS; PREDICTIVE VALUE; PREGNANCY DISORDER; PREIMPLANTATION GENETIC DIAGNOSIS; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; PROGENY; PROSPECTIVE STUDY; RECIPROCAL CHROMOSOME TRANSLOCATION; SENSITIVITY AND SPECIFICITY; SPONTANEOUS ABORTION;

ABORTION, SPONTANEOUS; ADULT; CHROMOSOME SEGREGATION; COHORT STUDIES; FEMALE; GENETIC TESTING; HETEROZYGOTE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; PREGNANCY; PREIMPLANTATION DIAGNOSIS; PROSPECTIVE STUDIES; TRANSLOCATION, GENETIC;

EID: 84884592146     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2013.9     Document Type: Article

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