Salivary biomarker analysis complementing regular clinical examination

Biomarkers in Medicine

Volumn 7, Issue 5, 2013, Pages 701-708

  Front, Eran ^a   Laster, Zvi ^a,b   Unis, Rim ^a   Gavish, Moshe ^c   Nagler, Rafael M ^c  

^a BARUCH PADEH MEDICAL CENTER   (Israel)

^b BAR ILAN UNIVERSITY   (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

biomarkers; inflammation; oxidative stress; periodontitis; saliva

Indexed keywords

ALBUMIN; ALPHA AMYLASE SALIVA ISOENZYME; BIOLOGICAL MARKER; CALCIUM; CARBONYL DERIVATIVE; CHLORIDE; INTERLEUKIN 1ALPHA; LACTATE DEHYDROGENASE; MAGNESIUM; PHOSPHATE; POTASSIUM; SODIUM; URIC ACID;

ADULT; ARTICLE; BIOCHEMICAL COMPOSITION; CLINICAL ARTICLE; CLINICAL EXAMINATION; DIAGNOSTIC ACCURACY; DISEASE MARKER; DISEASE SEVERITY; FEMALE; FULL MOUTH BLEEDING SCORE; FULL MOUTH PLAQUE SCORE; HUMAN; MALE; MOLECULAR INTERACTION; MOUTH EXAMINATION; OXIDATIVE STRESS; PATIENT MONITORING; PERIODONTITIS; SALIVA ANALYSIS; SALIVA LEVEL; SALIVATION; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY;

ADULT; BIOLOGICAL MARKERS; CLINICAL CHEMISTRY TESTS; FEMALE; HUMANS; MALE; MIDDLE AGED; PERIODONTITIS; SALIVA;

EID: 84884578612     PISSN: 17520363     EISSN: 17520371     Source Type: Journal    
DOI: 10.2217/bmm.13.76     Document Type: Article

References (32)

1. Armitage GC, Cullinan MP. Comparison of the clinical features of chronic and aggressive periodontitis. Periodontol. 2000 53, 12-27 (2010
2. Savage A, Eaton KA, Moles DR, Needleman I. A systematic review of definitions of periodontitis and methods that have been used to identify this disease. J. Clin. Periodontol. 36, 458-467 (2009
3. Buduneli N, Kinane DF. Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis. J. Clin. Periodontol. 38(Suppl. 11), 85-105 (2011
4. Nagler RM, Hershkovich O, Lischinsky S, Diamond E, Reznick AZ. Saliva analysis in the clinical setting: Revisiting an underused diagnostic tool. J. Investig. Med. 50, 214-225 (2002
5. Westfelt E, Bragd L, Socransky SS, Haffajee AD, Nyman S, Lindhe J. Improved periodontal conditions following therapy. J. Clin. Periodontol. 12, 283-293 (1985
6. Loe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol. Scand. 21, 533-551 (1963
7. Joss A, Adler R, Lang NP. Bleeding on probing. A parameter for monitoring periodontal conditions in clinical practice. J. Clin. Periodontol. 21(6), 402-408 (1994
8. Lang NP, Adler R, Joss A, Nyman S. Absence of bleeding on probing. An indicator of periodontal stability. J. Clin. Periodontol. 17, 714-721 (1990
9. Bahar G, Feinmesser R, Shpitzer T, Popovtzer A, Nagler RM. Salivary analysis in oral cancer patients: Reactive nitrogen species, and antioxidant profile. Cancer 109, 54-59 (2007
10. Nagler RM, Lischinsky S, Diamond E, Klein I, Reznick AZ. New insights into salivary lactate dehydrogenase of human subjects. J. Lab. Clin. Med. 137, 363-369 (2001
11. Saheb Jamee M, Eslami M, Atarbashi Moghadam F, Sarafnejad A. Salivary concentration of TNFa, IL1a, IL6, and IL8 in oral squamous cell carcinoma. Med. Oral. Patol. Oral Circ. Bucal. 13, e292-e295 (2008
12. Nagler RM, Klein I, Zarzhevsky N, Drigues N, Reznick AZ. Characterization of the differentiated antioxidant profile of human saliva. Free Radic. Biol. Med. 32, 268-277 (2002
13. Buss H, Chant P, Sluis KB, Domigan NM, Winterbourne CC. Protein carbonyl measurement by a sensitive ELISA method. Free Radic. Biol. Med. 23, 361-366 (1997
14. Estrov Z, Kurzrock R, Talpaz M. Interleukin-1 and its inhibitors: Implications for disease biology and therapy. Cancer Treat. Res. 80, 51-82 (1995
15. Gravallese EM. Bone destruction in arthritis. Ann. Rheum. Dis. 61(Suppl. 2), ii84-ii86 (2002
16. Suda T, Kobayashi K, Jimi E, Kalburgi N, Verma S. The molecular basis of osteoclast differentiation and activation. Novartis Found. Symp. 232, 235-250 (2001
17. Schenkels LC, Veerman EC, Nieuw Amerongen AV. Biochemical composition of human saliva in relation to other mucosal fluids. Crit. Rev. Oral Biol. Med. 6, 161-175 (1995
18. Koregol AC, More SP, Nainegali S, Kalburgi N, Verma S. Analysis of inorganic ions in gingival crevicular fluid as indicators of periodontal disease activity: A clinico-biochemical study. Contemp. Clin. Dent. 2, 278-282 (2011
19. Becerik S, Öztürk VO, Atmaca H, Atilla G, Emingil G. Gingival crevicular fluid and plasma acute-phase cytokine levels in different periodontal diseases. J. Periodontol. 83, 1304-1313 (2012
20. Erdemir EO, Erdemir A. The detection of salivary minerals in smokers and non-smokers with chronic periodontitis by the inductively coupled plasma-atomic emission spectrophotometry technique. J. Periodontol. 77, 990-995 (2006
21. Sculley DV, Langley-Evans SC. Salivary antioxidants and periodontal disease status. Proc. Nutr. Soc. 61, 137-143 (2002
22. Tsai CC, Chen HS, Chen SL et al. Lipid peroxidation: A possible role in the induction and progression of chronic periodontitis. J. Periodontal Res. 40, 378-384 (2005
23. Wei D, Zhang XL, Wang YZ, Yang CX, Chen G. Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy. Aust. Dent. J. 55, 70-78 (2010
24. Sculley DV, Langley-Evans SC. Periodontal disease is associated with lower antioxidant capacity in whole saliva and evidence of increased protein oxidation. Clin. Sci. (Lond.) 105, 167-172 (2003
25. Rathnayake N, Akerman S, Klinge B et al. Salivary biomarkers of oral health-a cross-sectional study. J. Clin. Periodontol. 40, 140-147 (2013
26. Dabra S, China K, Kaushik A. Salivary enzymes as diagnostic markers for detection of gingival/periodontal disease and their correlation with the severity of the disease. J. Indian Soc. Periodontol. 16, 358-364 (2012
27. Tóthová L, Celecová V, Celec P. Salivary markers of oxidative stress and their relation to periodontal and dental status in children. Dis. Markers 34, 9-15 (2013
28. Gursoy UK, Könönen E, Huumonen S et al. Salivary type I collagen degradation end-products and related matrix metalloproteinases in periodontitis. J. Clin. Periodontol. 40, 18-25 (2013
29. Rangé H, Léger T, Huchon C et al. Salivary proteome modifications associated with periodontitis in obese patients. J. Clin. Periodontol. 39, 799-806 (2012
30. Olayanju OA, Rahamon SK, Joseph IO, Arinola OG. Salivary immunoglobulin classes in Nigerians with periodontitis. J. Contemp. Dent. Pract. 13, 163-166 (2012
31. Sezer U, Ciçek Y, Canakçi CF. Increased salivary levels of 8-hydroxydeoxyguanosine may be a marker for disease activity for periodontitis. Dis. Markers 32, 165-172 (2012
32. Dabra S, Singh P. Evaluating the levels of salivary alkaline and acid phosphatase activities as biochemical markers for periodontal disease: A case series. Dent. Res. J. (Isfahan) 9, 41-45 (2012