Hunting for autoantibodies in multiple sclerosis

Neurology

Volumn 81, Issue 11, 2013, Pages 944-945

  Hemmer, Bernhard ^a,b,c   Srivastava, Rajneesh ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b Technische Universität München Munich Cluster for Systems Neurology   (Germany)

^c German Competence Network Multiple Sclerosis (KKNMS)   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BIOLOGICAL MARKER; CELL PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA CHAIN;

ANTIBODY RESPONSE; BRAIN TISSUE; BREAST CANCER; CEREBROSPINAL FLUID; CLINICAL PRACTICE; DISEASE ACTIVITY; DISEASE COURSE; EDITORIAL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION SYSTEM; HUMAN; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; LEUKEMIA; LYMPHOCYTE SUBPOPULATION; MAMMAL CELL; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MICROARRAY; PROTEIN PROCESSING; TISSUE INJURY; WHITE MATTER;

AUTOANTIBODIES; B-LYMPHOCYTES; HUMANS; MULTIPLE SCLEROSIS; T-LYMPHOCYTES;

EID: 84884555283     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3182a43e93     Document Type: Editorial

References (9)

1. McFarland HF, Martin R. Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol 2007;8:913-919.
2. McLaughlin KA, Wucherpfennig KW. B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. Adv Immunol 2008; 98:121-149.
3. Reiber H, Ungefehr S, Jacobi C. The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis. Mult Scler 1998;4:111-117.
4. Lennon VA, Wingerchuk DM, Kryzer TJ, et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 2004;364:2106-2112.
5. Brilot F, Dale RC, Selter RC, et al. Antibodies to native myelin oligodendrocyte glycoprotein in children with inflammatory demyelinating central nervous system disease. Ann Neurol 2009;66:833-842.
6. Srivastava R, Aslam M, Kalluri SR, et al. Potassium channel KIR4.1 as an immune target in multiple sclerosis. N Engl J Med 2012;367:115-123.
7. McLaughlin KA, Chitnis T, Newcombe J, et al. Agedependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol 2009;183: 4067-4076.
8. Breithaupt C, Schafer B, Pellkofer H, Huber R, Linington C, Jacob U. Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents. J Immunol 2008;181:1255-1263.
9. Querol L, Clark PL, Bailey MA, et al. Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Neurology 2013;81:956-963.